Tag: 108.16

Direct synthesis of 1-naphthylamines enabled by 6-endo-dig cyclization strategy using copper catalysis was written by Ma, Peng;Wang, Jianhui;Liu, Guiyan. And the article was included in Applied Organometallic Chemistry in 2022.Category: benzothiophene This article mentions the following:

A facile approach for the synthesis of substituted 1-naphthylamines I [R¹ = Ph, 2-FC₆H₄, 3-ClC₆H₄, etc.; R² = H, 7-F, 6-Cl, etc.; R³ = H, CH₂CH=CH₂; R⁴ = Ph, Bn, Cy, etc.; R³ = R⁴ = Me; R³R⁴ = CH₂CH₂OCH₂CH₂] via three-component 6-endo-dig cyclization of terminal alkynes with 2-bromoaryl ketones, primary or secondary amines in water under Pd-free conditions was described. The Cu(I) catalytic system avoided a fundamental problem related to these substrates, which competitively evolve through 5-endo-dig cyclization pathways under metal catalysis. This unique performance unlocked a rapid access to a diverse 1-naphthylamines library that previously required longer synthetic routes. The synthetic potential of this method was further demonstrated by the gram-scale synthesis, and the mechanism study showed that the reaction experienced sequential halide exchange, imine-enamine tautomerization and 6-endo-dig cyclization. In the experiment, the researchers used many compounds, for example, 3-Ethynylthiophene (cas: 67237-53-0Category: benzothiophene).

3-Ethynylthiophene (cas: 67237-53-0) belongs to benzothiophene derivatives. Benzothiophene scaffolds are of great importance due to its increased presence in bioactive molecules. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization.Category: benzothiophene

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Radical Hydro-Fluorosulfonylation of Unactivated Alkenes and Alkynes was written by Wang, Peng;Zhang, Honghai;Zhao, Mingqi;Ji, Shuangshuang;Lin, Lu;Yang, Na;Nie, Xingliang;Song, Jinshuai;Liao, Saihu. And the article was included in Angewandte Chemie, International Edition in 2022.Safety of 3-Ethynylthiophene This article mentions the following:

Here, reported the first establishment of radical hydro-fluorosulfonylation of alkenes, which was enabled by using 1-fluorosulfonyl 2-aryl benzoimidazolium (FABI) as an effective redox-active radical precursor. This method provided a new and facile approach for the synthesis of aliphatic sulfonyl fluorides from unactivated alkenes, and could be further applied to the late-stage modifications of natural products and peptides, as well as ligation of drugs in combination with click chem. Remarkably, this system could enable the radical hydro-fluorosulfonylation of alkynes, afforded valuable alkenylsulfonyl fluoride products with a rare, high Z-selectivity, which were normally less stable and more challenging to synthesize in comparison with the E-configured products. In the experiment, the researchers used many compounds, for example, 3-Ethynylthiophene (cas: 67237-53-0Safety of 3-Ethynylthiophene).

3-Ethynylthiophene (cas: 67237-53-0) belongs to benzothiophene derivatives. Benzothiophene scaffolds are of great importance due to its increased presence in bioactive molecules. It is also used in the manufacturing of dyes such as thioindigo.Safety of 3-Ethynylthiophene

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Regioselective Dichotomy in Ru(II)-Catalyzed C-H Annulation of Aryl Pyrazolidinones with 1,3-Diynes was written by Sontakke, Geetanjali S.;Ghosh, Chiranjit;Pal, Kuntal;Volla, Chandra M. R.. And the article was included in Journal of Organic Chemistry in 2022.SDS of cas: 67237-53-0 This article mentions the following:

Herein, authors present a substrate-controlled regiodivergent strategy for the selective synthesis of C3 or C2-alkynylated indoles via ruthenium-catalyzed [3 + 2]-annulation of readily available pyrazolidinones and 1,3-diynes. Remarkably, C3-alkynylated indoles were obtained in good yields when 1,4-diarylbuta-1,3-diynes were employed as the coupling partners. On the other hand, dialkyl-1,3-diynes led to the selective formation of C2-alkynylated indoles. The key features of the strategy are the operationally simple conditions and external-oxidant-free, broad-scope, and substrate-switchable indole synthesis. Scale-up reactions and further transformations expanded the synthetic utility of the protocol. In the experiment, the researchers used many compounds, for example, 3-Ethynylthiophene (cas: 67237-53-0SDS of cas: 67237-53-0).

3-Ethynylthiophene (cas: 67237-53-0) belongs to benzothiophene derivatives. Benzothiophene finds use in research as a starting material for the synthesis of larger, usually bioactive structures. Due to its aromaticity, thiophenes do not exhibit the same properties as conventional thioethers.SDS of cas: 67237-53-0

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Photocatalytic activity of an Anderson-type polyoxometalate with mixed copper(I)/copper(II) ions for visible-light enhancing heterogeneous catalysis was written by Qin, Lan;Ren, Ran;Huang, Xiaoxue;Xu, Xinyi;Shi, Hao;Huai, Ranran;Song, Nuan;Yang, Lu;Wang, Suna;Zhang, Daopeng;Zhou, Zhen. And the article was included in Journal of Solid State Chemistry in 2022.HPLC of Formula: 67237-53-0 This article mentions the following:

The development of new catalysts that exhibit catalytic activity and enhance the catalysis under light-irradiation could help eliminate the barrier between traditional catalysts and photocatalysts. Herein, an organic-inorganic hybrid Anderson-type polyoxometalate (noted as POM 1) was synthesized by incorporating a [MnMo₆O₁₈] cluster and two rare three-coordinated copper sites, which were connected by the organic [(OCH₂)₃CN=CH-4-Py] (Py = pyridine) moieties on both sides. The resultant POM 1 exhibited an enhanced luminescence property compared with the free [MnMo₆O₁₈] cluster. While in terms of photocatalytic activity, the prepared catalyst exhibited an excellent selective degradation ability toward a pos.-charged methylene blue dye in an aqueous solution Meanwhile, the X-ray photoelectron spectrometry anal. indicated the coexistence of Cu(I)/Cu(II) ions and suggested that the partly oxidized Cu(II) ions in 1 could be reduced to Cu(I) ions via the photoinduced electron transfer from the [MnMo₆O₁₈] unit. This in-situ reduction process provides an enhanced heterogeneous catalytic performance in terms of azide-alkyne cycloaddition, affording almost complete conversion within a 4 h irradiation using a 20 W household incandescent lamp as the light source at room temperature under solvent-free conditions. In the experiment, the researchers used many compounds, for example, 3-Ethynylthiophene (cas: 67237-53-0HPLC of Formula: 67237-53-0).

3-Ethynylthiophene (cas: 67237-53-0) belongs to benzothiophene derivatives. Benzothiophene is used as starting material for the synthesis of bioactive molecules. The core structure is a part of various pharmaceutical substances and natural products. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, and sertaconazole, and also BTCP.HPLC of Formula: 67237-53-0

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Nickel-catalyzed deaminative allenylation of amino acid derivatives: Catalytic activity enhanced by an amide-type NN₂ Pincer ligand was written by Zhang, Xingjie;Jiao, Chenchen;Qi, Di;Liu, Xiaopan;Zhang, Zhiguo;Zhang, Guisheng. And the article was included in Organic Letters in 2022.Related Products of 67237-53-0 This article mentions the following:

Herein, we report a general and practical nickel-catalyzed deaminative allenylation of amino acid derivatives with terminal alkynes. The well-designed, electron deficient, and sterically hindered amide-type NN₂ Pincer ligand was crucial to the success of this transformation, enabling the coupling to occur under mild conditions with high efficiency. The remarkable features of this chem. are its good scalability, its broad substrate scope, functional group tolerance, and the efficient modification of peptides, drugs, and natural products. In the experiment, the researchers used many compounds, for example, 3-Ethynylthiophene (cas: 67237-53-0Related Products of 67237-53-0).

3-Ethynylthiophene (cas: 67237-53-0) belongs to benzothiophene derivatives. Benzothiophene is used as starting material for the synthesis of bioactive molecules. The core structure is a part of various pharmaceutical substances and natural products. It is also used in the manufacturing of dyes such as thioindigo.Related Products of 67237-53-0

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem