Tag: 108.161

Copper-Catalyzed Cross-Coupling of Arylacetylenes with Bromodifluoroacetamides was written by Hu, Guo-Qin;Yao, Li-Wei;Gui, Shu-Sheng;Geng, Chuang;Zhang, Wen-Yan;Liu, Jing-Hui;Zhao, Bin. And the article was included in Synlett in 2022.SDS of cas: 4298-52-6 This article mentions the following:

A copper-catalyzed radical difluoroalkylation of arylacetylenes with bromodifluoroamides has been developed. The reaction exhibits good functional group tolerance and allows access to a variety of substituted α-alkynyl-α,α-difluoroacetamides in moderate to good yields. The potential for scale-up reaction and products derivatization also makes this method attractive for practical applications. Preliminary mechanistic studies suggest that a radical reaction pathway might be involved in the catalytic system. In the experiment, the researchers used many compounds, for example, 2-Ethynylthiophene (cas: 4298-52-6SDS of cas: 4298-52-6).

2-Ethynylthiophene (cas: 4298-52-6) belongs to benzothiophene derivatives. Benzothiophene is a fused ring compound of thiophene ring and benzene ring, which is an important class of heterocycles with advantageous structures. Due to its aromaticity, thiophenes do not exhibit the same properties as conventional thioethers.SDS of cas: 4298-52-6

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Alkali metal salts-assisted coupling reaction between fluorinated benzyl electrophiles and alkenylboronic acids was written by Xie, Wenna;Liu, Shiwen;Hammond, Gerald B.;Xu, Bo. And the article was included in New Journal of Chemistry in 2022.Computed Properties of C6H4S This article mentions the following:

Synthesis of ((aryl)trifluorobutenyl)arenes and ((aryl)fluorobutenyl)arenes (E)-ArCHR¹CH:CHR [Ar = Ph, 4-ClC₆H₄, 3-MeOC₆H₄, etc.; R = Ph, 4-MeC₆H₄, 4-MeOC₆H₄, etc.; R¹ = CF₃, CFH₂] via versatile transition metal-free cross-coupling reaction between fluorinated benzyl electrophiles and alkenylboronic acids in the presence of the equivalent amount of alkali metal salts such as K₃PO₄ was developed. This transition metal-free protocol gave good chem. yields for a wide range of substrates and demonstrates good functional group tolerance. In the experiment, the researchers used many compounds, for example, 2-Ethynylthiophene (cas: 4298-52-6Computed Properties of C6H4S).

2-Ethynylthiophene (cas: 4298-52-6) belongs to benzothiophene derivatives. Benzothiophenes are valuable heterocycles that are widely used in medicines, agrochemicals, and materials science. The different substitution patterns in these heterocycles offer new opportunities for drug discovery and other applications in materials science.Computed Properties of C6H4S

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Rhodium(III)-Catalyzed Regioselective C-H Annulation and Alkenylation of 2-Pyridones with Terminal Alkynes was written by Li, Jiajie;Xu, Xin;Luo, Zhenli;Yao, Zhen;Yang, Ji;Zhang, Xin;Xu, Lijin;Wang, Peng;Shi, Qian. And the article was included in Advanced Synthesis & Catalysis in 2022.Related Products of 4298-52-6 This article mentions the following:

Cp*Rh(III)-catalyzed regioselective C-H annulation and alkenylation of 2-pyridones with terminal alkynes was developed. The cationic Cp*Rh(III) catalytic system containing FeCl₃ additive enables annulation of 1-(2-pyridyl)-2-pyridones with terminal alkynes, providing efficient access to 5,7-diarylated 2-quinolinones I [R = H, 4-Me, 3-Br, etc.; R¹ = H, 4-Me, 5-F, etc.; Ar = Ph, 2-MeC₆H₄, 2-naphthyl, etc.]. The reaction pathway could be switched to alkenylation with [Cp*RhCl₂]₂ as the catalyst, NaOAc as the additive and HOAc as the solvent, affording C6-alkenylated 1-(2-pyridyl)-2-pyridones II [R² = Ph, 3-MeC₆H₄, 2-naphthyl, etc.; R³ = H, 4-Me, 3-Br, etc.] in high yields. These protocols accommodated a wide range of substrates with good functional group compatibility. In the experiment, the researchers used many compounds, for example, 2-Ethynylthiophene (cas: 4298-52-6Related Products of 4298-52-6).

2-Ethynylthiophene (cas: 4298-52-6) belongs to benzothiophene derivatives. Benzothiophene scaffolds are of great importance due to its increased presence in bioactive molecules. Due to its aromaticity, thiophenes do not exhibit the same properties as conventional thioethers.Related Products of 4298-52-6

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Iron-Catalyzed Alkylzincation of Terminal Alkynes was written by Huang, Qiang;Wang, Wei-Na;Zhu, Shou-Fei. And the article was included in ACS Catalysis in 2022.SDS of cas: 4298-52-6 This article mentions the following:

Although carbozincation of terminal alkynes is a promising method for the synthesis of alkenylzinc reagents, many challenges, especially the chemo-, regio-, and stereoselectivity, remain to be addressed. The authors herein report an operationally simple, mild method for Fe-catalyzed alkylzincation of terminal alkynes to produce a diverse array of alkenylzinc compounds in high yields with high anti-Markovnikov selectivity and high cis stereoselectivity. Using this method, the authors realized a cis alkylzincation of terminal alkynes, and the method has a wide substrate scope (being suitable for aryl, alkenyl, alkyl, and heteroatom-substituted acetylenes) and good functional group tolerance. Because the C(sp²)-Zn bonds of the products can be readily transformed, the method provides a competitive alternative to traditional methods for the selective synthesis of trisubstituted olefins. The Fe catalyst developed in this study exhibited irreplaceable reactivity in alkyne alkylzincation. In the experiment, the researchers used many compounds, for example, 2-Ethynylthiophene (cas: 4298-52-6SDS of cas: 4298-52-6).

2-Ethynylthiophene (cas: 4298-52-6) belongs to benzothiophene derivatives. Benzothiophene finds use in research as a starting material for the synthesis of larger, usually bioactive structures. It has been used as a raw material for the synthesis of biologically active structures and is found in pharmaceuticals such as leukotriene synthesis inhibitors and antifungals, as well as in many natural products.SDS of cas: 4298-52-6

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Homolytic N-S Bond Cleavage in Vinyl Triflimides Enabled by Triplet-Triplet Energy Transfer was written by Strauch, Christina;Schroeder, Sebastian;Grelier, Gwendal;Niggemann, Meike. And the article was included in Chemistry – A European Journal in 2022.HPLC of Formula: 4298-52-6 This article mentions the following:

Vinyl triflimides are a new compound class with unknown reactivity. A computational anal. identified homolytic cleavage of the N-Tf bond induced by triplet-triplet energy transfer (EnT) as a highly interesting reaction type that might be accessible. A combination of exptl. and mechanistic work verified this hypothesis and proved the generated radicals to be amenable to radical-radical coupling. Thereby, vinyl triflimides H₂C:C(Ar)NTf₂ (Ar = Ph, 4-BrC₆H₄, 2-thienyl, etc.) were transformed into a range of α-quaternary, β-trifluoromethylated amines ArC(R)(NHTf)CH₂CF₃ (R = Me, Et, CN, Ph, etc.) in a 1,2-difunctionalization reaction with no need for external CF₃ reagents. In the experiment, the researchers used many compounds, for example, 2-Ethynylthiophene (cas: 4298-52-6HPLC of Formula: 4298-52-6).

2-Ethynylthiophene (cas: 4298-52-6) belongs to benzothiophene derivatives. Benzothiophene is a fused ring compound of thiophene ring and benzene ring, which is an important class of heterocycles with advantageous structures. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization.HPLC of Formula: 4298-52-6

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

A convenient transformation of alkynes to α-hydroxy-α-CF₃-γ-ketoester derivatives via H₃PO₄-catalyzed tandem hydration and aldol condensation was written by Wang, Jiali;Yao, Jun;Jia, Chunqi;Hu, Dandan;Chen, Yun-Hua;Song, Jinyu;Zhang, Jun-Qi;Ren, Hongjun. And the article was included in Green Chemistry in 2022.Safety of 2-Ethynylthiophene This article mentions the following:

A robust metal-free catalytic strategy for the rapid construction of the valuable α-hydroxy-α-CF₃-γ-ketoester skeleton with cheap and easily available stock chems. (alkynes and trifluoropyruvate) as the starting material was described. This protocol showed very good functional group tolerance and was easily scaled up. Importantly, compared with transition metal-catalyzed methods, this strategy was made more environmentally friendly by employing a catalytic amount of H₃PO₄ as the catalyst. In the experiment, the researchers used many compounds, for example, 2-Ethynylthiophene (cas: 4298-52-6Safety of 2-Ethynylthiophene).

2-Ethynylthiophene (cas: 4298-52-6) belongs to benzothiophene derivatives. Benzothiophene is used as starting material for the synthesis of bioactive molecules. The core structure is a part of various pharmaceutical substances and natural products. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization.Safety of 2-Ethynylthiophene

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Electrochemical Dearomatizing Spirocyclization of Alkynes with Dimethyl 2-Benzylmalonates to Spiro[4.5]deca-trienones was written by Li, Laiqiang;Hou, Zhong-Wei;Li, Pinhua;Wang, Lei. And the article was included in Journal of Organic Chemistry in 2022.HPLC of Formula: 4298-52-6 This article mentions the following:

An electrochem. dearomatizing spirocyclization of alkynes with di-Me 2-benzylmalonates for the preparation of spiro[4.5]deca-trienones had been developed. This approach adopted ferrocene (Cp₂Fe) as an electrocatalyst to produce carbon-centered radical intermediates from C-H-based malonates, which obviated the forthputting of noble-metal reagents, sacrificial chem. oxidants and 2-bromomalonates. A wide variety of spiro compounds were efficiently prepared with satisfactory results under mild conditions. In the experiment, the researchers used many compounds, for example, 2-Ethynylthiophene (cas: 4298-52-6HPLC of Formula: 4298-52-6).

2-Ethynylthiophene (cas: 4298-52-6) belongs to benzothiophene derivatives. Benzothiophene is a fused ring compound of thiophene ring and benzene ring, which is an important class of heterocycles with advantageous structures. Due to its aromaticity, thiophenes do not exhibit the same properties as conventional thioethers.HPLC of Formula: 4298-52-6

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Integrating Terminal CoBr_n Salts into a 2D Cobalt(II) Coordination Polymer to Promote the β-(E)-Selective Hydroboration of Alkynes was written by Jia, Jun-Song;Wu, Tai-Xue;Fu, Yi-Jia;Hu, Zhi-Rong;Tang, Hai-Tao;Pan, Ying-Ming;Huang, Fu-Ping. And the article was included in Advanced Synthesis & Catalysis in 2022.Related Products of 4298-52-6 This article mentions the following:

In the present study, 2D Co(II) coordination polymer [[Co₅(4,4′-H₂dbpt)₂Br₁₀]·8(MeCOEt)]_n (CP-1, 4,4′-H₂dbpt = ), which integrate terminal CoBr_n (CoBr₂ and CoBr₃) sites immobilized on the framework, are synthesized at the gram level. As a special heterogeneous catalyst, CP-1 shows regioselectivity (β:α>99:1) and stereoselectivity (only E configuration) in the hydroboration of alkynes. The hydroboration reaction conditions are mild and cover a broad substrate range (31 examples). In addition, the heterogeneous catalyst can be recycled for at least five times. In the experiment, the researchers used many compounds, for example, 2-Ethynylthiophene (cas: 4298-52-6Related Products of 4298-52-6).

2-Ethynylthiophene (cas: 4298-52-6) belongs to benzothiophene derivatives. Benzothiophene finds use in research as a starting material for the synthesis of larger, usually bioactive structures. It is also used in the manufacturing of dyes such as thioindigo.Related Products of 4298-52-6

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Influence of π-Endcaps on the Performance of Functionalized Quinolines for p-Channel OFETs was written by Anjali, Anshika;Imran, Predhanekar Mohamed;Bhuvanesh, Nattamai S. P.;Nagarajan, Samuthira. And the article was included in Macromolecular Rapid Communications in 2022.Recommanded Product: 2-Ethynylthiophene This article mentions the following:

This study investigates the influence of aryl and ethynyl linkers as well the effect of various pi-end-groups on the performance of the quinoline-based organic field-effect transistors. A series of new functionalized quinolines with D-π-A-π-D and A-π-A-π-A architectures are designed and synthesized via the Sonagashira cross-coupling reaction. All the new compounds are well characterized and their photophys. properties are studied. The bottom gate-top contact-organic field-effect transistors devices are fabricated using the spin-coating technique. By employing the pre and post-annealing technique, films with uniform surface coverage are obtained. The variation in the end-groups results in versatile packing arrangements which determine their good charge transport properties. The p-channel transistor behavior is observed for all the new compounds Among the mols. studied, methoxyphenyl and thiophen-2-yl terminal functionalized with D-π-A-π-D architecture exhibit the higher p-channel transistor characteristics with hole mobilities of 1.39 and 1.33 cm² V^-1 s^-1, resp. The good charge carrier mobilities are supported by an electron-donating methoxy group and thiophene as the end-groups with high highest occupied MOs (HOMO) and lowest unoccupied MOs (LUMO) levels, extensive π-conjugation, and better self-assembly. In the experiment, the researchers used many compounds, for example, 2-Ethynylthiophene (cas: 4298-52-6Recommanded Product: 2-Ethynylthiophene).

2-Ethynylthiophene (cas: 4298-52-6) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The core structure is a part of various pharmaceutical substances and natural products. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, and sertaconazole, and also BTCP.Recommanded Product: 2-Ethynylthiophene

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Palladium-Catalyzed Tail-to-Tail Reductive Dimerization of Terminal Alkynes to 2,3-Dibranched Butadienes was written by Guo, Hongyu;Zhang, Sheng;Li, Yang;Yu, Xiaoqiang;Feng, Xiujuan;Yamamoto, Yoshinori;Bao, Ming. And the article was included in Angewandte Chemie, International Edition in 2022.Recommanded Product: 2-Ethynylthiophene This article mentions the following:

The palladium-catalyzed tail-to-tail reductive dimerization of terminal alkynes was described for the first time. Aromatic terminal alkynes bearing diverse and sensitive functional groups as well as aliphatic terminal alkynes are efficiently transformed to 2,3-dibranched butadienes H₂C(R)CC(R)CH₂ [R = Ph, 2-naphthyl, 2-thienyl, etc.]. The key to achieve a selective tail-to-tail reductive dimerization reaction is to control appropriately the acidity of the reaction solution, which is accomplished by a combined use of pivalic acid and para-toluenesulfonic acid. The tail-to-tail reductive dimerization reaction is proposed to proceed via a cationic alkenyl palladium intermediate under acidic conditions. In the experiment, the researchers used many compounds, for example, 2-Ethynylthiophene (cas: 4298-52-6Recommanded Product: 2-Ethynylthiophene).

2-Ethynylthiophene (cas: 4298-52-6) belongs to benzothiophene derivatives. Benzothiophene finds use in research as a starting material for the synthesis of larger, usually bioactive structures. Due to its aromaticity, thiophenes do not exhibit the same properties as conventional thioethers.Recommanded Product: 2-Ethynylthiophene

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem