Tag: 100-200

In 2019,Journal of the American Chemical Society included an article by Zhu, Xiaotao; Deng, Weili; Chiou, Mong-Feng; Ye, Changqing; Jian, Wujun; Zeng, Yuehua; Jiao, Yihang; Ge, Liang; Li, Yajun; Zhang, Xinhao; Bao, Hongli. HPLC of Formula: 88-15-3. The article was titled 《Copper-catalyzed radical 1,4-difunctionalization of 1,3-enynes with alkyl diacyl peroxides and N-fluorobenzenesulfonimide》. The information in the text is summarized as follows:

Many reactions involving allenyl ion species have been studied, but reactions involving allenyl radicals are less well understood, perhaps because of the inconvenience associated with the generation of short-lived allenyl radicals. We describe here a versatile method for the generation of allenyl radicals and their previously unreported applications in the intermol. 1,4-carbocyanation and 1,4-sulfimidocyanation of 1,3-enynes. With the assistance of the trifunctional reagents, alkyl diacyl peroxides or N-fluorobenzenesulfonimide, a range of synthetically challenging multi-substituted allenes can be prepared with high regioselectivity. These multi-substituted allenes can be easily transformed into synthetically useful structures such as fluorinated vinyl cyanides, lactones, functionalized allenyl amides, 1-aminonaphthalenes, and pyridin-2(1H)-ones, and several novel transformations are reported. The results of radical scavenger and radical clock experiments are consistent with the proposed allenyl radical pathway. D. functional theory (DFT) and IR spectroscopy studies suggest the formation of an isocyanocopper(II) species in the ligand exchange step. On the basis of the results of IR, DFT, and diastereoselectivity studies, an isocyanocopper(II)/copper(I) catalytic cycle is proposed, which differs from the previously considered Cu(III) mechanism in cyanation reactions. In the part of experimental materials, we found many familiar compounds, such as 1-Thiophen-2-yl-ethanone(cas: 88-15-3HPLC of Formula: 88-15-3)

1-Thiophen-2-yl-ethanone(cas: 88-15-3) belongs to thiophenes. Specialized thiophenes can be synthesized similarly using Lawesson’s reagent as the sulfidizing agent, or via the Gewald reaction, which involves the condensation of two esters in the presence of elemental sulfur. Another method is the Volhard–Erdmann cyclization. HPLC of Formula: 88-15-3

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

In 2019,Angewandte Chemie, International Edition included an article by Zhang, Linli; Tang, Yitian; Han, Zhaobin; Ding, Kuiling. Synthetic Route of C6H6OS. The article was titled 《Lutidine-Based Chiral Pincer Manganese Catalysts for Enantioselective Hydrogenation of Ketones》. The information in the text is summarized as follows:

A series of MnI complexes containing lutidine-based chiral pincer ligands (S,S) or (R,R) I (R = H, Me, t-Bu, Cl, OMe; R1 = i-Pr, Bn) with modular and tunable structures has been developed. The complex shows unprecedentedly high activities (up to 9800 TON; TON = turnover number), broad substrate scope (81 examples), good functional-group tolerance, and excellent enantioselectivities (85-98% ee) in the hydrogenation of various ketones, e.g., acetophenone. These aspects are rare in earth-abundant metal catalyzed hydrogenations. The utility of the protocol have been demonstrated in the asym. synthesis of a variety of key intermediates for chiral drugs. Preliminary mechanistic investigations indicate that an outer-sphere mode of substrate-catalyst interactions probably dominates the catalysis.1-Thiophen-2-yl-ethanone(cas: 88-15-3Synthetic Route of C6H6OS) was used in this study.

1-Thiophen-2-yl-ethanone(cas: 88-15-3) belongs to thiophenes. Specialized thiophenes can be synthesized similarly using Lawesson’s reagent as the sulfidizing agent, or via the Gewald reaction, which involves the condensation of two esters in the presence of elemental sulfur. Another method is the Volhard–Erdmann cyclization. Synthetic Route of C6H6OS

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

《The development of a one pot, regiocontrolled, three-component reaction for the synthesis of thieno[2,3-c]pyrroles》 was published in Organic & Biomolecular Chemistry in 2013. These research results belong to Hong, Cynthia M.; Statsyuk, Alexander V.. Category: benzothiophene The article mentions the following:

A three-component reaction has been developed that allows the regioselective synthesis of thieno[2,3-c]pyrroles, e.g. I. The reaction is based on the ability of 2-acetyl-3-thiophenecarboxaldehyde to react with amine and thiol nucleophiles to produce the corresponding tri-substituted thieno[2,3-c]pyrroles, with water as the only byproduct. The developed reaction expands the range of synthetically accessible, tri-substituted thieno[2,3-c]pyrroles. In the experimental materials used by the author, we found 2-(Thiophen-3-yl)-1,3-dioxolane(cas: 13250-82-3Category: benzothiophene)

2-(Thiophen-3-yl)-1,3-dioxolane(cas: 13250-82-3) is one of dioxolane. 1,3-Dioxolane derivatives are recognized as important motifs for the construction of numerous pharmacologically active molecules as antiviral, antifungal, anti-HIV, and adrenoreceptor antagonists.Category: benzothiophene

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Zhong, Feng; Pan, Zhi-Zhou; Zhou, Si-Wei; Zhang, Hai-Jun; Yin, Liang published their research in Journal of the American Chemical Society in 2021. The article was titled 《Copper(I)-Catalyzed Regioselective Asymmetric Addition of 1,4-Pentadiene to Ketones》.Reference of 1-Thiophen-2-yl-ethanone The article contains the following contents:

By using com. available 1,4-pentadiene as a pronucleophile, a copper(I)-catalyzed regioselective asym. allylation of ketones is achieved. A variety of chiral tertiary alcs. bearing a terminal (Z)-1,3-diene unit are generated in high (Z)/(E) ratio and high enantioselectivity. Both aromatic ketones and aliphatic ketones serve as suitable substrates. Furthermore, the reactions with (E)-C1(alkyl)-1,4-dienes proceed in moderate yields with acceptable enantioselectivity but with low (Z,E)/others ratio, which demonstrates the partial isomerization of (E)-allylcopper(I) species to (Z)-allylcopper(I) species through 1,3-migration. Subsequent Heck reaction and olefin metathesis compensate for the low efficiency with C1-1,4-dienes. The synthetic utility of the product is further demonstrated by a copper(I)-catalyzed regioselective borylation of the 1,3-diene group. In the experiment, the researchers used many compounds, for example, 1-Thiophen-2-yl-ethanone(cas: 88-15-3Reference of 1-Thiophen-2-yl-ethanone)

1-Thiophen-2-yl-ethanone(cas: 88-15-3) belongs to thiophenes. Specialized thiophenes can be synthesized similarly using Lawesson’s reagent as the sulfidizing agent, or via the Gewald reaction, which involves the condensation of two esters in the presence of elemental sulfur. Another method is the Volhard–Erdmann cyclization. Reference of 1-Thiophen-2-yl-ethanone

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Ghosh, Rahul; Jana, Narayan Ch.; Panda, Surajit; Bagh, Bidraha published their research in ACS Sustainable Chemistry & Engineering in 2021. The article was titled 《Transfer Hydrogenation of Aldehydes and Ketones in Air with Methanol and Ethanol by an Air-Stable Ruthenium-Triazole Complex》.Safety of 1-Thiophen-2-yl-ethanone The article contains the following contents:

Coordination of 1,4-disubstituted 1,2,3-triazoles with [(p-cymene)RuCl2]2 followed by dehydrochlorination in the presence of a base resulted in the formation of ruthenium complexes, resp. Both were tested for the transfer hydrogenation of aldehydes and ketones in air using ecol. benign and cheap ethanol as the hydrogen source in the presence of a catalytic amount of a base. Air-stable ruthenium complex was proved to be an active catalyst for the transfer hydrogenation of a wide variety of aromatic and aliphatic aldehydes and ketones bearing various functionalities. Catalyst ruthenium complex was also effective for the transfer hydrogenation of carbonyls using the simplest primary alc., methanol, under aerobic conditions. Under the present catalytic protocol, labile or reducible functionalities such as nitro, cyano, and ester groups were tolerated. Good selectivity was also observed for acyclic α,β-unsaturated carbonyls. However, this catalytic protocol was not selective for 2-cyclohexen-1-one as both alkene and keto moieties were reduced. The transfer hydrogenations are believed to proceed via a ruthenium-hydride intermediate. Finally, transfer hydrogenation of acetophenone using isopropanol as a commonly used hydrogen source was also performed and the sustainable and green credentials of these catalytic protocols utilizing methanol, ethanol, and isopropanol were compared with the help of the CHEM21 green metrics toolkit. The experimental part of the paper was very detailed, including the reaction process of 1-Thiophen-2-yl-ethanone(cas: 88-15-3Safety of 1-Thiophen-2-yl-ethanone)

1-Thiophen-2-yl-ethanone(cas: 88-15-3) belongs to thiophenes. Specialized thiophenes can be synthesized similarly using Lawesson’s reagent as the sulfidizing agent, or via the Gewald reaction, which involves the condensation of two esters in the presence of elemental sulfur. Another method is the Volhard–Erdmann cyclization. Safety of 1-Thiophen-2-yl-ethanone

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

《Synthesis, Structural Characterization, Thermogravimetric, and Molecular Modelling of Novel Mn(II), Co(II), and Ni(II) Metal Complexes Derived from New Synthesized 4,6-Diaryl-2-oxonicotinonitrile Ligand》 was written by Mohamed, A. A.; Asghar, B. H.; Moustafa, A. H.; El-Sayed, H. A.; El-Sayed, D.; Mohamed, A. S. A.; Asla, K. A.. Electric Literature of C6H6OSThis research focused ontransition metal thienyl pyridinone carbonitrile complex preparation; thermal stability transition metal thienyl pyridinone carbonitrile complex; DFT transition metal thienyl pyridinone carbonitrile complex; antimicrobial activity transition metal thienyl pyridinone carbonitrile complex. The article conveys some information:

Abstract: Novel coordination compounds of Mn(II), Co(II), and Ni(II) with a new 4-(4-chlorocyclohexyl)-2-oxo-6-(thien-2-yl)-1,2-dihydropyridine-3-carbonitrile ligand (L) were synthesized. M.p., elemental anal., spectroscopic techniques (IR, 1H NMR, UV-visible, and mass spectrometry), molar conductivity and thermo gravimetric analyzes were used to characterize the structures having the formulas: [Mn(L)2(H2O)2]SO4 (1), [Co(L)2(H2O)2]Cl2 (2), and [Ni(L)2(H2O)2]SO4·8H2O (3). The (L) reacts by 1 : 2 ratios with metal ions. Using IR spectral data, it was noticed that L ligand coordinates as neutral NO bidentate along with the oxygen of keto-lactam (NH-C:O) and nitrogen of carbonitrile (C≃N) groups. Compounds 1-3 are electrolytic in nature according to the conductivity measurements. Magnetic moment and UV-Visible data depicts the octahedral environment around the studied metal ion. Moreover, Thermal anal. granted a concept around the decaying manner of L and its complexes. It also assessed the quantity of water mols. in the complexe’s inner and outer spheres. For all complexes an octahedral geometry is proposed. TGA data shows the different degradations steps that were used to calculate valuable thermodn. and kinetic descriptors using two comparable methods. Furthermore, theor. studies by DFT demonstrate a high consistent with the exptl. data. Antimicrobial effectiveness of the L and its metal complexes were examined vs. a diversity of pathogenic G(+ve) and G(-ve) bacteria and fungi. The experimental process involved the reaction of 1-Thiophen-2-yl-ethanone(cas: 88-15-3Electric Literature of C6H6OS)

1-Thiophen-2-yl-ethanone(cas: 88-15-3) belongs to thiophenes. Reflecting their high stabilities, thiophenes arise from many reactions involving sulfur sources and hydrocarbons, especially unsaturated ones. Thiophenes are classically prepared by the reaction of 1,4-diketones, diesters, or dicarboxylates with sulfidizing reagents such as P4S10 such as in the Paal-Knorr thiophene synthesis. Electric Literature of C6H6OS

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

The author of 《Photobleaching dynamics in small molecule vs. polymer organic photovoltaic blends with 1,7-bis-trifluoromethylfullerene》 were Garner, Logan E.; Nellissery Viswanathan, Vinila; Arias, Dylan H.; Brook, Colin P.; Christensen, Steven T.; Ferguson, Andrew J.; Kopidakis, Nikos; Larson, Bryon W.; Owczarczyk, Zbyslaw R.; Pfeilsticker, Jason R.; Ramamurthy, Praveen C.; Strauss, Steven H.; Boltalina, Olga V.; Braunecker, Wade A.. And the article was published in Journal of Materials Chemistry A: Materials for Energy and Sustainability in 2018. Computed Properties of C7H8O2S The author mentioned the following in the article:

Two organic photovoltaic (OPV) donor materials (one polymer and one small mol.) are synthesized from the same constituent building blocks, namely thiophene units, cyclopentathiophene dione (CTD), and cyclopentadithiophene (CPDT). Photobleaching dynamics of these donor materials are then studied under white light illumination in air with blends of PC70BM and the bis-trifluoromethylfullerene 1,7-C60(CF3)2. For both the polymer and small mol. blends, C60(CF3)2 stabilizes the initial rate of photobleaching by a factor of 15 relative to PC70BM. However, once the small mol.:C60(CF3)2 blend bleaches to ∼80% of its initial optical d., the rate of photobleaching dramatically accelerates, which is not observed in the analogous polymer blend. We probe that phenomenon using time-resolved photoluminescence (TRPL) to measure PL quenching efficiencies at defined intervals during the photobleaching experiments The data indicates the small mol. donor and C60(CF3)2 acceptor significantly de-mix with time, after which the blend begins to bleach at approx. the same rate as the neat donor sample. The work suggests that perfluoroalkylfullerenes have great potential to stabilize certain OPV active layers toward photodegradation, provided their morphol. is stable.2-(Thiophen-3-yl)-1,3-dioxolane(cas: 13250-82-3Computed Properties of C7H8O2S) was used in this study.

2-(Thiophen-3-yl)-1,3-dioxolane(cas: 13250-82-3) is one of dioxolane. 1,3-Dioxolane derivatives are recognized as important motifs for the construction of numerous pharmacologically active molecules as antiviral, antifungal, anti-HIV, and adrenoreceptor antagonists.Computed Properties of C7H8O2S

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

《Two isostructural 3-(5-aryloxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)-1-(thiophen-2-yl)prop-2-en-1-ones: disorder and supramolecular assembly》 was written by Shaibah, Mohammed A. E.; Yathirajan, Hemmige S.; Manju, Nagaraj; Kalluraya, Balakrishna; Rathore, Ravindranath S.; Glidewell, Christopher. Application of 88-15-3 And the article was included in Acta Crystallographica, Section E: Crystallographic Communications in 2020. The article conveys some information:

Two new chalcones containing both pyrazole and thiophene substituents have been prepared and structurally characterized. 3-(3-Methyl-5-phenoxy-1-phenyl-1H-pyrazol-4-yl)-1-(thiophen-2-yl)prop-2-en-1-one, C23H18N2O2S (I), and 3-[3-methyl-5-(2-methylphenoxy)-1-phenyl-1H-pyrazol-4-yl]-1-(thiophen-2-yl)prop-2-en-1-one, C24H20N2O2S (II), are isomorphous as well as isostructural, and in each the thiophene substituent is disordered over two sets of at. sites having occupancies 0.844 (3) and 0.156 (3) in (I), and 0.883 (2) and 0.117 (2) in (II). In each structure, the mols. are linked into sheets by a combination of C-H···N and C-H···O hydrogen bonds. Comparisons are made with some related compounds In the experiment, the researchers used 1-Thiophen-2-yl-ethanone(cas: 88-15-3Application of 88-15-3)

1-Thiophen-2-yl-ethanone(cas: 88-15-3) belongs to thiophenes. Specialized thiophenes can be synthesized similarly using Lawesson’s reagent as the sulfidizing agent, or via the Gewald reaction, which involves the condensation of two esters in the presence of elemental sulfur. Another method is the Volhard–Erdmann cyclization. Application of 88-15-3

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

In 2019,Acta Crystallographica, Section E: Crystallographic Communications included an article by Majoumo-Mbe, Felicite; Nfor, Emmanuel Ngwang; Tsobnang, Patrice Kenfack; Eloundou, Valoise Brenda Nguepmeni; Yong, Joseph Ngwain; Iris Efeti, Ikome Ngwain. Synthetic Route of C6H6OS. The article was titled 《Synthesis, molecular and crystal structure of 1-(1,2-dihydrophthalazin-1-ylidene)-2-[1-(thiophen-2-yl)ethylidene]hydrazine》. The information in the text is summarized as follows:

The title compound, C14H12N4S, was synthesized by the condensation reaction of hydralazine and 2-acetylthiophene and during the reaction, a proton transfer from the imino nitrogen atom to one of the endocylic nitrogen atoms occurred. The compound crystallizes in the monoclinic crystal system with two independent mols. (mols. 1 and 2) in the asym. unit. In each mol., there is a slight difference in the orientation of the thiophene ring with respect to phthalazine ring system, mol. 1 showing a dihedral angle of 42.51 (1)° compared to 8.48 (1)° in mol. 2. This implies an r.m.s deviation of 0.428 (1) Å between the two mols. for the 19 non-H atoms. The two independent mols. are connected via two N-H···N hydrogen bonds, forming dimers which interact by two bifurcated π-π stacking interactions to build tetrameric motifs. The latter are packed in the ac plane via weak C-H···π interactions and along the b axis via C-H ···N and C-H···π interactions. This results a three-dimensional architecture with a tilted herringbone packing mode. The experimental process involved the reaction of 1-Thiophen-2-yl-ethanone(cas: 88-15-3Synthetic Route of C6H6OS)

1-Thiophen-2-yl-ethanone(cas: 88-15-3) belongs to thiophenes. Specialized thiophenes can be synthesized similarly using Lawesson’s reagent as the sulfidizing agent, or via the Gewald reaction, which involves the condensation of two esters in the presence of elemental sulfur. Another method is the Volhard–Erdmann cyclization. Synthetic Route of C6H6OS

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

The author of 《Manganese catalyzed α-methylation of ketones with methanol as a C1 source》 were Bruneau-Voisine, Antoine; Pallova, Lenka; Bastin, Stephanie; Cesar, Vincent; Sortais, Jean-Baptiste. And the article was published in Chemical Communications (Cambridge, United Kingdom) in 2019. HPLC of Formula: 88-15-3 The author mentioned the following in the article:

The direct α-methylation of ketones with methanol under hydrogen borrowing conditions using a well-defined manganese PN3P complex as a pre-catalyst was, for the first time, achieved. The reactions typically proceed at 120 °C for 20 h with 3 mol% pre-catalyst loading and in the presence of NaOtBu (50 mol%) as base. The scope of the reaction was extended to the α-methylation of esters. The results came from multiple reactions, including the reaction of 1-Thiophen-2-yl-ethanone(cas: 88-15-3HPLC of Formula: 88-15-3)

1-Thiophen-2-yl-ethanone(cas: 88-15-3) belongs to thiophenes. Reflecting their high stabilities, thiophenes arise from many reactions involving sulfur sources and hydrocarbons, especially unsaturated ones. Thiophenes are classically prepared by the reaction of 1,4-diketones, diesters, or dicarboxylates with sulfidizing reagents such as P4S10 such as in the Paal-Knorr thiophene synthesis. HPLC of Formula: 88-15-3

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem