Heterocyclic Building Blocks-Benzothiophene

Study of new luminophores for use in modern scintillation cocktails was written by Janda, Jiri;Rajchl, Erik. And the article was included in Journal of Luminescence in 2018.Synthetic Route of C26H26N2O2S This article mentions the following:

This paper deals with the study of 1-phenyl-3-(2,4,6-trimethyl-phenyl)-2-pyrazoline, 2,2′,7,7′-tetrakis(N,N-diphenyl-amino)-9,9′-spirobifluorene, 2-(4-biphenylyl)-6-phenylbenzoxazole and 9,9′-bifluorenyl as possible replacements of the existing and most widely used luminophore (2.5-diphenyloxazole (PPO)) in contemporary scintillators. The study is focused on the determination of emission wavelength, concentration optimization, the influence of the wavelength shifters POPOP and bis-MSB. In addition, the response to alpha and beta radiation were measured, in particular, the pulse length index (PLI) was determined Finally, yet importantly, the effect of emulsifiers on the shape of the spectrum and the solubility of the aqueous phase was tested. The results obtained were compared with the com. available Aqualight scintillation cocktail. In the experiment, the researchers used many compounds, for example, 2,5-Bis(5-(tert-butyl)benzo[d]oxazol-2-yl)thiophene (cas: 7128-64-5Synthetic Route of C26H26N2O2S).

2,5-Bis(5-(tert-butyl)benzo[d]oxazol-2-yl)thiophene (cas: 7128-64-5) belongs to benzothiophene derivatives. Benzothiophene finds use in research as a starting material for the synthesis of larger, usually bioactive structures. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, sertaconazole, and also BTCP.Synthetic Route of C26H26N2O2S

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Electrochemical Dearomatizing Spirocyclization of Alkynes with Dimethyl 2-Benzylmalonates to Spiro[4.5]deca-trienones was written by Li, Laiqiang;Hou, Zhong-Wei;Li, Pinhua;Wang, Lei. And the article was included in Journal of Organic Chemistry in 2022.HPLC of Formula: 4298-52-6 This article mentions the following:

An electrochem. dearomatizing spirocyclization of alkynes with di-Me 2-benzylmalonates for the preparation of spiro[4.5]deca-trienones had been developed. This approach adopted ferrocene (Cp₂Fe) as an electrocatalyst to produce carbon-centered radical intermediates from C-H-based malonates, which obviated the forthputting of noble-metal reagents, sacrificial chem. oxidants and 2-bromomalonates. A wide variety of spiro compounds were efficiently prepared with satisfactory results under mild conditions. In the experiment, the researchers used many compounds, for example, 2-Ethynylthiophene (cas: 4298-52-6HPLC of Formula: 4298-52-6).

2-Ethynylthiophene (cas: 4298-52-6) belongs to benzothiophene derivatives. Benzothiophene is a fused ring compound of thiophene ring and benzene ring, which is an important class of heterocycles with advantageous structures. Due to its aromaticity, thiophenes do not exhibit the same properties as conventional thioethers.HPLC of Formula: 4298-52-6

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Synthesis and photochromic activity of a new diarylethene bearing benzo[b]thiophene unit was written by Hossain, Mohammed Kamrul;Sanaullah, Abul Fazal Mohammad;Uddin, Mohammad Helal. And the article was included in Pakistan Journal of Scientific and Industrial Research, Series A: Physical Sciences in 2013.Related Products of 1195-14-8 This article mentions the following:

The synthesis of new photochromic compound 3-[2-(3,5-bismethoxymethoxymethylthiophen-2-yl)-3,3,4,4,5,5-hexafluorocyclopent-1-enyl]-2-methyl-benzo[b]thiophene was reported. In multistep synthesis from 2,4-dibromothiophene, benzo[b]thiophene was synthesized. This product exhibited photochromic properties upon irradiation with UV and visible light. In the experiment, the researchers used many compounds, for example, 2-Methylbenzo[b]thiophene (cas: 1195-14-8Related Products of 1195-14-8).

2-Methylbenzo[b]thiophene (cas: 1195-14-8) belongs to benzothiophene derivatives. Benzothiophenes are valuable heterocycles that are widely used in medicines, agrochemicals, and materials science. Due to its aromaticity, thiophenes do not exhibit the same properties as conventional thioethers.Related Products of 1195-14-8

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

A Mn(III) polyoxotungstate in the oxidation of organosulfur compounds by H₂O₂ at room temperature: an environmentally safe catalytic approach was written by Duarte, Tiago A. G.;Pires, Sonia M. G.;Santos, Isabel C. M. S.;Simoes, Mario M. Q.;Neves, M. Graca P. M. S.;Cavaleiro, Ana M. V.;Cavaleiro, Jose A. S.. And the article was included in Catalysis Science & Technology in 2016.Category: benzothiophene This article mentions the following:

The tetrabutylammonium (TBA) salt of a Keggin-type polyoxometalate (POM), with the chem. formula TBA₄H₂[BW₁₁Mn(H₂O)O₃₉]·H₂O, TBABW₁₁Mn, was evaluated as a catalyst in the oxidation by hydrogen peroxide of several organosulfur compounds, namely benzothiophene (BT), 2-methylbenzothiophene (2-MBT), 3-methylbenzothiophene (3-MBT), dibenzothiophene (DBT), 4-methyldibenzothiophene (4-MDBT) and 4,6-diethyldibenzothiophene (4,6-DEDBT), in acetonitrile at room temperature All compounds were oxidized to their corresponding sulfones with high conversion and selectivity. Following the excellent results achieved, the BW₁₁Mn/H₂O₂ in CH₃CN system was tested in the oxidation of model fuels (MFs) consisting of a mixture of BTs and DBTs in hexane (MF1 containing mainly BTs and MF2 containing predominantly DBTs). In both cases, the organosulfur compounds from the model fuels were fully converted into their corresponding sulfones. Envisaging the development of a promising desulfurization procedure, the extraction of sulfur compounds from MF2 was attempted after the catalytic oxidation process. More than 98 mol% was removed using an ethanol/H₂O mixture In the experiment, the researchers used many compounds, for example, 2-Methylbenzo[b]thiophene (cas: 1195-14-8Category: benzothiophene).

2-Methylbenzo[b]thiophene (cas: 1195-14-8) belongs to benzothiophene derivatives. Benzothiophene is used as starting material for the synthesis of bioactive molecules. The core structure is a part of various pharmaceutical substances and natural products. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, and sertaconazole, and also BTCP.Category: benzothiophene

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Designer Cathode Additive for Stable Interphases on High-Energy Anodes was written by Tian, Mengyu;Ben, Liubin;Yu, Hailong;Song, Ziyu;Yan, Yong;Zhao, Wenwu;Armand, Michel;Zhang, Heng;Zhou, Zhi-Bin;Huang, Xuejie. And the article was included in Journal of the American Chemical Society in 2022.Recommanded Product: 1,3,2-Dioxathiolane 2,2-dioxide This article mentions the following:

Rechargeable lithium-based batteries built with high-energy anode materials (e.g., silicon-based and silicon-derivative materials) are considered a feasible solution to satisfy the stringent requirements imposed by emerging markets, including elec. vehicles and grid storage, due to their higher energy d. compared to contemporary lithium-ion batteries. The robustness of the solid electrolyte interphase (SEI) layer on high-energy anodes is critical to achieve long-term and stable cycling performances of the batteries. Herein, we propose a new type of designer cathode additive (DCA), i.e., an ultrathin coating layer of elemental sulfur on the cathode, for the in situ formation of a thin and robust SEI layer on various types of high-energy anodes. The DCA elemental sulfur undergoes simultaneous oxidation and reduction paths, forming lithium alkyl sulfate (R-OSO₂OLi) and poly(ethylene oxide) (PEO)-like polymers on the anode surface. The as-formed R-OSO₂OLi/PEO-modified SEI layer has good lithium cation (Li⁺) permeability to facilitate fast ion transportation across the interphases and superior elasticity to adapt to large volume changes, which is particularly effective for improving the cycling efficiency of high-energy anodes (e.g., ca. 14-35% increase in capacity retention for the silicon-carbon composite (SiC) or silicon-tin alloy (Si-Sn)||LiFePO₄ cells). The present work opens a new avenue toward the practical deployment of high-energy rechargeable lithium-based batteries. In the experiment, the researchers used many compounds, for example, 1,3,2-Dioxathiolane 2,2-dioxide (cas: 1072-53-3Recommanded Product: 1,3,2-Dioxathiolane 2,2-dioxide).

1,3,2-Dioxathiolane 2,2-dioxide (cas: 1072-53-3) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The electrophilic substitution of benzothiophene systems is much less regioselective than that of indoles. It is found within the chemical structures of pharmaceutical drugs such as zileuton, raloxifene, and sertaconazole, and also BTCP.Recommanded Product: 1,3,2-Dioxathiolane 2,2-dioxide

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Integrating Terminal CoBr_n Salts into a 2D Cobalt(II) Coordination Polymer to Promote the β-(E)-Selective Hydroboration of Alkynes was written by Jia, Jun-Song;Wu, Tai-Xue;Fu, Yi-Jia;Hu, Zhi-Rong;Tang, Hai-Tao;Pan, Ying-Ming;Huang, Fu-Ping. And the article was included in Advanced Synthesis & Catalysis in 2022.Related Products of 4298-52-6 This article mentions the following:

In the present study, 2D Co(II) coordination polymer [[Co₅(4,4′-H₂dbpt)₂Br₁₀]·8(MeCOEt)]_n (CP-1, 4,4′-H₂dbpt = ), which integrate terminal CoBr_n (CoBr₂ and CoBr₃) sites immobilized on the framework, are synthesized at the gram level. As a special heterogeneous catalyst, CP-1 shows regioselectivity (β:α>99:1) and stereoselectivity (only E configuration) in the hydroboration of alkynes. The hydroboration reaction conditions are mild and cover a broad substrate range (31 examples). In addition, the heterogeneous catalyst can be recycled for at least five times. In the experiment, the researchers used many compounds, for example, 2-Ethynylthiophene (cas: 4298-52-6Related Products of 4298-52-6).

2-Ethynylthiophene (cas: 4298-52-6) belongs to benzothiophene derivatives. Benzothiophene finds use in research as a starting material for the synthesis of larger, usually bioactive structures. It is also used in the manufacturing of dyes such as thioindigo.Related Products of 4298-52-6

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Catalytic promiscuity enabled by photoredox catalysis in nicotinamide-dependent oxidoreductases was written by Biegasiewicz, Kyle F.;Cooper, Simon J.;Emmanuel, Megan A.;Miller, David C.;Hyster, Todd K.. And the article was included in Nature Chemistry in 2018.SDS of cas: 1072-53-3 This article mentions the following:

Strategies that provide enzymes with the ability to catalyze non-natural reactions are of considerable synthetic value. Photoredox catalysis has proved adept at expanding the synthetic repertoire of existing catalytic platforms, yet, in the realm of biocatalysis it has primarily been used for cofactor regeneration. Here we show that photoredox catalysts can be used to enable new catalytic function in nicotinamide-dependent enzymes. Under visible-light irradiation, xanthene-based photocatalysts enable a double-bond reductase (DBR) to catalyze an enantioselective deacetoxylation. Mechanistic experiments support the intermediacy of an α-acyl radical, formed after the elimination of acetate. Isotopic labeling experiments support nicotinamide as the source of the hydrogen atom. Preliminary calculations and mechanistic experiments suggest that binding to the protein attenuates the reduction potential of the starting material, an important feature for localizing radical formation to the enzyme active site. The generality of this approach is highlighted with the radical dehalogenation of α-bromoamides catalyzed by ketoreductases (KREDs) with Eosin Y as a photocatalyst. In the experiment, the researchers used many compounds, for example, 1,3,2-Dioxathiolane 2,2-dioxide (cas: 1072-53-3SDS of cas: 1072-53-3).

1,3,2-Dioxathiolane 2,2-dioxide (cas: 1072-53-3) belongs to benzothiophene derivatives. Benzothiophene is used as starting material for the synthesis of bioactive molecules. The core structure is a part of various pharmaceutical substances and natural products. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization.SDS of cas: 1072-53-3

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Combinatorial synthesis of new fluorescent scaffolds using click chemistry was written by Cleemann, Felix;Kum-Cheung, Wendy Loa;Karuso, Peter. And the article was included in Tetrahedron Letters in 2022.COA of Formula: C6H4S This article mentions the following:

Azides and acetylenes are bio-orthogonal functional groups that can be readily coupled using copper(I)- or ruthenium(II)- catalyzed 1,3-dipolar cycloaddition reactions. Using non-fluorescent aromatic azides and aromatic acetylenes, covering a range of electron rich and poor building blocks, the Huisgen cycloaddition afford 1,4-disubstituted or 1,5-disubstituted 1,2,3-triazoles. Using a combinatorial approach by running reaction in parallel in polypropylene 96-well plates we discovered several new fluorescent 1,2,3-triazoles scaffolds. These compounds show diverse interactions with biomols. that could find applications in biol. in, for example, fluorescence microscopy or biomol. quantification. In the experiment, the researchers used many compounds, for example, 3-Ethynylthiophene (cas: 67237-53-0COA of Formula: C6H4S).

3-Ethynylthiophene (cas: 67237-53-0) belongs to benzothiophene derivatives. Benzothiophene finds use in research as a starting material for the synthesis of larger, usually bioactive structures. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, and sertaconazole, and also BTCP.COA of Formula: C6H4S

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Desulfurization of benzo- and dibenzothiophenes with nickel boride was written by Back, Thomas G.;Yang, Kexin;Krouse, H. Roy. And the article was included in Journal of Organic Chemistry in 1992.Application In Synthesis of Dibenzo[b,d]thiophen-3-amine This article mentions the following:

Nickel boride, prepared from the reduction of nickel chloride hexahydrate with sodium borohydride in methanol-tetrahydrofuran, reduces benzothiophenes to alkylbenzenes and dibenzothiophenes to biphenyls. The reaction is rapid at or below room temperature and does not require protection from the atm. Best results are obtained when the nickel boride is generated in situ in the presence of the sulfur compound Hydroxyl, carboxyl, ester, and amino groups are unaffected while chloro, bromo, and nitro substituents are also reduced under these conditions. A short-lived intermediate, possibly a nickel hydride species, appears to be required in the desulfurization. Complexation of the substrate to the nickel boride surface, followed by stepwise reduction of the two CS bonds, occurs. The faster disappearance of dibenzothiophene containing the lighter ³²S isotope compared to that with ³⁴S [k(³²S)/k(³⁴S) = 1.005 to 1.006] suggests that CS bond cleavage is the rate determining step. In the experiment, the researchers used many compounds, for example, Dibenzo[b,d]thiophen-3-amine (cas: 25288-76-0Application In Synthesis of Dibenzo[b,d]thiophen-3-amine).

Dibenzo[b,d]thiophen-3-amine (cas: 25288-76-0) belongs to benzothiophene derivatives. Benzothiophene finds use in research as a starting material for the synthesis of larger, usually bioactive structures. It is found within the chemical structures of pharmaceutical drugs such as zileuton, raloxifene, and sertaconazole, and also BTCP.Application In Synthesis of Dibenzo[b,d]thiophen-3-amine

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Axially chiral 3,3′-bi(1-benzothiophene)-2,2′-dicarboxylic acid and its derivatives was written by Mezlova, Marie;Petrickova, Hana;Malon, Petr;Kozmik, Vaclav;Svoboda, Jiri. And the article was included in Collection of Czechoslovak Chemical Communications in 2003.Reference of 19492-99-0 This article mentions the following:

Ullmann dimerization of substituted Me 3-X-1-benzothiophene-2-carboxylates (X = Cl, Br) gave rise to the corresponding dimeric 3,3′-bi(1-benzothiophene) esters. Resolution of the title acid by fractional crystallization of its mono- and bisquininium salt afforded pure (R)- and (S)-enantiomers, the optical purity and absolute configuration of which was confirmed by CD spectrometry and by X-ray crystallog. Ullmann dimerization of some of the chiral oxazolines proceeded without any diastereodifferentiation. Reduction of some of the (R)- and (S)-products afforded the corresponding (R)- and (S)-diols, which served as chiral ligands in a model enantioselective reduction of acetophenone. (R)- and (S)-1-phenylethan-1-ol were formed. In the experiment, the researchers used many compounds, for example, Methyl 5-methoxybenzo[b]thiophene-2-carboxylate (cas: 19492-99-0Reference of 19492-99-0).

Methyl 5-methoxybenzo[b]thiophene-2-carboxylate (cas: 19492-99-0) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The electrophilic substitution of benzothiophene systems is much less regioselective than that of indoles. It is found within the chemical structures of pharmaceutical drugs such as zileuton, raloxifene, and sertaconazole, and also BTCP.Reference of 19492-99-0

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem