10133-22-9, 5-(Bromomethyl)benzo[b]thiophene is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of 5-bromomethyl-benzo [b] thiophene (1. 55g, 6.8mmol, 2.4 eq) and 1,1- dimethylethyl 4-[(2-methylpropyl) amino] piperidine-1-carboxylate (0. 71g, 2. 8mmol, 1 eq) in acetonitrile (25ml) is added potassium carbonate (0.62g, 4.4mmol, 1.6eq). The mixture is heated to reflux for 16 hours. The solution is filtered and the solvent removed in vacuo. The resulting oil is purified on a 40g Redisep column using a gradient of 0-20% ethyl acetate/iso-hexane to give 1, 1-dimethylethyl 4-f [ (1-benzothienyl-5-yl) methyl]- (2- methylpropyl) amino}-piperidine-l-carboxylate as an oil (1.12 g, 100 %). mass spectrum (LCMS): m/z= 403.5 (M++1), Rt= 3.38 (6 min gradient) ; 1H NMR (300 MHz, CDC13) : 8= 7. 80-7. 60 (2 H, m), 7.37-7. 33 (1 H, m), 7.32-7. 26 (1 H, m), 7.25-7. 20 (1 H, m), 4.17- 3.94 (2 H, m), 3.65 (2 H, s), 2. 65-2. 36 (3 H, m), 2.24-2. 10 (2 H, d), 1.71-1. 28 (5 H, m), 1.38 (9 H, s), 0.88-0. 69 (6 H, d).
10133-22-9 5-(Bromomethyl)benzo[b]thiophene 11160498, abenzothiophene compound, is more and more widely used in various.
Reference£º
Patent; ELI LILLY AND COMPANY; WO2005/92885; (2005); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem