Tag: 156.2022

Satonaka, Hajime et al. published their research in Bulletin of the Chemical Society of Japan in 1983 | CAS: 28686-90-0

Methyl 4-methylthiophene-2-carboxylate (cas: 28686-90-0) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The electrophilic substitution of benzothiophene systems is much less regioselective than that of indoles. The different substitution patterns in these heterocycles offer new opportunities for drug discovery and other applications in materials science.Reference of 28686-90-0

The substituent effects in thiophene compounds. I. Proton NMR and IR studies in methyl (substituted 2-thiophenecarboxylates) was written by Satonaka, Hajime. And the article was included in Bulletin of the Chemical Society of Japan in 1983.Reference of 28686-90-0 This article mentions the following:

The 1H NMR and the IR CO group stretching frequencies of Me (3-, 4-, and 5-substituted 2-thiophenecarboxylate)s are observed Good linear correlations between the chem. shifts of the ring protons in Me (4- and 5-substituted 2-thiophenecarboxylate)s and those of the corresponding protons in substituted thiophenes were observed The coupling constants in Me (substituted 2-thiophenecarboxylate)s gave good correlations against the corresponding ones in substituted thiophenes. The IR carbonyl stretching frequencies in Me (5-substituted 2-thiophenecarboxylate)s were correlated reasonably well with the chem. shifts of 5-protons in 2-substituted thiophenes. The coupling constants in Me 2-thiophenecarboxylate series varied linearly with the electronegativities of the substituents. In the experiment, the researchers used many compounds, for example, Methyl 4-methylthiophene-2-carboxylate (cas: 28686-90-0Reference of 28686-90-0).

Methyl 4-methylthiophene-2-carboxylate (cas: 28686-90-0) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The electrophilic substitution of benzothiophene systems is much less regioselective than that of indoles. The different substitution patterns in these heterocycles offer new opportunities for drug discovery and other applications in materials science.Reference of 28686-90-0

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

Feijen, J. et al. published their research in Recueil des Travaux Chimiques des Pays-Bas in 1970 | CAS: 28686-90-0

Methyl 4-methylthiophene-2-carboxylate (cas: 28686-90-0) belongs to benzothiophene derivatives. Functionalized benzothiophenes are important constructs found in molecules with wide ranging biological activity and in organic materials. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization.HPLC of Formula: 28686-90-0

Iso-anellated thienopyrroles. The chemistry of 5,6-dihydro-4H-thieno[2,3-c]pyrroles and 5H-thieno[2,3-c]pyrroles was written by Feijen, J.;Wynberg, Hans. And the article was included in Recueil des Travaux Chimiques des Pays-Bas in 1970.HPLC of Formula: 28686-90-0 This article mentions the following:

The ring-closure reaction of Me 2,3-bis(chloromethyl)thiophene-5-carboxylate with several primary amines gives a series of 4,6-dihydro-5H-thieno[2,3-c]pyrroles. Oxidation of some of these dihydro compounds, using aqueous H2O2 in methanol, furnishes the corresponding N-oxides. When the N atom possesses an aromatic substituent and the oxidation is carried out with aqueous H2O2 in formic acid, Meisenheimer rearrangement products instead of N-oxides are formed. The structure of one of the Meisenheimer products was elucidated by an independent synthesis of its degradation product. 5H-Thieno[2,3-c]pyrroles, such as I, are prepared by 3 sep. methods: (a) dehydration of the N-oxides; (b) autoxidation of the dihydrothieno[2,3-c]pyrroles; (c) dehydrogenation of the dihydro compounds with chloranil. In the experiment, the researchers used many compounds, for example, Methyl 4-methylthiophene-2-carboxylate (cas: 28686-90-0HPLC of Formula: 28686-90-0).

Methyl 4-methylthiophene-2-carboxylate (cas: 28686-90-0) belongs to benzothiophene derivatives. Functionalized benzothiophenes are important constructs found in molecules with wide ranging biological activity and in organic materials. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization.HPLC of Formula: 28686-90-0

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem