Tag: M.W=100-150

Zhuang, Shi-Yi published the artcileI2-DMSO Mediated N-H/α-C(sp3)-H Difunctionalization of Tetrahydroisoquinoline: Formal [2 + 2 + 1] Annulation for the Construction of Pyrrolo[2,1-a]isoquinoline Derivatives, SDS of cas: 1468-83-3, the main research area is pyrroloisoquinoline preparation; methyl ketone tetrahydroisoquinoline cascade formal cyclization iodine dimethyl sulfoxide.

An I2-DMSO mediated cascade reaction using Me ketones and 1,2,3,4-tetrahydroisoquinolines (THIQs) as com. available substrates has been developed for construction of pyrrolo[2,1-a]isoquinoline derivatives This metal-free process involves N-H/α-C(sp3)-H difunctionalization of THIQ. Two C-C bonds and one C-N bond are formed in one pot under mild conditions. Besides, a quaternary carbon center has been constructed in this transformation efficiently.

Organic Letters published new progress about Cyclization ([2 + 2 + 1]). 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, SDS of cas: 1468-83-3.

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Harsha, Kachigere b. published the artcileA green synthesis of 1,5-benzodiazepines using reusable-heterogeneous silica sulfuric acid catalyst under solvent-free conditions and their antileukemic activity, Application In Synthesis of 1468-83-3, the main research area is benzodiazepines silica sulfuric acid catalyst antileukemic activity green synthesis.

1,5-Benzodiazepine derivatives are readily assembled from o-phenylene diamine and ketones containg α-hydrogen atoms by means of simple cyclocondensation via sp3 C-H activation promoted by an efficient heterogeneous silica sulfuric acid catalyst. Eco-friendliness, good yields, easy workup, reusable catalyst, short reaction times, high atom economy and solvent-free conditions are the noteworthy features of this protocol. These benzodiazepines are chosen for the evaluation of antiproliferative activity against different leukemia cell lines. Among the investigated compounds, 3g is the best antiproliferative agent against all the cell lines tested. Also, current preliminary anal. showed that compound 3g phosphorylates ERK1/2 and induces G1 arrest in K562 cells.

Asian Journal of Chemistry published new progress about Antiproliferative agents. 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, Application In Synthesis of 1468-83-3.

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Peng, Yongzhen published the artcileEnantiocomplementary C-H Bond Hydroxylation Combining Photo-Catalysis and Whole-Cell Biocatalysis in a One-Pot Cascade Process, Computed Properties of 1468-83-3, the main research area is whole cell biocatalysis photocatalysis enantiocomplementary hydroxylation cascade.

Enantiocomplementary hydroxylation of alkyl aromatics through a one-pot photo-biocatalytic cascade reaction is described. The photoredox process is implemented in aqueous phase with O2 as oxidant and the subsequent (R)- or (S)-selective bioreduction is performed by whole cell system without the addition of the expensive cofactor (NADPH). This mild, operationally simple protocol transforms a wide variety of readily available aromatic compounds into valuable chiral alcs. with high yield (up to 90%) and stereoselectivity (up to 99%), thereby displaying important potentials in organic synthesis.

European Journal of Organic Chemistry published new progress about Biochemical reaction kinetics. 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, Computed Properties of 1468-83-3.

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Xu, Jun published the artcileA combination of heterogeneous catalysis and photocatalysis for the olefination of quinoxalin-2(1H)-ones with ketones in water: a green and efficient route to (Z)-enaminones, Safety of 3-Acetylthiophene, the main research area is enaminone quinoxalinone acylmethylene preparation diastereoselective green chem; quinoxalinone diastereoselective photochem olefination ketone.

Herein, a novel aqueous reaction for the olefination of quinoxalin-2(1H)-ones I (R1 = H, 5-Me, 6-OMe, 6,7-Cl2, etc.; R2 = H, Me, cyclohexylmethyl, allyl, Ph, 2,6-F2C6H3CH2, etc.) with ketones R3C(O)CH2R4 [R3 = Me, cyclopropyl, Ph, 3-thienyl, etc., R4 = H; R3R4 = (CH2)3, CH(cyclopentyl)CH2CH2] through a combinational strategy is described. This reaction features very mild conditions using a simple and cheap catalyst for the synthesis of (Z)-enaminones II in moderate-to-good yields. Such a methodol. successfully combines the heterogeneous Mannich reaction with photocatalysis, and provides a green and practical approach for the synthesis of potentially bioactive (Z)-enaminones with a 3,4-dihydroquinoxalin-2(1H)-one skeleton.

Green Chemistry published new progress about Diastereoselective synthesis. 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, Safety of 3-Acetylthiophene.

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Huang, Yubing published the artcileTransition-metal-free N-difluoromethylation of hydrazones with TMSCF2Br as the difluoromethylation reagent, SDS of cas: 1468-83-3, the main research area is tosyl hydrazone bromodifluoromethyl trimethylsilane difluoromethylation.

A novel and practical protocol to synthesize a series of N-difluoromethyl hydrazones via base-promoted N-difluoromethylation was reported. With hydrazones as chain substrates containing N-N bonds and TMSCF2Br as the difluoromethylation reagent, the reaction delivers N-difluoromethyl hydrazones in good yields, which exhibit good functional group tolerance and stereoselectivity.

Organic Chemistry Frontiers published new progress about Diastereoselective synthesis. 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, SDS of cas: 1468-83-3.

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Xing, Yidan published the artcileSynthesis of Tertiary Benzylic Nitriles via Nickel-Catalyzed Markovnikov Hydrocyanation of α-Substituted Styrenes, Safety of 3-Acetylthiophene, the main research area is benzylic nitrile preparation Markovnikov hydrocyanation styrene nickel catalyst.

The Markovnikov hydrocyanation of α-substituted styrenes enables the synthesis of tertiary benzylic nitriles under nickel catalysis. The Lewis-acid-free transformation features an unprecedented functional groups tolerance, including the -OH and -NH2 groups. A broad range of tertiary benzylic nitriles were obtained in good to excellent yields. In addition, an asym. version of this reaction was preliminarily investigated.

Organic Letters published new progress about Hydrocyanation (Markovnikov). 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, Safety of 3-Acetylthiophene.

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Fagbemi, Kehinde Oluwakemi published the artcileBioactive compounds, antibacterial and antioxidant activities of methanol extract of Tamarindus indica Linn., Application In Synthesis of 1468-83-3, the main research area is Tamarindus indica methanol extract bioactive compound antibacterial antioxidant activity.

Tamarindus indica is one of the tropical medicinal plants that has been attributed curative potential of numerous diseases by many rural dwellers. This study was designed to evaluate the antioxidant, antibacterial activities and also to determine the various chem. constituents responsible for its pharmacol. activities. The methanol extract of Tamarindus indica fruit pulp was analyzed by Gas Chromatog./Mass Spectrometer to determine the volatile compounds present. The antioxidant activities were performed using DPPH and FRAP method and the antibacterial activity was tested against some common pathogens by macro broth dilution method. The GCMS anal. shows the presence of 37 compounds, out of which 14 had their peak area percentages ≥ 1% and only two compounds had no reported pharmacol. activities. Most of the bioactive compounds including 5-Hydroxymethylfurfural (31.06%)-3-O-Methyl-d-glucose (16.31%), 1,6-anhydro-β-D-Glucopyranose (9.95%), 5-methyl-Furancarboxaldehyde (3.2%), Triethylenediamine (1.17%), 1-(2-furanyl)-1-Propcanone (2.18%), Me 2-furoate (3.14%), Levoglucosenone (3.21%), Me ester-Hepta-2,4-dienoic acid, (8.85%), 2,3-dihydro-3,5-dihydrox-4H-Pyran-4-one (3.4%), O-α-D-glucopyranosyl-(1.fwdarw.3)-β-D-fructofuranosyl-α-D-Glucopyranoside (2.18%), n-Hexadecanoic acid (1.38%), 2-Heptanol, acetate (1.29%), 5-[(5-methyl-2-fur-2-Furancarboxaldehyde)] (1.08%), 3-Methyl-2-furoic acid (1.05%) and cis-Vaccenic acid (2.85%)have been reported with different activities such as antibacterial, antifungal, antitubercular, anticancer, antioxidant and other prophylactic activities. The extract demonstrated inhibitory potential against all tested pathogen. However, Plesiomonas shigellosis ATCC 15903 and Bacillus pumillus ATCC 14884 are more sensitive with the MIC of 0.22 and 0.44 mg/mL resp. The antioxidant activity was relatively low due to the low phenolic content of the extract This shows that there is a strong correlation between antioxidant activities and phenolic content. GC-MS anal. revealed the presence of bioactive phytoconstituents with various biol. activities and this justifies the rationale behind its usage as a curative therapy by many local dwellers.

Scientific Reports published new progress about Acinetobacter calcoaceticus. 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, Application In Synthesis of 1468-83-3.

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Gao, Ya published the artcileDefluorinative Alkylation of Trifluoromethyl Alkenes with Soft Carbon Nucleophiles Enabled by a Catalytic Amount of Base, COA of Formula: C6H6OS, the main research area is gem difluoroalkene fluoro pyran preparation; trifluoromethyl alkene soft carbon nucleophile defluorinative alkylation.

Direct manipulation of readily accessible trifluoromethyl alkenes (TAs) represents an attractive approach to the preparation of diversified fluorine-containing compounds In this study, defluorinative alkylation reactions of TAs with a broad array of soft carbon nucleophiles have been documented. Nucleophilic substitutions occur enabled by a catalytic amount of base, providing access to tertiary alkyl substituted gem-difluoroalkenes and 2-fluoro-4H-pyrans. By extending the nucleophiles to silyl enol ethers, defluorination can be achieved in the absence of base to give gem-difluoroalkenes. This process, which eliminates the requirement of organometallic reagents, transition metals, or strong bases for the C-F bond cleavage, is applicable to late-stage modification of complex mols.

Advanced Synthesis & Catalysis published new progress about Alkylation (defluorinative). 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, COA of Formula: C6H6OS.

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Shen, Jiabin published the artcileSelective Mono- and Diamination of Ketones in a Combined Copper-Organocatalyst System, Recommanded Product: 3-Acetylthiophene, the main research area is pyrazole ketone chemoselective preparation; ketone azole copper organocatalyst mono amination; dipyrazole ketone chemoselective preparation; azole ketone copper organocatalyst di amination.

Herein, a simple and mild protocol for syntheses of α-pyrazoles I [R = 4-Me, 5-I, 3-Ph, etc.; Ar = Ph, 3-MeC6H4, 4-ClC6H4, etc.] and α,α-dipyrazole ketone derivatives II [R2 = R3 = H, 4-Cl, 4-Br, etc.; Ar1 = Ph, 3-FC6H4, 4-ClC6H4, etc.] via combined copper-organocatalyzed chemoselective mono- and diamination of ketones using azoles as amine source were reported. Various substrates were compatible and provided the corresponding products I and II in moderate to good yields.

Organic Letters published new progress about Amination (chemoselective). 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, Recommanded Product: 3-Acetylthiophene.

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Luo, Wenjun published the artcileSynthesis of W-Phos Ligand and Its Application in the Copper-Catalyzed Enantioselective Addition of Linear Grignard Reagents to Ketones, SDS of cas: 1468-83-3, the main research area is ketone Grignard reagent copper phosphine enantioselective regioselective addition; chiral tertiary alc preparation; Alcohols; Asymmetric Catalysis; Copper; Grignard Reagents; Ketones.

A novel family of PNP ligands (W-Phos) was designed and applied in copper-catalyzed asym. addition of linear Grignard reagents to aryl alkyl ketones, allowing facile access to versatile chiral tertiary alcs. in good to high yields with excellent enantioselectivities (up to 94% yield, 96% ee). The process was also used to synthesize chiral allylic tertiary alcs. from more challenging α,β-unsaturated ketones. Notably, the potential utility of this method was demonstrated in the gram-scale synthesis and modification of various densely functionalized medicinally relevant mols.

Angewandte Chemie, International Edition published new progress about Addition reaction catalysts, regioselective. 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, SDS of cas: 1468-83-3.

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem