Tag: M.W=400-500

Recommanded Product: XE991 Dihydrochloride. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: XE991 Dihydrochloride, is researched, Molecular C26H22Cl2N2O, CAS is 122955-13-9, about Functional brain imaging in larval zebrafish for characterising the effects of seizurogenic compounds acting via a range of pharmacological mechanisms. Author is Winter, Matthew J.; Pinion, Joseph; Tochwin, Anna; Takesono, Aya; Ball, Jonathan S.; Grabowski, Piotr; Metz, Jeremy; Trznadel, Maciej; Tse, Karen; Redfern, Will S.; Hetheridge, Malcolm J.; Goodfellow, Marc; Randall, Andrew D.; Tyler, Charles R..

Functional brain imaging using genetically encoded Ca2+ sensors in larval zebrafish is being developed for studying seizures and epilepsy as a more ethical alternative to rodent models. Despite this, few data have been generated on pharmacol. mechanisms of action other than GABAA antagonism. Assessing larval responsiveness across multiple mechanisms is vital to test the translational power of this approach, as well as assessing its validity for detecting unwanted drug-induced seizures and testing antiepileptic drug efficacy. Using light-sheet imaging, we systematically analyzed the responsiveness of 4 days post fertilisation (dpf; which are not considered protected under European animal experiment legislation) transgenic larval zebrafish to treatment with 57 compounds spanning more than 12 drug classes with a link to seizure generation in mammals, alongside eight compounds with no such link. We show 4dpf zebrafish are responsive to a wide range of mechanisms implicated in seizure generation, with cerebellar circuitry activated regardless of the initiating pharmacol. Anal. of functional connectivity revealed compounds targeting cholinergic and monoaminergic reuptake, in particular, showed phenotypic consistency broadly mapping onto what is known about neurotransmitter-specific circuitry in the larval zebrafish brain. Many seizure-associated compounds also exhibited altered whole brain functional connectivity compared with controls. This work represents a significant step forward in understanding the translational power of 4dpf larval zebrafish for use in neuropharmacol. studies and for studying the events driving transition from small-scale pharmacol. activation of local circuits, to the large network-wide abnormal synchronous activity associated with seizures.

This compound(XE991 Dihydrochloride)Recommanded Product: XE991 Dihydrochloride was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 2489531-02-2, is researched, Molecular C10H18FeN2NaO11, about Stability evaluation of iron and vitamin A during processing and storage of fortified pasta, the main research direction is fortified pasta micronutrient vitamin iron storage stability.COA of Formula: C10H18FeN2NaO11.

Pasta holds greater potential for improving the nutritional status of the population and its fortification with micronutrients like iron and vitamin A could be an effective strategy to provide the essential nutrients in the diet. This study quantified the losses of two different micronutrients (iron and vitamin A) in fortified pasta postprocessing and during storage for 4 mo. Chem. salts of iron, namely, ferric sodium ethylene diamine tetra-acetic acid (NaFeEDTA) and ferrous sulfate (FeSO4), were added to pasta formulation at 4,5,6 mg/100g and 6,7,8 mg/100g resp., whereas for vitamin A, retinyl acetate (RA) was added at 700, 800 and 900μg/100g. After processing, the prepared pasta with both iron salts showed retention of 94-95% for iron and 90-92% of vitamin A activity. Iron and vitamin A-fortified pasta with maximum retention during processing and exhibiting optimum color attributes and sensory score were stored alone and in combination (NaFeEDTA and RA) at 25 and 40°C in laminates (aluminum laminates) and polypropylene packets for a period of 4 mo and evaluated for changes in their iron and vitamin A contents. An overall retention of 93-95% of the iron and 56-62% of vitamin A was observed after 4 mo considering losses during processing and storage. Among the two packaging materials used, laminates retained more of iron and vitamin A activity than polypropylene. No difference in retention rates was observed for iron and vitamin A when fortified alone or in combination.

After consulting a lot of data, we found that this compound(2489531-02-2)COA of Formula: C10H18FeN2NaO11 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Winter, Matthew J.; Pinion, Joseph; Tochwin, Anna; Takesono, Aya; Ball, Jonathan S.; Grabowski, Piotr; Metz, Jeremy; Trznadel, Maciej; Tse, Karen; Redfern, Will S.; Hetheridge, Malcolm J.; Goodfellow, Marc; Randall, Andrew D.; Tyler, Charles R. published an article about the compound: XE991 Dihydrochloride( cas:122955-13-9,SMILESS:O=C1C2=C(C=CC=C2)C(CC3=CC=NC=C3)(CC4=CC=NC=C4)C5=CC=CC=C15.[H]Cl.[H]Cl ).Recommanded Product: 122955-13-9. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:122955-13-9) through the article.

Functional brain imaging using genetically encoded Ca2+ sensors in larval zebrafish is being developed for studying seizures and epilepsy as a more ethical alternative to rodent models. Despite this, few data have been generated on pharmacol. mechanisms of action other than GABAA antagonism. Assessing larval responsiveness across multiple mechanisms is vital to test the translational power of this approach, as well as assessing its validity for detecting unwanted drug-induced seizures and testing antiepileptic drug efficacy. Using light-sheet imaging, we systematically analyzed the responsiveness of 4 days post fertilisation (dpf; which are not considered protected under European animal experiment legislation) transgenic larval zebrafish to treatment with 57 compounds spanning more than 12 drug classes with a link to seizure generation in mammals, alongside eight compounds with no such link. We show 4dpf zebrafish are responsive to a wide range of mechanisms implicated in seizure generation, with cerebellar circuitry activated regardless of the initiating pharmacol. Anal. of functional connectivity revealed compounds targeting cholinergic and monoaminergic reuptake, in particular, showed phenotypic consistency broadly mapping onto what is known about neurotransmitter-specific circuitry in the larval zebrafish brain. Many seizure-associated compounds also exhibited altered whole brain functional connectivity compared with controls. This work represents a significant step forward in understanding the translational power of 4dpf larval zebrafish for use in neuropharmacol. studies and for studying the events driving transition from small-scale pharmacol. activation of local circuits, to the large network-wide abnormal synchronous activity associated with seizures.

Compounds in my other articles are similar to this one(XE991 Dihydrochloride)Recommanded Product: 122955-13-9, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Winter, Matthew J.; Pinion, Joseph; Tochwin, Anna; Takesono, Aya; Ball, Jonathan S.; Grabowski, Piotr; Metz, Jeremy; Trznadel, Maciej; Tse, Karen; Redfern, Will S.; Hetheridge, Malcolm J.; Goodfellow, Marc; Randall, Andrew D.; Tyler, Charles R. published an article about the compound: XE991 Dihydrochloride( cas:122955-13-9,SMILESS:O=C1C2=C(C=CC=C2)C(CC3=CC=NC=C3)(CC4=CC=NC=C4)C5=CC=CC=C15.[H]Cl.[H]Cl ).Electric Literature of C26H22Cl2N2O. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:122955-13-9) through the article.

Functional brain imaging using genetically encoded Ca2+ sensors in larval zebrafish is being developed for studying seizures and epilepsy as a more ethical alternative to rodent models. Despite this, few data have been generated on pharmacol. mechanisms of action other than GABAA antagonism. Assessing larval responsiveness across multiple mechanisms is vital to test the translational power of this approach, as well as assessing its validity for detecting unwanted drug-induced seizures and testing antiepileptic drug efficacy. Using light-sheet imaging, we systematically analyzed the responsiveness of 4 days post fertilisation (dpf; which are not considered protected under European animal experiment legislation) transgenic larval zebrafish to treatment with 57 compounds spanning more than 12 drug classes with a link to seizure generation in mammals, alongside eight compounds with no such link. We show 4dpf zebrafish are responsive to a wide range of mechanisms implicated in seizure generation, with cerebellar circuitry activated regardless of the initiating pharmacol. Anal. of functional connectivity revealed compounds targeting cholinergic and monoaminergic reuptake, in particular, showed phenotypic consistency broadly mapping onto what is known about neurotransmitter-specific circuitry in the larval zebrafish brain. Many seizure-associated compounds also exhibited altered whole brain functional connectivity compared with controls. This work represents a significant step forward in understanding the translational power of 4dpf larval zebrafish for use in neuropharmacol. studies and for studying the events driving transition from small-scale pharmacol. activation of local circuits, to the large network-wide abnormal synchronous activity associated with seizures.

Compounds in my other articles are similar to this one(XE991 Dihydrochloride)Electric Literature of C26H22Cl2N2O, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: Ethylenediaminetetraaceticacidferricsodiumsalttrihydrate( cas:2489531-02-2 ) is researched.Synthetic Route of C10H18FeN2NaO11.Sharma, N.; Sharma, S.; Singh, B.; Kaur, G. published the article 《Stability evaluation of iron and vitamin A during processing and storage of fortified pasta》 about this compound( cas:2489531-02-2 ) in Quality Assurance and Safety of Crops & Foods. Keywords: fortified pasta micronutrient vitamin iron storage stability. Let’s learn more about this compound (cas:2489531-02-2).

Pasta holds greater potential for improving the nutritional status of the population and its fortification with micronutrients like iron and vitamin A could be an effective strategy to provide the essential nutrients in the diet. This study quantified the losses of two different micronutrients (iron and vitamin A) in fortified pasta postprocessing and during storage for 4 mo. Chem. salts of iron, namely, ferric sodium ethylene diamine tetra-acetic acid (NaFeEDTA) and ferrous sulfate (FeSO4), were added to pasta formulation at 4,5,6 mg/100g and 6,7,8 mg/100g resp., whereas for vitamin A, retinyl acetate (RA) was added at 700, 800 and 900μg/100g. After processing, the prepared pasta with both iron salts showed retention of 94-95% for iron and 90-92% of vitamin A activity. Iron and vitamin A-fortified pasta with maximum retention during processing and exhibiting optimum color attributes and sensory score were stored alone and in combination (NaFeEDTA and RA) at 25 and 40°C in laminates (aluminum laminates) and polypropylene packets for a period of 4 mo and evaluated for changes in their iron and vitamin A contents. An overall retention of 93-95% of the iron and 56-62% of vitamin A was observed after 4 mo considering losses during processing and storage. Among the two packaging materials used, laminates retained more of iron and vitamin A activity than polypropylene. No difference in retention rates was observed for iron and vitamin A when fortified alone or in combination.

As far as I know, this compound(2489531-02-2)Synthetic Route of C10H18FeN2NaO11 can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.

Reference:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 122955-13-9, is researched, SMILESS is O=C1C2=C(C=CC=C2)C(CC3=CC=NC=C3)(CC4=CC=NC=C4)C5=CC=CC=C15.[H]Cl.[H]Cl, Molecular C26H22Cl2N2OJournal, Article, Research Support, Non-U.S. Gov’t, British Journal of Pharmacology called Functional brain imaging in larval zebrafish for characterising the effects of seizurogenic compounds acting via a range of pharmacological mechanisms, Author is Winter, Matthew J.; Pinion, Joseph; Tochwin, Anna; Takesono, Aya; Ball, Jonathan S.; Grabowski, Piotr; Metz, Jeremy; Trznadel, Maciej; Tse, Karen; Redfern, Will S.; Hetheridge, Malcolm J.; Goodfellow, Marc; Randall, Andrew D.; Tyler, Charles R., the main research direction is brain imaging larval zebrafish seizurogenic compound CNS safety pharmacol; 3Rs; CNS safety pharmacology; drug discovery/target validation; functional neuroimaging; neuropharmacology; seizures; zebrafish.Recommanded Product: XE991 Dihydrochloride.

Functional brain imaging using genetically encoded Ca2+ sensors in larval zebrafish is being developed for studying seizures and epilepsy as a more ethical alternative to rodent models. Despite this, few data have been generated on pharmacol. mechanisms of action other than GABAA antagonism. Assessing larval responsiveness across multiple mechanisms is vital to test the translational power of this approach, as well as assessing its validity for detecting unwanted drug-induced seizures and testing antiepileptic drug efficacy. Using light-sheet imaging, we systematically analyzed the responsiveness of 4 days post fertilisation (dpf; which are not considered protected under European animal experiment legislation) transgenic larval zebrafish to treatment with 57 compounds spanning more than 12 drug classes with a link to seizure generation in mammals, alongside eight compounds with no such link. We show 4dpf zebrafish are responsive to a wide range of mechanisms implicated in seizure generation, with cerebellar circuitry activated regardless of the initiating pharmacol. Anal. of functional connectivity revealed compounds targeting cholinergic and monoaminergic reuptake, in particular, showed phenotypic consistency broadly mapping onto what is known about neurotransmitter-specific circuitry in the larval zebrafish brain. Many seizure-associated compounds also exhibited altered whole brain functional connectivity compared with controls. This work represents a significant step forward in understanding the translational power of 4dpf larval zebrafish for use in neuropharmacol. studies and for studying the events driving transition from small-scale pharmacol. activation of local circuits, to the large network-wide abnormal synchronous activity associated with seizures.

This literature about this compound(122955-13-9)Recommanded Product: XE991 Dihydrochloridehas given us a lot of inspiration, and I hope that the research on this compound(XE991 Dihydrochloride) can be further advanced. Maybe we can get more compounds in a similar way.

Reference:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Stability evaluation of iron and vitamin A during processing and storage of fortified pasta, published in 2020, which mentions a compound: 2489531-02-2, Name is Ethylenediaminetetraaceticacidferricsodiumsalttrihydrate, Molecular C10H18FeN2NaO11, Product Details of 2489531-02-2.

Pasta holds greater potential for improving the nutritional status of the population and its fortification with micronutrients like iron and vitamin A could be an effective strategy to provide the essential nutrients in the diet. This study quantified the losses of two different micronutrients (iron and vitamin A) in fortified pasta postprocessing and during storage for 4 mo. Chem. salts of iron, namely, ferric sodium ethylene diamine tetra-acetic acid (NaFeEDTA) and ferrous sulfate (FeSO4), were added to pasta formulation at 4,5,6 mg/100g and 6,7,8 mg/100g resp., whereas for vitamin A, retinyl acetate (RA) was added at 700, 800 and 900μg/100g. After processing, the prepared pasta with both iron salts showed retention of 94-95% for iron and 90-92% of vitamin A activity. Iron and vitamin A-fortified pasta with maximum retention during processing and exhibiting optimum color attributes and sensory score were stored alone and in combination (NaFeEDTA and RA) at 25 and 40°C in laminates (aluminum laminates) and polypropylene packets for a period of 4 mo and evaluated for changes in their iron and vitamin A contents. An overall retention of 93-95% of the iron and 56-62% of vitamin A was observed after 4 mo considering losses during processing and storage. Among the two packaging materials used, laminates retained more of iron and vitamin A activity than polypropylene. No difference in retention rates was observed for iron and vitamin A when fortified alone or in combination.

In addition to the literature in the link below, there is a lot of literature about this compound(Ethylenediaminetetraaceticacidferricsodiumsalttrihydrate)Product Details of 2489531-02-2, illustrating the importance and wide applicability of this compound(2489531-02-2).

Reference:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: Ethylenediaminetetraaceticacidferricsodiumsalttrihydrate, is researched, Molecular C10H18FeN2NaO11, CAS is 2489531-02-2, about Stability evaluation of iron and vitamin A during processing and storage of fortified pasta.Recommanded Product: 2489531-02-2.

Pasta holds greater potential for improving the nutritional status of the population and its fortification with micronutrients like iron and vitamin A could be an effective strategy to provide the essential nutrients in the diet. This study quantified the losses of two different micronutrients (iron and vitamin A) in fortified pasta postprocessing and during storage for 4 mo. Chem. salts of iron, namely, ferric sodium ethylene diamine tetra-acetic acid (NaFeEDTA) and ferrous sulfate (FeSO4), were added to pasta formulation at 4,5,6 mg/100g and 6,7,8 mg/100g resp., whereas for vitamin A, retinyl acetate (RA) was added at 700, 800 and 900μg/100g. After processing, the prepared pasta with both iron salts showed retention of 94-95% for iron and 90-92% of vitamin A activity. Iron and vitamin A-fortified pasta with maximum retention during processing and exhibiting optimum color attributes and sensory score were stored alone and in combination (NaFeEDTA and RA) at 25 and 40°C in laminates (aluminum laminates) and polypropylene packets for a period of 4 mo and evaluated for changes in their iron and vitamin A contents. An overall retention of 93-95% of the iron and 56-62% of vitamin A was observed after 4 mo considering losses during processing and storage. Among the two packaging materials used, laminates retained more of iron and vitamin A activity than polypropylene. No difference in retention rates was observed for iron and vitamin A when fortified alone or in combination.

In addition to the literature in the link below, there is a lot of literature about this compound(Ethylenediaminetetraaceticacidferricsodiumsalttrihydrate)Recommanded Product: 2489531-02-2, illustrating the importance and wide applicability of this compound(2489531-02-2).

Reference:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Quality Control of Ethylenediaminetetraaceticacidferricsodiumsalttrihydrate. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: Ethylenediaminetetraaceticacidferricsodiumsalttrihydrate, is researched, Molecular C10H18FeN2NaO11, CAS is 2489531-02-2, about Stability evaluation of iron and vitamin A during processing and storage of fortified pasta. Author is Sharma, N.; Sharma, S.; Singh, B.; Kaur, G..

Pasta holds greater potential for improving the nutritional status of the population and its fortification with micronutrients like iron and vitamin A could be an effective strategy to provide the essential nutrients in the diet. This study quantified the losses of two different micronutrients (iron and vitamin A) in fortified pasta postprocessing and during storage for 4 mo. Chem. salts of iron, namely, ferric sodium ethylene diamine tetra-acetic acid (NaFeEDTA) and ferrous sulfate (FeSO4), were added to pasta formulation at 4,5,6 mg/100g and 6,7,8 mg/100g resp., whereas for vitamin A, retinyl acetate (RA) was added at 700, 800 and 900μg/100g. After processing, the prepared pasta with both iron salts showed retention of 94-95% for iron and 90-92% of vitamin A activity. Iron and vitamin A-fortified pasta with maximum retention during processing and exhibiting optimum color attributes and sensory score were stored alone and in combination (NaFeEDTA and RA) at 25 and 40°C in laminates (aluminum laminates) and polypropylene packets for a period of 4 mo and evaluated for changes in their iron and vitamin A contents. An overall retention of 93-95% of the iron and 56-62% of vitamin A was observed after 4 mo considering losses during processing and storage. Among the two packaging materials used, laminates retained more of iron and vitamin A activity than polypropylene. No difference in retention rates was observed for iron and vitamin A when fortified alone or in combination.

There are many compounds similar to this compound(2489531-02-2)Quality Control of Ethylenediaminetetraaceticacidferricsodiumsalttrihydrate. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

Reference:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Stability evaluation of iron and vitamin A during processing and storage of fortified pasta, published in 2020, which mentions a compound: 2489531-02-2, Name is Ethylenediaminetetraaceticacidferricsodiumsalttrihydrate, Molecular C10H18FeN2NaO11, SDS of cas: 2489531-02-2.

Pasta holds greater potential for improving the nutritional status of the population and its fortification with micronutrients like iron and vitamin A could be an effective strategy to provide the essential nutrients in the diet. This study quantified the losses of two different micronutrients (iron and vitamin A) in fortified pasta postprocessing and during storage for 4 mo. Chem. salts of iron, namely, ferric sodium ethylene diamine tetra-acetic acid (NaFeEDTA) and ferrous sulfate (FeSO4), were added to pasta formulation at 4,5,6 mg/100g and 6,7,8 mg/100g resp., whereas for vitamin A, retinyl acetate (RA) was added at 700, 800 and 900μg/100g. After processing, the prepared pasta with both iron salts showed retention of 94-95% for iron and 90-92% of vitamin A activity. Iron and vitamin A-fortified pasta with maximum retention during processing and exhibiting optimum color attributes and sensory score were stored alone and in combination (NaFeEDTA and RA) at 25 and 40°C in laminates (aluminum laminates) and polypropylene packets for a period of 4 mo and evaluated for changes in their iron and vitamin A contents. An overall retention of 93-95% of the iron and 56-62% of vitamin A was observed after 4 mo considering losses during processing and storage. Among the two packaging materials used, laminates retained more of iron and vitamin A activity than polypropylene. No difference in retention rates was observed for iron and vitamin A when fortified alone or in combination.

There are many compounds similar to this compound(2489531-02-2)SDS of cas: 2489531-02-2. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

Reference:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem