Tag: 22913-24-2

22913-24-2,22913-24-2, Methyl benzo[b]thiophene-2-carboxylate is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

fac-(NEt4)2[ReBr3(CO)3] (200 mg,0.260 mmol) was dissolved in methanol (10 ml). BSOC(24.98 mg, 0.130 mmol) was added as a solid and the resultingmixture was stirred at room temperature for 2 h. The productwas collected dried in vacuo (yield: 55 mg, 0.101 mmol, 78%). IR (KBr, cm-1): nuCO 2005, 1867.. UV-Vis: 211 nm,, epsilon = 2981 M-1 cm-1. 1H NMR(300 MHz, methanol-d4): delta 8.14 (s,1H), 8.02 (m, 2H), 7.51 (m, 2H), 3.92 (s, 3H). 13C NMR(150 MHz, methanol-d4): delta 143.4, 140.1, 138.0, 134.4, 131.8,128.2, 126.7, 126.2, 123.7. ICP-EOS: Recalcd: 34.33; Refound:34.39. Analysis calculated (%): C 28.79, H 1.49, S 5.91; found:C 28.19, H 1.42, S 5.82.

The synthetic route of 22913-24-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Nkoe, Pheello I.; Visser, Hendrik G.; Swart, Chantel; Brink, Alice; Schutte-Smith, Marietjie; Acta Crystallographica Section C: Structural Chemistry; vol. 74; (2018); p. 1116 – 1122;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.22913-24-2,Methyl benzo[b]thiophene-2-carboxylate,as a common compound, the synthetic route is as follows.

General procedure: To a solution of intermediate 2a-c (1 equiv.) in methanol was added 2N sodium hydroxide at ambient temperature. The reaction mixture was stirred for 4 h and the methanol was removed by rotary evaporation. The resultant mixture was adjusted to pH =5-6 with 1N HCl. The precipitated white solid was collected by filtration and dried to give the carboxylic acid intermediate (1a-c).4.7.1. benzo[b]thiophene-2-carboxylic acid (1a) 1H NMR (600 MHz, DMSO-d6) d 13.48 (s, 1H), 8.12 (s, 1H), 8.05(d, J = 8.1 Hz, 1H), 8.01 (d, J = 7.9 Hz, 1H), 7.53-7.49 (m, 1H), 7.48-7.44 (m, 1H).

#N/A

Reference£º
Article; Zhao, Shizhen; Wei, Peng; Wu, Mengya; Zhang, Xiangqian; Zhao, Liyu; Jiang, Xiaolin; Hao, Chenzhou; Su, Xin; Zhao, Dongmei; Cheng, Maosheng; Bioorganic and Medicinal Chemistry; vol. 26; 12; (2018); p. 3242 – 3253;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem