Tag: 178.016

A new route towards dithienoquinazoline and benzo[f]thieno[3,2-h]quinazoline systems using Pd-catalyzed intramolecular cyclization under microwave irradiation was written by Verbitskiy, Egor V.;Rusinov, Gennady L.;Chupakhin, Oleg N.;Charushin, Valery N.. And the article was included in ARKIVOC (Gainesville, FL, United States) in 2016.Safety of Benzo[b]thiophen-3-ylboronic acid This article mentions the following:

A novel synthetic route to novel thienoacene systems bearing a fused pyrimidine ring was proposed. The com. available 5-bromopyrimidine was used as the starting material to obtain various dithienoquinazoline and benzo[f]thieno[3,2-h]quinazoline systems through the Suzuki cross-coupling, nucleophilic aromatic substitution of hydrogen (the SN^H reaction) and finally palladium-catalyzed intramol. cyclization under microwave irradiation Redox properties of some of the new compounds were investigated. The data obtained show that these systems have plausible potential for use in organic electronic applications. In the experiment, the researchers used many compounds, for example, Benzo[b]thiophen-3-ylboronic acid (cas: 113893-08-6Safety of Benzo[b]thiophen-3-ylboronic acid).

Benzo[b]thiophen-3-ylboronic acid (cas: 113893-08-6) belongs to benzothiophene derivatives. Benzothiophene is used as starting material for the synthesis of bioactive molecules. The core structure is a part of various pharmaceutical substances and natural products. It has been used as a raw material for the synthesis of biologically active structures and is found in pharmaceuticals such as leukotriene synthesis inhibitors and antifungals, as well as in many natural products.Safety of Benzo[b]thiophen-3-ylboronic acid

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Phosphoric Acid Catalyzed Electrophilic Thiocyanation of Indoles: Access to SCN-Containing Aryl-Indole Compounds was written by Ye, Ai-Hui;Li, Zi-Hao;Ding, Tong-Mei;Ke, Hua;Chen, Zhi-Min. And the article was included in Chemistry – An Asian Journal in 2022.COA of Formula: C8H7BO2S This article mentions the following:

A phosphoric acid catalyzed electrophilic thiocyanation of 3-aryl indoles, which provides an efficient and modular approach to SCN-containing 3-aryl indole compounds, was developed for the first time. A variety of 2-SCN-3-aryl indoles were obtained with moderate to excellent yields. Furthermore, catalytic asym. manner of this reaction was also studied. Using chiral phosphoric acid as the catalyst, axially chiral SCN-containing 3-aryl indoles were obtained in moderate to good yields with moderate enantioselectivity. In the experiment, the researchers used many compounds, for example, Benzo[b]thiophen-3-ylboronic acid (cas: 113893-08-6COA of Formula: C8H7BO2S).

Benzo[b]thiophen-3-ylboronic acid (cas: 113893-08-6) belongs to benzothiophene derivatives. Benzothiophene is used as starting material for the synthesis of bioactive molecules. The core structure is a part of various pharmaceutical substances and natural products. It is found within the chemical structures of pharmaceutical drugs such as zileuton, raloxifene, and sertaconazole, and also BTCP.COA of Formula: C8H7BO2S

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Passerini-type reaction of boronic acids enables α-hydroxyketones synthesis was written by Yang, Kai;Zhang, Feng;Fang, Tongchang;Li, Chaokun;Li, Wangyang;Song, Qiuling. And the article was included in Nature Communications in 2021.COA of Formula: C8H7BO2S This article mentions the following:

Multicomponent reactions (MCRs) facilitate the rapid and diverse construction of mol. scaffolds with modularity and step economy. In this work, engagement of boronic acids as carbon nucleophiles culminates in a Passerini-type three-component coupling reaction towards the synthesis of an expanded inventory of α-hydroxyketones with skeletal diversity. In addition to the appealing features of MCRs, this protocol portrays good functional group tolerance, broad substrate scope under mild conditions and operational simplicity. The utility of this chem. is further demonstrated by amenable modifications of bioactive products and pharmaceuticals as well as in the functionalization of products to useful compounds In the experiment, the researchers used many compounds, for example, Benzo[b]thiophen-3-ylboronic acid (cas: 113893-08-6COA of Formula: C8H7BO2S).

Benzo[b]thiophen-3-ylboronic acid (cas: 113893-08-6) belongs to benzothiophene derivatives. Benzothiophene scaffolds are of great importance due to its increased presence in bioactive molecules. It is also used in the manufacturing of dyes such as thioindigo.COA of Formula: C8H7BO2S

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Rh-Catalyzed Highly Enantioselective Synthesis of Aliphatic Sulfonyl Fluorides was written by Moku, Balakrishna;Fang, Wan-Yin;Leng, Jing;Li, Linxian;Zha, Gao-Feng;Rakesh, K. P.;Qin, Hua-Li. And the article was included in iScience in 2019.Reference of 113893-08-6 This article mentions the following:

Rh-catalyzed, highly enantioselective (up to 99.8% ee) synthesis of aliphatic sulfonyl fluorides (R)/(S)-RCH(R¹)CH₂SO₂F (R = Ph, dibenzo[b,d]thiophen-4-yl, thiophen-3-yl, etc.; R¹ = naphthalen-1-yl, dibenzo[b,d]furan-4-yl, benzo[b]thiophen-3-yl, etc.) was accomplished. This protocol provides a portal to a class of novel 2-aryl substituted chiral sulfonyl fluorides, which are otherwise extremely difficult to access. This asym. synthesis has the feature of mild conditions, excellent functional group compatibility, and wide substrate scope (51 examples) generating a wide array of structurally unique chiral β-arylated sulfonyl fluoride (R)-2-(dibenzo[b,d]thiophen-4-yl)-2-phenylethanesulfonyl fluoride for sulfur(VI) fluoride exchange (SuFEx) click reaction and drug discovery. In the experiment, the researchers used many compounds, for example, Benzo[b]thiophen-3-ylboronic acid (cas: 113893-08-6Reference of 113893-08-6).

Benzo[b]thiophen-3-ylboronic acid (cas: 113893-08-6) belongs to benzothiophene derivatives. Benzothiophene finds use in research as a starting material for the synthesis of larger, usually bioactive structures. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization.Reference of 113893-08-6

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Synthesis of Triarylmethanes via Palladium-Catalyzed Suzuki Coupling of Trimethylammonium Salts and Arylboronic Acids was written by Zhang, Zhenming;Wang, Hui;Qiu, Nianli;Kong, Yujing;Zeng, Wenjuan;Zhang, Yongquan;Zhao, Junfeng. And the article was included in Journal of Organic Chemistry in 2018.Application of 113893-08-6 This article mentions the following:

An efficient palladium-catalyzed Suzuki coupling of 1,1-diarylmethyl-trimethylammonium triflates with arylboronic acids is reported. This reaction offers a novel approach to triarylmethane derivatives in good to excellent yields with the palladium-catalyzed C-N bond cleavage as the key feature. Broad substrate scope regarding both reaction partners are observed Moreover, reactive functional groups such as vinyl and formyl groups are conserved in this transformation. In the experiment, the researchers used many compounds, for example, Benzo[b]thiophen-3-ylboronic acid (cas: 113893-08-6Application of 113893-08-6).

Benzo[b]thiophen-3-ylboronic acid (cas: 113893-08-6) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The core structure is a part of various pharmaceutical substances and natural products. It has been used as a raw material for the synthesis of biologically active structures and is found in pharmaceuticals such as leukotriene synthesis inhibitors and antifungals, as well as in many natural products.Application of 113893-08-6

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Electro-alkynylation: Intramolecular Rearrangement of Trialkynylorganoborates for Chemoselective C(sp²)-C(sp) Bond Formation was written by Music, Arif;Nuber, Constantin M.;Lemke, Yannick;Spiess, Philipp;Didier, Dorian. And the article was included in Organic Letters in 2021.Quality Control of Benzo[b]thiophen-3-ylboronic acid This article mentions the following:

An alternative and complementary transformation for the synthesis of aryl- and heteroaryl-substituted alkynes RCCR¹ (R = 4-methylphenyl, 2-(4-fluorophenyl)ethenyl, 1-benzyl-1H-pyrazol-4-yl, etc.; R¹ = t-Bu, 2-phenylethyl, 4-methoxyphenyl, etc.) is presented that relies on a chemoselective electrocoupling process. Tetraorganoborate substrates were logically designed and simply accessed by transmetalations using readily or com. available organotrifluoroborate salts RBF₃K. In the experiment, the researchers used many compounds, for example, Benzo[b]thiophen-3-ylboronic acid (cas: 113893-08-6Quality Control of Benzo[b]thiophen-3-ylboronic acid).

Benzo[b]thiophen-3-ylboronic acid (cas: 113893-08-6) belongs to benzothiophene derivatives. Functionalized benzothiophenes are important constructs found in molecules with wide ranging biological activity and in organic materials. It is found within the chemical structures of pharmaceutical drugs such as zileuton, raloxifene, and sertaconazole, and also BTCP.Quality Control of Benzo[b]thiophen-3-ylboronic acid

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Enantioselective Synthesis of Atropisomers Featuring Pentatomic Heteroaromatics by Pd-Catalyzed C-H Alkynylation was written by Zhang, Shuo;Yao, Qi-Jun;Liao, Gang;Li, Xin;Li, Han;Chen, Hao-Ming;Hong, Xin;Shi, Bing-Feng. And the article was included in ACS Catalysis in 2019.Recommanded Product: 113893-08-6 This article mentions the following:

In the presence of Pd(OAc)₂ and L-tert-leucine, biaryl aldehydes containing five-membered rings such as I underwent enantioselective alkynylation with bromoalkynes such as (triisopropylsilyl)bromoacetylene mediated by silver(I) trifluoroacetate in AcOH/toluene to give nonracemic atropisomeric biaryls such as II. A wide range of atropisomers in which either C-N or C-C bonds serve as the atropisomeric axis and containing one or two five-membered rings at each end of the axis were obtained; various five-membered heteroarenes, including pyrroles, thiophenes, benzothiophenes, and benzofurans were compatible with the method. A nonracemic 3,3′-bisbenzothiophene was prepared in 93% ee by this method. DFT calculations of the racemization barriers for various biaryls indicated that the shape of the rings on the biaryl axis is important in determining the racemization barriers. In the experiment, the researchers used many compounds, for example, Benzo[b]thiophen-3-ylboronic acid (cas: 113893-08-6Recommanded Product: 113893-08-6).

Benzo[b]thiophen-3-ylboronic acid (cas: 113893-08-6) belongs to benzothiophene derivatives. Benzothiophene is a fused ring compound of thiophene ring and benzene ring, which is an important class of heterocycles with advantageous structures. Due to its aromaticity, thiophenes do not exhibit the same properties as conventional thioethers.Recommanded Product: 113893-08-6

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Design and facile synthesis of 6-(benzothiophen-3-yl)-3-para-substituted-[1,2,4] triazolo [3,4-a] phthalazine derivatives as anti-microbial agents was written by Prabhakar, V.;Sudhakar Babu, K.;Ravindranath, L. K.;Lakshmi Reddy, I.;Latha, J.. And the article was included in Research Journal of Chemical Sciences in 2016.Computed Properties of C8H7BO2S This article mentions the following:

The synthesis, characterization and screening the biol. activity of the series of 6-(benzothiophen-3-yl)-3-para-substituted-[1,2,4]triazolo[3,4-a]phthalazines I [R = H, 4-Me, 2,5-di-F, etc.] with good yields were reported. The synthesized compounds I were characterized by IR, ¹H-NMR, ¹³C-NMR and mass spectral data. The anti-microbial activity of the compounds I were screened by disk diffusion method. Compounds I [R = 4-F, 2,5-di-F, 4-F₃C] demonstrated good antimicrobial activity against all the tested microbial strains. Compound I [R = 2,5-di-F] was showed good antibacterial and antifungal activities. In the experiment, the researchers used many compounds, for example, Benzo[b]thiophen-3-ylboronic acid (cas: 113893-08-6Computed Properties of C8H7BO2S).

Benzo[b]thiophen-3-ylboronic acid (cas: 113893-08-6) belongs to benzothiophene derivatives. Benzothiophene finds use in research as a starting material for the synthesis of larger, usually bioactive structures. It is found within the chemical structures of pharmaceutical drugs such as zileuton, raloxifene, and sertaconazole, and also BTCP.Computed Properties of C8H7BO2S

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Substituted 1-methyl-4-phenylpyrrolidin-2-ones – Fragment-based design of N-methylpyrrolidone-derived bromodomain inhibitors was written by Hilton-Proctor, J. P.;Ilyichova, O.;Zheng, Z.;Jennings, I. G.;Johnstone, R. W.;Shortt, J.;Mountford, S. J.;Scanlon, M. J.;Thompson, P. E.. And the article was included in European Journal of Medicinal Chemistry in 2020.Application In Synthesis of Benzo[b]thiophen-3-ylboronic acid This article mentions the following:

The synthesis of a 4-Ph substituted analog – 1-methyl-4-phenylpyrrolidin-2-one – and the use of aryl substitution reactions as a divergent route for derivatives I (R = H, Br, Ph, 2-phenylethyl, etc.; R¹ = 2-Br, 4-Ph, morpholine-4-sulfonyl, etc.) were described. Ultimately, this has led to structurally complex, chiral compounds (R/S)-II (R² = H, Me; R³ = H, 3,4-dimethoxyphenyl; R⁴ = H, N,N-diethylsulfamoyl) with progressively improved affinity as inhibitors of bromodomain-containing protein 4. In the experiment, the researchers used many compounds, for example, Benzo[b]thiophen-3-ylboronic acid (cas: 113893-08-6Application In Synthesis of Benzo[b]thiophen-3-ylboronic acid).

Benzo[b]thiophen-3-ylboronic acid (cas: 113893-08-6) belongs to benzothiophene derivatives. Functionalized benzothiophenes are important constructs found in molecules with wide ranging biological activity and in organic materials. It is also used in the manufacturing of dyes such as thioindigo.Application In Synthesis of Benzo[b]thiophen-3-ylboronic acid

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Structure-Based Optimization of a Small Molecule Antagonist of the Interaction Between WD Repeat-Containing Protein 5 (WDR5) and Mixed-Lineage Leukemia 1 (MLL1) was written by Getlik, Matthaus;Smil, David;Zepeda-Velazquez, Carlos;Bolshan, Yuri;Poda, Gennady;Wu, Hong;Dong, Aiping;Kuznetsova, Ekaterina;Marcellus, Richard;Senisterra, Guillermo;Dombrovski, Ludmila;Hajian, Taraneh;Kiyota, Taira;Schapira, Matthieu;Arrowsmith, Cheryl H.;Brown, Peter J.;Vedadi, Masoud;Al-awar, Rima. And the article was included in Journal of Medicinal Chemistry in 2016.Recommanded Product: Benzo[b]thiophen-3-ylboronic acid This article mentions the following:

WD repeat-containing protein 5 (WDR5) is an important component of the multiprotein complex essential for activating mixed-lineage leukemia 1 (MLL1). Rearrangement of the MLL1 gene is associated with onset and progression of acute myeloid and lymphoblastic leukemias, and targeting the WDR5-MLL1 interaction may result in new cancer therapeutics. Our previous work showed that binding of small mol. ligands to WDR5 can modulate its interaction with MLL1, suppressing MLL1 methyltransferase activity. Initial structure-activity relationship studies identified N-(2-(4-methylpiperazin-1-yl)-5-substituted-phenyl) benzamides as potent and selective antagonists of this protein-protein interaction. Guided by crystal structure data and supported by in silico library design, we optimized the scaffold by varying the C-1 benzamide and C-5 substituents. This allowed us to develop the first highly potent (K_disp < 100 nM) small mol. antagonists of the WDR5-MLL1 interaction and demonstrate that N-(4-(4-methylpiperazin-1-yl)-3′-(morpholinomethyl)-[1,1′-biphenyl]-3-yl)-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridine-3-carboxamide 16d (OICR-9429) is a potent and selective chem. probe suitable to help dissect the biol. role of WDR5. In the experiment, the researchers used many compounds, for example, Benzo[b]thiophen-3-ylboronic acid (cas: 113893-08-6Recommanded Product: Benzo[b]thiophen-3-ylboronic acid).

Benzo[b]thiophen-3-ylboronic acid (cas: 113893-08-6) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The core structure is a part of various pharmaceutical substances and natural products. Due to its aromaticity, thiophenes do not exhibit the same properties as conventional thioethers.Recommanded Product: Benzo[b]thiophen-3-ylboronic acid

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem