Category: 88-15-3

《NH4OAc-Promoted Domino Route to Hydroxyarylated Unsymmetrical Pyridines under Neat Conditions》 was written by Prakash, Meher; Gudimella, Santosh K.; Lodhi, Rajni; Guin, Soumitra; Samanta, Sampak. COA of Formula: C6H6OS And the article was included in Journal of Organic Chemistry in 2020. The article conveys some information:

A new metal-, oxidant-, and solvent-free ecofriendly domino method has been established for modular synthesis of a diverse range of medicinally promising hydroxyarylated unsym. pyridines in good to high chem. yields with an excellent regioselectivity. This domino process involves a range of N-sulfonyl ketimines as C,N-binucleophiles, enolizable ketones, and aromatic/heteroaromatic aldehydes using ammonium acetate as an ideal promoter under neat conditions, which creates two new C-C bonds and one C-N bond. Notably, the neutral reaction conditions are mild enough to tolerate a range of functionalities and cover a variety of substrates, thus bestowing a powerful avenue to access tri- and tetrasubstituted pyridines including carbo- and heterocyclic fused ones. Interestingly, a practical, scalable, and high-yielding synthesis of pyridylphenol derivatives was successfully accomplished by our unique method. In the experiment, the researchers used many compounds, for example, 1-Thiophen-2-yl-ethanone(cas: 88-15-3COA of Formula: C6H6OS)

1-Thiophen-2-yl-ethanone(cas: 88-15-3) belongs to thiophenes. Specialized thiophenes can be synthesized similarly using Lawesson’s reagent as the sulfidizing agent, or via the Gewald reaction, which involves the condensation of two esters in the presence of elemental sulfur. Another method is the Volhard–Erdmann cyclization. COA of Formula: C6H6OS

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

《Iodide-Selective PVC Membrane Electrode Based on Copper Complex of 2-Acetylthiophene Semicarbazone as Carrier》 was written by Suman, Shankar; Singh, Ram. Formula: C6H6OS And the article was included in Analytical Chemistry Letters in 2020. The article conveys some information:

A highly selective poly(vinyl chloride) (PVC) membrane electrode based on copper (II) complex of 2 acetylthiophene semicarbazone as a new carrier for iodide selective electrode is fabricated with the composition of PVC (30%), plasticizer (64%), ionophore (4%) and lipophilic additive (2%). The prepared electrode has been found to exhibit the best sensitivity over a wide concentration range of 1×10-6 to 3.2×10-2 M with a near Nernstian response of 57.2 mV per decade over a wide pH range of 2.5 10.5. The detection limit for the electrode was found to be 5.50×10-7 M with the response time of 15 s and can be used for at least 3 mo without any considerable divergence in its potential response. In addition to this study using 1-Thiophen-2-yl-ethanone, there are many other studies that have used 1-Thiophen-2-yl-ethanone(cas: 88-15-3Formula: C6H6OS) was used in this study.

1-Thiophen-2-yl-ethanone(cas: 88-15-3) belongs to thiophenes. Specialized thiophenes can be synthesized similarly using Lawesson’s reagent as the sulfidizing agent, or via the Gewald reaction, which involves the condensation of two esters in the presence of elemental sulfur. Another method is the Volhard–Erdmann cyclization. Formula: C6H6OS

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

《Synthesis, single crystal structure, DNA binding and antioxidant properties of 5-(4-(dimethylamino)phenyl)-3-(thiophen-2-yl)-pyrazoline-1-carbothioamide》 was written by Rana, Manish; Fatima, Aysha; Siddiqui, Nazia; Dar, Sajad Hussain; Javed, Saleem; Rahisuddin. Reference of 1-Thiophen-2-yl-ethanoneThis research focused onthiophenyl pyrazoline carbothioamide preparation crystal structure DNA binding antioxidant. The article conveys some information:

5-(4-(Dimethylamino)phenyl)-3-(thiophen-2-yl)-pyrazoline-1-carbothioamide I was synthesized. The compound shows strong antioxidant activity with IC50 value of 0.632 ± 0.002μg/mL. The compound crystallizes as a monoclinic system, P21/c centro-sym. space group, Z = 8 and size of the corresponding unit cell: a = 11.7134(10) Å , b = 17.3334(15) Å , c = 16.9831(14) Å , α = 90, β = 108.038(2), γ = 90. DNA binding measurements (UV-vis., fluorescence, cyclic voltammetry and competitive assay using ethidium bromide) of compounds showed intercalative mode of interaction. The binding constant (Kb), Gibbs free energy (ΔG) of compound I were found to be 1.3 x 105 M-1 and -67.17 KJmol-1, resp. The calculated Ksv values at two different temperatures (298 and 303 K) are 3.02 x 103 and 2.16 x 103 M-1 resp. To optimize mol. structure and compute wavenumbers of normal vibrational modes, B3LYP method and 6-311 ++ G (d, p) basis set were used. Hirshfeld surface anal. provides a thorough illustration of the intermol. interactions on crystal surface, and fingerprint plots were discovered. Exptl. bond lengths and bond angles corroborated well with the computational parameters. The GIAO approach was used to estimate 1H-NMR and 13C-NMR chem. shifts, and compared to exptl. spectra. Electronic properties such as UV-Vis (in gas phase, ethanol and DMSO) were analyzed using TD-DFT method and the PCM solvent model, and results were compared to exptl. UV-Vis spectra. In the part of experimental materials, we found many familiar compounds, such as 1-Thiophen-2-yl-ethanone(cas: 88-15-3Reference of 1-Thiophen-2-yl-ethanone)

1-Thiophen-2-yl-ethanone(cas: 88-15-3) belongs to thiophenes. Reflecting their high stabilities, thiophenes arise from many reactions involving sulfur sources and hydrocarbons, especially unsaturated ones. Thiophenes are classically prepared by the reaction of 1,4-diketones, diesters, or dicarboxylates with sulfidizing reagents such as P4S10 such as in the Paal-Knorr thiophene synthesis. Reference of 1-Thiophen-2-yl-ethanone

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

《Accelerated Metal-Free Hydration of Alkynes within Milliseconds in Microdroplets》 was written by Zheng, Boyu; Jin, Xiaoxiao; Liu, Jinhua; Cheng, Heyong. Reference of 1-Thiophen-2-yl-ethanone And the article was included in ACS Sustainable Chemistry & Engineering in 2021. The article conveys some information:

Conversion of alkynes into ketones by hydration is one of the most fundamental organic addition reactions. Traditional methods for alkyne hydration suffer from usage of toxic and costly metals, excessive acids, harsh conditions, and long reaction times, bringing about an urgent desire to explore more efficient and green protocols to complete this transformation. A metal-free efficient protocol for the accelerated hydration of alkynes in microdroplets was successfully developed in this work to overcome these drawbacks. The hydration process was finished under room temperature using only 18 mol % sulfuric acid as the catalyst and acetonitrile as the solvent. Complete conversions were feasible on the low millisecond time scale in microdroplets for a wide range of alkynes bearing functional groups, including electron-withdrawing groups and electron-donating groups. This is in sharp contrast to trace amounts of ketones or none in 20 min in bulk phase. Compared to the bulk reaction under the same conditions, the reactions in microdroplets are accelerated by 4 to 5 orders of magnitude as seen by the increase in measured rate constants Further, the accelerated microdroplet hydration can be scaled up to an acetophenone amount of 57.2 ± 0.1 mg min-1 (3.43 ± 0.01 g h-1) by using 2 mol L-1 phenylacetylene sprayed at 300μL min-1. The microdroplet protocol offers several advantages including ultrahigh acceleration, complete conversion, mild reaction conditions (metal, light, and heat free), and minimal post purification, as well as a wide substrate scope, making it attractive for green and sustainable chem. After reading the article, we found that the author used 1-Thiophen-2-yl-ethanone(cas: 88-15-3Reference of 1-Thiophen-2-yl-ethanone)

1-Thiophen-2-yl-ethanone(cas: 88-15-3) belongs to thiophenes. Specialized thiophenes can be synthesized similarly using Lawesson’s reagent as the sulfidizing agent, or via the Gewald reaction, which involves the condensation of two esters in the presence of elemental sulfur. Another method is the Volhard–Erdmann cyclization. Reference of 1-Thiophen-2-yl-ethanone

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

In 2019,Angewandte Chemie, International Edition included an article by Hu, Yanhua; Zhang, Zhenfeng; Zhang, Jian; Liu, Yangang; Gridnev, Ilya D.; Zhang, Wanbin. Reference of 1-Thiophen-2-yl-ethanone. The article was titled 《Cobalt-Catalyzed Asymmetric Hydrogenation of C=N Bonds Enabled by Assisted Coordination and Nonbonding Interactions》. The information in the text is summarized as follows:

An efficient cobalt-catalyzed asym. hydrogenation of C=N bonds has been realized. Chiral hydrazines were obtained in high yields and with excellent enantioselectivities (95-98 % ee). The hydrogenation went smoothly at up to 2000 substrate/catalyst and on a gram scale. The success of this reaction relies on the presence of an NHBz group in the substrates, with the reactivity and enantioselectivity improved by an assisted coordination to the cobalt atom and a nonbonding interaction with the ligand. Furthermore, this reaction has practical applications for the synthesis of several useful chiral nitrogen-containing compounds In addition to this study using 1-Thiophen-2-yl-ethanone, there are many other studies that have used 1-Thiophen-2-yl-ethanone(cas: 88-15-3Reference of 1-Thiophen-2-yl-ethanone) was used in this study.

1-Thiophen-2-yl-ethanone(cas: 88-15-3) belongs to thiophenes. Specialized thiophenes can be synthesized similarly using Lawesson’s reagent as the sulfidizing agent, or via the Gewald reaction, which involves the condensation of two esters in the presence of elemental sulfur. Another method is the Volhard–Erdmann cyclization. Reference of 1-Thiophen-2-yl-ethanone

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

The author of 《One-Step Synthesis of Thieno[2,3-d]pyrimidin-4(3H)-ones via a Catalytic Four-Component Reaction of Ketones, Ethyl Cyanoacetate, S8, and Formamide》 were Shi, Taoda; Kaneko, Lynn; Sandino, Michael; Busse, Ryan; Zhang, Mae; Mason, Damian; Machulis, Jason; Ambrose, Andrew J.; Zhang, Donna D.; Chapman, Eli. And the article was published in ACS Sustainable Chemistry & Engineering in 2019. COA of Formula: C6H6OS The author mentioned the following in the article:

Thieno[2,3-d]pyrimidin-4(3H)-ones are important pharmacophores that have previously required a three-step synthesis with two chromatog. steps. We herein report a green approach to the synthesis of this pharmacol. important class of compounds, e.g. I, via a catalytic four-component reaction using a ketone, Et cyanoacetate, S8, and formamide. The reported reaction is characterized by step economy, reduced catalyst loading, and easy purification In the experiment, the researchers used many compounds, for example, 1-Thiophen-2-yl-ethanone(cas: 88-15-3COA of Formula: C6H6OS)

1-Thiophen-2-yl-ethanone(cas: 88-15-3) belongs to thiophenes. Reflecting their high stabilities, thiophenes arise from many reactions involving sulfur sources and hydrocarbons, especially unsaturated ones. Thiophenes are classically prepared by the reaction of 1,4-diketones, diesters, or dicarboxylates with sulfidizing reagents such as P4S10 such as in the Paal-Knorr thiophene synthesis. COA of Formula: C6H6OS

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Kaloglu, Murat; Kaloglu, Nazan; Ozdemir, Namik; Ozdemir, Ismail published an article in 2021. The article was titled 《The first use of [PdBr2(imidazolidin-2-ylidene)(pyridine)] catalysts in the direct C-H bond arylation of C2-substituted furan and thiophene》, and you may find the article in Research on Chemical Intermediates.Recommanded Product: 1-Thiophen-2-yl-ethanone The information in the text is summarized as follows:

In this study, four new 1,3-disubstituted imidazolinium salts as NHC ligand precursors I [R = 4-i-Pr, 4-Cl, 3,5-di-Me, 2,3,5,6-tetra-Me], and their four new PEPPSI-type palladium complexes II were synthesized. The structures of all new compounds were fully characterized by different spectroscopic and anal. techniques. The more detailed structural characterization of one of the palladium complexes was determined by single-crystal X-ray diffraction study. The catalytic activities of all palladium complexes were evaluated in the direct C-H bond arylation of 2-acetylfuran and 2-acetylthiophene with (hetero) aryl bromides and readily available and inexpensive aryl chlorides in presence of 1 mol% catalyst loading at 120°C. Under the given conditions, (hetero)aryl halides were successfully applied as the arylating reagents to achieve the C5-arylated furans/thiophenes III [R1 = Ph, 2-thienyl, 2-MeC6H4, etc.; Y = O, S] in acceptable to high yields. The experimental process involved the reaction of 1-Thiophen-2-yl-ethanone(cas: 88-15-3Recommanded Product: 1-Thiophen-2-yl-ethanone)

1-Thiophen-2-yl-ethanone(cas: 88-15-3) belongs to thiophenes. Reflecting their high stabilities, thiophenes arise from many reactions involving sulfur sources and hydrocarbons, especially unsaturated ones. Thiophenes are classically prepared by the reaction of 1,4-diketones, diesters, or dicarboxylates with sulfidizing reagents such as P4S10 such as in the Paal-Knorr thiophene synthesis. Recommanded Product: 1-Thiophen-2-yl-ethanone

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

The author of 《Palladium-Catalyzed C-H Arylation of Aliphatic and Aromatic Ketones using Dipeptide Transient Directing Groups》 were Cheng, Yaohang; Zheng, Jie; Tian, Chao; He, Yuhang; Zhang, Cong; Tan, Qi; An, Guanghui; Li, Guangming. And the article was published in Asian Journal of Organic Chemistry in 2019. Computed Properties of C6H6OS The author mentioned the following in the article:

Transition metal-catalyzed C-H bond functionalization is one of the most efficient tactics for diversification of ketones, e.g., 1-tetralone. Palladium-catalyzed C-H arylation of aliphatic and aromatic ketones has been achieved by utilizing an inexpensive dipeptide as a transient directing group. The tridentate coordination used in this reaction enhances the reactivity of the substrates and allows reduction of the loading of the directing group compounds to 20%. This approach allows rapid arylation of complex natural products, medicinal-chem.-related scaffolds, and even remote C(sp2)-H bonds. In the experiment, the researchers used 1-Thiophen-2-yl-ethanone(cas: 88-15-3Computed Properties of C6H6OS)

1-Thiophen-2-yl-ethanone(cas: 88-15-3) belongs to thiophenes. Reflecting their high stabilities, thiophenes arise from many reactions involving sulfur sources and hydrocarbons, especially unsaturated ones. Thiophenes are classically prepared by the reaction of 1,4-diketones, diesters, or dicarboxylates with sulfidizing reagents such as P4S10 such as in the Paal-Knorr thiophene synthesis. Computed Properties of C6H6OS

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Plevova, Kristina; Kisszekelyi, Peter; Vargova, Denisa; Andrejcak, Samuel; Toth, Viktor; Fertal, Lukas; Rakovsky, Erik; Filo, Juraj; Sebesta, Radovan published their research in Chemistry – A European Journal in 2021. The article was titled 《Diastereoselective Double C-H Functionalization of Chiral Ferrocenes with Heteroaromatics》.COA of Formula: C6H6OS The article contains the following contents:

Diastereoselective double C-H heteroarylation of chiral ferrocenes provides valuable compounds with multiple functionalities using mild reaction conditions and simple reagents. Pd-Complexes with chiral mono-protected amino acids afforded corresponding heteroarylated ferrocenyl amines in good yields and high diastereomeric purities. In this way, a variety of indole, thiophene, pyrrole, or furan substituents were introduced to the ferrocene moiety. Furthermore, a range of relevant functional groups, for example ketone, ester, chloro, nitro, or silyl, are tolerated by this method. An alternative combination of amino acid and ferrocenyl amine configurations was leveraged to provide the complementary diastereomeric products. The products of C-H heteroarylation can be transformed into corresponding phosphines. Absolute configurations of CH-activation products were confirmed by the combination of X-ray crystallog. anal. and CD spectroscopy. 19F NMR kinetic study and DFT calculations provided insights into the reaction mechanism and reasons governing stereoinduction. The experimental part of the paper was very detailed, including the reaction process of 1-Thiophen-2-yl-ethanone(cas: 88-15-3COA of Formula: C6H6OS)

1-Thiophen-2-yl-ethanone(cas: 88-15-3) belongs to thiophenes. Specialized thiophenes can be synthesized similarly using Lawesson’s reagent as the sulfidizing agent, or via the Gewald reaction, which involves the condensation of two esters in the presence of elemental sulfur. Another method is the Volhard–Erdmann cyclization. COA of Formula: C6H6OS

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

《One-Pot Transfer Hydrogenation Reductive Amination of Aldehydes and Ketones by Iridium Complexes “”on Water””》 was written by Ouyang, Lu; Xia, Yanping; Liao, Jianhua; Luo, Renshi. Safety of 1-Thiophen-2-yl-ethanone And the article was included in European Journal of Organic Chemistry in 2020. The article conveys some information:

An efficient and practical one-pot transfer hydrogenation reductive amination of aldehydes and ketones with amines has been developed by using iridium complexes as catalysts and formic acid as hydrogen source in aqueous solution, providing an environmentally friendly methodol. for the construction of a wide range of functionalized amine compounds in excellent yields (≈ 80%-95%). This effective methodol. can be scaled up to gram scale with 0.1 mol-% catalyst loading and also be employed in the synthesis of medical substances such as Meclizine. In the experiment, the researchers used 1-Thiophen-2-yl-ethanone(cas: 88-15-3Safety of 1-Thiophen-2-yl-ethanone)

1-Thiophen-2-yl-ethanone(cas: 88-15-3) belongs to thiophenes. Reflecting their high stabilities, thiophenes arise from many reactions involving sulfur sources and hydrocarbons, especially unsaturated ones. Thiophenes are classically prepared by the reaction of 1,4-diketones, diesters, or dicarboxylates with sulfidizing reagents such as P4S10 such as in the Paal-Knorr thiophene synthesis. Safety of 1-Thiophen-2-yl-ethanone

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem