With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1196-19-6,3-(Bromomethyl)benzo[b]thiophene,as a common compound, the synthetic route is as follows.,1196-19-6
740 mg (2.8 mmol) of 4-methoxy-2nitrotrifluoroanilide were dissolved in 5 ml of dimethylformamide followed by the sequential addition of 503 mg (3.64 mmol) of potassium carbonate and 773 mg (3.4 mmol) of 3-bromomethylbenzothiophene and heating to 100 C. After 12 hours, 5 ml of 5 M aqueous sodium hydroxide solution were added and refluxed, as is, for 1 hour. After 15 minutes, the solution was cooled to room temperature followed by the addition of 10 ml of water and extraction with chloroform. After washing the organic phase twice with 25 ml of saturated brine and drying with magnesium sulfate, it was concentrated and dried under reduced pressure. The residue was then purified by silica gel column chromatography (hexane:ethyl acetate=60:1) to obtain 400 mg of ((benzothiophene-3-yl)methyl)(4-methoxy-2-nitrophenyl)amine in the form of an orange powder (yield: 44%).
As the paragraph descriping shows that 1196-19-6 is playing an increasingly important role.
Reference£º
Patent; Tsuchiya, Naoki; Matsumoto, Yoshiyuki; Saitou, Hiroshi; Mizuno, Tsuyoshi; US2004/10004; (2004); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem