Tag: 20532-28-9

20532-28-9, 5-Aminobenzothiophene is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,20532-28-9

EXAMPLE 61 Benzo[b]thiophen-5-yl-(6-methyl-pyrido[3,4-d]pyrimidin-4-yl)-aminehydrochloride This material was prepared from 6-methyl-pyrido[3,4-d]pyrimid -4-one (1.0 eq.) and 5-amino-benzo[b]thiophene (1.5 eq.) as described for Example 60. The polymer was filtered off and washed several times with 30% methanol/70% chloroform. Triethylamine (3.0 eq) was added to the filtrate and washings before they were concentrated in vacuo. The residue was flash chromatographed on silica in 10% methanol/methylenechloride to afford 135 mg of product as the free base (LC-MS: 293(MH+)). This material was dissolved in a minimum volume of chloroform and 1 mole equivalent of HCl in ether was added dropwise with stirring. The reaction mixture was diluted with ether (4volumes) and the precipitated title product was filtered and dried in vacuo (152 mg; M.P. 273-276 C.; LC-MS: 293 (MH+); anal. RP-HPLC:4.10 min.).

The synthetic route of 20532-28-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Pfizer Inc; US6395733; (2002); B1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20532-28-9,5-Aminobenzothiophene,as a common compound, the synthetic route is as follows.

A solution of 540 mg of benzo[b]thiophen-5-ylamine in 5 ml of diethyl ethoxymethylenemalonate is stirred at 130C for 1.5 hours. The reaction mixture is then diluted with ethyl acetate. It is washed with saturated aqueous sodium chloride solution, dried over sodium sulphate and concentrated in vacuo. The crude product is purified by column chromatography on silica gel with a hexane/ethyl acetate mixture. 1.88 g of product are obtained.1H-NMR (CDCl3): delta= 1.30-1.45 (6H); 4.20-4.38 (4H); 7.16 (1 H); 7.30 (1 H); 7.51 (1H); 7.58 (1H); 7.86 (1 H); 8.60 (1H) 11.12 (1 H).

As the paragraph descriping shows that 20532-28-9 is playing an increasingly important role.

Reference£º
Patent; BAYER SCHERING PHARMA AKTIENGESELLSCHAFT; WO2007/147578; (2007); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem