Tag: M.W:200-300

4923-87-9, 5-Bromobenzothiophene is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5-Bromobenzothiophene (1.60 g, 7.51 mmol) and dichloromethyl methyl ether (1.29 g, 11.3 mmol) were dissolved in anhydrous 1,2-dichloroethane (75 mL). Titanium tetrachloride (2.14 g, 11.3 mmol) was added, turning the solution dark. After one hour at room temperature, the reaction was poured into a mixture of saturated aqueous NaHCO3 and ice. The mixture was stirred for about 30 minutes and then was extracted with DCM (2¡Á100 mL). The extracts were concentrated and chromatographed (0 to 5% ethyl acetate in hexane) to yield 5-bromo-benzo[b]thiophene-3-carbaldehyde (1.32 g). The 5-bromobenzothiophene-3-carboxaldehyde (1.20 g, 4.98 mmol) and sulfamide (4.0 g, 42 mmol) were combined in anhydrous ethanol (25 mL) and heated to reflux for three days. The reaction was cooled to room temperature and sodium borohydride (0.207 g, 5.47 mmol) was added. After five hours, water (50 ml) was added and the solution was extracted with chloroform (3¡Á50 mL). The extracts were concentrated, suspended in a minimal amount of DCM, and filtered to provide the title compound as a yellow solid.1H NMR (DMSO-d6): delta 8.12 (1H, d, J=1.8 Hz), 7.97 (1H, d, J=8.6), 7.71 (1H, s), 7.52 (1H, dd, J=8.6, 1.9 Hz), 7.12 (1H, t, J=6.3 Hz), 6.72 (2H, s), 4.28 (2H, d, J=6.2 Hz).

4923-87-9, The synthetic route of 4923-87-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Smith-Swintosky, Virginia L.; US2007/191449; (2007); A1;; ; Patent; Smith-Swintosky, Virginia L.; US2007/191450; (2007); A1;; ; Patent; Smith-Swintosky, Virginia L.; US2007/191452; (2007); A1;,
Benzothiophene – Wikipedia
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20699-85-8,Methyl 5-aminobenzo[b]thiophene-2-carboxylate,as a common compound, the synthetic route is as follows.

To a solution of 3-chloro-2-methylbenzenesulphonyl chloride (46 mg, 0.20 mmol) in dichloromethane (2 mL) was added pyridine (40 muL, 0.48 mmol) and the mixture was stirred under N2 for 5 min, after which time 5-amino-benzo [b] thiophene-2-carboxylic acid methyl ester (40 mg, 0.19 mmol) was added. The resulting mixture was stirred for 2 h at room temperature, then saturated NaHCO3 solution (6 mL) was added and the mixture was extracted into ethyl acetate (12 mL). The organic phase was washed with brine, dried (Na2SO4), filtered and evaporated to give a residue that was purified using flash chromatography to afford a pale yellow solid (65 mg, 85%), single spot at Rf 0.52 (2: 1 hexane: ethyl acetate). mp 173.6-174. 2C, HPLC purity 99% (tR 2.13 min in 10% water- acetonitrile).’H NMR (CDCI3) : 5 7.91 (1H, s), 7.88 (1H, d, J=7.9 Hz), 7.70 (1H, d, J=8.7 Hz), 7.55-7. 52 (2H, m), 7.18 (1H, t, J=8.0 Hz), 7.12 (1H, dd, J=8.7, 2.2 Hz), 6.98 (1H, s, N-H), 3.92 (3H, s), 2.73 (3H, s). LCMS: 394.12 (M-). FAB-MS (MH+, C17H14CINO4S2) calcd 395.0053, found 395.0045., 20699-85-8

Big data shows that 20699-85-8 is playing an increasingly important role.

Reference£º
Patent; STERIX LIMITED; WO2005/42513; (2005); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1423-61-6,7-Bromobenzo[b]thiophene,as a common compound, the synthetic route is as follows.

Preparation 1; 2-Benzo[]thiophen-7-yl-4,4,5,5-tetramethyl-[l,3,2]dioxaborolane; Combine 7-bromo-benzo[?]thiophene (426 mg, 2 mmol), bis(pinacolato)diboron (756 mg, 3 mmol), [l,l ‘-bis(diphenylphosphino)ferrocene]dichloropalladium (II), complex with dichloromethane (1 : 1) (81 mg, 0.1 mmol), potassium acetate (294 mg, 3 mmol) in dimethyl sulfoxide (DMSO) (10 mL) in a flask. Bubble nitrogen through the mixture for 5 min. Seal the flask and put it into an oil bath and heat at 100 0C for 4 hours. Dilute the mixture with chloroform/isopropanol (3/1). Wash the solution with saturated aqueous sodium chloride. Dry the organic solution over sodium sulfate. Concentrate the solution in vacuo to a dark residue. Purify by column chromatography (hexane to 20 % ethyl acetate in hexane) to afford the title compound (342 mg, 66 %) as a colorless solid. MS (ES) m/z 261 [M+ 1]+., 1423-61-6

As the paragraph descriping shows that 1423-61-6 is playing an increasingly important role.

Reference£º
Patent; ELI LILLY AND COMPANY; WO2008/76705; (2008); A1;,
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Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.26018-73-5,6-Chlorobenzo[b]thiophene-2-carboxylic acid,as a common compound, the synthetic route is as follows.,26018-73-5

To a solution of 6-chlorobenzothiophene-2-carboxylic acid Xl-9b (1.00 g, 4.70 mmol) inDMA (5 ml) was added DBU (2.86 g, 18.8 mmol) and reaction mixture was heated in10 microwave at 200C for 1 h. Progress of the reaction was monitored by TLC. Aftercompletion, the reaction mixture was diluted with H20 (30 ml) and extracted with EtOAc(3 x 20 ml). The organic layer was separated, dried over anhydrous Na2S04 andconcentrated under vacuum to afford 6-chlorobenzothiophene Xl-9 (0.51 g) as an offwhitesolid.15 This compound was used as such for the next reaction without further purification.20Yield: 65%1H NMR (400 MHz, DMSO-d5) o 7.41 (dd, J=8.56, 1.71 Hz, 1 H) 7.47 (d, J=5.38 Hz, 1 H)7.80 (d, J=5.38 Hz, 1 H) 7.89 (d, J=8.80 Hz, 1 H) 8.17 (d, J=0.98 Hz, 1 H).

As the paragraph descriping shows that 26018-73-5 is playing an increasingly important role.

Reference£º
Patent; UCB PHARMA GMBH; MUELLER, Christa E.; PEGURIER, Cecile; DELIGNY, Michael Louis Robert; EL-TAYEB, Ali; HOCKEMEYER, Joerg; LEDECQ, Marie; MERCIER, Joel; PROVINS, Laurent; BOSHTA, Nader M.; BHATTARAI, Sanjay; NAMASIVAYAM, Vigneshwaran; FUNKE, Mario; SCHWACH, Lukas; GOLLOS, Sabrina; VON LAUFENBERG, Daniel; BARRE, Anais; (493 pag.)WO2018/122232; (2018); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

4923-87-9,4923-87-9, 5-Bromobenzothiophene is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a 50 mL two-neck flask were added 5-bromobenzo[b]thiophene (231.1 mg, 1.08 mmol), dichloromethane (8 mL) and formic acid (0.25 mL), then H2O2 (0.15 mL, 30%) was added dropwise. The mixture was stirred at rt overnight. After the reaction was completed, to the mixture was added saturated brine (20 mL). The resulting mixture was extracted with DCM (20 mL*3). The combined organic layers were dried over anhydrous Na2SO4, and filtered. The filtrate was concentrated in vacuo, and the residue was purified by silica-gel column chromatography (PE:EtOAc=10:1, V/V) to give a white solid (240 mg, 90.9%). MS(ESI, pos.ion)m/z:244.9 (M+1);

The synthetic route of 4923-87-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Sunshine Lake Pharma Co., Ltd.; WANG, Xiaojun; ZHOU, Pingjian; YANG, Chuanwen; HUANG, Changwei; XIONG, Shaohui; ZHANG, Yingjun; ZHANG, Jiancun; (139 pag.)EP3342765; (2018); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

35212-85-2, Methyl 3-aminobenzo[b]thiophene-2-carboxylate is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 1 1-(Benzothiophen-3-yl)piperazine To a solution of methyl 3-aminobenzothiophene-2-carboxylate [prepared by the method of J. R. Beck, J. Org. Chem. 1972, 37, 3224] (6.5 g, 31.4 mmol) in N-methylpyrrolidinone (30 ml) was added 1-methylpiperazine and the reaction mixture was heated to 178 C. for 4 h. After cooling the mixture was poured into water and the product extracted with diethyl ether (3*100 ml), the extracts were washed with water (1*100 ml) and brine (1*100 ml), combined and dried (MgSO4). Concentration of the extracts yielded 3-aminobenzothiophene (5.9 g), which was used without purification., 35212-85-2

As the paragraph descriping shows that 35212-85-2 is playing an increasingly important role.

Reference£º
Patent; Merck Sharpe & Dohme Ltd.; US5432177; (1995); A;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.360576-01-8,Methyl 6-bromobenzo[b]thiophene-2-carboxylate,as a common compound, the synthetic route is as follows.

12141] A mixture of 500 mg of methyl 6-bromobenzo[b] thiophene-2-carboxylate, 877mg of tributyl vinyl tin, 213mg of tetrakis(triphenylphosphine)palladium (0), and 4 ml of toluene was stirred for 5 hours at 1100 C. under a nitrogen atmosphere. After the reaction mixture was cooled to room temperature, an aqueous saturated ammonium chloride solution and ethyl acetate were added thereto, and insoluble matter was separated by filtration. Extraction was performed on the filtrate by using ethyl acetate, and the organic layer was washed with saturated saline, dried over magnesium sulfate, and then concentrated under reduced pressure. The residues were subjected to silica gel colunm chromatography, thereby obtaining 229mg of methyl 6-vinylbenzo[b]thiophene-2-car- boxylate (hereinafier, described as a ?compound 32 of the present invention?).12142] Compound 32 of the Present Invention%_)%%%%%L5/ _12143] ?H-NMR (CDC13) oe: 8.03 (s, 1H), 7.84-7.81 (m,2H), 7.52-7.50 (m, 1H), 6.82 (dd, 1H, J=17.6, 11.0Hz), 5.87(d, 1H, J=17.6 Hz), 5.36 (d, 1H, J=11.0 Hz), 3.95 (s, 3H).

360576-01-8, The synthetic route of 360576-01-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SUMITOMO CHEMICAL COMPANY, LIMITED; Mukumoto, Fujio; Tamaki, Hiroaki; Kusaka, Shintaro; Iwakoshi, Mitsuhiko; US2015/282482; (2015); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

1423-61-6, 7-Bromobenzo[b]thiophene is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 6; Preparation of Compound 49; Step A – Synthesis of Compound 49 A; A solution of 7-bromothiophene (8.0 g, 37.5 mmol) in ether (50 mL) was cooled to -78 C and treated dropwise with n-BuLi (1.6 M solution in hexanes, 1.0 eq.) and the resulting reaction was allowed to stir at -78 C for 20 minutes. The reaction mixture was then diluted with DMF (dry 5.4 g, 67.4 mmol) and allowed to stirat -78 0C for 1 hour. The reaction mixture was then diluted with water and extracted into ether. The combined organic layers were dried (MgSO4), filtered, concentrated in vacuo and purified using flash column chromatography on silica gel to provide compound 49A as a colorless liquid.; Example 7; Preparation of Compound 52; Step A – Synthesis of Compound 52A; A solution of 7-bromothiophene (8.0 g, 37.5 mmol) in ether (50 mL) was cooled to -78 C, then n-BuLi (1.6 M soln in hexanes, 1.0 eq.) was added dropwise and the resulting reaction was allowed to stir at -78 0C for 20 minutes. The reaction mixture was diluted with DMF (dry 5.4 g, 67.4 mmol) and allowed to stir at -78 0C for 1 hour. The reaction mixture was then quenched with water and the resulting solution was extracted into ether. The combined organic layers were dried (MgSO4), filtered, and concentrated in vacuo to provide a crude residue which was purified using flash column chromatography on silica gel to provide compound 52A as a colorless liquid., 1423-61-6

1423-61-6 7-Bromobenzo[b]thiophene 12045538, abenzothiophene compound, is more and more widely used in various.

Reference£º
Patent; SCHERING CORPORATION; WO2008/82484; (2008); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem