Kolbus, Anna’s team published research in Journal of Fluorescence in 2019 | CAS: 88-15-3

1-Thiophen-2-yl-ethanone(cas: 88-15-3) belongs to thiophenes. Specialized thiophenes can be synthesized similarly using Lawesson’s reagent as the sulfidizing agent, or via the Gewald reaction, which involves the condensation of two esters in the presence of elemental sulfur. Another method is the Volhard–Erdmann cyclization. Name: 1-Thiophen-2-yl-ethanone

In 2019,Journal of Fluorescence included an article by Kolbus, Anna; Danel, Andrzej; Grabka, Danuta; Kucharek, Mateusz; Szary, Karol. Name: 1-Thiophen-2-yl-ethanone. The article was titled 《Spectral Properties of Highly Emissive Derivative of Coumarin with N,N-Diethylamino, Nitrile and Tiophenecarbonyl Moieties in Water-Methanol Mixture》. The information in the text is summarized as follows:

The new derivative of coumarin (E)-3-[7-(diethyloamino)-2-oxo-chromen-3yl]-2-(tiophene-2-carbonyl)prop-2-enenitrile (NOSQ) was easy synthesized with com. substrates as a result of the search of new Michael type addition sensors based on coumarins. Spectral properties of highly emissive NOSQ were investigated by steady state anal. (absorption and fluorescence measurements) and time-resolved anal. (fluorescence lifetime measurements). The effect of water-methanol mixture on the photophys. properties of the NOSQ mol. was analyzed. With increasing of volumetric fraction of water the intensity of absorbance and fluorescence was strongly reduced. The NOSQ quantum yield in methanol was quite high and the first portions of water caused a significant increase in this value. Water, which is usually a quencher, in this case caused the increase in the quantum yield. The fluorescence lifetimes had second-order decay and the values of fluorescence lifetime increased with increasing alc. content. D. functional theory (DFT) calculations and exptl. data remained in agreement and showed that the interaction between the NOSQ mol. and the solvent affects the appearance of the new conformer. The experimental part of the paper was very detailed, including the reaction process of 1-Thiophen-2-yl-ethanone(cas: 88-15-3Name: 1-Thiophen-2-yl-ethanone)

1-Thiophen-2-yl-ethanone(cas: 88-15-3) belongs to thiophenes. Specialized thiophenes can be synthesized similarly using Lawesson’s reagent as the sulfidizing agent, or via the Gewald reaction, which involves the condensation of two esters in the presence of elemental sulfur. Another method is the Volhard–Erdmann cyclization. Name: 1-Thiophen-2-yl-ethanone

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

Kuzu, Burak’s team published research in Journal of Fluorescence in 2021 | CAS: 88-15-3

1-Thiophen-2-yl-ethanone(cas: 88-15-3) belongs to thiophenes. Specialized thiophenes can be synthesized similarly using Lawesson’s reagent as the sulfidizing agent, or via the Gewald reaction, which involves the condensation of two esters in the presence of elemental sulfur. Another method is the Volhard–Erdmann cyclization. COA of Formula: C6H6OS

Kuzu, Burak; Ekmekci, Zeynep; Tan, Meltem; Menges, Nurettin published an article in 2021. The article was titled 《Excited State Intramolecular Proton Transfer (ESIPT)-Based Sensor for Ion Detection》, and you may find the article in Journal of Fluorescence.COA of Formula: C6H6OS The information in the text is summarized as follows:

C-2 and C-5 substituted imidazole skeleton was synthesized through a one-pot two-step strategy. Synthesized mol. emits the light on ESIPT (excited-state intramol. proton transfer). This mol. was utilized for its proton donor ability, and we have observed that fluoride and cyanide ions can be detected selectively. Different cations and anions were selected to observe the response of the synthesized mol. However, there were not any fluorometric and colorimetric response except for fluoride and cyanide ions. Detection limits of fluoride and cyanide ions were found to be 9.22μM and 11.48μM, resp. 1H-NMR spectra for the solution of the sensor and TBAF (tetrabuthylammoniumfluoride) were used for the identification of [L]-[HF2]- species. 3 equivalent TBAF saturated the solution of the sensor in d6-DMSO, and some of the proton resonances shifted to upfield due to the through-bond effect. The disappearance of NH proton with 0.5 equivalent TBAF or TBACN (tetrabuthylammoniumcyanide) showed that there was a proton abstraction by fluoride and cyanide ions, instead of the hydrogen bond. Solid-state application was utilized, and paper test strips were applied. Emission differences emerged when the sensor loaded strips were reacted with TBAF. Time resolved experiments revealed that solution of the sensor and TBAF in DMSO have multiexponential decay, and one of the lifetime was measured as 13.4 ns. In addition to this study using 1-Thiophen-2-yl-ethanone, there are many other studies that have used 1-Thiophen-2-yl-ethanone(cas: 88-15-3COA of Formula: C6H6OS) was used in this study.

1-Thiophen-2-yl-ethanone(cas: 88-15-3) belongs to thiophenes. Specialized thiophenes can be synthesized similarly using Lawesson’s reagent as the sulfidizing agent, or via the Gewald reaction, which involves the condensation of two esters in the presence of elemental sulfur. Another method is the Volhard–Erdmann cyclization. COA of Formula: C6H6OS

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

Chandra, Dinesh’s team published research in Tetrahedron Letters in 2020 | CAS: 88-15-3

1-Thiophen-2-yl-ethanone(cas: 88-15-3) belongs to thiophenes. Reflecting their high stabilities, thiophenes arise from many reactions involving sulfur sources and hydrocarbons, especially unsaturated ones. Thiophenes are classically prepared by the reaction of 1,4-diketones, diesters, or dicarboxylates with sulfidizing reagents such as P4S10 such as in the Paal-Knorr thiophene synthesis. Safety of 1-Thiophen-2-yl-ethanone

《Direct synthesis of secondary amides from ketones through Beckmann rearrangement using O-(mesitylsulfonyl)hydroxylamine》 was written by Chandra, Dinesh; Verma, Saumya; Pandey, Chandra Bhan; Yadav, Ajay K.; Kumar, Puneet; Tiwari, Bhoopendra; Jat, Jawahar L.. Safety of 1-Thiophen-2-yl-ethanone And the article was included in Tetrahedron Letters in 2020. The article conveys some information:

A highly efficient direct method for the preparation of secondary amides and lactams from ketones using O-(mesitylsulfonyl)hydroxylamine (MSH) was developed. The reactions proceeded rapidly at room temperature under mild condition without requiring any additive and tolerate multiple functional groups. A simple aqueous work-up often furnished the products in excellent yield with high purity. In addition to this study using 1-Thiophen-2-yl-ethanone, there are many other studies that have used 1-Thiophen-2-yl-ethanone(cas: 88-15-3Safety of 1-Thiophen-2-yl-ethanone) was used in this study.

1-Thiophen-2-yl-ethanone(cas: 88-15-3) belongs to thiophenes. Reflecting their high stabilities, thiophenes arise from many reactions involving sulfur sources and hydrocarbons, especially unsaturated ones. Thiophenes are classically prepared by the reaction of 1,4-diketones, diesters, or dicarboxylates with sulfidizing reagents such as P4S10 such as in the Paal-Knorr thiophene synthesis. Safety of 1-Thiophen-2-yl-ethanone

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

Shangpliang, O. Risuklang’s team published research in ACS Omega in 2019 | CAS: 88-15-3

1-Thiophen-2-yl-ethanone(cas: 88-15-3) belongs to thiophenes. Reflecting their high stabilities, thiophenes arise from many reactions involving sulfur sources and hydrocarbons, especially unsaturated ones. Thiophenes are classically prepared by the reaction of 1,4-diketones, diesters, or dicarboxylates with sulfidizing reagents such as P4S10 such as in the Paal-Knorr thiophene synthesis. Application of 88-15-3

The author of 《PTSA-Catalyzed Reaction of Alkyl/Aryl Methyl Ketones with Aliphatic Alcohols in the Presence of Selenium Dioxide: A Protocol for the Generation of an α-Ketoacetals Library》 were Shangpliang, O. Risuklang; Wanniang, Kmendashisha; Kshiar, Baskhemlang; Marpna, Ibakyntiew D.; Lipon, Tyrchain Mitre; Mizar, Pushpak; Myrboh, Bekington. And the article was published in ACS Omega in 2019. Application of 88-15-3 The author mentioned the following in the article:

A novel approach has been developed for the synthesis of a wide range of α-ketoacetals by the reaction of alkyl/aryl Me ketones and aliphatic alcs. in presence of selenium dioxide catalyzed by p-toluenesulfonic acid (PTSA). This method represents a general route to obtain a wide variety of α-ketoacetals in a simple, rapid and practical manner. This approach is particularly attractive because of the easily availability of the starting materials, mild reaction temperature and good yields of the products. The resulting α-ketoacetals are of much synthetic value as organic intermediates. In addition to this study using 1-Thiophen-2-yl-ethanone, there are many other studies that have used 1-Thiophen-2-yl-ethanone(cas: 88-15-3Application of 88-15-3) was used in this study.

1-Thiophen-2-yl-ethanone(cas: 88-15-3) belongs to thiophenes. Reflecting their high stabilities, thiophenes arise from many reactions involving sulfur sources and hydrocarbons, especially unsaturated ones. Thiophenes are classically prepared by the reaction of 1,4-diketones, diesters, or dicarboxylates with sulfidizing reagents such as P4S10 such as in the Paal-Knorr thiophene synthesis. Application of 88-15-3

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

Su, Biyun’s team published research in Current Organic Synthesis in 2019 | CAS: 88-15-3

1-Thiophen-2-yl-ethanone(cas: 88-15-3) belongs to thiophenes. Specialized thiophenes can be synthesized similarly using Lawesson’s reagent as the sulfidizing agent, or via the Gewald reaction, which involves the condensation of two esters in the presence of elemental sulfur. Another method is the Volhard–Erdmann cyclization. Quality Control of 1-Thiophen-2-yl-ethanone

In 2019,Current Organic Synthesis included an article by Su, Biyun; Li, Yaning; Pan, Dandan; Faida, Paison; Yan, Tingyu; Qu, Zhan. Quality Control of 1-Thiophen-2-yl-ethanone. The article was titled 《Microwave Irradiation Syntheses and Crystal Structures of Two Series of Novel Fivemembered Heterocyclic Mono-Imine Compounds》. The information in the text is summarized as follows:

In order to increase the coordination ability of heteroatom N and S to center metals, CH3 group was introduced into the side arm of pyrrole imine and thiophene imine resp., to get two series of novel five-membered heterocyclic imine compounds, mono(imino)pyrroles and mono(imino)thiophenes. Two series of novel five-membered heterocyclic compounds with the mono-imine group were synthesized from the p-toluene sulfonic acid catalyzed Schiff base condensation of anilines and 2-acetylpyrrole/ 2-acetylthiophene resp., using CH3 group to substitute the common H atom on the side arm of pyrrole imine/ thiophene imine. All the heterocyclic mono-imine compounds were characterized adequately by means of 1H NMR, 13C NMR, FT-IR, elementary anal., as well as X-ray crystallog. diffraction. The reactivity differences between two precursor 2-acetylpyrrole and 2-acetylthiophene with aromatic amines were compared and discussed in detail. Compared to traditional heating methods, the solvent-free microwave irradiation seemed more efficient to prepare these series of five-membered heterocyclic mono-imine compounds, which resulted in a higher yield and cleaner product. In addition to this study using 1-Thiophen-2-yl-ethanone, there are many other studies that have used 1-Thiophen-2-yl-ethanone(cas: 88-15-3Quality Control of 1-Thiophen-2-yl-ethanone) was used in this study.

1-Thiophen-2-yl-ethanone(cas: 88-15-3) belongs to thiophenes. Specialized thiophenes can be synthesized similarly using Lawesson’s reagent as the sulfidizing agent, or via the Gewald reaction, which involves the condensation of two esters in the presence of elemental sulfur. Another method is the Volhard–Erdmann cyclization. Quality Control of 1-Thiophen-2-yl-ethanone

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

Chen, Chao’s team published research in Advanced Synthesis & Catalysis in 2019 | CAS: 88-15-3

1-Thiophen-2-yl-ethanone(cas: 88-15-3) belongs to thiophenes. Reflecting their high stabilities, thiophenes arise from many reactions involving sulfur sources and hydrocarbons, especially unsaturated ones. Thiophenes are classically prepared by the reaction of 1,4-diketones, diesters, or dicarboxylates with sulfidizing reagents such as P4S10 such as in the Paal-Knorr thiophene synthesis. Name: 1-Thiophen-2-yl-ethanone

The author of 《Iron-Enabled Utilization of Air as the Terminal Oxidant Leading to Aerobic Oxidative Deoximation by Organoselenium Catalysis》 were Chen, Chao; Zhang, Xu; Cao, Hongen; Wang, Fang; Yu, Lei; Xu, Qing. And the article was published in Advanced Synthesis & Catalysis in 2019. Name: 1-Thiophen-2-yl-ethanone The author mentioned the following in the article:

In contrast to conventional organoselenium-catalyzed oxidation reactions that require peroxide oxidants such as hydrogen peroxide, in this work we found that, addition of a low loading of iron (II) could enable the successful utilization of air as the terminal oxidant in organoselenium-catalyzed oxidative deoximation reaction of ketoximes. This led to a new mild and relatively green aerobic oxidative deoximation method. Control reactions and XPS anal. suggest that iron is crucial in the catalytic cycle, working to prohibit the deactivation of selenium catalyst through an iron-catalyzed aerobic oxidation of low valent selenium species by air to the active high valent selenium species. Since air can be utilized as the terminal oxidant, this work may contribute to the advance of organoselenium catalysis. In the experimental materials used by the author, we found 1-Thiophen-2-yl-ethanone(cas: 88-15-3Name: 1-Thiophen-2-yl-ethanone)

1-Thiophen-2-yl-ethanone(cas: 88-15-3) belongs to thiophenes. Reflecting their high stabilities, thiophenes arise from many reactions involving sulfur sources and hydrocarbons, especially unsaturated ones. Thiophenes are classically prepared by the reaction of 1,4-diketones, diesters, or dicarboxylates with sulfidizing reagents such as P4S10 such as in the Paal-Knorr thiophene synthesis. Name: 1-Thiophen-2-yl-ethanone

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

Kasimbi, D.’s team published research in Oriental Journal of Chemistry in 2019 | CAS: 88-15-3

1-Thiophen-2-yl-ethanone(cas: 88-15-3) belongs to thiophenes. Specialized thiophenes can be synthesized similarly using Lawesson’s reagent as the sulfidizing agent, or via the Gewald reaction, which involves the condensation of two esters in the presence of elemental sulfur. Another method is the Volhard–Erdmann cyclization. SDS of cas: 88-15-3

In 2019,Oriental Journal of Chemistry included an article by Kasimbi, D.; Reddy, K. Hussain; Devanna, N.. SDS of cas: 88-15-3. The article was titled 《Synthesis, spectral characterization and antibacterial activity of functionalized hydrazones》. The information in the text is summarized as follows:

New hydrazones have been synthesized by condensing 2-acetylthiophene with acetic hydrazide and benzhydrazide. The synthesized hydrazones viz. 2-acetylthiophene acetylhydrazone (ATAH), 2-acetylthiophene benzoylhydrazone (ATBH) were characterized in the light of physicochem. and anal. data. Structures of ATAH and ATBH has been confirmed by FT-IR, 1H-NMR and Mass spectral data. The hydrazones are screened for their anti-bacterial activity against E. coli, Bacillus cereus, Staphylococcus aureus and Pseudomonas aeruginosa. Acetylhydrazones were found to show more antibacterial activity than the corresponding benzoylhydrazones. In addition to this study using 1-Thiophen-2-yl-ethanone, there are many other studies that have used 1-Thiophen-2-yl-ethanone(cas: 88-15-3SDS of cas: 88-15-3) was used in this study.

1-Thiophen-2-yl-ethanone(cas: 88-15-3) belongs to thiophenes. Specialized thiophenes can be synthesized similarly using Lawesson’s reagent as the sulfidizing agent, or via the Gewald reaction, which involves the condensation of two esters in the presence of elemental sulfur. Another method is the Volhard–Erdmann cyclization. SDS of cas: 88-15-3

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

Guo, Xuanhua’s team published research in Organic Chemistry Frontiers in 2020 | CAS: 88-15-3

1-Thiophen-2-yl-ethanone(cas: 88-15-3) belongs to thiophenes. Specialized thiophenes can be synthesized similarly using Lawesson’s reagent as the sulfidizing agent, or via the Gewald reaction, which involves the condensation of two esters in the presence of elemental sulfur. Another method is the Volhard–Erdmann cyclization. Synthetic Route of C6H6OS

《Synthesis and application of α-carbonyl nitrile oxides》 was published in Organic Chemistry Frontiers in 2020. These research results belong to Guo, Xuanhua; Xu, Guangqiang; Zhou, Li; Yan, Huating; Hao, Xin-Qi; Wang, Qinggang. Synthetic Route of C6H6OS The article mentions the following:

An efficient and robust method to synthesize α-carbonyl nitrile oxide intermediates from ketones using tertbutyl nitrite was developed to afford two series of α-carbonyl isoxazoles I [R = Me, Ph, 4-MeC6H4, etc.] and α-carbonyl furoxans II [R1 = Ph, 2-furanyl, 2-naphthyl, etc.] in good to excellent yields. Excellent functional group tolerance and broad substrate scope were observed in this protocol. The practical utility of this protocol was demonstrated in gram-scale experiments and synthesis of some bioactive mols. In the experiment, the researchers used 1-Thiophen-2-yl-ethanone(cas: 88-15-3Synthetic Route of C6H6OS)

1-Thiophen-2-yl-ethanone(cas: 88-15-3) belongs to thiophenes. Specialized thiophenes can be synthesized similarly using Lawesson’s reagent as the sulfidizing agent, or via the Gewald reaction, which involves the condensation of two esters in the presence of elemental sulfur. Another method is the Volhard–Erdmann cyclization. Synthetic Route of C6H6OS

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

Ghannam, Iman A. Y.’s team published research in Bioorganic Chemistry in 2019 | CAS: 88-15-3

1-Thiophen-2-yl-ethanone(cas: 88-15-3) belongs to thiophenes. Specialized thiophenes can be synthesized similarly using Lawesson’s reagent as the sulfidizing agent, or via the Gewald reaction, which involves the condensation of two esters in the presence of elemental sulfur. Another method is the Volhard–Erdmann cyclization. Computed Properties of C6H6OS

In 2019,Bioorganic Chemistry included an article by Ghannam, Iman A. Y.; Abd El-Meguid, Eman A.; Ali, Islam H.; Sheir, Donia H.; El Kerdawy, Ahmed M.. Computed Properties of C6H6OS. The article was titled 《Novel 2-arylbenzothiazole DNA gyrase inhibitors: Synthesis, antimicrobial evaluation, QSAR and molecular docking studies》. The information in the text is summarized as follows:

A series of new 2-arylbenzothiazole derivatives I [R = EtO, NHNH2, NHN=CHC6H5, etc.] was synthesized and tested for their antimicrobial activity against different Gram-pos., Gram-neg. bacteria and yeast using ciprofloxacin and fluconazole as pos. controls for the antibacterial and antifungal activities, resp. The target compounds I showed stronger inhibitory activity against Gram-neg. than Gram-pos. bacteria. The min. inhibitory concentration (MIC) values were determined for tested compounds I that showed zone of inhibition ≥ 13 mm. Based on the MIC values for the tested compounds against E. coli, compounds I [R = EtO, NHNH2, 3-MeO-4-HOC6H3CH=NNH, 4-FC6H4CH=NNH, 4-NCC6H4CH=NNH, 2-[(1,5-dimethyl-3-oxo-2-phenyl-pyrazol-4-yl)methylene]hydrazino, 2-[(5-methyl-2-furyl)methylene]hydrazino, 4-HOC6H4C(CH3)=NNH, 3-HOC6H4C(CH3)=NNH, 4-O2NC6H4C(CH3)=NNH, 2-(2-oxoindolin-3-ylidene)hydrazino] were selected and tested for their E. coli gyrase inhibitory activity. The tested compounds I showed moderate inhibitory activity against E. coli gyrase. Compounds I [R = NHNH2, 3-MeO-4-HOC6H3CH=NNH, 2-[(1,5-dimethyl-3-oxo-2-phenyl-pyrazol-4-yl)methylene]hydrazino, 2-[(5-methyl-2-furyl)methylene]hydrazino, 4-HOC6H4C(CH3)=NNH] displayed high inhibitory activity against E. coli gyrase with IC50 values below 10 μM, however, they were less active than ciprofloxacin (E. coli gyrase IC50 = 1.14 μM). Moreover, compound I [R = 3-MeO-4-HOC6H3CH=NNH] exhibited the highest anti-gyrase activity over other tested compounds I (E. coli gyrase IC50 = 4.85 μM). Quant. structure-activity relationship (QSAR) study was also implemented for the newly synthesized compounds I. The QSAR study indicated that structural feature that governed anti-microbial activity for benzothiazole derivatives I was their structural hydrophilic-lipophilic balance what agreed with chem. intuition where this balance governed their cellular absorption and so their antimicrobial activity. Mol. docking showed that the newly synthesized compounds I possessed required structural feature for E. coli gyrase B inhibition through interaction with key amino acids Asp73 and Gly77. The results came from multiple reactions, including the reaction of 1-Thiophen-2-yl-ethanone(cas: 88-15-3Computed Properties of C6H6OS)

1-Thiophen-2-yl-ethanone(cas: 88-15-3) belongs to thiophenes. Specialized thiophenes can be synthesized similarly using Lawesson’s reagent as the sulfidizing agent, or via the Gewald reaction, which involves the condensation of two esters in the presence of elemental sulfur. Another method is the Volhard–Erdmann cyclization. Computed Properties of C6H6OS

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

Das, Siuli’s team published research in Journal of Organic Chemistry in 2019 | CAS: 88-15-3

1-Thiophen-2-yl-ethanone(cas: 88-15-3) belongs to thiophenes. Reflecting their high stabilities, thiophenes arise from many reactions involving sulfur sources and hydrocarbons, especially unsaturated ones. Thiophenes are classically prepared by the reaction of 1,4-diketones, diesters, or dicarboxylates with sulfidizing reagents such as P4S10 such as in the Paal-Knorr thiophene synthesis. Quality Control of 1-Thiophen-2-yl-ethanone

Quality Control of 1-Thiophen-2-yl-ethanoneIn 2019 ,《Metal-Ligand Cooperative Approach To Achieve Dehydrogenative Functionalization of Alcohols to Quinolines and Quinazolin-4(3H)-ones under Mild Aerobic Conditions》 appeared in Journal of Organic Chemistry. The author of the article were Das, Siuli; Sinha, Suman; Samanta, Deepannita; Mondal, Rakesh; Chakraborty, Gargi; Brandao, Paula; Paul, Nanda D.. The article conveys some information:

A simple metal-ligand cooperative approach for the dehydrogenative functionalization of alcs. to various substituted quinolines and quinazolin-4(3H)-ones under relatively mild reaction conditions (≤90 °C) is reported. Simple and easy-to-prepare air-stable Cu(II) complexes featuring redox-active azo-aromatic scaffolds, 2-arylazo-(1,10-phenanthroline) (L1,2), are used as catalyst. A wide variety of substituted quinolines and quinazolin-4(3H)-ones were synthesized in moderate to good isolated yields via dehydrogenative coupling reactions of various inexpensive and easily available starting materials under aerobic conditions. A few control experiments and deuterium labeling studies were carried out to understand the mechanism of the dehydrogenative coupling reactions, which indicate that both copper and the coordinated azo-aromatic ligand participate in a cooperative manner during the catalytic cycle. In the experiment, the researchers used 1-Thiophen-2-yl-ethanone(cas: 88-15-3Quality Control of 1-Thiophen-2-yl-ethanone)

1-Thiophen-2-yl-ethanone(cas: 88-15-3) belongs to thiophenes. Reflecting their high stabilities, thiophenes arise from many reactions involving sulfur sources and hydrocarbons, especially unsaturated ones. Thiophenes are classically prepared by the reaction of 1,4-diketones, diesters, or dicarboxylates with sulfidizing reagents such as P4S10 such as in the Paal-Knorr thiophene synthesis. Quality Control of 1-Thiophen-2-yl-ethanone

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem