20532-34-7, Benzo[b]thiophen-5-ylmethanol is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
(5-Bromomethyl)benzo[b]thiophene (15b). To a stirred solution of benzo[b]thiophen-5-ylmethanol (14b) (100 mg, 0.61 mmol) in dry dichloromethane (15 mL) and under argon, PPh3 (290 mg, 1.09 mmol) and then CBr4 (240 mg, 0.73 mmol) were added. After stirring for 1 h, diethyl ether was added and the resulting precipitate was filtered and washed with diethyl ether. The solvents were removed under reduced pressure and the crude residue was purified by flash chromatography eluting with (10:90) diethyl ether/hexanes to afford bromide 15b (129 mg, 93%) as a white amorphous solid. 1H NMR (250 MHz, CDCl3) delta 7.86 (m, 2H, 2*ArH), 7.49 (d, 1H, J=5.5 Hz, ArH), 7.39 (d, 1H, J=8.7 Hz, ArH), 7.33 (d, 1H, J=5.5 Hz, ArH) and 4.66 (s, 2H, CH2O) ppm. 13 C NMR (63 MHz, CDCl3) delta 139.7 (C), 139.7 (C), 133.8 (C), 127.4 (CH), 125.2 (CH), 123.9 (CH), 123.7 (CH), 122.8 (CH) and 34.1 (CH2) ppm. MS (CI) m/z (%) 227 and 229 (MH+). HRMS calcd for C9H3S79Br (MH+): 226.9530; found, 226.9532.
20532-34-7 Benzo[b]thiophen-5-ylmethanol 2795446, abenzothiophene compound, is more and more widely used in various.
Reference£º
Patent; UNIVERSIDADE DE SANTIAGO DE COMPOSTELA; US2011/313032; (2011); A1;,
Benzothiophene – Wikipedia
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