Tag: 100-200

A photochromic liquid crystal system was written by Frigoli, Michel;Mehl, Georg H.. And the article was included in ChemPhysChem in 2003.Recommanded Product: 90560-10-4 This article mentions the following:

A photochromic liquid crystal system based on a photochromic core, 1,2-bis(2-methylbenzo[b]thiophen-3-yl)hexafluorocyclopentene system connected to two cyanobiphenyl groups via spacers of ten methylene groups was synthesized. The successful synthesis of the system indicates that the concept of sep. individual functionalities of a photochromic core and mesogens, linked by flexible spacers in a modular approach, allows the design of materials where the mesomorphic phase structure and range, and, addnl., the absorption characteristics, can be modulated in a controlled manner by irradiation In the experiment, the researchers used many compounds, for example, 6-Methoxybenzo[b]thiophene (cas: 90560-10-4Recommanded Product: 90560-10-4).

6-Methoxybenzo[b]thiophene (cas: 90560-10-4) belongs to benzothiophene derivatives. Benzothiophenes are valuable heterocycles that are widely used in medicines, agrochemicals, and materials science. Due to its aromaticity, thiophenes do not exhibit the same properties as conventional thioethers.Recommanded Product: 90560-10-4

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

New approach to the synthesis of 2-substituted benzothiophenes and their hetero analogs was written by Brown, Kenneth J.;Meth-Cohn, Otto. And the article was included in Tetrahedron Letters in 1974.HPLC of Formula: 55219-11-9 This article mentions the following:

Ozonolysis of thiophene gave 34% (o-OCHC6H4)2S2 (I) which with RCH2CO2H (R = CO2H, CN, Ph, 2-thienyl, 3-thienyl, BzNH, AcNH) gave 2-R-substituted benzothiophenes (II). Similarly, I with MeNO2 gave 2-nitrothiophene. I was also prepared by LiAlH4 reduction of (o-HO2CC6H4)2S2 followed by MnO2 oxidation Similarly the pyrazole III gave the thienopyrazole IV. In the experiment, the researchers used many compounds, for example, Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9HPLC of Formula: 55219-11-9).

Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9) belongs to benzothiophene derivatives. Benzothiophene finds use in research as a starting material for the synthesis of larger, usually bioactive structures. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization.HPLC of Formula: 55219-11-9

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Reinvestigating Old Pharmacophores: Are 4-Aminoquinolines and Tetraoxanes Potential Two-Stage Antimalarials? was written by Terzic, Natasa;Konstantinovic, Jelena;Tot, Miklos;Burojevic, Jovana;Djurkovic-Djakovic, Olgica;Srbljanovic, Jelena;Stajner, Tijana;Verbic, Tatjana;Zlatovic, Mario;Machado, Marta;Albuquerque, Ines S.;Prudencio, Miguel;Sciotti, Richard J.;Pecic, Stevan;D’Alessandro, Sarah;Taramelli, Donatella;Solaja, Bogdan A.. And the article was included in Journal of Medicinal Chemistry in 2016.Quality Control of 5-Fluoro-1-benzothiophene-2-carboxylic acid This article mentions the following:

The syntheses and antiplasmodial activities of various substituted aminoquinolines coupled to an adamantane carrier are described. The compounds exhibited pronounced in vitro and in vivo activity against Plasmodium berghei in the Thompson test. Tethering a fluorine atom to the aminoquinoline C(3) position afforded fluoroaminoquinolines that act as intrahepatocytic parasite inhibitors, with compound 25 having an IC₅₀ = 0.31 μM and reducing the liver load in mice by up to 92% at 80 mg/kg dose. Screening our peroxides as inhibitors of liver stage infection revealed that the tetraoxane pharmacophore itself is also an excellent liver stage P. berghei inhibitor (78: IC₅₀ = 0.33 μM). Up to 91% reduction of the parasite liver load in mice was achieved at 100 mg/kg. Examination of tetraoxane 78 against the transgenic 3D7 strain expressing luciferase under a gametocyte-specific promoter revealed its activity against stage IV-V Plasmodium falciparum gametocytes (IC₅₀ = 1.16 ± 0.37 μM). To the best of our knowledge, compounds 25 and 78 are the first examples of either an 4-aminoquinoline or a tetraoxane liver stage inhibitors. In the experiment, the researchers used many compounds, for example, 5-Fluoro-1-benzothiophene-2-carboxylic acid (cas: 70060-13-8Quality Control of 5-Fluoro-1-benzothiophene-2-carboxylic acid).

5-Fluoro-1-benzothiophene-2-carboxylic acid (cas: 70060-13-8) belongs to benzothiophene derivatives. Benzothiophene scaffolds are of great importance due to its increased presence in bioactive molecules. It has been used as a raw material for the synthesis of biologically active structures and is found in pharmaceuticals such as leukotriene synthesis inhibitors and antifungals, as well as in many natural products.Quality Control of 5-Fluoro-1-benzothiophene-2-carboxylic acid

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Cu-Catalyzed Cyanation of Arylboronic Acids with Acetonitrile: A Dual Role of TEMPO was written by Zhu, Yamin;Li, Linyi;Shen, Zengming. And the article was included in Chemistry – A European Journal in 2015.Recommanded Product: 55219-11-9 This article mentions the following:

The cyanation of arylboronic acids using acetonitrile as the “CN” source was achieved under a Cu(cat.)/TEMPO system (TEMPO = 2,2,6,6-tetramethylpiperidine N-oxide). The broad substrate scope includes a variety of electron-rich and electron-poor arylboronic acids, which react well to give the cyanated products in high to excellent yields. Mechanistic studies revealed that TEMPO-CH₂CN, generated in situ, is an active cyanating reagent and shows high reactivity for the formation of the CN^– moiety. Moreover, TEMPO acts as a cheap oxidant to enable the reaction to be catalytic in copper. In the experiment, the researchers used many compounds, for example, Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9Recommanded Product: 55219-11-9).

Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9) belongs to benzothiophene derivatives. Benzothiophene is used as starting material for the synthesis of bioactive molecules. The core structure is a part of various pharmaceutical substances and natural products. It is found within the chemical structures of pharmaceutical drugs such as zileuton, raloxifene, and sertaconazole, and also BTCP.Recommanded Product: 55219-11-9

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Synthesis and evaluation of benzo[b]thiophene derivatives as inhibitors of alkaline phosphatases was written by Li, Lina;Chang, Lei;Pellet-Rostaing, Stephane;Liger, Francois;Lemaire, Marc;Buchet, Rene;Wu, Yuqing. And the article was included in Bioorganic & Medicinal Chemistry in 2009.Recommanded Product: Benzo[b]thiophene-2-carbonitrile This article mentions the following:

Presence of basic calcium phosphate in knee joints of osteoarthritis patients could be prevented by inhibiting tissue non-specific alk. phosphatase (TNAP) activity. Levamisole or the L stereoisomer of tetramisole (a known TNAP inhibitor) has been used as a treatment for curing rheumatoid arthritis but its therapeutical use is limited due to side effects. We report the synthesis and the TNAP inhibition property of benzo[b]thiophene derivatives, among which benzothiopheno-tetramisole and benzothiopheno-2,3-dehydrotetramisole, which could be involved in a drug therapy for osteoarthritis. Two water soluble racemic benzothiopheno-tetramisole and -2,3-dehydrotetramisole with apparent inhibition constants K _i = 85 ± 6 μM and 135 ± 3 μM (n = 3) comparable to that of enantiomeric levamisole 93 ± 4 μM were found. Several novel derivatives showed more pronounced inhibition properties towards intestinal alk. phosphatase than TNAP. In the experiment, the researchers used many compounds, for example, Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9Recommanded Product: Benzo[b]thiophene-2-carbonitrile).

Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9) belongs to benzothiophene derivatives. Benzothiophenes are valuable heterocycles that are widely used in medicines, agrochemicals, and materials science. The different substitution patterns in these heterocycles offer new opportunities for drug discovery and other applications in materials science.Recommanded Product: Benzo[b]thiophene-2-carbonitrile

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

An aerobic Cu-mediated practical approach to aromatic nitriles using cyanide anions as the nitrogen source was written by Gu, Lijun;Jin, Cheng;Zhang, Hongtao;Liu, Jiyan;Li, Ganpeng;Yang, Zhi. And the article was included in Organic & Biomolecular Chemistry in 2016.HPLC of Formula: 55219-11-9 This article mentions the following:

A Cu-mediated cyanation of aryl Me ketones using cyanide anions as the nitrogen source was achieved to provide aromatic nitriles in moderate to good yields. The reaction tolerates a variety of synthetically important functional groups. In the experiment, the researchers used many compounds, for example, Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9HPLC of Formula: 55219-11-9).

Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9) belongs to benzothiophene derivatives. Benzothiophenes are valuable heterocycles that are widely used in medicines, agrochemicals, and materials science. It is also used in the manufacturing of dyes such as thioindigo.HPLC of Formula: 55219-11-9

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Synthesis of estradiol backbone mimics via the Stille reaction using copper(II) oxide as co-reagent was written by Floeistrup, Erik;Goede, Patrick;Stroemberg, Roger;Malm, Johan. And the article was included in Tetrahedron Letters in 2011.Reference of 90560-10-4 This article mentions the following:

Sterically hindered 2-phenylbenzo[b]thiophenes I (R¹ = H, HO; R² = H, Me; R³ = H, Me) and biaryls II (R⁴ = HO, PhCH₂O; R⁵ = CHO) that can serve as templates for mimics of the estradiol backbone were prepared in modest to good yields by the Stille reaction using CuO as a coreagent. Due to the neutral conditions applied in the Stille reaction, protection strategies were unnecessary for hydroxy containing coupling partners. Ligandless coupling conditions were also evaluated. In the experiment, the researchers used many compounds, for example, 6-Methoxybenzo[b]thiophene (cas: 90560-10-4Reference of 90560-10-4).

6-Methoxybenzo[b]thiophene (cas: 90560-10-4) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The electrophilic substitution of benzothiophene systems is much less regioselective than that of indoles. It has been used as a raw material for the synthesis of biologically active structures and is found in pharmaceuticals such as leukotriene synthesis inhibitors and antifungals, as well as in many natural products.Reference of 90560-10-4

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Application of directed metalation in synthesis. Part 2. An expedient synthesis of methoxybenzo[b]thiophenes was written by Mukherjee, Chandrani;De, Asish. And the article was included in Synlett in 2002.HPLC of Formula: 90560-10-4 This article mentions the following:

A short, simple and expedient synthesis of substituted benzo[b]thiophenes involving directed ortho lithiation-side-chain deprotonation-cyclization-reduction is described. This method is a valuable improvement over earlier syntheses of the same class of compounds, both with respect to the number of steps and overall yields. In the experiment, the researchers used many compounds, for example, 6-Methoxybenzo[b]thiophene (cas: 90560-10-4HPLC of Formula: 90560-10-4).

6-Methoxybenzo[b]thiophene (cas: 90560-10-4) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The electrophilic substitution of benzothiophene systems is much less regioselective than that of indoles. It has been used as a raw material for the synthesis of biologically active structures and is found in pharmaceuticals such as leukotriene synthesis inhibitors and antifungals, as well as in many natural products.HPLC of Formula: 90560-10-4

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Ring opening/closure reactions of novel diheteroarylethenes derivatives. Solvent effects was written by Vazquez, Alvaro J.;Nudelman, Norma Sbarbati. And the article was included in Journal of Physical Organic Chemistry in 2012.COA of Formula: C9H8OS This article mentions the following:

Three novel diarylethenes, 3,3′-(3,3,4,4,5,5-hexafluoro-1-cyclopentene-1,2-diyl)bis[2-methyl-benzo[b]thiophene] (I), 3-[3,3,4,4,5,5-hexafluoro-2-(2-methylbenzo[b]thien-3-yl)-1-cyclopenten-1-yl]-6-methoxy-2-methyl-benzo[b]thiophene (II), and 3-[3,3,4,4,5,5-hexafluoro-2-(2-methylbenzo[b]thien-3-yl)-1-cyclopenten-1-yl]-6-methoxy-2-methyl-7-nitro-benzo[b]thiophene (III), were synthesized and their photochem. optical properties studied in four solvents (n-hexane, toluene, acetonitrile and methanol). It was determined that these compounds dramatically increase the light absorption in the visible region upon exposure to UV light, showing two absorption maxima at 420 nm and 520 nm, resp. The observed change is completely reverted upon exposure to visible light. The three compounds demonstrate negligible fatigue, excellent stability in the four solvents, and absence of photodegradation and thermal back reactions. This paper also describes a complete study of solvent effects on the kinetics of the ring opening and cycloreversion. While, the UV spectra are little sensitive both to the substitution pattern and to the solvent influence, the kinetics of ring opening/cycloreversion reactions exhibit a more interesting behavior that differs from other diarylethenes reported in the literature. The cyclization kinetics shows a complex order, well fitted by an exponential equation, while the cycloreversion presents first-order kinetics. The whole complex reaction scheme can be explained by the unusual presence of two conformers of the open form, a parallel and an antiparallel conformation. Though other alternative mechanism could explain the kinetics, addnl. evidence is consistent with the conformational equilibrium proposed: i.e. the solvent influence on the kinetics of the nitro-substituted substrate, and the double signals for the Me protons and for the methoxy protons (when present) observed in the NMR spectra. These observations are relevant in relation to the application of these novel diarylethenes as potential optical materials. Copyright © 2012 John Wiley & Sons, Ltd. In the experiment, the researchers used many compounds, for example, 6-Methoxybenzo[b]thiophene (cas: 90560-10-4COA of Formula: C9H8OS).

6-Methoxybenzo[b]thiophene (cas: 90560-10-4) belongs to benzothiophene derivatives. Benzothiophene scaffolds are of great importance due to its increased presence in bioactive molecules. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization.COA of Formula: C9H8OS

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Late-stage Pd-catalyzed Cyanations of Aryl/Heteroaryl Halides in Aqueous Micellar Media was written by Thakore, Ruchita R.;Takale, Balaram S.;Singhania, Vani;Gallou, Fabrice;Lipshutz, Bruce H.. And the article was included in ChemCatChem in 2021.Category: benzothiophene This article mentions the following:

New technol. was described that enables late stage ppm Pd-catalyzed cyanations of highly complex mols., as well as a wide variety of aryl and heteroaryl halides possessing sensitive functional groups. These reactions are efficient in water containing nanomicelles, formed from a com. available and inexpensive surfactant. The implications for advancing drug synthesis and discovery are apparent. In the experiment, the researchers used many compounds, for example, Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9Category: benzothiophene).

Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9) belongs to benzothiophene derivatives. Benzothiophene finds use in research as a starting material for the synthesis of larger, usually bioactive structures. It is also used in the manufacturing of dyes such as thioindigo.Category: benzothiophene

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem