Tag: M.W=600-700

Raju, Telugu Bhim published the artcileHighly efficient and facile alkylation of 4H-cyclopenta-[2,1-b:3,4-b’]dithiophene in water, Safety of 2,6-Dibromo-4,4-bis(6-bromohexyl)-4H-cyclopenta[1,2-b:5,4-b’]dithiophene, the publication is RSC Advances (2014), 4(71), 37738-37745, database is CAplus.

A new and highly convenient method to perform alkylation of 4H-cyclopenta-[2,1-b:3,4-b’]dithiophene (CPDT) in aqueous conditions is reported. This method was also extended to successfully perform alkylation of 2,6-dibromo-4H-cyclopenta-[2,1-b:3,4-b’]dithiophene for the first time. This facile method has several advantages such as the exclusive use of water instead of high boiling toxic solvents, simple separation of the defect free dialkylated CPDT product I (Y = H, Br; R = hexyl, octyl, 5-bromopentyl, etc.) and the use of mild reaction conditions. Despite using mild reagents and reaction conditions, very high yields of up to 98% pure dialkylated CPDT products I are obtained much more readily by this method in less time than literature procedures. The desired dialkylated product with the alkyl halides used here.

RSC Advances published new progress about 1426829-76-6. 1426829-76-6 belongs to benzothiophene, auxiliary class Other Aromatic Heterocyclic,Bromide, name is 2,6-Dibromo-4,4-bis(6-bromohexyl)-4H-cyclopenta[1,2-b:5,4-b’]dithiophene, and the molecular formula is C21H26Br4S2, Safety of 2,6-Dibromo-4,4-bis(6-bromohexyl)-4H-cyclopenta[1,2-b:5,4-b’]dithiophene.

Referemce:
https://en.wikipedia.org/wiki/Benzothiophene,
Benzothiophene | C8H6S – PubChem

Jiang, Yuyan published the artcileAmphiphilic semiconducting polymer as multifunctional nanocarrier for fluorescence/photoacoustic imaging guided chemo-photothermal therapy, Name: 2,6-Dibromo-4,4-bis(6-bromohexyl)-4H-cyclopenta[1,2-b:5,4-b’]dithiophene, the publication is Biomaterials (2017), 168-177, database is CAplus and MEDLINE.

Chemo-photothermal nanotheranostics has the advantage of synergistic therapeutic effect, providing opportunities for optimized cancer therapy. However, current chemo-photothermal nanotheranostic systems generally comprise more than three components, encountering the potential issues of unstable nanostructures and unexpected conflicts in optical and biophys. properties among different components. We herein synthesize an amphiphilic semiconducting polymer (PEG-PCB) and utilize it as a multifunctional nanocarrier to simplify chemo-photothermal nanotheranostics. PEG-PCB has a semiconducting backbone that not only serves as the diagnostic component for near-IR (NIR) fluorescence and photoacoustic (PA) imaging, but also acts as the therapeutic agent for photothermal therapy. In addition, the hydrophobic backbone of PEG-PCB provides strong hydrophobic and π-π interactions with the aromatic anticancer drug such as doxorubicin for drug encapsulation and delivery. Such a trifunctionality of PEG-PCB eventually results in a greatly simplified nanotheranostic system with only two components but multimodal imaging and therapeutic capacities, permitting effective NIR fluorescence/PA imaging guided chemo-photothermal therapy of cancer in living mice. Our study thus provides a mol. engineering approach to integrate essential properties into one polymer for multimodal nanotheranostics.

Biomaterials published new progress about 1426829-76-6. 1426829-76-6 belongs to benzothiophene, auxiliary class Other Aromatic Heterocyclic,Bromide, name is 2,6-Dibromo-4,4-bis(6-bromohexyl)-4H-cyclopenta[1,2-b:5,4-b’]dithiophene, and the molecular formula is C21H26Br4S2, Name: 2,6-Dibromo-4,4-bis(6-bromohexyl)-4H-cyclopenta[1,2-b:5,4-b’]dithiophene.

Referemce:
https://en.wikipedia.org/wiki/Benzothiophene,
Benzothiophene | C8H6S – PubChem

Li, Jingchao published the artcileOrganic Semiconducting Pro-nanostimulants for Near-Infrared Photoactivatable Cancer Immunotherapy, Formula: C21H26Br4S2, the publication is Angewandte Chemie, International Edition (2019), 58(36), 12680-12687, database is CAplus and MEDLINE.

In this study, an organic semiconducting pro-nanostimulant (OSPS) with a near-IR (NIR) photoactivatable immunotherapeutic action for synergetic cancer therapy is presented. OSPS comprises a semiconducting polymer nanoparticle (SPN) core and an immunostimulant conjugated through a singlet oxygen (¹O₂) cleavable linkers. Upon NIR laser irradiation, OSPS generates both heat and ¹O₂ to exert combinational phototherapy not only to ablate tumors but also to produce tumor-associated antigens. More importantly, NIR irradiation triggers the cleavage of ¹O₂-cleavable linkers, triggering the remote release of the immunostimulants from OSPS to modulate the immunosuppressive tumor microenvironment. Thus, the released tumor-associated antigens in conjunction with activated immunostimulants induce a synergistic antitumor immune response after OSPS-mediated phototherapy, resulting in the inhibited growth of both primary/distant tumors and lung metastasis in a mouse xenograft model, which is not observed for sole phototherapy.

Angewandte Chemie, International Edition published new progress about 1426829-76-6. 1426829-76-6 belongs to benzothiophene, auxiliary class Other Aromatic Heterocyclic,Bromide, name is 2,6-Dibromo-4,4-bis(6-bromohexyl)-4H-cyclopenta[1,2-b:5,4-b’]dithiophene, and the molecular formula is C21H26Br4S2, Formula: C21H26Br4S2.

Referemce:
https://en.wikipedia.org/wiki/Benzothiophene,
Benzothiophene | C8H6S – PubChem

Lyu, Yan published the artcileDendronized Semiconducting Polymer as Photothermal Nanocarrier for Remote Activation of Gene Expression, Recommanded Product: 2,6-Dibromo-4,4-bis(6-bromohexyl)-4H-cyclopenta[1,2-b:5,4-b’]dithiophene, the publication is Angewandte Chemie, International Edition (2017), 56(31), 9155-9159, database is CAplus and MEDLINE.

Regulation of transgene systems is needed to develop innovative medicines. However, noninvasive remote control of gene expression has been rarely developed and remains challenging. We herein synthesize a near-IR (NIR) absorbing dendronized semiconducting polymer (DSP) and utilize it as a photothermal nanocarrier not only to efficiently deliver genes but also to spatiotemporally control gene expression in conjunction with heat-inducible promoter. DSP has a high photothermal conversion efficiency (44.2 %) at 808 nm, permitting fast transduction of NIR light into thermal signals for intracellular activation of transcription. Such a DSP-mediated remote activation can rapidly and safely result in 25- and 4.5-fold increases in the expression levels of proteins in living cells and mice, resp. This study thus provides a promising approach to optically regulate transgene systems for on-demand therapeutic transgene dosing.

Angewandte Chemie, International Edition published new progress about 1426829-76-6. 1426829-76-6 belongs to benzothiophene, auxiliary class Other Aromatic Heterocyclic,Bromide, name is 2,6-Dibromo-4,4-bis(6-bromohexyl)-4H-cyclopenta[1,2-b:5,4-b’]dithiophene, and the molecular formula is C21H26Br4S2, Recommanded Product: 2,6-Dibromo-4,4-bis(6-bromohexyl)-4H-cyclopenta[1,2-b:5,4-b’]dithiophene.

Referemce:
https://en.wikipedia.org/wiki/Benzothiophene,
Benzothiophene | C8H6S – PubChem

Zhang, Maojie published the artcileA Large-Bandgap Conjugated Polymer for Versatile Photovoltaic Applications with High Performance, Quality Control of 1514905-24-8, the publication is Advanced Materials (Weinheim, Germany) (2015), 27(31), 4655-4660, database is CAplus and MEDLINE.

Herein, we synthesized a new copolymer PM6 based on 4,8-bis(5-(2-ethylhexyl)-4-fluorothiophen-2-yl)benzo[1,2-b:4,5-b’]dithiophene(BDT-F) and 1,3-bis(thiophen-2-yl)-5,7-bis(2-ethylhexyl)benzo-[1,2-c:4,5-c’]dithiophene-4,8-dione (BDD). The optical, electrochem., and photovoltaic properties, the mol. packing pattern, and the morphol. of the blend lms were investigated. Compared with the nonfluorinated derivative PBDTBDD, PM6 exhibited a similar optical bandgap of 1.80 eV and a deeper HOMO level of -5.45 eV (-5.25 eV for PBDTBDD), which is beneficial for a high V_oc. BHJ PSCs based on PM6/PC71 BM with both conventional and inverted device structures were fabricated and showed promising photovoltaic performance: a high V_oc of 0.98 V and a PCE of 8% for the conventional devices and up to 9.2% for the inverted devices. Furthermore, the PM6/PC71BM based semitransparent device exhibited a PCE of 5.7%, which is among the highest values obtained for a semitransparent single-junction device. In addition, we found that the neat film of PM6 exhibited strong crystallinity and a dominant face on packing with respect to the electrodes, which is advantageous for charge transport. These results indicate that PM6 is a promising material for photovoltaic application.

Advanced Materials (Weinheim, Germany) published new progress about 1514905-24-8. 1514905-24-8 belongs to benzothiophene, auxiliary class Organic Photo-Voltaic Materials, OPV,BDT Donors, name is 4,8-Bis(5-(2-ethylhexyl)-4-fluorothiophen-2-yl)benzo[1,2-b:4,5-b’]dithiophene, and the molecular formula is C12H9N3O4, Quality Control of 1514905-24-8.

Referemce:
https://en.wikipedia.org/wiki/Benzothiophene,
Benzothiophene | C8H6S – PubChem

Zhang, Maojie published the artcileSynergistic effect of fluorination on molecular energy level modulation in highly efficient photovoltaic polymers, Safety of 4,8-Bis(5-(2-ethylhexyl)-4-fluorothiophen-2-yl)benzo[1,2-b:4,5-b’]dithiophene, the publication is Advanced Materials (Weinheim, Germany) (2014), 26(7), 1118-1123, database is CAplus and MEDLINE.

Four newly designed donor-acceptor polymers were prepared and characterized. The results clearly, show that fluorination on the donor and the acceptor moieties has little influence on the optical properties, but a synergistic effect on lowering their mol. energy levels. Accordingly, the photovoltaic measurements show that the PSC (polymer solar cell) device based on the tri- P2fluorinated polymer, PBT-3F, shows an enhanced PCE of 8.6%, which is among the highest for PSCs with a single heterojuncνtion structure. Therefore, introducing fluorine atoms onto the appropriate positions of the donor units in D-A polymers will be a promising method to effectively tune their mol. energy levels of for applications in PSCs.

Advanced Materials (Weinheim, Germany) published new progress about 1514905-24-8. 1514905-24-8 belongs to benzothiophene, auxiliary class Organic Photo-Voltaic Materials, OPV,BDT Donors, name is 4,8-Bis(5-(2-ethylhexyl)-4-fluorothiophen-2-yl)benzo[1,2-b:4,5-b’]dithiophene, and the molecular formula is C12H14BNO2, Safety of 4,8-Bis(5-(2-ethylhexyl)-4-fluorothiophen-2-yl)benzo[1,2-b:4,5-b’]dithiophene.

Referemce:
https://en.wikipedia.org/wiki/Benzothiophene,
Benzothiophene | C8H6S – PubChem

Lyu, Yan published the artcileA Photolabile Semiconducting Polymer Nanotransducer for Near-Infrared Regulation of CRISPR/Cas9 Gene Editing, COA of Formula: C21H26Br4S2, the publication is Angewandte Chemie, International Edition (2019), 58(50), 18197-18201, database is CAplus and MEDLINE.

Noninvasive regulation of CRISPR/Cas9 gene editing is conducive to understanding of gene function and development of gene therapy; however, it remains challenging. Herein, a photolabile semiconducting polymer nanotransducer (pSPN) is synthesized to act as the gene vector to deliver CRISPR/Cas9 plasmids into cells and also as the photoregulator to remotely activate gene editing. pSPN comprises a ¹O₂-generating backbone grafted with polyethylenimine brushes through ¹O₂-cleavable linkers. NIR photoirradiation spontaneously triggers the cleavage of gene vectors from pSPN, resulting in the release of CRISPR/Cas9 plasmids and subsequently initiating gene editing. This system affords 15- and 1.8-fold enhancement in repaired gene expression relative to the nonirradiated controls in living cells and mice, resp. As this approach does not require any specific modifications on biomol. components, pSPN represents the first generic nanotransducer for in vivo regulation of CRISPR/Cas9 gene editing.

Angewandte Chemie, International Edition published new progress about 1426829-76-6. 1426829-76-6 belongs to benzothiophene, auxiliary class Other Aromatic Heterocyclic,Bromide, name is 2,6-Dibromo-4,4-bis(6-bromohexyl)-4H-cyclopenta[1,2-b:5,4-b’]dithiophene, and the molecular formula is C21H26Br4S2, COA of Formula: C21H26Br4S2.

Referemce:
https://en.wikipedia.org/wiki/Benzothiophene,
Benzothiophene | C8H6S – PubChem

Li, Jingchao published the artcilePhotoactivatable Organic Semiconducting Pro-nanoenzymes, Safety of 2,6-Dibromo-4,4-bis(6-bromohexyl)-4H-cyclopenta[1,2-b:5,4-b’]dithiophene, the publication is Journal of the American Chemical Society (2019), 141(9), 4073-4079, database is CAplus and MEDLINE.

Therapeutic enzymes hold great promise for cancer therapy; however, in vivo remote control of enzymic activity to improve their therapeutic specificity remains challenging. This study reports the development of an organic semiconducting pro-nanoenzyme (OSPE) with a photoactivatable feature for metastasis-inhibited cancer therapy. Upon near-IR (NIR) light irradiation, this pro-nanoenzyme not only generates cytotoxic singlet oxygen (¹O₂) for photodynamic therapy (PDT), but also triggers a spontaneous cascade reaction to induce the degradation of RNA specifically in tumor microenvironment. More importantly, OSPE-mediated RNA degradation is found to downregulate the expression of metastasis-related proteins, contributing to the inhibition of metastasis after treatment. Such a photoactivated and cancer-specific synergistic therapeutic action of OSPE enables complete inhibition of tumor growth and lung metastasis in mouse xenograft model, which is not possible for the counterpart PDT nanoagent. Thus, our study proposes a phototherapeutic-proenzyme approach toward complete-remission cancer therapy.

Journal of the American Chemical Society published new progress about 1426829-76-6. 1426829-76-6 belongs to benzothiophene, auxiliary class Other Aromatic Heterocyclic,Bromide, name is 2,6-Dibromo-4,4-bis(6-bromohexyl)-4H-cyclopenta[1,2-b:5,4-b’]dithiophene, and the molecular formula is C21H26Br4S2, Safety of 2,6-Dibromo-4,4-bis(6-bromohexyl)-4H-cyclopenta[1,2-b:5,4-b’]dithiophene.

Referemce:
https://en.wikipedia.org/wiki/Benzothiophene,
Benzothiophene | C8H6S – PubChem

Xu, Cheng published the artcileSecond Near-Infrared Light-Activatable Polymeric Nanoantagonist for Photothermal Immunometabolic Cancer Therapy, HPLC of Formula: 1426829-76-6, the publication is Advanced Materials (Weinheim, Germany) (2021), 33(36), 2101410, database is CAplus and MEDLINE.

Immunometabolic modulation offers new opportunities to treat cancers as it is highly associated with cancer progression and immunosuppressive microenvironment. However, traditional regimens using nonselective small-mol. immunomodulators lead to the off-target adverse effects and insufficient therapeutic outcomes. Herein a second near-IR (NIR-II) photothermally activatable semiconducting polymeric nanoantagonist (ASPA) for synergistic photothermal immunometabolic therapy of cancer is reported. ASPA backbone is obtained by conjugating vipadenant, an antagonist to adenosine A2A receptor, onto NIR-II light-absorbing semiconducting polymer via an azo-based thermolabile linker. Under deep-penetrating NIR-II photoirradiation, ASPA induces tumor thermal ablation and subsequently immunogenic cell death, triggers the cleavage of thermolabile linker, and releases the antagonist to block the immunosuppressive adenosinergic pathway. Such a remotely controlled immunometabolic regulation potentiates cytotoxic T cell functions while suppresses regulatory T cell activities, leading to efficient primary tumor inhibition, pulmonary metastasis prevention, and long-term immunol. memory. Thereby, this work provides a generic polymeric approach for precise spatiotemporal regulation of cancer immunometabolism.

Advanced Materials (Weinheim, Germany) published new progress about 1426829-76-6. 1426829-76-6 belongs to benzothiophene, auxiliary class Other Aromatic Heterocyclic,Bromide, name is 2,6-Dibromo-4,4-bis(6-bromohexyl)-4H-cyclopenta[1,2-b:5,4-b’]dithiophene, and the molecular formula is C5H10Cl3O3P, HPLC of Formula: 1426829-76-6.

Referemce:
https://en.wikipedia.org/wiki/Benzothiophene,
Benzothiophene | C8H6S – PubChem

Zhang, Zhongqiang published the artcilePhosphate ester side-chain modified conjugated polymer for hybrid solar cells, Application of 2,6-Dibromo-4,4-bis(6-bromohexyl)-4H-cyclopenta[1,2-b:5,4-b’]dithiophene, the publication is Journal of Applied Polymer Science (2017), 134(26), n/a, database is CAplus.

Although nanocrystals have several advantages of tunable bandgap and high carrier mobility, it is still challenging to achieve high-performance polymer: nanocrystals hybrid solar cells (HSC) due to the complicated surface problem. Many efforts have been devoted to replace the long alkyl chain on the surface of nanocrystals to improve the charge transfer and transport. We modified the alkyl chain in poly[2,6-(4,4-bis(2-ethylhexyl)-4H-cyclopenta[2,1-b;3,4-b’]-dithiophene)-alt-4,7-(2,1,3-benzothiadiazole)] (PCPDTBT) by phosphate ester. Due to its strong affinity to CdSe nanocrystals, the resulting polymers can spontaneously exchange the long chain ligands in 1-step process. With the improved morphol. of polymer: CdSe blended film, a power conversion efficiency (PCE) of 3.12% was achieved for hybrid solar cells. © 2017 Wiley Periodicals, Inc., J. Appl. Polym. Sci. 2017, 134, 45003.

Journal of Applied Polymer Science published new progress about 1426829-76-6. 1426829-76-6 belongs to benzothiophene, auxiliary class Other Aromatic Heterocyclic,Bromide, name is 2,6-Dibromo-4,4-bis(6-bromohexyl)-4H-cyclopenta[1,2-b:5,4-b’]dithiophene, and the molecular formula is 0, Application of 2,6-Dibromo-4,4-bis(6-bromohexyl)-4H-cyclopenta[1,2-b:5,4-b’]dithiophene.

Referemce:
https://en.wikipedia.org/wiki/Benzothiophene,
Benzothiophene | C8H6S – PubChem