Tag: 214.2829

Liu, Hong-Wei et al. published their research in Organic Letters in 2019 | CAS: 3988-77-0

3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one (cas: 3988-77-0) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The electrophilic substitution of benzothiophene systems is much less regioselective than that of indoles. It is also used in the manufacturing of dyes such as thioindigo.Computed Properties of C13H10OS

Zinc-Mediated Reductive Cyclization of [60]Fullerene with Enones and Subsequent Dehydration under Solvent-Free and Ball-Milling Conditions was written by Liu, Hong-Wei;Xu, Hui;Shao, Gang;Wang, Guan-Wu. And the article was included in Organic Letters in 2019.Computed Properties of C13H10OS This article mentions the following:

The zinc-mediated solvent-free reaction of [60]fullerene with enones and water and the subsequent treatment of a base afford various [60]fullerene-fused cyclopentanols using the ball-milling technique. A plausible reaction mechanism is proposed on the basis of control experiments In addition, the formed [60]fullerene-fused cyclopentanols can be further dehydrated to provide [60]fullerene-fused cyclopentenes. In the experiment, the researchers used many compounds, for example, 3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one (cas: 3988-77-0Computed Properties of C13H10OS).

3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one (cas: 3988-77-0) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The electrophilic substitution of benzothiophene systems is much less regioselective than that of indoles. It is also used in the manufacturing of dyes such as thioindigo.Computed Properties of C13H10OS

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

Yang, Gongming et al. published their research in Tetrahedron Letters in 2015 | CAS: 3988-77-0

3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one (cas: 3988-77-0) belongs to benzothiophene derivatives. Functionalized benzothiophenes are important constructs found in molecules with wide ranging biological activity and in organic materials. The different substitution patterns in these heterocycles offer new opportunities for drug discovery and other applications in materials science.Electric Literature of C13H10OS

Facile synthesis of pyrimidines via iminium catalyzed [4+2] reaction of α,β-unsaturated ketones with 1,3,5-triazines was written by Yang, Gongming;Chen, Lei;Wang, Jian;Jia, Qianfa;Wei, Jia;Du, Zhiyun. And the article was included in Tetrahedron Letters in 2015.Electric Literature of C13H10OS This article mentions the following:

[4+2] Cycloaddition of α,β-unsaturated ketones with 1,3,5-triazine via iminium catalysis has been developed. E.g., in presence of morpholine and K2CO3 in DMF, reaction of PhCH:CHCOMe with 1,3,5-triazine gave 79% pyrimidine derivative I. This method can prepare pyrimidines with high levels of regioselectivity and with good yields. In the experiment, the researchers used many compounds, for example, 3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one (cas: 3988-77-0Electric Literature of C13H10OS).

3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one (cas: 3988-77-0) belongs to benzothiophene derivatives. Functionalized benzothiophenes are important constructs found in molecules with wide ranging biological activity and in organic materials. The different substitution patterns in these heterocycles offer new opportunities for drug discovery and other applications in materials science.Electric Literature of C13H10OS

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

Ozdemir, Zuhal et al. published their research in Archiv der Pharmazie (Weinheim, Germany) in 2008 | CAS: 3988-77-0

3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one (cas: 3988-77-0) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The core structure is a part of various pharmaceutical substances and natural products. It is also used in the manufacturing of dyes such as thioindigo.Reference of 3988-77-0

Synthesis and studies on antidepressant and anticonvulsant activities of some 3-(2-thienyl)pyrazoline derivatives was written by Ozdemir, Zuhal;Kandilci, H. Burak;Gumusel, Bulent;Calis, Unsal;Bilgin, A. Altan. And the article was included in Archiv der Pharmazie (Weinheim, Germany) in 2008.Reference of 3988-77-0 This article mentions the following:

In this study, the synthesis of twelve 3-(2-thienyl)pyrazoline derivatives are described. The structures of all compounds were confirmed by UV, IR, 1H-NMR, mass spectral data, and microanalyses. In the pharmacol. studies, antidepressant and anticonvulsant activities of these compounds have been screened. The antidepressant activities of the compounds were investigated by Porsolt’s behavioral despair test (forced swimming) on albino mice and compared with tranylcypromine. Among the compounds examined, the compounds I (R1 = 2-thienyl; R2 = Me, Ph) showed significant antidepressant activity. Anticonvulsant activities of the compounds were determined by maximal electroshock seizure (MES) and s.c. pentylenetetrazole (metrazol) (scMet.) tests, neurotoxicities were determined by rotarod toxicity test on albino mice. Compound I (R1 = R2 = Ph) was found to be protective against MES in the range of 30-300 mg/kg dose levels at four hours. None of the synthesized compounds showed neurotoxicity at 30-300 mg/kg dose levels. In the experiment, the researchers used many compounds, for example, 3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one (cas: 3988-77-0Reference of 3988-77-0).

3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one (cas: 3988-77-0) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The core structure is a part of various pharmaceutical substances and natural products. It is also used in the manufacturing of dyes such as thioindigo.Reference of 3988-77-0

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

Peng, Cheng et al. published their research in Organic & Biomolecular Chemistry in 2017 | CAS: 3988-77-0

3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one (cas: 3988-77-0) belongs to benzothiophene derivatives. Benzothiophenes are valuable heterocycles that are widely used in medicines, agrochemicals, and materials science. It has been used as a raw material for the synthesis of biologically active structures and is found in pharmaceuticals such as leukotriene synthesis inhibitors and antifungals, as well as in many natural products.Related Products of 3988-77-0

Lanthanide amide-catalyzed one-pot functionalization of isatins: synthesis of spiro[cyclopropan-1,3′-oxindoles] and 2-oxoindolin-3-yl phosphates was written by Peng, Cheng;Zhai, Jiaojiao;Xue, Mingqiang;Xu, Fan. And the article was included in Organic & Biomolecular Chemistry in 2017.Related Products of 3988-77-0 This article mentions the following:

Lanthanide amide-catalyzed one-pot reaction of isatins I (R1 = H, 7-F, 5-CH3, etc.; R2 = C2H5, CH2CH=CH2, CH2C6H5), di-Et phosphite and activated alkenes R3CH=C(R4)R5 [R3 = H, C6H5, C(O)2C2H5, etc.; R4 = H, CH3, C(O)C6H5, etc.; R5 = C(O)2CH3, P(O)(OCH3)2] was developed and a series of spiro[cyclopropan-1,3′-oxindoles] II was obtained in moderate to excellent yields. The reaction is stereoselective and the two substituents at the 2 and 3-positions of the cyclopropane in the major product are in the trans configuration. A four-step mechanism involving the Pudovik reaction, Brook rearrangement, Michael addition, and intramol. nucleophilic substitution is proposed, and an umpolung strategy was used in the process. In the experiment, the researchers used many compounds, for example, 3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one (cas: 3988-77-0Related Products of 3988-77-0).

3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one (cas: 3988-77-0) belongs to benzothiophene derivatives. Benzothiophenes are valuable heterocycles that are widely used in medicines, agrochemicals, and materials science. It has been used as a raw material for the synthesis of biologically active structures and is found in pharmaceuticals such as leukotriene synthesis inhibitors and antifungals, as well as in many natural products.Related Products of 3988-77-0

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

Song, Huifang et al. published their research in Journal of Organic Chemistry in 2022 | CAS: 3988-77-0

3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one (cas: 3988-77-0) belongs to benzothiophene derivatives. Benzothiophene is a fused ring compound of thiophene ring and benzene ring, which is an important class of heterocycles with advantageous structures. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, sertaconazole, and also BTCP.Product Details of 3988-77-0

Asymmetric Hydrophosphonylation of α,β-Unsaturated Ketones Catalyzed by Rare-Earth Metal Complexes Bearing Trost Ligands was written by Song, Huifang;Sun, Yuli;Lu, Chengrong;Zhao, Bei. And the article was included in Journal of Organic Chemistry in 2022.Product Details of 3988-77-0 This article mentions the following:

Chiral dinuclear rare-earth metal complexes RE2Ln2 (n = 1, RE = Y (1), Eu (2), Nd (3), La (4), Gd (5); n = 2, RE = Eu (6), Gd (7)) stabilized by the corresponding Trost ligands H3L1 or H3L2 (H3L1 = (S,S)-2,6-bis[2-(hydroxydiphenylmethyl)pyrrolidin-1-ylmethyl]-4-methylphenol, H3L2 = (S,S)-2,6-bis[2-(hydroxydiphenylmethyl)pyrrolidin-1-ylmethyl]-4-chlorophenol) were prepared and three unknown complexes 5–7 were characterized by x-ray diffraction anal. The chiral rare-earth metal complexes 1–7 displayed high reactivity in the asym. hydrophosphonylation of α,β-unsaturated ketones, and 5 mol % of complex 7 together with 10 mol % of chiral diamine (1S,2S)-1,2-cyclohexanediamine are the optimal catalyst combination. Various hydrophosphonylation products with excellent yields and high to excellent enantiomeric excess (ee) values were obtained in toluene (up to 99% yield, >99% ee). In the experiment, the researchers used many compounds, for example, 3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one (cas: 3988-77-0Product Details of 3988-77-0).

3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one (cas: 3988-77-0) belongs to benzothiophene derivatives. Benzothiophene is a fused ring compound of thiophene ring and benzene ring, which is an important class of heterocycles with advantageous structures. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, sertaconazole, and also BTCP.Product Details of 3988-77-0

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

Ingle, A. V. et al. published their research in Oriental Journal of Chemistry in 2010 | CAS: 3988-77-0

3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one (cas: 3988-77-0) belongs to benzothiophene derivatives. Benzothiophene is a fused ring compound of thiophene ring and benzene ring, which is an important class of heterocycles with advantageous structures. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, sertaconazole, and also BTCP.Application In Synthesis of 3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one

Synthesis of 3,5-disubsituted pyrazolines and their derivatives was written by Ingle, A. V.;Doshi, A. G.;Raut, A. W.. And the article was included in Oriental Journal of Chemistry in 2010.Application In Synthesis of 3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one This article mentions the following:

2-Acetylthiophene condenses with different aromatic aldehyde in ethanol in the presence of aqueous NaOH to give 1-(2′-thienyl)-3-(substituted phenyl)-2-propen-1-ones (Ia-e) which react with hydrazine hydrate in ethanol to give pyrazolines (IIa-e). Similarly, 1-(2′-thienyl)-3-(substituted phenyl)-2-propen-1-ones (Ia-e) react with Ph hydrazine hydrochloride in the presence of ethanol medium and 1,2 drops of NaOH (2N) to give 1-Ph pyrazolines (IIIa-e). (Ia-e) react with 2,4-dinitro Ph hydrazine in presence of ethanol medium to give 1-(2,4-dinitro phenyl) pyrazolines (IVa-e) and also they react with semicarbazide hydrochloride in presence of ethanol medium and 1,2 drops of NaOH (2N) to give 1-carboxamido pyrazolines (Va-e). Pyrazolines (IIa-e) react with acetic acid to give 1-acetyl pyrazolines (VIa-e), as well as with benzoyl chloride in pyridine medium to give 1-benzoyl pyrazolines (VIIa-e). IIa-e also react with 1:1 HCl and 10% sodium nitrite to give 1-nitroso pyrazolines (VIIIa-e). Characterization and structural elucidation were done on the basis of m.ps. determination, anal. and spectral studies. In the experiment, the researchers used many compounds, for example, 3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one (cas: 3988-77-0Application In Synthesis of 3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one).

3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one (cas: 3988-77-0) belongs to benzothiophene derivatives. Benzothiophene is a fused ring compound of thiophene ring and benzene ring, which is an important class of heterocycles with advantageous structures. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, sertaconazole, and also BTCP.Application In Synthesis of 3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

Kumar, Togiti Uday et al. published their research in Journal of Heterocyclic Chemistry in 2019 | CAS: 3988-77-0

3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one (cas: 3988-77-0) belongs to benzothiophene derivatives. Benzothiophene scaffolds are of great importance due to its increased presence in bioactive molecules. It has been used as a raw material for the synthesis of biologically active structures and is found in pharmaceuticals such as leukotriene synthesis inhibitors and antifungals, as well as in many natural products.HPLC of Formula: 3988-77-0

Application of Polyphosphoric Acid-Mediated Acyl Migration for Regiospecific Synthesis of Diverse 2-Acylpyrroles from Chalcones was written by Kumar, Togiti Uday;Thigulla, Yadagiri;Rangan, Krishnan;Bhattacharya, Anupam. And the article was included in Journal of Heterocyclic Chemistry in 2019.HPLC of Formula: 3988-77-0 This article mentions the following:

A metal-free approach for the synthesis of 2-acylpyrroles was reported. Synthesis of the target mol. started from chalcones and carried out in two steps. Initial step involved the conversion of chalcones to corresponding 4-substituted-3-acylpyrroles by reaction with TosMIC. In the subsequent step, target mols. were obtained in modest to good yields by polyphosphoric acid-mediated acyl rearrangement of 3-acylpyrroles to their 2-acyl congeners. The crucial final step was amenable to diverse substitutions on pyrrole ring. Preliminary experiment for the determination of mechanism indicated the involvement of acylium ion. In the experiment, the researchers used many compounds, for example, 3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one (cas: 3988-77-0HPLC of Formula: 3988-77-0).

3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one (cas: 3988-77-0) belongs to benzothiophene derivatives. Benzothiophene scaffolds are of great importance due to its increased presence in bioactive molecules. It has been used as a raw material for the synthesis of biologically active structures and is found in pharmaceuticals such as leukotriene synthesis inhibitors and antifungals, as well as in many natural products.HPLC of Formula: 3988-77-0

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

Gomha, Sobhi M. et al. published their research in Journal of Heterocyclic Chemistry in 2020 | CAS: 3988-77-0

3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one (cas: 3988-77-0) belongs to benzothiophene derivatives. Functionalized benzothiophenes are important constructs found in molecules with wide ranging biological activity and in organic materials. It has been used as a raw material for the synthesis of biologically active structures and is found in pharmaceuticals such as leukotriene synthesis inhibitors and antifungals, as well as in many natural products.Electric Literature of C13H10OS

Green synthesis, molecular docking and pharmacological evaluation of new triazolo-thiadiazepinylcoumarin derivatives as sedative-hypnotic scaffold was written by Gomha, Sobhi M.;Abdel-aziz, Hassan M.;Abolibda, Tariq Z.;Hassan, Shaimaa A.;Abdalla, Mohamed M.. And the article was included in Journal of Heterocyclic Chemistry in 2020.Electric Literature of C13H10OS This article mentions the following:

4-Amino-5-mercapto-4H-1,2,4-triazole was used as a key intermediate for the preparation of 1,2,4-triazolo[3,4-b][1,3,4]thiadiazepine derivatives I [X = H, Me, OMe, Cl], II [Y = CN, COOEt; Ar = 2-furanyl, Ph, 4-methylphenyl, 4-chlorophenyl] and III via reactions with the appropriate chalcones, α,β-unsaturated carbonitrile derivatives resp. The identity of the synthesized compounds was elucidated via their spectral data and elemental anal. Moreover, the sedative-hypnotic activity of the newly synthesized compounds were evaluated and showed excellent activities especially compounds II [Y = CN, Ar = 4-methylphenyl; Y = COOEt, Ar = 4-methylphenyl] and III. Also, their structure activity relationship was clearly demonstrated and showed that the electron-donating groups enhance activities while electron-withdrawing groups decrease activities. The mol. docking of the most active derivative III against γ-amino butyric acid (GABA) receptor was performed by the MOE 2014 program. The acquired outcomes demonstrated that the most active compounds could be a helpful model for future structure, adjustment and examination to build more active analogs. In the experiment, the researchers used many compounds, for example, 3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one (cas: 3988-77-0Electric Literature of C13H10OS).

3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one (cas: 3988-77-0) belongs to benzothiophene derivatives. Functionalized benzothiophenes are important constructs found in molecules with wide ranging biological activity and in organic materials. It has been used as a raw material for the synthesis of biologically active structures and is found in pharmaceuticals such as leukotriene synthesis inhibitors and antifungals, as well as in many natural products.Electric Literature of C13H10OS

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

Tanpure, Sudhakar Dattatray et al. published their research in ACS Catalysis in 2022 | CAS: 3988-77-0

3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one (cas: 3988-77-0) belongs to benzothiophene derivatives. Benzothiophene is a fused ring compound of thiophene ring and benzene ring, which is an important class of heterocycles with advantageous structures. Due to its aromaticity, thiophenes do not exhibit the same properties as conventional thioethers.COA of Formula: C13H10OS

Gold(I)-Catalyzed Highly Diastereo- and Enantioselective Constructions of Bicyclo[3.2.1]oct-6-ene Frameworks via (4 + 3)-Cycloadditions was written by Tanpure, Sudhakar Dattatray;Kuo, Tung-Chun;Cheng, Mu-Jeng;Liu, Rai-Shung. And the article was included in ACS Catalysis in 2022.COA of Formula: C13H10OS This article mentions the following:

A one-pot construction of bicyclo[3.2.1]oct-6-ene frameworks involved gold-catalyzed (4 + 3)-cycloadditions between 2-(1-alkynyl)-2-alken-1-ones and substituted cyclopentadienes; diastereoselectivity (dr >25:1) and enantioselectivity (up to 99.9% ee) were achieved with a chiral gold catalyst. DFT calculations suggested a three-step ionic mechanism for the cycloadditions of gold-containing 1,3-dipoles with cyclopentadienes, in which an exo-spatial arrangement was preferable. In the experiment, the researchers used many compounds, for example, 3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one (cas: 3988-77-0COA of Formula: C13H10OS).

3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one (cas: 3988-77-0) belongs to benzothiophene derivatives. Benzothiophene is a fused ring compound of thiophene ring and benzene ring, which is an important class of heterocycles with advantageous structures. Due to its aromaticity, thiophenes do not exhibit the same properties as conventional thioethers.COA of Formula: C13H10OS

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

Ozdemir, Ahmet et al. published their research in Pharmaceutical Chemistry Journal in 2014 | CAS: 3988-77-0

3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one (cas: 3988-77-0) belongs to benzothiophene derivatives. Benzothiophene finds use in research as a starting material for the synthesis of larger, usually bioactive structures. It is also used in the manufacturing of dyes such as thioindigo.Product Details of 3988-77-0

Synthesis and Biological Evaluation of a New Series of Pyrazolines as New Anticandidal Agents was written by Ozdemir, Ahmet;Altintop, Mehlika Dilek;Kaplancikli, Zafer Asim;Turan-Zitouni, Gulhan;Ciftci, Gulsen Akalin;Demirci, Fatih. And the article was included in Pharmaceutical Chemistry Journal in 2014.Product Details of 3988-77-0 This article mentions the following:

New pyrazoline derivatives bearing an oxadiazole moiety were synthesized via the reaction of 1-(chloroacetyl)-3-(2-furyl/thienyl)-5-aryl-2-pyrazolines with 5-substituted-1,3,4-oxadiazole-2(3H)-thiones in the presence of potassium carbonate. The pyrazolines were screened for their antifungal activity against various Candida species and compared with ketoconazole. Among these compounds, the most effective derivatives were evaluated for their cytotoxicity against NIH/3T3 cells. 2-({2-[5-(4-Bromophenyl)-3-(2-furyl)-4,5-dihydro-1H-pyrazol-1-yl]-2-oxoethyl}thio)-5-(2-cyclopentylethyl)-1,3,4-oxadiazole can be identified as the most potent antifungal agent against C. tropicalis due to its inhibitory effect on C. tropicalis and low toxicity to NIH/3T3 cells. In the experiment, the researchers used many compounds, for example, 3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one (cas: 3988-77-0Product Details of 3988-77-0).

3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one (cas: 3988-77-0) belongs to benzothiophene derivatives. Benzothiophene finds use in research as a starting material for the synthesis of larger, usually bioactive structures. It is also used in the manufacturing of dyes such as thioindigo.Product Details of 3988-77-0

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem