Tag: 100-200

Modulation of the absorption, fluorescence, and liquid-crystal properties of functionalized diarylethene derivatives was written by Frigoli, Michel;Mehl, Georg H.. And the article was included in Chemistry – A European Journal in 2004.Application In Synthesis of 6-Methoxybenzo[b]thiophene This article mentions the following:

Systematic variation of the mol. symmetry in a photochromic system based on a 1,2-bis(2-methylbenzo[b]thiophen-3-yl)hexafluorocyclopentene group, connected by decyl spacers to two cyanobiphenyl groups as mesogens, allows for a systematic investigation of the correlations between mol. shape and symmetry, electronic effects, photochromic conversion and liquid-crystalline properties. In the experiment, the researchers used many compounds, for example, 6-Methoxybenzo[b]thiophene (cas: 90560-10-4Application In Synthesis of 6-Methoxybenzo[b]thiophene).

6-Methoxybenzo[b]thiophene (cas: 90560-10-4) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The core structure is a part of various pharmaceutical substances and natural products. Due to its aromaticity, thiophenes do not exhibit the same properties as conventional thioethers.Application In Synthesis of 6-Methoxybenzo[b]thiophene

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

N-(4-(4-(2,3-Dichloro- or 2-methoxyphenyl)piperazin-1-yl)butyl)heterobiarylcarboxamides with Functionalized Linking Chains as High Affinity and Enantioselective D3 Receptor Antagonists was written by Newman, Amy Hauck;Grundt, Peter;Cyriac, George;Deschamps, Jeffrey R.;Taylor, Michelle;Kumar, Rakesh;Ho, David;Luedtke, Robert R.. And the article was included in Journal of Medicinal Chemistry in 2009.Application of 70060-13-8 This article mentions the following:

In the present report, the D3 receptor pharmacophore is modified in the 2,3-diCl- and 2-OCH₃-phenylpiperazine class of compounds with the goal to improve D3 receptor affinity and selectivity. This extension of structure-activity relationships (SAR) has resulted in the identification of the first enantioselective D3 antagonists (R- and S-22) to be reported, wherein enantioselectivity is more pronounced at D3 than at D2, and that a binding region on the second extracellular loop (E2) may play a role in both enantioselectivity and D3 receptor selectivity. Moreover, we have discovered some of the most D3-selective compounds reported to date that show high affinity (K_i = 1 nM) for D3 and ∼400-fold selectivity over the D2 receptor subtype. Several of these analogs showed exquisite selectivity for D3 receptors over >60 other receptors, further underscoring their value as in vivo research tools. These lead compounds also have appropriate phys. characteristics for in vivo exploration and therefore will be useful in determining how intrinsic activity at D3 receptors tested in vitro is related to behaviors in animal models of addiction and other neuropsychiatric disorders. In the experiment, the researchers used many compounds, for example, 5-Fluoro-1-benzothiophene-2-carboxylic acid (cas: 70060-13-8Application of 70060-13-8).

5-Fluoro-1-benzothiophene-2-carboxylic acid (cas: 70060-13-8) belongs to benzothiophene derivatives. Functionalized benzothiophenes are important constructs found in molecules with wide ranging biological activity and in organic materials. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, and sertaconazole, and also BTCP.Application of 70060-13-8

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Benzo[b]naphtho[1,2-d]thiophene Sulfoxides: Biomimetic Synthesis, Photophysical Properties, and Applications was written by Shen, Xian-Yan;Li, Man;Zhou, Tai-Ping;Huang, Ji-Rong. And the article was included in Angewandte Chemie, International Edition in 2022.Name: 6-Methoxybenzo[b]thiophene This article mentions the following:

A practical synthesis of nonsym. thiophene-fused aromatic systems has been developed that was inspired by the biodegradation of benzothiophene. For the first time, the photophys. properties of a series of π-conjugated benzo[b]naphtho[1,2-d]thiophene (BNT) sulfoxides, I [R = H, Br, MeO, 4-FC₆H₄, R¹ = H, Br, Me, MeO, R² = Br, Cl, CN, etc., R³ = H, Br, MeO, Ph, 3-O₂NC₆H₄, 4-MeOC₆H₄, 4-FC₆H₄, R⁴ = H, Br, MeO, Ph, 3-O₂NC₆H₄, 4-MeOC₆H₄, 4-FC₆H₄, R⁵ = Br, Cl, 2-methoxy-3-pyridinyl, etc., R⁶ = H, Br, Me, R⁷ = H, Br, MeO, 4-FC₆H₄], were explored both in solution and in the solid state. The excellent fluorescence characteristics enable various applications of these compounds In the experiment, the researchers used many compounds, for example, 6-Methoxybenzo[b]thiophene (cas: 90560-10-4Name: 6-Methoxybenzo[b]thiophene).

6-Methoxybenzo[b]thiophene (cas: 90560-10-4) belongs to benzothiophene derivatives. Benzothiophene finds use in research as a starting material for the synthesis of larger, usually bioactive structures. The different substitution patterns in these heterocycles offer new opportunities for drug discovery and other applications in materials science.Name: 6-Methoxybenzo[b]thiophene

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Direct release of nitriles from solid phase was written by Hone, N. D.;Payne, L. J.;Tice, C. M.. And the article was included in Tetrahedron Letters in 2001.Product Details of 55219-11-9 This article mentions the following:

Cleavage conditions are described which allow resin-bound secondary amides to be liberated from Sieber or Rink resin as nitriles. The method was applied to the synthesis of a series of cyano biaryls. In the experiment, the researchers used many compounds, for example, Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9Product Details of 55219-11-9).

Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9) belongs to benzothiophene derivatives. Benzothiophenes are valuable heterocycles that are widely used in medicines, agrochemicals, and materials science. Due to its aromaticity, thiophenes do not exhibit the same properties as conventional thioethers.Product Details of 55219-11-9

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

A novel synthesis of benzo[b]thiophene was written by Liao, Zutai;Lv, Xuehao;Tao, Ming. And the article was included in Research on Chemical Intermediates in 2013.Reference of 55219-11-9 This article mentions the following:

A convenient method of preparation of benzo[b]thiophene by the using 2-chlorobenzaldehyde and 2-mercaptoacetonitrile as starting materials was reported. The process comprises two steps, neither of which was reported previously. The reactions in this work are clean and efficient. In the experiment, the researchers used many compounds, for example, Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9Reference of 55219-11-9).

Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The core structure is a part of various pharmaceutical substances and natural products. Due to its aromaticity, thiophenes do not exhibit the same properties as conventional thioethers.Reference of 55219-11-9

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Chloro-oxime derivatives as novel small molecule chaperone amplifiers was written by Zhou, Yuefen;Vu, Khang;Chen, Yongsheng;Pham, John;Brady, Thomas;Liu, Gang;Chen, Jinhua;Nam, Joonwoo;Murali Mohan Reddy, P. S.;Au, Qingyan;Yoon, Il Sang;Tremblay, Marie-Helene;Yip, Gary;Cher, Charmian;Zhang, Bin;Barber, Jack R.;Ng, Shi Chung. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2009.SDS of cas: 55219-11-9 This article mentions the following:

Chloro-oxime derivatives were investigated as novel small mol. chaperone amplifiers. Lead optimization led to the discovery of compounds that displayed potent HSF1 activation activity, significant cytoprotection in MG-132 stress, ER stress and PolyQ stress cell models (EC₅₀ < 10 μM). In the experiment, the researchers used many compounds, for example, Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9SDS of cas: 55219-11-9).

Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The electrophilic substitution of benzothiophene systems is much less regioselective than that of indoles. It has been used as a raw material for the synthesis of biologically active structures and is found in pharmaceuticals such as leukotriene synthesis inhibitors and antifungals, as well as in many natural products.SDS of cas: 55219-11-9

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

A practical synthesis of 2-carbonylbenzo[b]thiophenes was written by Hsiao, Chi Nung;Bhagavatula, Lakshmi;Pariza, Richard J.. And the article was included in Synthetic Communications in 1990.Computed Properties of C9H5NS This article mentions the following:

The sequential reduction and alkylation of 2-HSC₆H₄CO₂H gave 2-RCH₂SC₆H₄CH₂OH [R = COMe, COPh, COCMe₃, CO₂Et, cyano, CH(OMe)₂]. The oxidation and intramol. aldol condensation of the latter gave the title compounds I (same R). In the experiment, the researchers used many compounds, for example, Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9Computed Properties of C9H5NS).

Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9) belongs to benzothiophene derivatives. Benzothiophene is used as starting material for the synthesis of bioactive molecules. The core structure is a part of various pharmaceutical substances and natural products. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization.Computed Properties of C9H5NS

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Iron(II)-Catalyzed Direct Cyanation of Arenes with Aryl(cyano)iodonium Triflates was written by Shu, Zhibin;Ji, Wenzhi;Wang, Xi;Zhou, Yujing;Zhang, Yan;Wang, Jianbo. And the article was included in Angewandte Chemie, International Edition in 2014.Application In Synthesis of Benzo[b]thiophene-2-carbonitrile This article mentions the following:

A direct oxidative cyanation of arenes under iron [Fe(II)] catalysis with [3,5-bis(trifluoromethyl)phenyl](cyano)iodonium triflate (DFCT) as the cyanation agent has been developed. The reaction is applicable to wide range of aromatic substrates, including polycyclic structures and heteroaromatic compounds Under optimized conditions the synthesis of the target compounds was achieved using acetic acid iron(2+) salt (2:1) [iron(II) acetate] as catalyst and cyano[4-(trifluoromethyl)phenyl]iodonium trifluoromethanesulfonate (1:1) as cyano group source. Starting materials included 1,4-dimethylbenzene (alkyl arene), naphthalene, anthracene, phenanthrene, 1-[tris(1-methylethyl)silyl]-1H-pyrrole, 1-[(4-methylphenyl)sulfonyl]-1H-pyrrole, benzo[b]thiophene, benzofuran, 1-(3-methyl-1H-indol-1-yl)-ethanone (indole derivative),. The title compounds thus formed included aromatic nitriles, such as benzonitrile derivatives, 9-anthracenecarbonitrile, 1-naphthalenecarbonitrile, 1-[(4-methylphenyl)sulfonyl]-1H-pyrrole-2-carbonitrile, 9-phenanthrenecarbonitrile, benzo[b]thiophene-2-carbonitrile, etc. In the experiment, the researchers used many compounds, for example, Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9Application In Synthesis of Benzo[b]thiophene-2-carbonitrile).

Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9) belongs to benzothiophene derivatives. Benzothiophene is used as starting material for the synthesis of bioactive molecules. The core structure is a part of various pharmaceutical substances and natural products. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, and sertaconazole, and also BTCP.Application In Synthesis of Benzo[b]thiophene-2-carbonitrile

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

A General and Convenient Catalytic Synthesis of Nitriles from Amides and Silanes was written by Zhou, Shaolin;Junge, Kathrin;Addis, Daniele;Das, Shoubhik;Beller, Matthias. And the article was included in Organic Letters in 2009.Recommanded Product: 55219-11-9 This article mentions the following:

A new and convenient protocol for the catalytic dehydration of aromatic and aliphatic amides using silanes in the presence of catalytic amounts of fluoride is presented. The synthesis of aliphatic and aromatic nitriles proceeds with high selectivity under mild conditions. Notably, a wide substrate range is converted in good to excellent yields. In the experiment, the researchers used many compounds, for example, Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9Recommanded Product: 55219-11-9).

Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9) belongs to benzothiophene derivatives. Benzothiophene scaffolds are of great importance due to its increased presence in bioactive molecules. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization.Recommanded Product: 55219-11-9

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Preparation of polyfunctional nitriles by the cyanation of functionalized organozinc halides with p-toluenesulfonyl cyanide was written by Klement, Ingo;Lennick, Klaus;Tucker, Charles E.;Knochel, Paul. And the article was included in Tetrahedron Letters in 1993.Quality Control of Benzo[b]thiophene-2-carbonitrile This article mentions the following:

Various alkyl, alkenyl, alkynyl, benzylic, aromatic or heterocyclic organozinc halides bearing functional groups such as an ester, a boronic ester, a cyanide, a halide or a trialkoxysilyl group react under mild conditions with p-toluenesulfonyl cyanide (TosCN) affording polyfunctional nitriles in 69-93% yields. Thus, (E)-Cl(CH₂)₃CH:CHZnI was treated sequentially with BuLi, ZnI₂, and TosCN in THF to give 72% (E)-Cl(CH₂)₃CH:CHCN. In the experiment, the researchers used many compounds, for example, Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9Quality Control of Benzo[b]thiophene-2-carbonitrile).

Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9) belongs to benzothiophene derivatives. Benzothiophene is a fused ring compound of thiophene ring and benzene ring, which is an important class of heterocycles with advantageous structures. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, and sertaconazole, and also BTCP.Quality Control of Benzo[b]thiophene-2-carbonitrile

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem