75894-07-4, 2-(Benzo[b]thiophen-2-yl)acetic acid is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
EXAMPLE 131 N-[4-[2-(3,4-Dimethoxyphenyl)ethyl]phenyl]-3-hydroxy-alpha -oxo-benzo[b]thiophene-2-acetamide (See Scheme I, Formula I, Wherein Q is I4, Wherein b is zero; y is 2; R5 is hydrogen; R6 is 4-[2-(3,4-dimethoxyphenyl)ethyl]) To a stirred solution of benzo[b]thiophene-2-acetic acid, 3-hydroxy-alpha-oxo (Fries and Bartholomaus, Annalen, 405, 391 (1914)) (44.44 g, 0.2 mole) and 4-(3,4-dimethoxyphenethyl)aniline (51.46 g, 0.2 mole) in methylene chloride (2.5 l) and tetrahydrofuran (1 l) under nitrogen at -7 C. is added a solution of dicyclohexycarbodiimide (41.7 g, 0.202 mole) in methylene chloride (200 ml) over a period of 55 minutes. The mixture is stirred at -7 to 0 C. for two hours and at room temperature overnight. The precipitate is collected by filtration and washed with methylene chloride to give a solid, consisting of the product and dicyclohexylurea. Evaporation of the mother liquor under reduced pressure below 45 C. gives a solid, which is combined with the first crop, dissolved in ~4 1 of boiling chloroform and left at room temperature overnight. Dicyclohexylurea (26 g) is removed by filtration and the filtrate is chromatographed on 1 kg of silica gel. Elution with chloroform gives 61.4 g of a solid. Recrystallization from tetrahydrofuran yields 53.2 g (57.6%) of a light-yellow crystalline solid, mp 204-205 C., 75894-07-4
The synthetic route of 75894-07-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Warner-Lambert Company; US4761424; (1988); A;,
Benzothiophene – Wikipedia
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