Tag: 108.161

Cobalt-catalyzed branched selective hydroallylation of terminal alkynes was written by Chen, Jieping;Ying, Jiale;Lu, Zhan. And the article was included in Nature Communications in 2022.Related Products of 4298-52-6 This article mentions the following:

Here, authors reported a cobalt-hydride-catalyzed Markovnikov-type hydroallylation of terminal alkynes with allylic electrophile to access valuable and branched skipped dienes (1,4-dienes) with good regioselectivity. This operationally simple protocol exhibits excellent functional group tolerance and exceptional substrate scope. The reactions could be carried out in gram-scale with TON (turn over number) up to 1160, and the products could be easily derivatized. The preliminary mechanism of electrophilic allylation of α-selective cobalt alkenyl intermediate was proposed based on deuterium labeling experiment and kinetic studies. In the experiment, the researchers used many compounds, for example, 2-Ethynylthiophene (cas: 4298-52-6Related Products of 4298-52-6).

2-Ethynylthiophene (cas: 4298-52-6) belongs to benzothiophene derivatives. Functionalized benzothiophenes are important constructs found in molecules with wide ranging biological activity and in organic materials. It is also used in the manufacturing of dyes such as thioindigo.Related Products of 4298-52-6

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Chemoselective electrocatalytic hydroboration of alkynes with pinacolborane was written by Qiu, Hui;Lv, Kang;Qu, Haoqi;Zhang, Xuguang;Yuan, Taoyue;Yao, Weiwei;Xue, Fei;Ma, Mengtao. And the article was included in Journal of Molecular Structure in 2022.COA of Formula: C6H4S This article mentions the following:

A green and sustainable non-catalytic electrochem. hydroboration of various alkynes ArCCH with HBpin has been reported for the first time, giving arylvinylboronates (E)-ArCH:CHBpin. Under catalyst-free and additive-free mild reaction conditions the corresponding alkenyl boronic esters were obtained in good to excellent yields within 30 min at room temperature A plausible reaction mechanism was proposed based on the corresponding experiments In the experiment, the researchers used many compounds, for example, 2-Ethynylthiophene (cas: 4298-52-6COA of Formula: C6H4S).

2-Ethynylthiophene (cas: 4298-52-6) belongs to benzothiophene derivatives. Benzothiophene is a fused ring compound of thiophene ring and benzene ring, which is an important class of heterocycles with advantageous structures. It has been used as a raw material for the synthesis of biologically active structures and is found in pharmaceuticals such as leukotriene synthesis inhibitors and antifungals, as well as in many natural products.COA of Formula: C6H4S

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Sustainable synthesis of pyrazoles using alcohols as the primary feedstock by an iron catalyzed tandem C-C and C-N coupling approach was written by Mondal, Rakesh;Guin, Amit Kumar;Pal, Subhasree;Mondal, Sucheta;Paul, Nanda D.. And the article was included in Organic Chemistry Frontiers in 2022.Category: benzothiophene This article mentions the following:

Authors report two new efficient iron-catalyzed synthetic strategies for multicomponent synthesis of tri-substituted pyrazoles using biomass-derived alcs. as the primary feedstock. A well-defined, bench stable, and easy to prepare Fe(II)-catalyst bearing a tridentate pincer 2-(phenyldiazenyl)-1,10-phenanthroline was used as the catalyst. A wide variety of tri-substituted pyrazoles were prepared via dehydrogenative coupling of alcs., and aryl hydrazines with secondary alcs. and alkynes, resp. These methods eliminate the potential use of any pre-functionalized starting materials, noble metal catalysts, oxidants, or additives producing various substituted pyrazoles in moderate to good isolated yields via sequential C-C and C-N bond formation. A series of control experiments and spectroscopic studies were performed to understand the plausible mechanism of these multicomponent reactions. In the experiment, the researchers used many compounds, for example, 2-Ethynylthiophene (cas: 4298-52-6Category: benzothiophene).

2-Ethynylthiophene (cas: 4298-52-6) belongs to benzothiophene derivatives. Benzothiophene scaffolds are of great importance due to its increased presence in bioactive molecules. It has been used as a raw material for the synthesis of biologically active structures and is found in pharmaceuticals such as leukotriene synthesis inhibitors and antifungals, as well as in many natural products.Category: benzothiophene

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Selective Ni-catalyzed cross-electrophile coupling of alkynes, fluoroalkyl halides and vinyl halides was written by Dai, Yubei;Wang, Fang;Zhu, Shengqing;Chu, Lingling. And the article was included in Chinese Chemical Letters in 2022.Electric Literature of C6H4S This article mentions the following:

A Ni-catalyzed three-component cross-electrophile coupling of alkynes with alkenyl halides and fluoroalkyl halides to generate fluoroalkyl-incorporated 1,3-dienes was reported. This mild and operationally simple protocol was distinguished by its broad substrate scope and excellent chemo-, regio- and stereoselectivity, offering a new and organometallic agent-free platform for the construction of fluoroalkyl-incorporated diene motifs. Preliminary mechanistic studies were conducted to probe the potential reaction pathway. In the experiment, the researchers used many compounds, for example, 2-Ethynylthiophene (cas: 4298-52-6Electric Literature of C6H4S).

2-Ethynylthiophene (cas: 4298-52-6) belongs to benzothiophene derivatives. Benzothiophene is used as starting material for the synthesis of bioactive molecules. The core structure is a part of various pharmaceutical substances and natural products. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, sertaconazole, and also BTCP.Electric Literature of C6H4S

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Iron-catalyzed [3 + 2 + 1] annulation of 2-aminobenzimidazoles/3-aminopyrazoles and aromatic alkynes using N,N-dimethylaminoethanol as a one carbon synthon for the synthesis of pyrimido[1,2-a]benzimidazoles and pyrimido[1,2-b]indazoles was written by Qin, Zemin;Zhang, Ruiqin;Ying, Shenpeng;Ma, Yongmin. And the article was included in Organic Chemistry Frontiers in 2022.Application In Synthesis of 2-Ethynylthiophene This article mentions the following:

A simple and efficient method for the synthesis of pyrimido[1,2-a]benzimidazoles I (R = R¹ = H, Cl; R² = Ph, 1-naphthyl, 2-thienyl, etc.; R³ = H, Me, Ph, thiophen-3-yl, etc.) and pyrimido[1,2-b]indazoles II (R⁴ = H, Cl, F; R⁵ = H, Me, Br) from 2-aminobenzimidazoles/3-aminoindazoles, alkynes R²CCR³ and N,N-dimethylaminoethanol by a three-component [3+2+1] annulation catalyzed by FeCl₃ has been established, where N,N-dimethylaminoethanol was applied as a methine source. Good tolerance of the reaction makes this method applicable to construct biol. active pyrimido[1,2-a]benzimidazoles and pyrimido[1,2-b]indazoles. In addition, regioselective aryl substituted pyrimido[1,2-a]benzimidazoles were synthesized in the presence of TfOH. Replacement of alkynes with acetaldehydes gave the same pyrimido[1,2-a]benzimidazoles and pyrimido[1,2-b]indazoles. In the experiment, the researchers used many compounds, for example, 2-Ethynylthiophene (cas: 4298-52-6Application In Synthesis of 2-Ethynylthiophene).

2-Ethynylthiophene (cas: 4298-52-6) belongs to benzothiophene derivatives. Benzothiophene scaffolds are of great importance due to its increased presence in bioactive molecules. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, and sertaconazole, and also BTCP.Application In Synthesis of 2-Ethynylthiophene

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Simultaneous Immobilization of CO₂ and H₂S by Propargyl Amines under Mild Conditions: Efficient Synthesis of Thiazolidine-2-ones was written by Wu, Jiakai;He, Rongting;Cheng, Siliu;Han, Limin;Hong, Hailong;Zhu, Ning. And the article was included in ACS Sustainable Chemistry & Engineering in 2022.Application In Synthesis of 2-Ethynylthiophene This article mentions the following:

A series of thiazolidine-2-one derivatives were synthesized by a three-component reaction of carbon dioxide, hydrogen sulfide, and propargyl amines under mild conditions. The simultaneous incorporation of carbon dioxide and hydrogen sulfide into the same organic product was realized. Moreover, a reaction mechanism was proposed based on the detailed NMR and FTIR study, which indicated that propargyl amine reacted with CO₂ first to form carbamate, followed by O/S exchange with H₂S to form thiocarbamate and the final cyclization of thiocarbamate to form thiazolidine-2-one. In the experiment, the researchers used many compounds, for example, 2-Ethynylthiophene (cas: 4298-52-6Application In Synthesis of 2-Ethynylthiophene).

2-Ethynylthiophene (cas: 4298-52-6) belongs to benzothiophene derivatives. Benzothiophene is a fused ring compound of thiophene ring and benzene ring, which is an important class of heterocycles with advantageous structures. The different substitution patterns in these heterocycles offer new opportunities for drug discovery and other applications in materials science.Application In Synthesis of 2-Ethynylthiophene

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Palladium-catalyzed stereo-selective three-component cis-1,2-arylalkynylation of bicyclic alkenes with aryltriflates and terminal alkynes was written by Xu, Tianhao;Zhou, Xiangbing;Han, Yuhui;Zhang, Liangwei;Liu, Long;Huang, Tianzeng;Li, Chunya;Tang, Zhi;Wan, Shungang;Chen, Tieqiao. And the article was included in Tetrahedron Letters in 2022.Quality Control of 2-Ethynylthiophene This article mentions the following:

Synthesis of (1S,2R,3S,4R)-2-(arylethynyl)-3-(aryl)bicyclo[2.2.1]heptanes I [R = Ph, 4-MeC₆H₄, 4-FC₆H₄, etc.; Ar = Ph, 2-MeC₆H₄, 4-MeOC₆H₄, etc.; R¹ = H, C(O)Me] via a palladium-catalyzed stereo-selective cis-1,2-arylalkynylation of bicyclic alkenes with aryl triflates and terminal alkynes was developed. This reaction showed high functional group tolerance and could be applied to the modification of bioactive mols. This three-component reaction provided a practical method for preparing the value-added bicyclo[2.2.1]heptanes derivatives In the experiment, the researchers used many compounds, for example, 2-Ethynylthiophene (cas: 4298-52-6Quality Control of 2-Ethynylthiophene).

2-Ethynylthiophene (cas: 4298-52-6) belongs to benzothiophene derivatives. Functionalized benzothiophenes are important constructs found in molecules with wide ranging biological activity and in organic materials. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization.Quality Control of 2-Ethynylthiophene

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Modular Synthesis of Enantioenriched α-Chiral Homoallylic Amidines Enabled by Relay Ir/Cu Catalysis was written by Li, Ting-Peng;Li, Ren-Sha;Hu, Wei;Xie, Jia-Xin;Xu, Minghui;Feng, Chun;Ni, Hai-Liang;Yu, Wen-Hao;Hu, Ping;Wang, Bi-Qin;Cao, Peng. And the article was included in Organic Letters in 2022.Electric Literature of C6H4S This article mentions the following:

The cascade of Ir-catalyzed enantioselective allylic amination and Cu-catalyzed alkyne-azide cycloaddition was designed for the asym. synthesis of homoallylic amidines, e.g., I. The nucleophilic addition of an in situ-generated enantioenriched tertiary allylamine to a ketenimine intermediate triggers a rapid and stereospecific zwitterionic aza-Claisen rearrangement in a 1,3-chiral transfer manner. The approach allowed modular access to enantioenriched α-chiral homoallylic amidines in high yields with a high level of enantiomeric purity. In the experiment, the researchers used many compounds, for example, 2-Ethynylthiophene (cas: 4298-52-6Electric Literature of C6H4S).

2-Ethynylthiophene (cas: 4298-52-6) belongs to benzothiophene derivatives. Benzothiophene finds use in research as a starting material for the synthesis of larger, usually bioactive structures. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, and sertaconazole, and also BTCP.Electric Literature of C6H4S

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

A novel type of radical-addition-induced β-fragmentation and ensuing remote functionalization was written by Li, Xin;Shui, Yang;Shen, Pingkang;Wang, Yi-Peng;Zhang, Chi;Feng, Chao. And the article was included in Chem in 2022.Computed Properties of C6H4S This article mentions the following:

Herein, authors report a strategically novel synthetic protocol for the efficient construction of α-trifluoromethyl-β-amino ketone and α-sulfonyl-β-amino ketone derivatives 4-Isoxazoline is introduced, for the first time, as a class of effective nucleophilic SOMOphile (SOMO, single occupied MO) that readily reacts with electrophilic open-shell species such as trifluoromethyl radical and sulfonyl radical through a cascade of the homolytic addition/β-fragmentation manifold. The underlying polar effect is ascribed as the dominant factor that guarantees the cascade process both in high reaction efficiency and regioselectivity. This protocol is characterized by its mild reaction conditions and broad substrate scope, whereas the ease of acquiring enantiopure α-polyfluoroalkyl-β-amino ketone derivatives with readily accessed chiral 4-isoxazolines adds extra merit to this reaction. In the experiment, the researchers used many compounds, for example, 2-Ethynylthiophene (cas: 4298-52-6Computed Properties of C6H4S).

2-Ethynylthiophene (cas: 4298-52-6) belongs to benzothiophene derivatives. Benzothiophenes are valuable heterocycles that are widely used in medicines, agrochemicals, and materials science. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, sertaconazole, and also BTCP.Computed Properties of C6H4S

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Carboxamide-Directed Stereospecific Couplings of Chiral Tertiary Alkyl Halides with Terminal Alkynes was written by Akagawa, Hiroki;Tsuchiya, Naoki;Morinaga, Asuka;Katayama, Yu;Sumimoto, Michinori;Nishikata, Takashi. And the article was included in ACS Catalysis in 2022.HPLC of Formula: 4298-52-6 This article mentions the following:

Herein, the stereospecific Sonogashira coupling of chiral α-halocarboxamides possessing a tert-alkyl moiety R¹R²C(X)(C(O)NHR³) (R¹ = Me, Et; R² = Bu, iso-Bu, Ph, 4-methylphenyl; R³ = Ph, 2,6-diisopropylphenyl, 4-chlorophenyl, etc.; X = Br, Cl) and alkynes R⁴CCH (R⁴ = trimethylsilyl, cyclohexylmethyl, thiophen-3-yl, etc.) was reported. This reaction produces a series of chiral tert-alkylated alkynes R¹R²C(CCR⁴)(C(O)NHR³) in a stereoretentive manner. In this reaction, both the CuBr/bathophen catalyst system and carboxamide directing group are essential for achieving the high enantiospecificities of the couplings. Mechanistic studies of this reaction revealed that the alkynyl copper species is the key intermediate that coordinates to the carboxamide group of chiral α-bromocarboxamide. In the experiment, the researchers used many compounds, for example, 2-Ethynylthiophene (cas: 4298-52-6HPLC of Formula: 4298-52-6).

2-Ethynylthiophene (cas: 4298-52-6) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The electrophilic substitution of benzothiophene systems is much less regioselective than that of indoles. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, sertaconazole, and also BTCP.HPLC of Formula: 4298-52-6

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem