Tag: 214.2829

Synthesis and biological evaluation of some novel pyrazoline derivatives was written by Satyanarayana, D.;Revanasiddappa, B. C.;Neema, K. V.. And the article was included in Indian Journal of Heterocyclic Chemistry in 2013.COA of Formula: C13H10OS This article mentions the following:

Chalcones were prepared by reacting 2-acetylthiophene and aromatic aldehydes in presence of NaOH in alc. medium. The resultant chalcones underwent selective cyclization with Ph hydrazine to yield the title compounds pyrazoline derivatives The structures of the synthesized compounds were confirmed by IR, ¹H NMR, Mass spectra and elemental anal. These compounds were screened for their antimicrobial and antifungal activity. Some of the final synthesized compounds have exhibited promising antibacterial activity against Gram neg. bacteria and promising antifungal activity against A. flavus. In the experiment, the researchers used many compounds, for example, 3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one (cas: 3988-77-0COA of Formula: C13H10OS).

3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one (cas: 3988-77-0) belongs to benzothiophene derivatives. Benzothiophene is used as starting material for the synthesis of bioactive molecules. The core structure is a part of various pharmaceutical substances and natural products. It has been used as a raw material for the synthesis of biologically active structures and is found in pharmaceuticals such as leukotriene synthesis inhibitors and antifungals, as well as in many natural products.COA of Formula: C13H10OS

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Pentanidium-catalyzed enantioselective phase-transfer conjugate addition reactions was written by Ma, Ting;Fu, Xiao;Kee, Choon Wee;Zong, Lili;Pan, Yuanhang;Huang, Kuo-Wei;Tan, Choon-Hong. And the article was included in Journal of the American Chemical Society in 2011.Reference of 3988-77-0 This article mentions the following:

A new chiral entity, pentanidium, has been shown to be an excellent chiral phase-transfer catalyst. The enantioselective Michael addition reactions of tert-Bu glycinate-benzophenone Schiff base with various α,β-unsaturated acceptors provide adducts with high enantioselectivities. A successful gram-scale experiment at a low catalyst loading of 0.05 mol % indicates the potential for practical applications of this methodol. Phosphoglycine ester analogs can also be utilized as the Michael donor, affording enantioenriched α-aminophosphonic acid derivatives and phosphonic analogs of (S)-proline. In the experiment, the researchers used many compounds, for example, 3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one (cas: 3988-77-0Reference of 3988-77-0).

3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one (cas: 3988-77-0) belongs to benzothiophene derivatives. Benzothiophenes are valuable heterocycles that are widely used in medicines, agrochemicals, and materials science. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, and sertaconazole, and also BTCP.Reference of 3988-77-0

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Metal-Free Dehydrogenative Double C-H Sulfuration To Access Thieno[2,3-b]indoles Using Elemental Sulfur was written by Liu, Jianming;Zhang, Yanyan;Yue, Yuanyuan;Wang, Zhixian;Shao, Huibin;Zhuo, Kelei;Lv, Qingzhang;Zhang, Zhiguo. And the article was included in Journal of Organic Chemistry in 2019.Recommanded Product: 3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one This article mentions the following:

A base-promoted metal-free approach for the synthesis of thieno[2,3-b]indole derivatives is reported. This method combined four C-H σ-bond cleavage reactions of two different kinds of C-H bonds and two C-S σ-bond formation processes. A series of thieno[2,3-b]indoles were obtained starting from 3-benzylindole derivatives with good yields and high regioselectivity, with the elemental sulfur serving as a cheap and readily available sulfur source. Good efficiency could be maintained even when the reaction was performed on a gram scale. A plausible mechanism was proposed on the basis of mechanistic studies. In the experiment, the researchers used many compounds, for example, 3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one (cas: 3988-77-0Recommanded Product: 3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one).

3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one (cas: 3988-77-0) belongs to benzothiophene derivatives. Benzothiophene scaffolds are of great importance due to its increased presence in bioactive molecules. It is also used in the manufacturing of dyes such as thioindigo.Recommanded Product: 3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Fly-ash:H₂O catalyzed aqueous phase cyclization of chalcones: synthesis of some substituted pyrazole-1-carbothioamides and spectral correlations in 3-(3,4-dimethylphenyl)-5-(substituted phenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamides was written by Thirunarayanan, G.;Sekar, K. G.. And the article was included in Organic Chemistry: An Indian Journal in 2013.Recommanded Product: 3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one This article mentions the following:

Substituted 1-thiocarbamoyl pyrazolines I (R¹ = Me, Ph, 4-MeOC₆H₄, 2-thienyl, 3,4-Me₂C₆H₃, etc.; R² = Ph, 4-MeOC₆H₄, 2-furyl, 2-thienyl, etc.) were synthesized by solvent-free aqueous phase fly-ash:H₂O catalyzed cyclization of chalcones R¹C(O)CH:CHR² and thiosemicarbazide in higher than 75% yields. The spectral data of the compounds I (R¹ = 3,4-Me₂C₆H₃; R² = Ph, 4-MeOC₆H₄, 2-BrC₆H₄, 4-BrC₆H₄, etc.) was correlated using single and multi-linear regression anal. In the experiment, the researchers used many compounds, for example, 3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one (cas: 3988-77-0Recommanded Product: 3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one).

3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one (cas: 3988-77-0) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The electrophilic substitution of benzothiophene systems is much less regioselective than that of indoles. Due to its aromaticity, thiophenes do not exhibit the same properties as conventional thioethers.Recommanded Product: 3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Synthesis of bulky-tailed sulfonamides incorporating pyrido[2,3-d][1,2,4]triazolo[4,3-a]pyrimidin-1(5H)-yl) moieties and evaluation of their carbonic anhydrases I, II, IV and IX inhibitory effects was written by Fares, Mohamed;Eladwy, Radwa A.;Nocentini, Alessio;Abd El Hadi, Soha R.;Ghabbour, Hazem A.;Abdel-Megeed, Ashraf;Eldehna, Wagdy M.;Abdel-Aziz, Hatem A.;Supuran, Claudiu T.. And the article was included in Bioorganic & Medicinal Chemistry in 2017.Reference of 3988-77-0 This article mentions the following:

Using celecoxib as lead, two novel series of sulfonamides incorporating the pyridotriazolopyrimidine scaffold have been synthesized and evaluated in vitro as inhibitors against four relevant human (h) carbonic anhydrases (CAs, EC 4.2.1.1), the cytosolic and ubiquitous hCA I and II as well as the transmembrane hCA IV and hCA IX. Most of the reported sulfonamides acted as efficient, low micromolar inhibitors of hCAI, II and IV, whereas they displayed higher efficacy in inhibiting the tumor-associated isoform hCA IX. Many derivates herein reported showed better hCA IX vs. hCA II selectivity ratios compared to celecoxib or acetazolamide. Considering isoform IX is a validated target for the diagnosis and treatment of hypoxic tumors, discovery of selective CA IX inhibitors represents a promising step to unveil more effective anticancer therapies. In the experiment, the researchers used many compounds, for example, 3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one (cas: 3988-77-0Reference of 3988-77-0).

3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one (cas: 3988-77-0) belongs to benzothiophene derivatives. Benzothiophene is used as starting material for the synthesis of bioactive molecules. The core structure is a part of various pharmaceutical substances and natural products. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization.Reference of 3988-77-0

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Preheated fly-ash catalyzed aldol condensation: efficient synthesis of chalcones and antimicrobial activities of some 3-thienyl chalcones was written by Arulkumaran, Ranganathan;Vijayakumar, Sambandhamoorthy;Sakthinathan, S. Pazhanivel;Kamalakkannan, Dakshnamoorthy;Ranganathan, Kaliyaperumal;Suresh, Ramamoorthy;Sundararajan, Rajasekaran;Vanangamudi, Ganesan;Thirunarayanan, Ganesamoorthy. And the article was included in Journal of the Chilean Chemical Society in 2013.Formula: C13H10OS This article mentions the following:

In the present study the authors have prepared a series of chalcone derivatives by a solvent-free aldol condensation mediated by microwave irradiation The synthesis of the target compounds was achieved using heat-treated fly ash (ash residue) as a catalyst. The yields of the ketones are more than 60%. The synthesized chalcones were characterized by their anal., phys. and spectral data. The antimicrobial activities of substituted styryl 3-thienyl ketones were studied using the Bauer-Kirby method. The title compounds thus formed included 3-(4-nitrophenyl)-1-(3-thienyl)-2-propen-1-one (I) and related substances, such as 2-thiophene derivatives, naphthalene derivatives, benzenamine derivatives, halobenzene derivatives, phenol derivatives, etc. In the experiment, the researchers used many compounds, for example, 3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one (cas: 3988-77-0Formula: C13H10OS).

3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one (cas: 3988-77-0) belongs to benzothiophene derivatives. Functionalized benzothiophenes are important constructs found in molecules with wide ranging biological activity and in organic materials. It is found within the chemical structures of pharmaceutical drugs such as zileuton, raloxifene, and sertaconazole, and also BTCP.Formula: C13H10OS

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Synthesis of Novel Chiral Phosphoric Acid-Bearing Two Acidic Phenolic Hydroxyl Groups and its Catalytic Evaluation for Enantioselective Friedel-Crafts Alkylation of Indoles and Enones was written by Liu, Xiong-Li;Yu, Zhang-Biao;Pan, Bo-Wen;Chen, Lin;Feng, Ting-Ting;Zhou, Ying. And the article was included in Journal of Heterocyclic Chemistry in 2015.Category: benzothiophene This article mentions the following:

A novel chiral phosphoric acid catalyst bearing two acidic phenolic hydroxyl groups was synthesized. Its catalytic activity as a chiral Bronsted acid has been examined in the enantioselective Friedel-Crafts alkylation of indoles and enones as a model reaction. In comparison with the other chiral phosphoric acid catalysts, the reaction catalyzed by the novel chiral catalyst afforded the desired 3-substituted indoles I (R¹ = H, OCH₃, Br; R² = H, CH; R³ = Ph, n-Pr, 2-naphthyl, 2-thienyl, 2-furyl; R⁴ = Ph, CH₃, 2-thienyl, 4-ClC₆H₄, 4-CH₃OC₆H₄) in a higher enantioselectivity (up to 69% ee). In the experiment, the researchers used many compounds, for example, 3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one (cas: 3988-77-0Category: benzothiophene).

3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one (cas: 3988-77-0) belongs to benzothiophene derivatives. Benzothiophene is used as starting material for the synthesis of bioactive molecules. The core structure is a part of various pharmaceutical substances and natural products. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, and sertaconazole, and also BTCP.Category: benzothiophene

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Pyrrolo[1,2-a]quinoxalines from chalcones: An alternate route was written by Togiti, Uday Kumar;Shukla, Adarash Kumar;Bhattacharya, Anupam. And the article was included in Tetrahedron Letters in 2021.Application In Synthesis of 3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one This article mentions the following:

The synthesis of 2,4-disubstituted pyrrolo[1,2-a]quinoxalines from chalcones is reported. The key steps used are polyphosphoric acid (PPA) assisted acyl rearrangement of the pyrrole ring and Fe catalyzed reduction-cyclization leading to 2,4-disubstituted pyrrolo[1,2-a]quinoxalines. Despite the utilization of comparatively unreactive aromatic ketones, modest to good yields were obtained. In the experiment, the researchers used many compounds, for example, 3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one (cas: 3988-77-0Application In Synthesis of 3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one).

3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one (cas: 3988-77-0) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The electrophilic substitution of benzothiophene systems is much less regioselective than that of indoles. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, and sertaconazole, and also BTCP.Application In Synthesis of 3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Enantioselective aza-Michael reaction of hydrazide to chalcones through the nonactivated amine moiety conjugated addition was written by Jiang, Jun;Cai, Yunfei;Chen, Weiliang;Lin, Lili;Liu, Xiaohua;Feng, Xiaoming. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2011.Application of 3988-77-0 This article mentions the following:

The catalytic asym. aza-Michael reaction of benzoyl hydrazine toward chalcones through the nonactivated amine moiety conjugated addition was facilitated by the developed N,N’-dioxide-Sc(OTf)₃ complex under mild conditions, affording the pharmacol. and synthetically useful products in moderate to high yields with up to 97% ee. In the experiment, the researchers used many compounds, for example, 3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one (cas: 3988-77-0Application of 3988-77-0).

3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one (cas: 3988-77-0) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The core structure is a part of various pharmaceutical substances and natural products. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, sertaconazole, and also BTCP.Application of 3988-77-0

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Chemoselective Hydrosilylation of the α,β-Site Double Bond in α,β- and α,β,γ,δ-Unsaturated Ketones Catalyzed by Macrosteric Borane Promoted by Hexafluoro-2-propanol was written by Zhan, Xiao-Yu;Zhang, Hua;Dong, Yu;Yang, Jian;He, Shuai;Shi, Zhi-Chuan;Tang, Lei;Wang, Ji-Yu. And the article was included in Journal of Organic Chemistry in 2020.Recommanded Product: 3988-77-0 This article mentions the following:

The B(C₆F₅)₃-catalyzed chemoselective hydrosilylation of α,β- and α,β,γ,δ-unsaturated ketones into the corresponding asym. ketones in mild reaction conditions is developed. Nearly 50 substrates including those bearing reducible functional groups such as alkynyl, alkenyl, cyano, and aromatic heterocycles are chemoselectively hydrosilylation in good to excellent yields. Isotope-labeling studies revealed that HFIP also served as hydrogen source in the process. In the experiment, the researchers used many compounds, for example, 3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one (cas: 3988-77-0Recommanded Product: 3988-77-0).

3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one (cas: 3988-77-0) belongs to benzothiophene derivatives. Benzothiophene finds use in research as a starting material for the synthesis of larger, usually bioactive structures. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, sertaconazole, and also BTCP.Recommanded Product: 3988-77-0

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem