Category: 638-02-8

Highly fluorescent response of 4-(2,5-dimethylthiophen-3-yl)-2- hydroxyphenylbenzothiazole toward BF₃·Et₂O and Zn²⁺ was written by Liu, Yingfan;Li, Xiaochuan;Min, Kyeong Su;Son, Young-A.. And the article was included in Molecular Crystals and Liquid Crystals in 2018.Related Products of 638-02-8 The following contents are mentioned in the article:

In this contribution, the emission response of 4-(2,5-dimethylthiophen-3-yl)-2-(2-hydroxyphenyl)benzothiazole (THBT) was investigated in detail. The exptl. shows that Zn²⁺ could induce fluorescence increasing in THF. Especially, the quenched emission of THBT was significantly enhanced with 0.76 quantum yield. Due to the coordination of Zn²⁺, the excited state intramol. proto transfer (ESIPT) was inhibited and leads to emission quenching correspondingly. The strong emission could ascribe to the Zn-THBT complex. As well, the addition of BF₃·Et₂O also could form fluorine-boron complex and inhibit ESIPT effect. Addnl., the BF complex is also a strong blue emitter. Therefore, strong blue emission upon BF₃·Et₂O addition to THBT in dioxane was found. The possible coordinating mechanisms of THBT coordinate with Zn²⁺ and BF₃·Et₂O were given. This study involved multiple reactions and reactants, such as 2,5-Dimethylthiophene (cas: 638-02-8Related Products of 638-02-8).

2,5-Dimethylthiophene (cas: 638-02-8) belongs to benzothiophene derivatives. Benzothiophene scaffolds are of great importance due to its increased presence in bioactive molecules. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, and sertaconazole, and also BTCP.Related Products of 638-02-8

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Prediction of flash points of pure organic compounds: Evaluation of the DIPPR database was written by Alibakhshi, A.;Mirshahvalad, H.;Alibakhshi, S.. And the article was included in Process Safety and Environmental Protection in 2017.Formula: C6H8S The following contents are mentioned in the article:

The flash point is one of the most important flammability properties of compounds for the design of inherently safe processes. Many models have been developed to predict the flash point using the DIPPR database. However, for only 740 of the 1628 organic compounds available in the DIPPR database, the data for both flash point and normal b.p. were exptl. determined For the other compounds, at least one of these properties was predicted and therefore is not appropriate for model development. The present study introduces a model to predict the flash points of pure organic compounds using their mol. structures and normal b.ps. The new model exploits the equality of the relative errors observed for the normal b.p. and flash point values predicted using the Joback method. Consequently, the relative error of the predicted normal b.ps. can be used as a scaling factor to modify the predicted flash points. The ability of the model to evaluate the accuracy of a database was investigated. The ratio of the relative error of the predicted flash point to the relative error of the predicted normal b.p. obtained using the Joback method was proposed as a measure to evaluate the accuracy of flash point data. This study involved multiple reactions and reactants, such as 2,5-Dimethylthiophene (cas: 638-02-8Formula: C6H8S).

2,5-Dimethylthiophene (cas: 638-02-8) belongs to benzothiophene derivatives. Functionalized benzothiophenes are important constructs found in molecules with wide ranging biological activity and in organic materials. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, and sertaconazole, and also BTCP.Formula: C6H8S

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Microwave-Assisted Synthesis, Physicochemical, and Optical Properties of Extended Pi (π) Bond Pyrazoline Derivative was written by Zayed, Mohie E. M.;Kumar, Parveen. And the article was included in Polycyclic Aromatic Compounds in 2021.Related Products of 638-02-8 The following contents are mentioned in the article:

The title compound 2-(3-(2,5-dimethylthiophen-3-yl)-5-(2,4,5-trimethoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl)benzo[d]thiazole (DTPH) was synthesized by the reaction of (E)-1-(2,5-dimethylthiophen-3-yl)-3-(2,4,5-trimethoxyphenyl)prop-2-en-1-one (DTPO) with 2-hydrazinyl benzothiazole under microwave irradiation Chalcone was synthesized by the reaction of 1-(2,5-dimethylthiophen-3-yl)ethan-1-one with 2,4,5-trimethoxybenzaldehyde under same conditions. The structure of the DTPH was confirmed by the spectroscopic techniques (IR, ¹H-NMR, ¹³C-NMR, EI-MS) and elemental anal. The physicochem. behavior of newly synthesized DTPH was determined in different solvents. As a result of the measurements, a large red shift in the fluorescence of the DTPH studied was observed, when the polarity of the solvents increases (n-Hexane to DMSO). Optical properties of DTPH such as dipole moment, oscillator strength, stokes shift, and fluorescence quantum yields were determined in different polarities of the solvents. The effect of cationic and anionic surfactant such as CTAB and SDS on DTPH dye was also studied to determine the critical micelle concentration of CTAB and SDS surfactants. This study involved multiple reactions and reactants, such as 2,5-Dimethylthiophene (cas: 638-02-8Related Products of 638-02-8).

2,5-Dimethylthiophene (cas: 638-02-8) belongs to benzothiophene derivatives. Functionalized benzothiophenes are important constructs found in molecules with wide ranging biological activity and in organic materials. It has been used as a raw material for the synthesis of biologically active structures and is found in pharmaceuticals such as leukotriene synthesis inhibitors and antifungals, as well as in many natural products.Related Products of 638-02-8

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Targeted analyte deconvolution and identification by four-way parallel factor analysis using three-dimensional gas chromatography with mass spectrometry data was written by Watson, Nathanial E.;Prebihalo, Sarah E.;Synovec, Robert E.. And the article was included in Analytica Chimica Acta in 2017.Related Products of 638-02-8 The following contents are mentioned in the article:

Comprehensive three-dimensional gas chromatog. with time-of-flight mass spectrometry (GC³-TOFMS) creates an opportunity to explore a new paradigm in chemometric anal. Using this newly described instrument and the well understood Parallel Factor Anal. (PARAFAC) model the authors present one option for use of the novel GC³-TOFMS data structure. The authors present a method which builds upon previous work in both GC³ and targeted anal. using PARAFAC to simplify some of the implementation challenges previously discovered. Conceptualizing the GC³-TOFMS instead as a 1-dimensional gas chromatograph with GC × GC-TOFMS detection the authors allow the instrument to create the PARAFAC target window natively. Each 1st dimension modulation thus creates a full GC × GC-TOFMS chromatogram fully amenable to PARAFAC. A simple mixture of 115 compounds and a diesel sample are interrogated through this methodol. All test analyte targets are successfully identified in both mixtures Mass spectral matching of the PARAFAC loadings to library spectra yielded results >900 in 40 of 42 test analyte cases. Twenty-nine of these cases produced match values >950. This study involved multiple reactions and reactants, such as 2,5-Dimethylthiophene (cas: 638-02-8Related Products of 638-02-8).

2,5-Dimethylthiophene (cas: 638-02-8) belongs to benzothiophene derivatives. Benzothiophene is a fused ring compound of thiophene ring and benzene ring, which is an important class of heterocycles with advantageous structures. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, sertaconazole, and also BTCP.Related Products of 638-02-8

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Roles of different initial Maillard intermediates and pathways in meat flavor formation for cysteine-xylose-glycine model reaction systems was written by Hou, Li;Xie, Jianchun;Zhao, Jian;Zhao, Mengyao;Fan, Mengdie;Xiao, Qunfei;Liang, Jingjing;Chen, Feng. And the article was included in Food Chemistry in 2017.HPLC of Formula: 638-02-8 The following contents are mentioned in the article:

To explore initial Maillard reaction pathways and mechanisms for maximal formation of meaty flavors in heated cysteine-xylose-glycine systems, model reactions with synthesized initial Maillard intermediates, Gly-Amadori, TTCA (2-threityl-thiazolidine-4-carboxylic acids) and Cys-Amadori, were investigated. Relative relativities were characterized by spectrophotometrically monitoring the development of colorless degradation intermediates and browning reaction products. Aroma compounds formed were determined by solid-phase microextraction combined with GC-MS and GC-olfactometry. Gly-Amadori showed the fastest reaction followed by Cys-Amadori then TTCA. Free glycine accelerated reaction of TTCA, whereas cysteine inhibited that of Gly-Amadori due to association forming relatively stable thiazolidines. Cys-Amadori/Gly had the highest reactivity in development of both meaty flavors and brown products. TTCA/Gly favored yielding meaty flavors, whereas Gly-Amadori/Cys favored generation of brown products. Conclusively, initial formation of TTCA and pathway involving TTCA with glycine were more applicable to efficiently produce processed-meat flavorings in a cysteine-xylose-glycine system. This study involved multiple reactions and reactants, such as 2,5-Dimethylthiophene (cas: 638-02-8HPLC of Formula: 638-02-8).

2,5-Dimethylthiophene (cas: 638-02-8) belongs to benzothiophene derivatives. Benzothiophenes are valuable heterocycles that are widely used in medicines, agrochemicals, and materials science. The different substitution patterns in these heterocycles offer new opportunities for drug discovery and other applications in materials science.HPLC of Formula: 638-02-8

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

S,O-Ligand-Promoted Pd-Catalyzed C-H Olefination of Thiophenes was written by Alvarez-Casao, Yolanda;Fernandez-Ibanez, M. Angeles. And the article was included in European Journal of Organic Chemistry in 2019.Category: benzothiophene The following contents are mentioned in the article:

An efficient palladium(II)-catalyzed C-H olefination of thiophenes was developed to afford thiophenyl acrylates I [R¹ = Me, CO₂Me, Cl, etc.; R² = 3-methoxy-3-oxo-prop-1-enyl, 3-butoxy-3-oxo-prop-1-enyl, 3-(dimethylamino)-3-oxo-prop-1-enyl, etc.; R³ = H, 3-methoxy-3-oxo-prop-1-enyl, 3-butoxy-3-oxo-prop-1-enyl, 3-(dimethylamino)-3-oxo-prop-1-enyl, etc.] and II [R⁴ = 3-ethoxy-3-oxo-prop-1-enyl, 3-butoxy-3-oxo-prop-1-enyl, 3-(dimethylamino)-3-oxo-prop-1-enyl, etc.; R⁵ = H, Me, OMe, etc.; R⁶ = H, 3-butoxy-3-oxo-prop-1-enyl; R⁷ = H, 3-butoxy-3-oxo-prop-1-enyl] using an easily accessible bidentate S,O-ligand. The catalytic system promoted the C-2 olefination of a wide range of thiophenes bearing both electron donating and withdrawing groups under mild conditions. This methodol. provided a direct path toward the synthesis of I and II which were difficult to obtain via other C-H functionalization routes. The S,O-ligand was responsible for the broad substrate scope and high levels of C-2 selectivity in compounds I. This study involved multiple reactions and reactants, such as 2,5-Dimethylthiophene (cas: 638-02-8Category: benzothiophene).

2,5-Dimethylthiophene (cas: 638-02-8) belongs to benzothiophene derivatives. Functionalized benzothiophenes are important constructs found in molecules with wide ranging biological activity and in organic materials. It is also used in the manufacturing of dyes such as thioindigo.Category: benzothiophene

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

An approach for the calculation of vaporization enthalpies of aromatic and heteroaromatic compounds at 298.15 K applicable to supercooled liquids was written by Solomonov, Boris N.;Yagofarov, Mikhail I.. And the article was included in Journal of Molecular Liquids in 2020.Safety of 2,5-Dimethylthiophene The following contents are mentioned in the article:

An approach for the calculation of the vaporization enthalpies of aromatic and heteroaromatic compounds at T = 298.15 K with accuracy competitive with experiment was proposed. The vaporization enthalpies may be calculated from the solution enthalpies of liquid and solvation enthalpies in benzene. The solution enthalpies of liquids were shown to be constant within a given type of aromatic compounds For a set of 67 liquid and 41 solid aromatic and heteroaromatic compounds not capable of intermol. hydrogen bonding, it was exptl. demonstrated that the solution enthalpies of liquids or supercooled liquids in benzene were equal to 1 ± 1 kJ·mol^-1. The way to consider intermol. hydrogen bonding, e.g., in phenol, aniline, pyrrole derivatives, was also proposed. The methods for solvation enthalpy calculation were proposed previously. The calculated and literature vaporization enthalpies values of 415 aromatic and heteroaromatic compounds were compared. Average absolute deviation amounted to 1.3 kJ·mol^-1. The proposed approach is especially valuable for calculation of the vaporization enthalpies of low-volatile compounds, including those solid at T = 298.15 K. This study involved multiple reactions and reactants, such as 2,5-Dimethylthiophene (cas: 638-02-8Safety of 2,5-Dimethylthiophene).

2,5-Dimethylthiophene (cas: 638-02-8) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The core structure is a part of various pharmaceutical substances and natural products. The different substitution patterns in these heterocycles offer new opportunities for drug discovery and other applications in materials science.Safety of 2,5-Dimethylthiophene

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Characterization of the Key Aroma Compounds in Two Differently Dried Toona sinensis (A. Juss.) Roem. by Means of the Molecular Sensory Science Concept was written by Zhai, Xiaoting;Granvogl, Michael. And the article was included in Journal of Agricultural and Food Chemistry in 2019.Reference of 638-02-8 The following contents are mentioned in the article:

A systematic approach for the characterization of the key aroma-active compounds in sun-dried Toona sinensis (SDTS) and vacuum-dried T. sinensis (VDTS) was performed by means of the mol. sensory science concept. A total of 64 aroma-active compounds were identified via gas chromatog.-olfactometry (GC-O) and gas chromatog.-mass spectrometry (GC-MS). Aroma extract dilution anal. (AEDA) and static headspace dilution anal. revealed 39 odorants in SDTS and 32 odorants in VDTS with flavor dilution (FD) factors from 8 to 4096, with the highest for vanillin and eugenol in both samples. Stable isotope dilution anal. (SIDA) and an internal standard method were applied to quantitate 42 odorants, revealing 35 compounds in concentrations above their resp. odor thresholds in SDTS and 29 compounds in VDTS, resp. Calculation of odor activity values (OAVs) indicated 2-isopropyl-3-methoxypyrazine, eugenol, and β-ionone with the highest OAVs in both samples. Recombination experiments of the overall aromas of SDTS and VDTS by mixing the odorants with OAVs ≥1 in their naturally occurring concentrations proved the successful identification and quantitation of the resp. key odorants. This study involved multiple reactions and reactants, such as 2,5-Dimethylthiophene (cas: 638-02-8Reference of 638-02-8).

2,5-Dimethylthiophene (cas: 638-02-8) belongs to benzothiophene derivatives. Functionalized benzothiophenes are important constructs found in molecules with wide ranging biological activity and in organic materials. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization.Reference of 638-02-8

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

New insight into the formation mechanism of 2-furfurylthiol in the glucose-cysteine reaction with ribose was written by Liu, Huan;Wang, Zhenyu;Hui, Teng;Fang, Fei;Zhang, Dequan. And the article was included in Food Research International in 2021.Reference of 638-02-8 The following contents are mentioned in the article:

The mol. formation mechanism of 2-furfurylthiol in the glucose-cysteine reaction is not reported. Knowledge of the mol. interaction of glucose and ribose on the generation of 2-furfurylthiol is still unclear. The carbon module labeling (CAMOLA) tech. approach was applied to elucidate the formation mechanism of 2-furfurylthiol in the glucose-cysteine reaction. The effect of ribose on the glucose-cysteine reaction was also evaluated. The results showed that 2-furfural and 2-furanmethanol were important intermediates for the formation of 2-furfurylthiol. Irresp. of the heating time, 2-furfurylthiol was mainly generated from an intact C5 glucose skeleton (88-89%), whereas the recombination of glucose fragments had minimal contribution. 2-Furfural could be generated from the Maillard reaction between glucose and cysteine or glucose alone, which further formed 2-furanmethanol. Immediately, 2-furfurylthiol could arise from the reaction of 2-furanmethanol and H2S from cysteine. Moreover, the reaction of glucose, ribose, and cysteine could generate 2-furfural, 2-furanmethanol, and 2-furfurylthiol by an addition effect confirmed by the model reaction and food system. This study involved multiple reactions and reactants, such as 2,5-Dimethylthiophene (cas: 638-02-8Reference of 638-02-8).

2,5-Dimethylthiophene (cas: 638-02-8) belongs to benzothiophene derivatives. Benzothiophene scaffolds are of great importance due to its increased presence in bioactive molecules. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, and sertaconazole, and also BTCP.Reference of 638-02-8

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Chemoselective Catalytic Dehydrogenative Cross-Coupling of 2-Acylimidazoles: Mechanistic Investigations and Synthetic Scope was written by Tanaka, Tsukushi;Hashiguchi, Kayoko;Tanaka, Takafumi;Yazaki, Ryo;Ohshima, Takashi. And the article was included in ACS Catalysis in 2018.Application In Synthesis of 2,5-Dimethylthiophene The following contents are mentioned in the article:

Chemoselective iron-catalyzed dehydrogenative cross-coupling using 2-acylimidazoles is described. The addition of a phosphine oxide ligand substantially facilitated the generation of tert-butoxy radicals from di-tert-Bu peroxide, allowing for efficient benzylic C-H bond cleavage under mild conditions. Extensive mechanistic studies revealed that the enolization of 2-acylimidazole proceeded through dual iron catalyst activation, followed by subsequent chemoselective cross-coupling with a benzyl radical over an undesired benzyl radical-derived homocoupling dimer that inevitably formed in earlier reported conditions. A variety of alkylarenes, aliphatic alkane, and functionalized 2-acylimidazoles were applicable, demonstrating the synthetic utility of the present catalysis. Contiguous all-carbon quaternary carbons were constructed through dehydrogenative cross-coupling. The catalytic chemoselective activation of 2-acylimidazole over bidentate coordinative and much more acidic malonate diester was particular noteworthy. Catalytic oxidative cross-enolate coupling of two distinct carboxylic acid equivalent was also achieved using acetonitrile as a coupling partner. This study involved multiple reactions and reactants, such as 2,5-Dimethylthiophene (cas: 638-02-8Application In Synthesis of 2,5-Dimethylthiophene).

2,5-Dimethylthiophene (cas: 638-02-8) belongs to benzothiophene derivatives. Benzothiophene finds use in research as a starting material for the synthesis of larger, usually bioactive structures. It is found within the chemical structures of pharmaceutical drugs such as zileuton, raloxifene, and sertaconazole, and also BTCP.Application In Synthesis of 2,5-Dimethylthiophene

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem