Wang, Xian-Jin et al. published their research in New Journal of Chemistry in 2017 | CAS: 55219-11-9

Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The core structure is a part of various pharmaceutical substances and natural products. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization.HPLC of Formula: 55219-11-9

Cyanation of aromatic/vinylic boronic acids with α-cyanoacetates was written by Wang, Xian-Jin;Zhang, Song-Lin. And the article was included in New Journal of Chemistry in 2017.HPLC of Formula: 55219-11-9 This article mentions the following:

A friendly protocol was reported to achieve cyanation of aromatic and vinylic boronic acids using nontoxic and readily available α-cyanoacetates as a cyano source under aerobic conditions. Many aryl/vinyl boronic acids (as well as some iodides and bromides) were amenable substrates to give aryl nitriles ArCN [Ar = 4-MeOC6H4, 3-quinolinyl, 2-benzothienyl, etc.] and acrylonitriles I [R1 = H, Ph; R2 = Ph, 4-MeOC6H4, 4-BrC6H4; R3 = H, Ph]. This cyanation method provided a safe and operationally convenient alternative to traditional ones requiring toxic cyanide salts. In the experiment, the researchers used many compounds, for example, Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9HPLC of Formula: 55219-11-9).

Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The core structure is a part of various pharmaceutical substances and natural products. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization.HPLC of Formula: 55219-11-9

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

Shimojo, Hiroyuki et al. published their research in Synthesis in 2013 | CAS: 55219-11-9

Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9) belongs to benzothiophene derivatives. Benzothiophene is a fused ring compound of thiophene ring and benzene ring, which is an important class of heterocycles with advantageous structures. It is found within the chemical structures of pharmaceutical drugs such as zileuton, raloxifene, and sertaconazole, and also BTCP.COA of Formula: C9H5NS

Simple one-pot conversion of alcohols into nitriles was written by Shimojo, Hiroyuki;Moriyama, Katsuhiko;Togo, Hideo. And the article was included in Synthesis in 2013.COA of Formula: C9H5NS This article mentions the following:

Various benzylic and primary alcs. were efficiently converted into the corresponding nitriles in good yields at room temperature by treatment with Me3COCl, I2, or 1,3-diiodo-5,5-dimethylhydantoin in the presence of TEMPO, followed by treatment with I2 and aqueous NH3. The nitriles were obtained in good yields and high purities simply by extraction of the reaction mixture with CHCl3 and subsequent removal of the solvent. In the experiment, the researchers used many compounds, for example, Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9COA of Formula: C9H5NS).

Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9) belongs to benzothiophene derivatives. Benzothiophene is a fused ring compound of thiophene ring and benzene ring, which is an important class of heterocycles with advantageous structures. It is found within the chemical structures of pharmaceutical drugs such as zileuton, raloxifene, and sertaconazole, and also BTCP.COA of Formula: C9H5NS

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

Zhu, Jianming et al. published their research in Synthesis in 2016 | CAS: 55219-11-9

Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9) belongs to benzothiophene derivatives. Benzothiophene finds use in research as a starting material for the synthesis of larger, usually bioactive structures. It is found within the chemical structures of pharmaceutical drugs such as zileuton, raloxifene, and sertaconazole, and also BTCP.Application In Synthesis of Benzo[b]thiophene-2-carbonitrile

Facile Synthesis of Substituted 4-Alkoxy-2-oxazolines and Exploration of the Reaction Mechanism was written by Zhu, Jianming;Li, Xiaolong;Wang, Guimin;Li, Bo;Xu, Zhijian;Tian, Shikai;Hall, Adrian;Shen, Jingshan;Shi, Jiye;Zhu, Weiliang. And the article was included in Synthesis in 2016.Application In Synthesis of Benzo[b]thiophene-2-carbonitrile This article mentions the following:

Substituted 4-alkoxy-2-oxazolines, e.g., I [R = H, (2,3-MeO)2, 4-F, etc.], have been synthesized via the reaction of nitriles with beta-hydroxyacetals promoted by trifluoromethanesulfonic acid. The reaction is proposed to be initiated by the protonation of the acetals to produce carbocations that are then attacked by nitrogen atom of the nitriles, followed by an intramol. cyclization reaction to form the 4-alkoxy-2-oxazolines. The proposed reaction mechanism has been validated by quantum chem. calculations, key intermediate synthesis, and NMR spectra. In the experiment, the researchers used many compounds, for example, Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9Application In Synthesis of Benzo[b]thiophene-2-carbonitrile).

Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9) belongs to benzothiophene derivatives. Benzothiophene finds use in research as a starting material for the synthesis of larger, usually bioactive structures. It is found within the chemical structures of pharmaceutical drugs such as zileuton, raloxifene, and sertaconazole, and also BTCP.Application In Synthesis of Benzo[b]thiophene-2-carbonitrile

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

Hu, Fangdong et al. published their research in Organic Letters in 2021 | CAS: 90560-10-4

6-Methoxybenzo[b]thiophene (cas: 90560-10-4) belongs to benzothiophene derivatives. Benzothiophenes are valuable heterocycles that are widely used in medicines, agrochemicals, and materials science. It has been used as a raw material for the synthesis of biologically active structures and is found in pharmaceuticals such as leukotriene synthesis inhibitors and antifungals, as well as in many natural products.Recommanded Product: 6-Methoxybenzo[b]thiophene

Enantioselective Hydroarylation or Hydroalkenylation of Benzo[b]thiophene 1,1-Dioxides with Organoboranes was written by Hu, Fangdong;Jia, Jie;Li, Ximing;Xia, Ying. And the article was included in Organic Letters in 2021.Recommanded Product: 6-Methoxybenzo[b]thiophene This article mentions the following:

An efficient protocol for the asym. hydroarylation and hydroalkenylation of benzo[b]thiophene 1,1-dioxides with organoboranes was developed. The combination of a rhodium(I) precatalyst and a chiral diene ligand constituted the catalytic system, which enabled the facile synthesis of 2,3-dihydrobenzo[b]thiophene 1,1-dioxides I [R = H, 5-Me, 7-Me, etc.; R1 = H, Me, Et, i-Pr; Ar = Ph, 2-naphthyl, 3-thienyl, (E)-styryl, etc.] in good yields with high enantioselectivities. The merging of this asym. hydroarylation with the downstream alkylations delivered 2,3-dihydrobenzo[b]thiophene 1,1-dioxides that contain two continuous quaternary stereocenters with high enantioselectivities in a diastereodivergent manner. In the experiment, the researchers used many compounds, for example, 6-Methoxybenzo[b]thiophene (cas: 90560-10-4Recommanded Product: 6-Methoxybenzo[b]thiophene).

6-Methoxybenzo[b]thiophene (cas: 90560-10-4) belongs to benzothiophene derivatives. Benzothiophenes are valuable heterocycles that are widely used in medicines, agrochemicals, and materials science. It has been used as a raw material for the synthesis of biologically active structures and is found in pharmaceuticals such as leukotriene synthesis inhibitors and antifungals, as well as in many natural products.Recommanded Product: 6-Methoxybenzo[b]thiophene

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

Mu, Delong et al. published their research in Chemical Communications (Cambridge, United Kingdom) in 2022 | CAS: 90560-10-4

6-Methoxybenzo[b]thiophene (cas: 90560-10-4) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The electrophilic substitution of benzothiophene systems is much less regioselective than that of indoles. The different substitution patterns in these heterocycles offer new opportunities for drug discovery and other applications in materials science.COA of Formula: C9H8OS

Enantioselective synthesis of acyclic monohydrosilanes by steric hindrance assisted C-H silylation was written by Mu, Delong;Pan, Shuqiong;Wang, Xiaoyu;Liao, Xiaoyun;Huang, Yong;Chen, Jiean. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2022.COA of Formula: C9H8OS This article mentions the following:

Herein, a rhodium-catalyzed desymmetrization of dihydrosilanes with heterocyclic compounds via intermol. dehydrogenative C-H silylation is developed. The strategy tolerates a variety of thianaphthene and thiophene derivatives, giving rise to a wide range of silicon-stereogenic acyclic monohydrosilanes. Several rare skeletons featuring bis-silicon-stereogenic centers were also designed to enhance the library’s diversity further. Preliminary mechanistic studies reveal that the surrounding spatial environment of the Si-center plays a crucial role in enabling intermol. C-H silylation preferentially. In the experiment, the researchers used many compounds, for example, 6-Methoxybenzo[b]thiophene (cas: 90560-10-4COA of Formula: C9H8OS).

6-Methoxybenzo[b]thiophene (cas: 90560-10-4) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The electrophilic substitution of benzothiophene systems is much less regioselective than that of indoles. The different substitution patterns in these heterocycles offer new opportunities for drug discovery and other applications in materials science.COA of Formula: C9H8OS

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

Zhou, Shaolin et al. published their research in Chemical Communications (Cambridge, United Kingdom) in 2009 | CAS: 55219-11-9

Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The core structure is a part of various pharmaceutical substances and natural products. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, and sertaconazole, and also BTCP.Application In Synthesis of Benzo[b]thiophene-2-carbonitrile

New catalytic properties of iron complexes. Dehydration of amides to nitriles was written by Zhou, Shaolin;Addis, Daniele;Das, Shoubhik;Junge, Kathrin;Beller, Matthias. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2009.Application In Synthesis of Benzo[b]thiophene-2-carbonitrile This article mentions the following:

Various iron carbonyl clusters such as Fe2(CO)9 or [Et3NH][HFe3(CO)11] catalyzed the dehydration of amides into the corresponding nitriles in the presence of silanes in high yields. This novel protocol showed good functional group tolerance and wide substrate scope. In the experiment, the researchers used many compounds, for example, Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9Application In Synthesis of Benzo[b]thiophene-2-carbonitrile).

Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The core structure is a part of various pharmaceutical substances and natural products. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, and sertaconazole, and also BTCP.Application In Synthesis of Benzo[b]thiophene-2-carbonitrile

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

Miyagi, Kotaro et al. published their research in European Journal of Organic Chemistry in 2013 | CAS: 55219-11-9

Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9) belongs to benzothiophene derivatives. Benzothiophenes are valuable heterocycles that are widely used in medicines, agrochemicals, and materials science. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, sertaconazole, and also BTCP.Quality Control of Benzo[b]thiophene-2-carbonitrile

One-Pot Transformation of Carboxylic Acids into Nitriles was written by Miyagi, Kotaro;Moriyama, Katsuhiko;Togo, Hideo. And the article was included in European Journal of Organic Chemistry in 2013.Quality Control of Benzo[b]thiophene-2-carbonitrile This article mentions the following:

A variety of aromatic and aliphatic carboxylic acids were smoothly converted into the corresponding nitriles in good yields in a one-pot procedure by treatment with Et iodide/K2CO3/18-crown-6, followed by sodium diisobutyl-tert-butoxyaluminum hydride (SDBBA-H), and finally treatment with mol. iodine or 1,3-diiodo-5,5-dimethylhydantoin (DIH), and aqueous ammonia. This method is useful for the conversion of various aromatic and aliphatic carboxylic acids into the corresponding nitriles in a one-pot procedure. In the experiment, the researchers used many compounds, for example, Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9Quality Control of Benzo[b]thiophene-2-carbonitrile).

Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9) belongs to benzothiophene derivatives. Benzothiophenes are valuable heterocycles that are widely used in medicines, agrochemicals, and materials science. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, sertaconazole, and also BTCP.Quality Control of Benzo[b]thiophene-2-carbonitrile

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

Angeloni, Annino Sante et al. published their research in Annali di Chimica (Rome, Italy) in 1963 | CAS: 90560-10-4

6-Methoxybenzo[b]thiophene (cas: 90560-10-4) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The electrophilic substitution of benzothiophene systems is much less regioselective than that of indoles. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, sertaconazole, and also BTCP.Reference of 90560-10-4

Benzothiophenes. II.Ultraviolet and nuclear magnetic resonance (N.M.R.) spectra of some methoxybenzothiophenes was written by Angeloni, Annino Sante;Tramontini, Maurilio. And the article was included in Annali di Chimica (Rome, Italy) in 1963.Reference of 90560-10-4 This article mentions the following:

Ultraviolet spectra of 3-, 4-, 5-, 6-, and 7-methoxybenzothiophenes are presented. They are essentially similar to those of the Me derivatives Spectra of the methoxythioanisoles are presented in terms of their possible contribution to the benzothiophene chromophore. In the N.M.R. spectra, τ MeO = 5.79-6.22, and the Me derivatives have τ Me = 7.43-7.63. The o-, m-, and p-methoxythiophenetoles show a singlet from the MeO at about 6.20 τ, a CH2 quadruplet at about 7.20 τ, and a Me triplet at about 8.70 τ. Similarly, the methoxythioanisoles have r MeO of ∼6.2 and τ Me of ∼7.6. In 5-methoxybenzothiophene, the MeO group has τ = 5.79; this is clearly lower than the other derivatives, which are about the same as the τ values for MeO in the methoxythioanisoles and closer to τ = 5.92 of anisole itself. Distillation of the crude mixture from the cyclization of m-methoxyphenyl 2,2-dimethoxyethyl sulfide gave ∼35% of a mixture of 4- and 6-methoxybenzothiophene, b16 = 105-144°. The mixture was chromatographed on alumina. The 1st fractions gave the picrate of 4-methoxybenzothiophene, m. 108-9° (10%) (alc.). The same compound was obtained by the methylation of 4-hydroxybenzothiophene. The last fractions gave 15% of 6-methoxybenzothiophene, m. 38-9°. o-Methoxythiophenetole was prepared (66%) by treating an alk. solution of o-MeOC6H3SH with (EtO)2SO2. Repeated distillation at 123° at 12 mm. gave the product, m-Methoxythiophenetole, b12 125° (65%), was prepared similarly. In the experiment, the researchers used many compounds, for example, 6-Methoxybenzo[b]thiophene (cas: 90560-10-4Reference of 90560-10-4).

6-Methoxybenzo[b]thiophene (cas: 90560-10-4) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The electrophilic substitution of benzothiophene systems is much less regioselective than that of indoles. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, sertaconazole, and also BTCP.Reference of 90560-10-4

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

Geng, Hui et al. published their research in Tetrahedron in 2015 | CAS: 55219-11-9

Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9) belongs to benzothiophene derivatives. Benzothiophene is a fused ring compound of thiophene ring and benzene ring, which is an important class of heterocycles with advantageous structures. The different substitution patterns in these heterocycles offer new opportunities for drug discovery and other applications in materials science.Reference of 55219-11-9

Versatile and chemoselective transformation of aliphatic and aromatic secondary amides to nitriles was written by Geng, Hui;Huang, Pei-Qiang. And the article was included in Tetrahedron in 2015.Reference of 55219-11-9 This article mentions the following:

Triflic anhydride in combination with 2-fluoropyridine effectively dehydrates secondary amides to afford nitriles under mild reaction conditions. The reaction is general in scope and compatible with the use of aliphatic, α,β-unsaturated, aromatic and heteroaromatic amides bearing either secondary, tertiary, or benzylic N-alkyl groups. The reaction also shows good to excellent chemoselectivity for the secondary amide and tolerates several labile functional groups. Under optimized conditions the synthesis of the target compounds was achieved using amides as starting materials, such as N-(isopropyl)benzenebutanamide, N-(isopropyl)benzenepropanamide, adamantanecarboxamide derivatives, N-(tert-butyl)benzamide, 3-(phenyl)-2-propenamide derivatives (unsaturated amides), 1,3-benzodioxole-5-carboxamide, 2-thiophenecarboxamide (thiophene), benzo[b]thiophene-2-carboxamide derivatives, (aminocarbonyl)benzoic acid derivatives In the experiment, the researchers used many compounds, for example, Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9Reference of 55219-11-9).

Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9) belongs to benzothiophene derivatives. Benzothiophene is a fused ring compound of thiophene ring and benzene ring, which is an important class of heterocycles with advantageous structures. The different substitution patterns in these heterocycles offer new opportunities for drug discovery and other applications in materials science.Reference of 55219-11-9

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

Mohr, Yorck et al. published their research in Green Chemistry in 2020 | CAS: 90560-10-4

6-Methoxybenzo[b]thiophene (cas: 90560-10-4) belongs to benzothiophene derivatives. Benzothiophene is a fused ring compound of thiophene ring and benzene ring, which is an important class of heterocycles with advantageous structures. It has been used as a raw material for the synthesis of biologically active structures and is found in pharmaceuticals such as leukotriene synthesis inhibitors and antifungals, as well as in many natural products.Safety of 6-Methoxybenzo[b]thiophene

Nickel-catalyzed and Li-mediated regiospecific C-H arylation of benzothiophenes was written by Mohr, Yorck;Hisler, Gaelle;Grousset, Leonie;Roux, Yoann;Quadrelli, Elsje Alessandra;Wisser, Florian M.;Canivet, Jerome. And the article was included in Green Chemistry in 2020.Safety of 6-Methoxybenzo[b]thiophene This article mentions the following:

A nickel-based catalytic system for the regiospecific C2-H arylation of benzothiophenes with aryl iodides to afford 2-aryl benzothiophenes I [R1 = H, 5-Me, 5-F, etc.; Ar = Ph, 4-FC6H4, 1-naphthyl, etc.] was established. NiCl2(bpy) was used as a catalyst in combination with LiHMDS as a base in dioxane. The catalytic system was applicable to a variety of functionalized benzothiophenes, as well as other heteroarenes including thiophene, benzodithiophene, benzofuran and selenophene in combination with iodo aryl electrophiles. The role of LiHMDS as a uniquely potent base and a postulated mechanism were discussed. The applicability of this system was finally demonstrated for the synthesis of an intermediate of an active pharmaceutical ingredient. In the experiment, the researchers used many compounds, for example, 6-Methoxybenzo[b]thiophene (cas: 90560-10-4Safety of 6-Methoxybenzo[b]thiophene).

6-Methoxybenzo[b]thiophene (cas: 90560-10-4) belongs to benzothiophene derivatives. Benzothiophene is a fused ring compound of thiophene ring and benzene ring, which is an important class of heterocycles with advantageous structures. It has been used as a raw material for the synthesis of biologically active structures and is found in pharmaceuticals such as leukotriene synthesis inhibitors and antifungals, as well as in many natural products.Safety of 6-Methoxybenzo[b]thiophene

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem