Tag: 200-300

Tetrahydrobenzothiophene inhibitors of hepatitis C virus NS5B polymerase was written by LaPorte, M. G.;Lessen, T. A.;Leister, L.;Cebzanov, D.;Amparo, E.;Faust, C.;Ortlip, D.;Bailey, T. R.;Nitz, T. J.;Chunduru, S. K.;Young, D. C.;Burns, C. J.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2006.Recommanded Product: 95211-67-9 The following contents are mentioned in the article:

A novel series of selective HCV NS5B RNA dependent RNA polymerase inhibitors has been disclosed. These compounds contain an appropriately substituted tetrahydrobenzothiophene scaffold. This communication will detail the SAR and activities of this series. This study involved multiple reactions and reactants, such as Ethyl 2-amino-4-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate (cas: 95211-67-9Recommanded Product: 95211-67-9).

Ethyl 2-amino-4-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate (cas: 95211-67-9) belongs to benzothiophene derivatives. Benzothiophene finds use in research as a starting material for the synthesis of larger, usually bioactive structures. The different substitution patterns in these heterocycles offer new opportunities for drug discovery and other applications in materials science.Recommanded Product: 95211-67-9

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Novel Small Molecule Inhibitors of MDR Mycobacterium tuberculosis by NMR Fragment Screening of Antigen 85C was written by Scheich, Christoph;Puetter, Vera;Schade, Markus. And the article was included in Journal of Medicinal Chemistry in 2010.Application In Synthesis of Ethyl 2-amino-4-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate The following contents are mentioned in the article:

Protein target-based discovery of novel antibiotics has been largely unsuccessful despite rich genome information. Particularly in need are new antibiotics for tuberculosis, which kills 1.6 million people annually and shows a rapid increase in multiple-drug-resistant cases. By combining fragment-based drug discovery with early whole cell antibacterial screening, we discovered novel ligand-efficient inhibitors of multiple-drug resistant Mycobacterium tuberculosis (Mtb), which bind to the substrate site of the Mtb protein antigen 85C, hitherto unused in Mtb chemotherapy. This study involved multiple reactions and reactants, such as Ethyl 2-amino-4-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate (cas: 95211-67-9Application In Synthesis of Ethyl 2-amino-4-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate).

Ethyl 2-amino-4-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate (cas: 95211-67-9) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The electrophilic substitution of benzothiophene systems is much less regioselective than that of indoles. The different substitution patterns in these heterocycles offer new opportunities for drug discovery and other applications in materials science.Application In Synthesis of Ethyl 2-amino-4-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Structure-activity relationship study of novel tissue transglutaminase inhibitors was written by Duval, Eric;Case, April;Stein, Ross L.;Cuny, Gregory D.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2005.Recommanded Product: 95211-67-9 The following contents are mentioned in the article:

Thieno[2,3-d]pyrimidin-4-one acyl hydrazide derivatives, e.g., I, were discovered as moderately potent inhibitors of TGase 2 (tissue transglutaminase) utilizing a fluorescence-based assay that measured TGase 2 catalyzed incorporation of the dansylated Lys derivative α-N-Boc-Lys-CH₂-CH₂-dansyl into the protein substrate N,N-dimethylated-casein. A SAR study revealed that the acyl hydrazide thioether side-chain and the thiophene ring were critical to inhibitory activity. This study involved multiple reactions and reactants, such as Ethyl 2-amino-4-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate (cas: 95211-67-9Recommanded Product: 95211-67-9).

Ethyl 2-amino-4-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate (cas: 95211-67-9) belongs to benzothiophene derivatives. Benzothiophene is a fused ring compound of thiophene ring and benzene ring, which is an important class of heterocycles with advantageous structures. It is found within the chemical structures of pharmaceutical drugs such as zileuton, raloxifene, and sertaconazole, and also BTCP.Recommanded Product: 95211-67-9

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Proton magnetic resonance spectra of some benzo[b]thiophene derivatives was written by Chapman, Norman Bellamy;Ewing, David F.;Scrowston, R. M.;Westwood, R.. And the article was included in Journal of the Chemical Society [Section] C: Organic in 1968.Computed Properties of C11H9BrO2S The following contents are mentioned in the article:

Attempts are made to correlate the chem. shifts in the 100 Mc./sec. 1H N.M.R. spectra of 42 benzo[b]thiophene derivatives with the substituents present in the mol., and the relations are rationalized where possible. Coupling constants are also recorded, and their dependence on bond order and on other factors is discussed. The changes in the chem. shifts and coupling constants when the benzo[b]thiophenes are oxidized to the 1,1-dioxides are recorded and discussed. 43 references. This study involved multiple reactions and reactants, such as Ethyl 5-bromobenzo[b]thiophene-2-carboxylate (cas: 13771-68-1Computed Properties of C11H9BrO2S).

Ethyl 5-bromobenzo[b]thiophene-2-carboxylate (cas: 13771-68-1) belongs to benzothiophene derivatives. Functionalized benzothiophenes are important constructs found in molecules with wide ranging biological activity and in organic materials. It is also used in the manufacturing of dyes such as thioindigo.Computed Properties of C11H9BrO2S

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

An efficient aromatization of 2-amino-4,5,6,7-tetrahydrobenzo-[b]thiophene-3-carboxylates in dimethyl sulfoxide catalyzed by p-toluenesulfonic acid was written by Adib, Mehdi;Soheilizad, Mehd;Rajai-daryasaraei, Saideh;Mirzaei, Peiman. And the article was included in Synlett in 2015.Application In Synthesis of Ethyl 2-amino-4-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate The following contents are mentioned in the article:

An oxidation-aromatization of alkyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylates, is reported. The Gewald product, obtained from three-component condensation reaction between a cyclohexanone, an alkyl cyanoacetate, and sulfur, underwent an oxidation reaction in DMSO in the presence of a catalytic amount of p-toluenesulfonic acid to give the corresponding alkyl 2-aminobenzo[b]thiophene-3-carboxylate, e.g., I, in excellent yield. This study involved multiple reactions and reactants, such as Ethyl 2-amino-4-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate (cas: 95211-67-9Application In Synthesis of Ethyl 2-amino-4-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate).

Ethyl 2-amino-4-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate (cas: 95211-67-9) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The electrophilic substitution of benzothiophene systems is much less regioselective than that of indoles. It is found within the chemical structures of pharmaceutical drugs such as zileuton, raloxifene, and sertaconazole, and also BTCP.Application In Synthesis of Ethyl 2-amino-4-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

A Simple Synthesis of Alkyl 2-Aminobenzo[b]thiophene-3-carboxylates via an Unexpected Dehydrogenation of Alkyl 2-Amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylates was written by Adib, Mehdi;Bayanati, Maryam;Soheilizad, Mehdi;Ghazvini, Helia Janatian;Tajbakhsh, Mahmood;Amanlou, Massoud. And the article was included in Synlett in 2014.Recommanded Product: 95211-67-9 The following contents are mentioned in the article:

A simple method for the preparation of alkyl 2-aminobenzo[b]thiophene-3-carboxylates is described. Alkyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylates, generated from the Gewald three-component reaction between cyclohexanones, alkyl cyanoacetates, and sulfur, undergo dehydrogenation in benzonitrile under an air atm. to afford alkyl 2-aminobenzo[b]thiophene-3-carboxylates in good to excellent yields. This study involved multiple reactions and reactants, such as Ethyl 2-amino-4-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate (cas: 95211-67-9Recommanded Product: 95211-67-9).

Ethyl 2-amino-4-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate (cas: 95211-67-9) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The core structure is a part of various pharmaceutical substances and natural products. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, sertaconazole, and also BTCP.Recommanded Product: 95211-67-9

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

A solvent less synthesis of 2-aminothiophenes via the Gewald reaction under ultrasonic conditions was written by de C. F. dos Santos, Bruno Dias;Forero, Josue S. Bello;de Carvalho, Erika M.;Jones, Joel Jr.;da Silva, Flavia M.. And the article was included in Heterocyclic Letters in 2012.Category: benzothiophene The following contents are mentioned in the article:

A simple, fast and efficient one-pot, three-component, solvent less procedure for the synthesis of 2-aminothiophene derivatives under ultrasonic conditions was developed. The combined advantages of sonochem., such as mild reaction conditions, good yield and short reaction times, enabled progress to be made on the synthesis of 2-aminothiophenes via the Gewald reaction. This study involved multiple reactions and reactants, such as Ethyl 2-amino-4-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate (cas: 95211-67-9Category: benzothiophene).

Ethyl 2-amino-4-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate (cas: 95211-67-9) belongs to benzothiophene derivatives. Benzothiophene is a fused ring compound of thiophene ring and benzene ring, which is an important class of heterocycles with advantageous structures. It is found within the chemical structures of pharmaceutical drugs such as zileuton, raloxifene, and sertaconazole, and also BTCP.Category: benzothiophene

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Pharmacologically active benzo[b]thiophene derivatives. III. 2-Substituted compounds was written by Chapman, Norman Bellamy;Clarke, Kenneth;Saraf, S. D.. And the article was included in Journal of the Chemical Society [Section] C: Organic in 1967.Application of 13771-68-1 The following contents are mentioned in the article:

cf. CA 62, 6450f; 65, 18549g. A number of N-(5-substituted-2-benzo[b]thenyl)ethanolamines (I) and the corresponding N-Me and N-Et derivatives were prepared by condensation of the 5-substituted 2-chloromethylbenzo[b]thiophenes with ethanolamine, N-methylethanolamine, or N-ethylethanolamine. These amino alcs. treated with SOCl2 in dry CHCl3 gave the corresponding β-chloroethylamines (II). 2-Acetyl-5-bromo- and -5-chlorobenzo[b]thiophene were prepared Bromination of these ketones, followed by condensation with several secondary amines, gave oxo amines, which were reduced with NaBH4 in aqueous MeOH to give corresponding amino alcs., some of which reacted with SOCl2 in dry CHCl3 as above. This study involved multiple reactions and reactants, such as Ethyl 5-bromobenzo[b]thiophene-2-carboxylate (cas: 13771-68-1Application of 13771-68-1).

Ethyl 5-bromobenzo[b]thiophene-2-carboxylate (cas: 13771-68-1) belongs to benzothiophene derivatives. Benzothiophene scaffolds are of great importance due to its increased presence in bioactive molecules. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, and sertaconazole, and also BTCP.Application of 13771-68-1

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Synthesis and pharmacological activities of some 3-substituted thienopyrimidin-4-one-2-thiones was written by Cannito, A.;Perrissin, M.;Luu Duc, Cuong;Huguet, F.;Gaultier, C.;Narcisse, G.. And the article was included in European Journal of Medicinal Chemistry in 1990.COA of Formula: C12H17NO2S The following contents are mentioned in the article:

The condensation of substituted 2-amino-3-carbethoxythiophenes with Me, Et and Ph isothiocyanate yields the corresponding thienylthioureas which cyclize in EtOH saturated with dry hydrochloric acid to form 3-substituted thieno[2,3-d]pyrimidin-4(3H)-one-2-thiones. Thirty-five compounds, 21 thienylthioureas and 14 thienopyrimidin-4-one-2-thiones, have been screened for their analgesic and antiinflammatory activities. The i.p. administration of these products at a dose of 1000 mg/kg shows that they are not toxic (one excepted). Some compounds show analgesic and antiinflammatory activities equivalent to those of acetylsalicylic acid. This study involved multiple reactions and reactants, such as Ethyl 2-amino-4-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate (cas: 95211-67-9COA of Formula: C12H17NO2S).

Ethyl 2-amino-4-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate (cas: 95211-67-9) belongs to benzothiophene derivatives. Benzothiophene is a fused ring compound of thiophene ring and benzene ring, which is an important class of heterocycles with advantageous structures. It is also used in the manufacturing of dyes such as thioindigo.COA of Formula: C12H17NO2S

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Amine-functional polysiloxanes (AFPs) as efficient polymeric organocatalyst for amino catalysis: efficient multicomponent Gewald reaction, α-allylic alkylation of aldehydes, and Knoevenagel condensation was written by Zheng, Zhan-Jiang;Liu, Lu-Xin;Gao, Guang;Dong, Hong;Jiang, Jian-Xiong;Lai, Guo-Qiao;Xu, Li-Wen. And the article was included in RSC Advances in 2012.Safety of Ethyl 2-amino-4-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate The following contents are mentioned in the article:

In this article, for the first time, we describe that com. available and environmentally benign amine-functional polysiloxanes (AFPs) could be used as highly efficient metal-free amino catalysts in multicomponent Gewald reactions, α-allylic alkylations of aldehydes, and Knoevenagel condensations. Using catalytic amounts of AFPs, these transformations, including the Gewald reactions of ketones, sulfur, and Et 2-cyanoacetate, α-allylic alkylations of aldehydes and Knoevenagel condensations of aldehydes and the methylene-activated substrates may be carried out under mild conditions to give corresponding products in good yields. This study involved multiple reactions and reactants, such as Ethyl 2-amino-4-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate (cas: 95211-67-9Safety of Ethyl 2-amino-4-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate).

Ethyl 2-amino-4-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate (cas: 95211-67-9) belongs to benzothiophene derivatives. Benzothiophenes are valuable heterocycles that are widely used in medicines, agrochemicals, and materials science. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, and sertaconazole, and also BTCP.Safety of Ethyl 2-amino-4-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem