Tag: 3541-37-5

3541-37-5, Benzo[b]thiophene-2-carboxaldehyde is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a mixture of benzo[b]thiophene-2-carbaldehyde (3 g, 18.6 mmol) and core 1 (4 g, 12.4 mmol) in anhydrous CH3CN (100 mL) was added TFA (424 mg 3.7 mmol) at 25C. The mixture was agitated for 6 hours. The reaction mixture became a clear solution and then a solid appeared. The solid was collected by filtration and washed with CH3CN to provide 9a (5.4 g, 69 % yield)

3541-37-5, As the paragraph descriping shows that 3541-37-5 is playing an increasingly important role.

Reference£º
Patent; MERCK SHARP & DOHME CORP.; TONG, Ling; YU, Wensheng; KOZLOWSKI, Joseph A.; CHEN, Lei; SELYUTIN, Oleg; KIM, Seong Heon; DWYER, Michael; HU, Bin; ZHONG, Bin; WAI, Dahai; HAO, Jinglai; SHEN, Changmao; LEI, Zhixin; WANG, Weijun; WO2014/110688; (2014); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3541-37-5,Benzo[b]thiophene-2-carboxaldehyde,as a common compound, the synthetic route is as follows.

Example 4: Synthesis o -(benzothiophen-2-yl)-2-hydroxyethylsulfamide[0097] 2-Amino-l-benzo[b]thiophen-2-yl-ethanol hydrochloride salt. To a stirring solution of benzo[b]thiophene-2-carbaldehyde (1.0 g, 6.16 mmol) and trimethylsilyl cyanide (0.92 mL, 6.78 mmol) in dichloromethane (8 mL) at room temperature under nitrogen was added a few crystals of zinc iodide. The mixture was stirred at this temperature for 20 hours and concentrated. The residue was dissolved in borane in tetrahydrofuran (1M, 13.6 mL) and heated to reflux for 5 hours. The mixture was cooled to room temperature and concentrated. The syrup was dissolved in methanol (25 mL), treated with hydrogen chloride (4M in dioxane, 6.8 mL), and heated to reflux for 2 hours, and then concentrated. The solid obtained was dissolved in hydrochloric acid (2N, 10 mL) and extracted twice with diethyl ether. The aqueous solution was concentrated, crystallized from methanol/ether, and dried in vacuum oven to give a yellow (770 mg,54%)., 3541-37-5

As the paragraph descriping shows that 3541-37-5 is playing an increasingly important role.

Reference£º
Patent; ADVANCED NEURAL DYNAMICS, INC.; FOX CHASE CHEMICAL DIVERSITY CENTER, INC.; SMITH, Garry, Robert; BRENNEMAN, Douglas, Eric; REITZ, Allen, B.; DU, Yanming; WO2011/97337; (2011); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3541-37-5,Benzo[b]thiophene-2-carboxaldehyde,as a common compound, the synthetic route is as follows.

1 g of 4-bromophenylacetonitrile (5.1 mmol) and 825 mg ofbenzo[b]thiophene-2-carboxaldehyde (5.1 mmol) were dissolvedin dry MeOH (30 mL) and stirred at 0 C for 5 min 380 mg of odium methoxide (7.1 mmol) were added in small portions, and themixture was stirred for 15 min at 0 C and then for 4 h at roomtemperature. The resulting precipitate was collected using a sinteredglass filter, washed with 10 mL of MeOH, then with water anddried to give 1.56 g of the alpha,beta-unsaturated nitrile 7 as a yellow solid(90%); Rf 0.36 (cyclohexane/EtOAc, 90:10); m.p 160-162 C ; 1HNMR (300 MHz, CDCl3): d (ppm): 7.37-7.45 (m, 2H), 7.52-7.60 (m,4H), 7.69 (s, 1H, Hvinyl), 7.82-7.87 (m, 3H); 13C NMR (75 MHz,CDCl3): delta(ppm): 109.68 (C), 117.35 (CN), 122.43 (CH), 123.58 (C),124.65 (CH), 125.12 (CH), 126.67 (CH), 127.33 (2CH), 130.01 (CH),132.31 (2CH) 132.86 (C), 134.86 (CH), 137.37 (C), 138.69 (C), 141.28(C); HRMS (MALDI-TOF) Calcd for (C17H10BrNS): [M]+: 338.9717.Found: 338.9711.

3541-37-5 Benzo[b]thiophene-2-carboxaldehyde 736500, abenzothiophene compound, is more and more widely used in various.

Reference£º
Article; Hafedh, Nesrine; Aloui, Faouzi; Raouafi, Sondes; Journal of Molecular Structure; vol. 1165; (2018); p. 126 – 131;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3541-37-5,Benzo[b]thiophene-2-carboxaldehyde,as a common compound, the synthetic route is as follows.

Step 1: A solution of benzo [b]thiophene-2-carbaldehyde (1.0 g, 6.17 mmol) and carbon tetrabromide (3.1 g, 9.25 mmol) in methylene chloride (50 mL) was cooled to 0C. A solution of triphenylphosphine (4.86 g, 18.3 mmol) in methylene chloride (20 mL) was added dropwise. After 1/2 hour the solution was placed on a plug of silica gel and eluted with 20% ethyl acetate: hexane. Concentration of the eluent resulted in the isolation of 1.3 g (67%) of 2- (2, 2-Dibromo-vinvl)-benzofblthiophene as a yellow oil, which was used as such in the next step.

The synthetic route of 3541-37-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; WYETH; WO2005/37807; (2005); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3541-37-5,Benzo[b]thiophene-2-carboxaldehyde,as a common compound, the synthetic route is as follows.

General procedure: Representative Procedure for Mukaiyama Aldol Reactions of Me2C C(OMe)OSiMe3 with Aryl Aldehydes Catalyzed by 1-5. To an oven-dried 10-mL vial equipped with a magnetic stirring bar and a septum was added acetonitrile (5 mL), 1 (0.03 mmol), and aldehyde (1.0 mmol). The mixture was stirred for 30 min at room temperature, followed by addition of Me2C C(OMe)OSiMe3 (1.2 mmol). When the reaction was judged to be complete by TLC, the reaction was quenched by adding 2 N HCl (3 mL) solution followed by stirring the reaction mixture for an additional 3 h at room temperature. The reaction mixture was extracted with methylene chloride and dried over Na2SO4, the solution was filtered and dried on a rotavap apparatus, and then the crude product was purified by silica gel column chromatography (EtOAc:hexanes = 1:9).

As the paragraph descriping shows that 3541-37-5 is playing an increasingly important role.

Reference£º
Article; Kim, So Han; Yoon, Sungwoo; Kim, Youngjo; Verkade, John G.; Phosphorus, Sulfur and Silicon and the Related Elements; vol. 189; (2014); p. 1193 – 1206;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3541-37-5,Benzo[b]thiophene-2-carboxaldehyde,as a common compound, the synthetic route is as follows.

General procedure: A mixture of appropriate piperazine base (i-vi, 1 mmol), aldehydes (1a-1d, 1 mmol) and around 1.1-1.3 mmol quantity of TMSCN was taken in 5-8 mL water. After stirring for a while, 10 mg Indium powder was added to the reaction mixture and the resulted reaction mass was allowed to stir at room temperature for 45 min-2.5 h. After the completion ofthe reaction as monitored by Thin Layer Chro-matography using toluene: acetone (8:2) or ethyl acetate: n-nexane (8:2) solvent system, after treatment with diethyl ether or ethyl acetate, solution was filtered and washed with water and brine followed by anhydrous sodium sulphate treatment to dry. The residue was purified by silica gel column chromatography (ethyl acetate: n-hexane) to afford compounds 2i-5vi.

3541-37-5 Benzo[b]thiophene-2-carboxaldehyde 736500, abenzothiophene compound, is more and more widely used in various.

Reference£º
Article; Patel, Rahul V.; Patel, Jigar K.; Nile, Shivraj H.; Park, Se Won; Letters in drug design and discovery; vol. 10; 5; (2013); p. 462 – 470;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

3541-37-5, Benzo[b]thiophene-2-carboxaldehyde is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

4-Bromophenylacetonitrile (1 g, 5.1 mmol) and benzo[b]thiophene-2-carboxaldehyde (825 mg, 5.1 mmol) are dissolved in 30 mL of dry MeOH and stirred at 0 C for 10 min. Sodium methoxide (380 mg, 7.1 mmol) was added in small portions, and the solution was stirred for 15 min at 0 C and then for 6 h at room temperature. The precipitate was collected by filtration, washed with 10 mL of MeOH, then with water, and dried at 50 C to give the alpha,beta-unsaturated nitrile 3 as a yellow powder (1.55 g, 90%); Rf = 0.36 (cyclohexane/EtOAc, 90:10); mp = 160-162 C; 1H NMR (300 MHz, CDCl3): delta (ppm): 7.37-7.45 (m, 2H), 7.52-7.60 (m, 4H), 7.69 (s, 1H, Hvinyl), 7.82-7.87 (m, 3H); 13C NMR (75 MHz, CDCl3): delta (ppm): 109.68 (C), 117.35 (CN), 122.43 (CH), 123.58 (C), 124.65 (CH), 125.12 (CH), 126.67 (CH), 127.33 (2CH), 130.01 (CH), 132.31 (2CH) 132.86 (C), 134.86 (CH), 137.37 (C), 138.69 (C), 141.28 (C); HRMS (MALDI-TOF): [M]+ calcd for (C17H10BrNS), 338.9717; found, 338.9711.

As the paragraph descriping shows that 3541-37-5 is playing an increasingly important role.

Reference£º
Article; Hafedh, Nesrine; Aloui, Faouzi; Dorcet, Vincent; Barhoumi, Houcine; Comptes Rendus Chimie; vol. 21; 7; (2018); p. 652 – 658;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3541-37-5,Benzo[b]thiophene-2-carboxaldehyde,as a common compound, the synthetic route is as follows.

To a solution of benzo[b]thiophene-2-carboxaldehyde (2?mmol) in ethanol (5?mL), 4-ethylthiosemicarbazide (2?mmol) and acetic acid (0.5?mL) were added. The mixture was stirred for 10?min?at 80?C. After cooling to room temperature, the white precipitate was obtained. The white solid was collected by filtration and the crude product was further purified by recrystallization from ethanol. (E)-2-(benzo[b]thiophen-2-ylmethylene)-N-ethylhydrazine-1-carbothioamide was obtained (BS2C-ETSC). The other two compounds, (E)-2-(benzo[b]thiophen-2-ylmethylene)hydrazine-1-carbothioamide (BS2C-TSC) and (E)-2-(benzo[b]thiophen-2-ylmethylene)-N-methylhydrazine-1-carbothioamide (BS2C-MTSC) were prepared with the same procedure as BS2C-ETSC.

As the paragraph descriping shows that 3541-37-5 is playing an increasingly important role.

Reference£º
Article; Qiao, Yuqian; Che, Yuanyuan; Yu, Yuming; Tang, Yakun; Liu, Lang; Zhao, Xianmei; Zhao, Jianzhang; Dyes and Pigments; vol. 156; (2018); p. 326 – 331;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

3541-37-5, Benzo[b]thiophene-2-carboxaldehyde is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a dry glass reaction tube purged with argon and equipped with a magnetic stir bar were added molecular sieves (3-4 A, 100 mg), aldehyde 3a (46 mg, 0.25 mmol), Pd-gamma-Fe2O3 (24 mg, 5 mol% Pd), and cyclohexane (1 mL) and the sealed tube was heated at 130 C for 24 h. The reaction mixture was decanted with the help of an external magnet and the catalyst was washed with CH2Cl2 (5 x 5 mL). The crude product was purified by dry-flash chromatography (SiO2: hexane) to afford 4a (31 mg, 82%) as a white solid; mp 66-68 C.

The synthetic route of 3541-37-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Ajda?i?, Vladimir; Nikoli?, Andrea; Simi?, Stefan; Manojlovi?, Dragan; Stojanovi?, Zoran; Nikodinovic-Runic, Jasmina; Opsenica, Igor M.; Synthesis; vol. 50; 1; (2018); p. 119 – 126;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem