Tag: 124.1158

Light-driven post-translational installation of reactive protein side chains was written by Josephson, Brian;Fehl, Charlie;Isenegger, Patrick G.;Nadal, Simon;Wright, Tom H.;Poh, Adeline W. J.;Bower, Ben J.;Giltrap, Andrew M.;Chen, Lifu;Batchelor-McAuley, Christopher;Roper, Grace;Arisa, Oluwatobi;Sap, Jeroen B. I.;Kawamura, Akane;Baldwin, Andrew J.;Mohammed, Shabaz;Compton, Richard G.;Gouverneur, Veronique;Davis, Benjamin G.. And the article was included in Nature (London, United Kingdom) in 2020.Application of 1072-53-3 This article mentions the following:

Post-translational modifications (PTMs) greatly expand the structures and functions of proteins in nature1,2. Although synthetic protein functionalization strategies allow mimicry of PTMs3,4, as well as formation of unnatural protein variants with diverse potential functions, including drug carrying5, tracking, imaging6 and partner crosslinking7, the range of functional groups that can be introduced remains limited. Here we describe the visible-light-driven installation of side chains at dehydroalanine residues in proteins through the formation of carbon-centered radicals that allow C-C bond formation in water. Control of the reaction redox allows site-selective modification with good conversions and reduced protein damage. In situ generation of boronic acid catechol ester derivatives generates RH2C· radicals that form the native (β-CH2-γ-CH2) linkage of natural residues and PTMs, whereas in situ potentiation of pyridylsulfonyl derivatives by Fe(II) generates RF2C· radicals that form equivalent β-CH2-γ-CF2 linkages bearing difluoromethylene labels. These reactions are chem. tolerant and incorporate a wide range of functionalities (more than 50 unique residues/side chains) into diverse protein scaffolds and sites. Initiation can be applied chemoselectively in the presence of sensitive groups in the radical precursors, enabling installation of previously incompatible side chains. The resulting protein function and reactivity are used to install radical precursors for homolytic on-protein radical generation; to study enzyme function with natural, unnatural and CF2-labeled post-translationally modified protein substrates via simultaneous sensing of both chemo- and stereoselectivity; and to create generalized ′alkylator proteins′ with a spectrum of heterolytic covalent-bond-forming activity (i.e., reacting diversely with small mols. at one extreme or selectively with protein targets through good mimicry at the other). Post-translational access to such reactions and chem. groups on proteins could be useful in both revealing and creating protein function. In the experiment, the researchers used many compounds, for example, 1,3,2-Dioxathiolane 2,2-dioxide (cas: 1072-53-3Application of 1072-53-3).

1,3,2-Dioxathiolane 2,2-dioxide (cas: 1072-53-3) belongs to benzothiophene derivatives. Benzothiophene is a fused ring compound of thiophene ring and benzene ring, which is an important class of heterocycles with advantageous structures. It is also used in the manufacturing of dyes such as thioindigo.Application of 1072-53-3

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

The Effect of Methyl Acetate, Ethylene Sulfate, and Carbonate Blends on the Parasitic Heat Flow of NMC532/Graphite Lithium Ion Pouch Cells was written by Glazier, S. L.;Li, Jing;Ma, Xiaowei;Ellis, L. D.;Allen, J. P.;Gering, Kevin L.;Dahn, J. R.. And the article was included in Journal of the Electrochemical Society in 2018.SDS of cas: 1072-53-3 This article mentions the following:

The formulation of solvent systems can have a severe impact on the lifetime, rate performance, and temperature performance of lithium ion cells. Me acetate (MA) has been found to increase rate and temperature performance of carbonate solvents, but decreased cell lifetime. This work used ultra-high precision coulometry, in-situ gas anal., and isothermal microcalorimetry to investigate a recently reported promising high rate additive blend of fluoroethylene carbonate (FEC) and 1,3,2-dioxathiolane-2,2-dioxide (DTD) in LiNi_0.5Mn_0.3Co_0.2O₂/graphite pouch cells. Solvent systems composed of blends of ethylene carbonate (EC), Et Me carbonate (EMC), and di-Me carbonate (DMC) were investigated, with additions of 0%, 20% and 40% wt MA. MA was found to decrease the coulombic efficiency and increase slippage, parasitic heat flow, and gas volume The addition of just 1% wt of DTD to 2% FEC improved the performance of cells containing 20% and 40% MA to that of cells containing no MA and 20% MA, resp., under 4.3 V. Results suggest the neg. impact of MA originates from increased electrolyte oxidation at the pos. electrode. Addnl., blends of MA in EC:EMC and EC:DMC (3:7 wt) were tested head-to-head, yielding a small improvement to parasitic heat flow and UHPC performance when cells used EC:EMC. In the experiment, the researchers used many compounds, for example, 1,3,2-Dioxathiolane 2,2-dioxide (cas: 1072-53-3SDS of cas: 1072-53-3).

1,3,2-Dioxathiolane 2,2-dioxide (cas: 1072-53-3) belongs to benzothiophene derivatives. Benzothiophene finds use in research as a starting material for the synthesis of larger, usually bioactive structures. The different substitution patterns in these heterocycles offer new opportunities for drug discovery and other applications in materials science.SDS of cas: 1072-53-3

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Intramolecular Kulinkovich-de Meijere reactions of various disubstituted alkenes bearing amide groups was written by Madelaine, Claire;Ouhamou, Nouara;Chiaroni, Angele;Vedrenne, Emeline;Grimaud, Laurence;Six, Yvan. And the article was included in Tetrahedron in 2008.Category: benzothiophene This article mentions the following:

A range of amides fitted with (E) or (Z) disubstituted alkene groups were prepared and evaluated in intramol. Kulinkovich-de Meijere reactions. The corresponding aminocyclopropanes, e.g., I, were obtained with high diastereoselectivity. Good yields could be achieved with substrates bearing suitable substitutions at the olefin moieties. In the experiment, the researchers used many compounds, for example, 1,3,2-Dioxathiolane 2,2-dioxide (cas: 1072-53-3Category: benzothiophene).

1,3,2-Dioxathiolane 2,2-dioxide (cas: 1072-53-3) belongs to benzothiophene derivatives. Benzothiophene is a fused ring compound of thiophene ring and benzene ring, which is an important class of heterocycles with advantageous structures. The different substitution patterns in these heterocycles offer new opportunities for drug discovery and other applications in materials science.Category: benzothiophene

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Synthesis and Electrochemical Performance of Spheroid LiNi_1/3Co_1/3Mn_1/3O₂ in the Electrolyte Modified by Ethylene Sulfate and Methylene Methanedisulfonate was written by Cui, Yongli;Yang, Chao;Zhuang, Zhiheng;Wang, Mingzhen;Zhuang, Quanchao. And the article was included in Journal of Inorganic and Organometallic Polymers and Materials in 2018.Electric Literature of C2H4O4S This article mentions the following:

In this study, spheroid LiNi_1/3Co_1/3Mn_1/3O₂ (NCM111) cathode material were synthesized using LiOH with Ni_0.5Co_0.2Mn_0.3(OH)₂ precursor by a simple solid-state reaction, and characterized by X-ray diffraction and SEM. Electrochem. behavior of NCM111 was investigated by electrochem. impedance spectroscopy (EIS) combining with cyclic voltammogram (CV) and charge/discharge test in the 1 M LiPF₆-EC:EMC electrolyte with ethylene sulfate (DTD) and methylene methanedisulfonate (MMDS) additives either singly or in combination with high cutoff voltage of 3.0-4.5 V at room temperature of 25 °C or elevated temperature of 55 °C. It was found that DTD additive can increase the initial coulombic efficiency of NCM111, and the spheroid NCM111 can obtain the maximum initial discharge capacity of 177.81 mAh/g with the 2 wt% DTD, and keep 92.29% capacity retention after 80 cycles. The MMDS additives would decrease the initial discharge capacity of the NCM111, and enhance significantly long cycle life of the NCM111 with the capacity retention of 99.23% over 80 cycles at high voltage of 4.5 V. The additive combination 2 wt% DTD + 1 wt% MMDS was an optimal additive combination, demonstrating the 102.2% capacity retention over 80 cycles at room temperature and the 94.2% capacity retention over 70 cycles at elevated temperature of 55 °C. EIS results revealed that the additive blend of 2 wt% DTD + 1 wt% MMDS can drastically lower the kinetics impedance and suppress the growth rate of R_ct for the NCM111 electrode. In the experiment, the researchers used many compounds, for example, 1,3,2-Dioxathiolane 2,2-dioxide (cas: 1072-53-3Electric Literature of C2H4O4S).

1,3,2-Dioxathiolane 2,2-dioxide (cas: 1072-53-3) belongs to benzothiophene derivatives. Functionalized benzothiophenes are important constructs found in molecules with wide ranging biological activity and in organic materials. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, and sertaconazole, and also BTCP.Electric Literature of C2H4O4S

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Development of a Scalable Route for a Highly Polar Heterocyclic Aminocyclopropyl Building Block was written by Schafer, Gabriel;Ahmetovic, Muhamed;Fleischer, Tony;Abele, Stefan. And the article was included in Organic Process Research & Development in 2020.Quality Control of 1,3,2-Dioxathiolane 2,2-dioxide This article mentions the following:

A robust and scalable route toward key heterocyclic building block 1-(pyrimidin-2-yl)cyclopropan-1-amine hydrochloride from cyclopropanated starting material 1-amino-1-cyclopropanecarbonitrile hydrochloride was successfully developed. The key to success was the construction of a pyrimidine ring via cyclization from an amidine intermediate and a bench-stable 2-chloro vinamidinium hexafluorophosphate salt. The cyclization was performed under mild conditions, and the resulting 4-chloropyrimidine derivative was isolated in high yield and purity. The final hydrogenation was intensively optimized: A combination of Pd(OH)₂/C as a catalyst and NaOMe as a base at 1 bar H₂ pressure in MeOH simultaneously cleaved the Cbz group and dechlorinated the pyrimidine ring while at the same time suppressing the over-reduction of the pyrimidine ring to below 1.0%. After acidification with HCl, followed by removal of the catalyst and NaCl by filtration, the final product was isolated in high yield and purity as a bench-stable off-white solid. The overall yield of the five-step sequence was 57%. In the experiment, the researchers used many compounds, for example, 1,3,2-Dioxathiolane 2,2-dioxide (cas: 1072-53-3Quality Control of 1,3,2-Dioxathiolane 2,2-dioxide).

1,3,2-Dioxathiolane 2,2-dioxide (cas: 1072-53-3) belongs to benzothiophene derivatives. Benzothiophene is used as starting material for the synthesis of bioactive molecules. The core structure is a part of various pharmaceutical substances and natural products. It is also used in the manufacturing of dyes such as thioindigo.Quality Control of 1,3,2-Dioxathiolane 2,2-dioxide

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Photoenzymatic generation of unstabilized alkyl radicals: An asymmetric reductive cyclization was written by Clayman, Phillip D.;Hyster, Todd K.. And the article was included in Journal of the American Chemical Society in 2020.Recommanded Product: 1,3,2-Dioxathiolane 2,2-dioxide This article mentions the following:

Flavin-dependent ‘ene’-reductases (ERED) can generate stabilized alkyl radicals when irradiated with visible light, however, they are not known to form unstabilized radicals. Here, we report an enantioselective radical cyclization using alkyl iodides as precursors to unstabilized nucleophilic radicals. Evidence suggests this species is accessed by photoexcitation of a charge-transfer complex that forms between flavin and substrate within the protein active site. Stereoselective delivery of a hydrogen atom from the flavin semiquinone to the prochiral radical formed after cyclization provides high levels of enantioselectivity across a variety of substrates. Moreover, we find that redox-active esters can be used in lieu of alkyl iodides as radical precursors. Overall, this transformation demonstrates that photoenzymic catalysis can address long-standing selectivity challenges in the radical literature through the generation and stereocontrol of highly reactive nucleophilic radicals within ERED active sites. In the experiment, the researchers used many compounds, for example, 1,3,2-Dioxathiolane 2,2-dioxide (cas: 1072-53-3Recommanded Product: 1,3,2-Dioxathiolane 2,2-dioxide).

1,3,2-Dioxathiolane 2,2-dioxide (cas: 1072-53-3) belongs to benzothiophene derivatives. Functionalized benzothiophenes are important constructs found in molecules with wide ranging biological activity and in organic materials. It is also used in the manufacturing of dyes such as thioindigo.Recommanded Product: 1,3,2-Dioxathiolane 2,2-dioxide

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Optimizing electrolyte additive loadings in NMC532/graphite cells: vinylene carbonate and ethylene sulfate was written by Taskovic, T.;Thompson, L. M.;Eldesoky, A.;Lumsden, M. D.;Dahn, J. R.. And the article was included in Journal of the Electrochemical Society in 2021.Formula: C2H4O4S This article mentions the following:

A matrix of LiNi_0.5Mn_0.3Co_0.2O₂/graphite cells filled with 1.33 m LiPF6 in EC:EMC:DMC (ethylene carbonate: Et Me carbonate: di-Me carbonate) (25:5:70 by volume) electrolyte and different weight percentages of vinylene carbonate (VC) and ethylene sulfate (DTD) electrolyte additives underwent prolonged charge-discharge cycling at 20°C and 40°C. The volume of gas produced during formation and cycle testing was measured. The impedance spectra of the cells before and after cycling was measured. After testing, the electrolyte was extracted for study by NMR spectroscopy (NMR) and gas chromatog./mass spectroscopy (GC-MS) to determine what changes in electrolyte composition had occurred. Some cells had their neg. electrodes studied by scanning micro-X-ray fluorescence to quantify the amount of transition metals that transferred from the pos. electrode to the neg. electrode during the testing. Cells containing 1% VC or 2% VC with an addnl. 1% DTD by weight had the best capacity retention and lowest impedance growth. NMR and GC-MS suggest that these additive combinations promote increased electrolyte salt consumption which may represent a source of lithium to replenish the lithium inventory. Only a small amount of transition metals (0.03% or less) originating from the pos. electrode active material was found on the neg. electrode after testing. Most cells had over 1500 cycles at both 20°C and 40°C conditions. In the experiment, the researchers used many compounds, for example, 1,3,2-Dioxathiolane 2,2-dioxide (cas: 1072-53-3Formula: C2H4O4S).

1,3,2-Dioxathiolane 2,2-dioxide (cas: 1072-53-3) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The electrophilic substitution of benzothiophene systems is much less regioselective than that of indoles. The different substitution patterns in these heterocycles offer new opportunities for drug discovery and other applications in materials science.Formula: C2H4O4S

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Effect of electrolyte additives on the performance of high nickel Li-ion battery was written by Zhou, Mi;Wang, Xi-min;Yuan, Yin-nan;Cao, Zhang;Zheng, Hong-he. And the article was included in Dianchi in 2022.Related Products of 1072-53-3 This article mentions the following:

Application effects of electrolyte additives, including vinylene carbonate (VC), 1,3-propanesultone (PS), fluoroethylene carbonate (FEC), ethylene sulfate (DTD) in high nickel (Ni) [n (Ni) ≥80%] cathode material Li-ion battery were studied. The electrochem. performance, syngas and morphol. of anode interface of LiNi_0.8Co_0.1Mn_0.1O₂ (NCM811) |SiO_x/graphite pouch battery and Li|SiO_x/graphite button cell were analyzed. Except for PS, the other additives did not influence the initial capacity of SiOx/graphite electrode, VC and PS contributed to an increase of the interface impedance of SiO_x/graphite. For pouch battery, VC, PS and FEC could decrease the gas evolution, but the gas production of DTD increased and the main gases were alkanes. The battery using FEC owned the best room temperature and low temperature rate capability, the discharge capacity at 25°C and -20°C was 92.0% and 68.2% compared with nominal capacity at 0.5 C, 75.2% and 21.5% at 2.0 C. After stored at 60°C for 14 d, the capacity recovery rate and retention rate were 63.3% and 48.5% for the battery using FEC, resp., the voltage drop was 2.7%, the battery using DTD was 72.4%, 63.6% and 1.3%, resp. The battery using DTD and FEC had the best high temperature and room temperature cycle performance, resp. SEM anal. showed that in the battery using FEC, the anode interface of SiO_x/graphite after high temperature cycle was covered with more coating materials, thick film formation and rough surface. In the experiment, the researchers used many compounds, for example, 1,3,2-Dioxathiolane 2,2-dioxide (cas: 1072-53-3Related Products of 1072-53-3).

1,3,2-Dioxathiolane 2,2-dioxide (cas: 1072-53-3) belongs to benzothiophene derivatives. Benzothiophene is a fused ring compound of thiophene ring and benzene ring, which is an important class of heterocycles with advantageous structures. The different substitution patterns in these heterocycles offer new opportunities for drug discovery and other applications in materials science.Related Products of 1072-53-3

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Hindering rollover failure of Li[Ni_0.5Mn_0.3Co_0.2]O₂/graphite pouch cells during long-term cycling was written by Ma, Xiaowei;Harlow, Jessie E.;Li, Jing;Ma, Lin;Hall, David S.;Buteau, Samuel;Genovese, Matthew;Cormier, Marc;Dahn, J. R.. And the article was included in Journal of the Electrochemical Society in 2019.Synthetic Route of C2H4O4S This article mentions the following:

Eventual rapid capacity loss or rollover failure of Li-ion cells during long-term cycling (> 3000 cycles in many cases) at room temperature was studied with Li[Ni_0.5Mn_0.3Co_0.2]O₂/graphite pouch cells. The effects of pos. electrode material coating, electrolyte additives, upper cutoff voltage, LiPF₆ concentration, cell rest periods, electrode thickness, graphite type and electrolyte solvent formulation were probed. Cells were tested under 1C charge and discharge with rate maps (discharges at C/20, C/2, 1C, 2C, 3C) applied every 100 cycles. The loss of high rate capability (3C) is an early warning of impending rollover failure. Electrochem. impedance spectroscopy (EIS) and studies of sym. cells made using electrodes from disassembled cells demonstrate that impedance growth at the pos. electrode and associated d.c. resistance growth is responsible for rollover failure in these cells. Ultra-high precision coulometry (UHPC) shows that cells that were charged to higher voltages, which increase the rate of electrolyte oxidation, or show higher rates of electrolyte oxidation at the same cutoff potential due to changes in electrolyte formulation, normally are more prone to eventual rollover failure. To avoid rollover and extend the cycling life of Li-ion cells, it is important to choose optimal cell chemistries, some of which are enumerated. In the experiment, the researchers used many compounds, for example, 1,3,2-Dioxathiolane 2,2-dioxide (cas: 1072-53-3Synthetic Route of C2H4O4S).

1,3,2-Dioxathiolane 2,2-dioxide (cas: 1072-53-3) belongs to benzothiophene derivatives. Benzothiophenes are valuable heterocycles that are widely used in medicines, agrochemicals, and materials science. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, and sertaconazole, and also BTCP.Synthetic Route of C2H4O4S

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem