Category: 88-15-3

In 2019,ACS Omega included an article by Gawali, Suhas Shahaji; Pandia, Biplab Keshari; Pal, Souvik; Gunanathan, Chidambaram. SDS of cas: 88-15-3. The article was titled 《Manganese(I)-Catalyzed Cross-Coupling of Ketones and Secondary Alcohols with Primary Alcohols》. The information in the text is summarized as follows:

Catalytic cross-coupling of ketones and secondary alcs. with primary alcs. is reported. An abundant manganese based pincer catalyst catalyzes the reactions. Low loading of catalyst (2 mol %) and catalytic use of a mild base (5-10 mol %) are sufficient for efficient cross-coupling. Various aryl and heteroaryl ketones are catalytically cross-coupled with primary alcs. to provide the selective α-alkylated products. Challenging α-ethylation of ketones is also attained using ethanol as an alkylating reagent. Further, direct use of secondary alcs. in the reaction results in in situ oxidation to provide the ketone intermediates, which undergo selective α-alkylation. The reaction proceeds via the borrowing hydrogen pathway. The catalyst oxidizes the primary alcs. to aldehydes, which undergo subsequent aldol condensation with ketones, promoted by catalytic amount of Cs2CO3, to provide the α,β-unsaturated ketone intermediates. The hydrogen liberated from oxidation of alcs. is used for hydrogenation of α,β-unsaturated ketone intermediates. Notably either water or water and dihydrogen are the only byproducts in these environmentally benign catalytic processes. Mechanistic studies allowed inferring all the intermediates involved. Dearomatization-aromatization metal-ligand cooperation in the catalyst facilitates the facile O-H bond activation of both primary and secondary alcs. and the resultant manganese alkoxide complexes produce corresponding carbonyl compounds, perhaps via β-hydride elimination. The manganese(I) hydride intermediate plays dual role as it hydrogenates α,β-unsaturated ketones and liberates mol. hydrogen to regenerate the catalytically active dearomatized intermediate. Metal-ligand cooperation allows all the manganese intermediate to exist in same oxidation state (+1) and plays an important role in these catalytic cross-coupling reactions. The experimental part of the paper was very detailed, including the reaction process of 1-Thiophen-2-yl-ethanone(cas: 88-15-3SDS of cas: 88-15-3)

1-Thiophen-2-yl-ethanone(cas: 88-15-3) belongs to thiophenes. Specialized thiophenes can be synthesized similarly using Lawesson’s reagent as the sulfidizing agent, or via the Gewald reaction, which involves the condensation of two esters in the presence of elemental sulfur. Another method is the Volhard–Erdmann cyclization. SDS of cas: 88-15-3

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Category: benzothiopheneIn 2022 ,《Synthesis of Novel Tritopic Hydrazone Ligands: Spectroscopy, Biological Activity, DFT, and Molecular Docking Studies》 was published in Molecules. The article was written by Rupa, Sharmin Akther; Moni, Rassel Md.; Patwary, Abdul Majed Md.; Mahmud, Mayez Md.; Haque, Aminul Md.; Uddin, Jamal; Abedin, S. M. Tareque. The article contains the following contents:

Polytopic organic ligands with hydrazone moiety are at the forefront of new drug research among many others due to their unique and versatile functionality and ease of strategic ligand design. Quantum chem. calculations of these polyfunctional ligands can be carried out in silico to determine the thermodn. parameters. In this study two new tritopic dihydrazide ligands, N′2, N′6-bis[(1E)-1-(thiophen-2-yl) ethylidene] pyridine-2,6-dicarbohydrazide (L1) and N′2, N′6-bis[(1E)-1-(1H-pyrrol-2-yl) ethylidene] pyridine-2,6-dicarbohydrazide (L2) were successfully prepared by the condensation reaction of pyridine-2,6-dicarboxylic hydrazide with 2-acetylthiophene and 2-acetylpyrrole. The FT-IR, 1H, and 13C NMR, as well as mass spectra of both L1 and L2, were recorded and analyzed. Quantum chem. calculations were performed at the DFT/B3LYP/cc-pvdz/6-311G+(d,p) level of theory to study the mol. geometry, vibrational frequencies, and thermodn. properties including changes of ΔH, ΔS, and ΔG for both the ligands. The optimized vibrational frequency and (1H and 13C) NMR obtained by B3LYP/cc-pvdz/6-311G+(d,p) showed good agreement with exptl. FT-IR and NMR data. Frontier MO (FMO) calculations were also conducted to find the HOMO, LUMO, and HOMO-LUMO gaps of the two synthesized compounds To investigate the biol. activities of the ligands, L1 and L2 were tested using in vitro bioassays against some Gram-neg. and Gram-pos. bacteria and fungus strains. In addition, mol. docking was used to study the mol. behavior of L1 and L2 against tyrosinase from Bacillus megaterium. The outcomes revealed that both L1 and L2 can suppress microbial growth of bacteria and fungi with variable potency. The antibacterial activity results demonstrated the compound L2 to be potentially effective against Bacillus megaterium with inhibition zones of 12 mm while the mol. docking study showed the binding energies for L1 and L2 to be -7.7 and -8.8 kcal mol-1, resp., with tyrosinase from Bacillus megaterium. In addition to this study using 1-Thiophen-2-yl-ethanone, there are many other studies that have used 1-Thiophen-2-yl-ethanone(cas: 88-15-3Category: benzothiophene) was used in this study.

1-Thiophen-2-yl-ethanone(cas: 88-15-3) belongs to thiophenes. Reflecting their high stabilities, thiophenes arise from many reactions involving sulfur sources and hydrocarbons, especially unsaturated ones. Thiophenes are classically prepared by the reaction of 1,4-diketones, diesters, or dicarboxylates with sulfidizing reagents such as P4S10 such as in the Paal-Knorr thiophene synthesis. Category: benzothiophene

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

The author of 《Nonbifunctional Outer-Sphere Strategy Achieved Highly Active α-Alkylation of Ketones with Alcohols by N-Heterocyclic Carbene Manganese (NHC-Mn)》 were Lan, Xiao-Bing; Ye, Zongren; Huang, Ming; Liu, Jiahao; Liu, Yan; Ke, Zhuofeng. And the article was published in Organic Letters in 2019. Name: 1-Thiophen-2-yl-ethanone The author mentioned the following in the article:

The unusual nonbifunctional outer-sphere strategy was successfully utilized in developing an easily accessible N-heterocyclic carbene manganese (NHC-Mn) system for highly active α-alkylation of ketones with alcs. This system was efficient for a wide range of ketones and alcs. under mild reaction conditions, and also for the green synthesis of quinoline derivatives The direct outer-sphere mechanism and the high activity of the present system demonstrate the potential of nonbifunctional outer-sphere strategy in catalyst design for acceptorless dehydrogenative transformations. The experimental process involved the reaction of 1-Thiophen-2-yl-ethanone(cas: 88-15-3Name: 1-Thiophen-2-yl-ethanone)

1-Thiophen-2-yl-ethanone(cas: 88-15-3) belongs to thiophenes. Specialized thiophenes can be synthesized similarly using Lawesson’s reagent as the sulfidizing agent, or via the Gewald reaction, which involves the condensation of two esters in the presence of elemental sulfur. Another method is the Volhard–Erdmann cyclization. Name: 1-Thiophen-2-yl-ethanone

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Related Products of 88-15-3In 2020 ,《CF3SO2Na-Mediated, UV-Light-Induced Friedel-Crafts Alkylation of Indoles with Ketones/Aldehydes and Bioactivities of Products》 was published in Organic Letters. The article was written by Yang, Tianbao; Lu, Huiai; Shu, Yixuan; Ou, Yifeng; Hong, Ling; Au, Chak-Tong; Qiu, Renhua. The article contains the following contents:

A concise, one-step route to produce 3,3′-diindolylmethanes (DIMs) from simple indoles and ketones or aldehydes is reported. The key step is the ready formation of indole derivatives that involves the in situ conversion of CF3SO2Na reagent to ·CF3 under oxygen or air (1.0 atm) and UV irradiation It is disclosed that most of the obtained DIMs show anticancer activities in human bladder cancer cell lines EJ and T24. In the experiment, the researchers used 1-Thiophen-2-yl-ethanone(cas: 88-15-3Related Products of 88-15-3)

1-Thiophen-2-yl-ethanone(cas: 88-15-3) belongs to thiophenes. Reflecting their high stabilities, thiophenes arise from many reactions involving sulfur sources and hydrocarbons, especially unsaturated ones. Thiophenes are classically prepared by the reaction of 1,4-diketones, diesters, or dicarboxylates with sulfidizing reagents such as P4S10 such as in the Paal-Knorr thiophene synthesis. Related Products of 88-15-3

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Reference of 1-Thiophen-2-yl-ethanoneIn 2019 ,《Rhodium-Catalyzed C-H/C-H Cross Coupling of Benzylthioethers or Benzylamines with Thiophenes Enabled by Flexible Directing Groups》 appeared in Organic Letters. The author of the article were Yang, Shiping; Cheng, Rui; Zhao, Tingxing; Luo, Anping; Lan, Jingbo; You, Jingsong. The article conveys some information:

Reported herein is an efficient synthetic protocol to ortho-functionalized 2-aryl thiophenes via Rh(III)-catalyzed C-H/C-H cross coupling of benzylthioethers or benzylamines with thiophenes. Both ortho- and meta-substituted benzylthioethers give monoheteroarylated products, while ortho-unhindered substrates mainly provide diheteroarylated benzylthioethers. The C-H/C-H cross coupling of benzylamines with thiophenes exclusively generates diheteroarylated benzaldehydes. Mechanistic study discloses a three-step tandem process involving the ortho-C-H diheteroarylation of benzylamine, the oxidation of benzylamine to imine, and the hydrolysis of imine to aldehyde. In the experimental materials used by the author, we found 1-Thiophen-2-yl-ethanone(cas: 88-15-3Reference of 1-Thiophen-2-yl-ethanone)

1-Thiophen-2-yl-ethanone(cas: 88-15-3) belongs to thiophenes. Reflecting their high stabilities, thiophenes arise from many reactions involving sulfur sources and hydrocarbons, especially unsaturated ones. Thiophenes are classically prepared by the reaction of 1,4-diketones, diesters, or dicarboxylates with sulfidizing reagents such as P4S10 such as in the Paal-Knorr thiophene synthesis. Reference of 1-Thiophen-2-yl-ethanone

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

In 2019,Dalton Transactions included an article by Ganguli, Kasturi; Shee, Sujan; Panja, Dibyajyoti; Kundu, Sabuj. Quality Control of 1-Thiophen-2-yl-ethanone. The article was titled 《Cooperative Mn(I)-complex catalyzed transfer hydrogenation of ketones and imines》. The information in the text is summarized as follows:

The synthesis and reactivity of Mn(I) complexes bearing bifunctional ligands comprising both the amine N-H and benzimidazole fragments I and II (R = H, Me; R1 = H, Me, phenyl; R2 = H, Me) are reported. Among the various ligands, the N-((1H-benzimidazol-2-yl)methyl)aniline ligand containing Mn(I) complex II (R = R2 = H; R1 = Ph) presented higher reactivity in the transfer hydrogenation (TH) of ketones R3C(O)R4 (R3 = Ph, thiophen-2-yl, cyclopropyl, etc.; R4 = Me, propan-2-yl, tert-Bu, etc.; R3R4 = 9H-fluoren-9-yl, 1,2,3,4-tetrahydronaphthalen-1-yl, cyclohexyl) in 2-propanol. Exptl., it was established that both the benzimidazole and amine N-H proton played a vital role in the enhancement of the catalytic activity. Utilizing this system, a wide range of ketones R3C(O)R4 and aldehydes R5CHO (R5 = 4-CH3C6H4, thiophen-2-yl, pentyl, etc.) was reduced efficiently. Notably, the TH of several imines R6R7C=NR8 (R6 = 4-OCH3C6H4, thiophen-2-yl, naphthalen-2-yl, etc.; R7 = H, Me, Et; R8 = C6H5, 4-OCH3C6H4, CH3(CH2)3, etc.), as well as chemoselective reduction of unsaturated ketones, was achieved in the presence of this catalyst. DFT calculations were carried out to understand the plausible reaction mechanism which disclosed that the transfer hydrogenation reaction followed a concerted outer-sphere mechanism. After reading the article, we found that the author used 1-Thiophen-2-yl-ethanone(cas: 88-15-3Quality Control of 1-Thiophen-2-yl-ethanone)

1-Thiophen-2-yl-ethanone(cas: 88-15-3) belongs to thiophenes. Specialized thiophenes can be synthesized similarly using Lawesson’s reagent as the sulfidizing agent, or via the Gewald reaction, which involves the condensation of two esters in the presence of elemental sulfur. Another method is the Volhard–Erdmann cyclization. Quality Control of 1-Thiophen-2-yl-ethanone

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Li, Hui; Su, Miaodong; Nie, Zhiwen; Yang, Tonglin; Luo, Weiping; Liu, Qiang; Guo, Cancheng published their research in Advanced Synthesis & Catalysis in 2021. The article was titled 《Effective [3+1+1+1] Cycloaddition to Six-Membered Carbocycle Based on DMSO as Dual Carbon Synthon》.Category: benzothiophene The article contains the following contents:

A [3+1+1+1] cycloaddition was developed among 2-arylpropenes RC(=CH2)CH3 (R = ethyloxidanyl, Ph, 4-nitrophenyl, etc.), ketones such as 3-oxo-3-phenylpropanenitrile, cyclohexanone, 1-phenylethan-1-one, etc. and DMSO in the presence of K2S2O8, wherein the 2-arylpropene provides three carbons, ketone offers one carbon, and DMSO as dual carbon donor contributes two carbons to the six-membered carbocycle. It gave the cyclohexene motif I (R1 = Ph, 2-nitrophenyl, thiophen-2-yl, etc.; R2 = H, CN, C(O)Ph) and spirocyclohexene skeleton e.g., II. Four C-C bonds formed in this process. Both propylene and ketone could be well tolerated and give the corresponding cyclohexene I or spirocyclohexene motif e.g., II in useful yields. Based on the controlled experiments, a possible mechanism was proposed. In the experiment, the researchers used 1-Thiophen-2-yl-ethanone(cas: 88-15-3Category: benzothiophene)

1-Thiophen-2-yl-ethanone(cas: 88-15-3) belongs to thiophenes. Specialized thiophenes can be synthesized similarly using Lawesson’s reagent as the sulfidizing agent, or via the Gewald reaction, which involves the condensation of two esters in the presence of elemental sulfur. Another method is the Volhard–Erdmann cyclization. Category: benzothiophene

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Application In Synthesis of 1-Thiophen-2-yl-ethanoneIn 2019 ,《Divergent synthesis and evaluation of the in vitro cytotoxicity profiles of 3,4-ethylenedioxythiophenyl-2-propen-1-one analogues》 was published in ChemMedChem. The article was written by Karunakaran, Jayachandran; Dhatchana Moorthy, Nachiappan; Chowdhury, Somenath Roy; Iqbal, Saleem; Majumder, Hemanta K.; Gunasekaran, Krishnasamy; Vellaichamy, Elangovan; Mohanakrishnan, Arasambattu K.. The article contains the following contents:

A new series of thiophene derivatives I [R = (E)-3,4,5-tri-MeOC6H2CH=CHC(O), 3,4,5-tri-MeOC6H2C(O), 2-amino-6-(4-bromophenyl)pyrimidin-4-yl, etc.; R1 = H, Me; R2 = H; R1R2 = O(CH2)2O; R3 = H, 2-thienyl] were synthesized by condensation reaction and evaluated for their in vitro cytotoxicity effects against five human cancer cell lines. Preliminary structure-activity relationships of compounds I were also established. The 3,4-ethylenedioxythiophene (EDOT)-appended enones demonstrated significant cytotoxicity against human cancer cell lines. The most active compound I [R = (E)-3,4,5-tri-MeOC6H2C(O)CH=CH; R1R2 = O(CH2)2O; R3 = H] (GI50=110 nM), severely inhibited clonogenic potential of cancer cells and induced cell-cycle arrest in G2/M phase and caused an accumulation of HCT116 colon cancer cells with >4 N DNA content. Also, compound I [R = (E)-3,4,5-tri-MeOC6H2C(O)CH=CH; R1R2 = O(CH2)2O; R3 = H] exhibited weak inhibition of the enzymic activity of human topoisomerase I. Mol. docking studies indicated preferential binding of the compounds I to ATP-binding pocket of human checkpoint 2 kinase (Chk2) catalytic domain, thus, identifying a novel diaryl 2-propenone chemotype for development of potent inhibitors of Chk2. The results came from multiple reactions, including the reaction of 1-Thiophen-2-yl-ethanone(cas: 88-15-3Application In Synthesis of 1-Thiophen-2-yl-ethanone)

1-Thiophen-2-yl-ethanone(cas: 88-15-3) belongs to thiophenes. Reflecting their high stabilities, thiophenes arise from many reactions involving sulfur sources and hydrocarbons, especially unsaturated ones. Thiophenes are classically prepared by the reaction of 1,4-diketones, diesters, or dicarboxylates with sulfidizing reagents such as P4S10 such as in the Paal-Knorr thiophene synthesis. Application In Synthesis of 1-Thiophen-2-yl-ethanone

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Product Details of 88-15-3In 2021 ,《Ruthenium-catalyzed hydrogenation of aromatic ketones using chiral diamine and monodentate achiral phosphine ligands》 appeared in Catalysis Communications. The author of the article were Wang, Mengna; Zhang, Ling; Sun, Hao; Chen, Qian; Jiang, Jian; Li, Linlin; Zhang, Lin; Li, Li; Li, Chun. The article conveys some information:

The Ru-catalyzed asym. hydrogenation of ketones with chiral diamine and monodentate achiral phosphine has been developed. A wide range of ketones were hydrogenated to afford the corresponding chiral secondary alcs. in good to excellent enantioselectivities (up to 98.1% ee). In addition, an appropriate mechanism for the asym. hydrogenation was proposed and verified by NMR spectroscopy. In the experiment, the researchers used many compounds, for example, 1-Thiophen-2-yl-ethanone(cas: 88-15-3Product Details of 88-15-3)

1-Thiophen-2-yl-ethanone(cas: 88-15-3) belongs to thiophenes. Reflecting their high stabilities, thiophenes arise from many reactions involving sulfur sources and hydrocarbons, especially unsaturated ones. Thiophenes are classically prepared by the reaction of 1,4-diketones, diesters, or dicarboxylates with sulfidizing reagents such as P4S10 such as in the Paal-Knorr thiophene synthesis. Product Details of 88-15-3

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

In 2019,New Journal of Chemistry included an article by Wang, Weifan; Luo, Man; Yao, Weiwei; Ma, Mengtao; Pullarkat, Sumod A.; Xu, Li; Leung, Pak-Hing. Recommanded Product: 88-15-3. The article was titled 《Catalyst-free and solvent-free hydroboration of ketones》. The information in the text is summarized as follows:

The hydroboration of a wide range of ketones with pinacolborane can be achieved under catalyst-free and solvent-free conditions to provide the corresponding boronic esters in quant. yields. A large gram-scale hydroboration of acetophenone with HBpin under the same conditions was also performed to afford the alc. product in a high yield thus demonstrating the scalability of the newly developed simple protocol. In the part of experimental materials, we found many familiar compounds, such as 1-Thiophen-2-yl-ethanone(cas: 88-15-3Recommanded Product: 88-15-3)

1-Thiophen-2-yl-ethanone(cas: 88-15-3) belongs to thiophenes. Specialized thiophenes can be synthesized similarly using Lawesson’s reagent as the sulfidizing agent, or via the Gewald reaction, which involves the condensation of two esters in the presence of elemental sulfur. Another method is the Volhard–Erdmann cyclization. Recommanded Product: 88-15-3

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem