Category: 638-02-8

Potassium Carbonate to Unlock a GaCl₃-Catalyzed C-H Propargylation of Arenes was written by Vayer, Marie;Rodrigues, Sophie;Miaskiewicz, Solene;Gatineau, David;Gimbert, Yves;Gandon, Vincent;Bour, Christophe. And the article was included in ACS Catalysis in 2022.Application of 638-02-8 The following contents are mentioned in the article:

A gallium-catalyzed C-H propargylation of electron-rich arenes using bromoallenes is described. The development of this reaction was first hampered by a side hydroarylation process catalyzed by adventitious protons, easily generated from the solvent (1,2-dichloroethane). This hidden Bronsted acid catalysis could be bypassed by using K₂CO₃ as insoluble base. The unexpected compatibility of this base with the Lewis acid catalyst GaCl₃ allowed a strictly gallium-catalyzed process that was thoroughly studied by kinetics, ⁷¹Ga NMR experiments and DFT computations. The GaCl₃/K₂CO₃ system triggers the C-H propargylation of a wide range of arenes and heteroaromatics using a variety of bromoallenes. This study involved multiple reactions and reactants, such as 2,5-Dimethylthiophene (cas: 638-02-8Application of 638-02-8).

2,5-Dimethylthiophene (cas: 638-02-8) belongs to benzothiophene derivatives. Functionalized benzothiophenes are important constructs found in molecules with wide ranging biological activity and in organic materials. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, sertaconazole, and also BTCP.Application of 638-02-8

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Determination of individual sulfur-containing compounds in gas condensate and petrol by gas chromatography was written by Afanas’ev, I. P.;Gorshkova, T. A.;Arystanbekova, S. A.;Lapina, M. S.;Volynskii, A. B.. And the article was included in Journal of Analytical Chemistry in 2017.Synthetic Route of C6H8S The following contents are mentioned in the article:

A procedure is developed for the determination of more than 60 individual sulfur-containing compounds (SCC) in liquid hydrocarbon raw materials and in liquid fuels using gas chromatog. on a 25-m WCOT column, inner diameter 0.32 mm, with a nonpolar dimethylpolysiloxane stationary phase (layer thickness 5 μm) and chemiluminescence detection. SCC were identified by individual standard substances and published data. Quant. determination was carried out by the internal standard method. The results of determination of individual SCC in petrol and stable gas condensate are presented. The most high-boiling SCC found in significant amounts (more than 0.005 wt % of sulfur) were C₂-benzothiophenes (in petrol) and C₄-dibenzothiophenes (in gas condensate). This study involved multiple reactions and reactants, such as 2,5-Dimethylthiophene (cas: 638-02-8Synthetic Route of C6H8S).

2,5-Dimethylthiophene (cas: 638-02-8) belongs to benzothiophene derivatives. Benzothiophene is a fused ring compound of thiophene ring and benzene ring, which is an important class of heterocycles with advantageous structures. The different substitution patterns in these heterocycles offer new opportunities for drug discovery and other applications in materials science.Synthetic Route of C6H8S

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

C-H heteroarylation of aromatics via catalyst free S_N2′ coupling cycloaromatization was written by Lu, Qixing;Wang, Tao;Wu, Qian;Cheng, Lijing;Luo, Han;Liu, Lei;Chu, Guobiao;Wang, Lufeng;Li, Baosheng. And the article was included in Green Chemistry in 2022.HPLC of Formula: 638-02-8 The following contents are mentioned in the article:

The construction of a carbon-carbon bond is the most fundamental aspect of synthetic chem. In this study, authors developed a catalyst-free S_N2′ reaction of β-OTf-substituted enamides with aromatics to obtain aryl-substituted aza-1,4-dicarbonyl compounds that can be in situ transformed into aryl-imidazole, aryl-thiazole, and aryl-oxazole in one-pot operation, thus achieving C-H heteroarylation of aromatics This simple, efficient, clean and scalable strategy, which provides difficult-to-realize biaryl products, is compatible with various aromatics having varying complexities. This method can be used for the late-stage modification of various com. pharmaceuticals or functional materials and offers an orthogonal approach for constructing biaryl compounds This study involved multiple reactions and reactants, such as 2,5-Dimethylthiophene (cas: 638-02-8HPLC of Formula: 638-02-8).

2,5-Dimethylthiophene (cas: 638-02-8) belongs to benzothiophene derivatives. Benzothiophenes are valuable heterocycles that are widely used in medicines, agrochemicals, and materials science. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization.HPLC of Formula: 638-02-8

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Light-Responsive Pyrazine-Based Systems: Probing Aromatic Diarylethene Photocyclization was written by Milic, Jovana V.;Schaack, Cedric;Hellou, Nora;Isenrich, Florin;Gershoni-Poranne, Renana;Neshchadin, Dmytro;Egloff, Sylvain;Trapp, Nils;Ruhlmann, Laurent;Boudon, Corinne;Gescheidt, Georg;Crassous, Jeanne;Diederich, Francois. And the article was included in Journal of Physical Chemistry C in 2018.Reference of 638-02-8 The following contents are mentioned in the article:

Here, we present an investigation of the photocyclization of novel aromatic diarylethene (DAE) systems 1-3 based on pyrazine, quinoxaline, and helicene scaffolds. These prospective photoswitches were designed using d. functional theory calculations and analyzed in solution and in the solid state by cyclic and rotating disk voltammetry, UV visible and transient absorption spectroscopy, as well as X-ray crystallog. Addnl., nucleus-independent chem. shift calculations were performed to investigate the influence of aromaticity on the photocyclization ability. While pyrazine-2,3-diyl-extended DAE system 1 demonstrated photoswitching ability with short lifetimes of the cyclized form, the more aromatic quinoxaline analog 2 did not feature any photocyclization. Further extension of these aromatic systems into helicene-DAE 3 resulted in the stabilization of the cyclized form through the conserved backbone aromaticity, accompanied by enhanced photochromism. This study paves the way toward the generation of aromatic DAE photoswitches for light-controlled mol. systems in the future. This study involved multiple reactions and reactants, such as 2,5-Dimethylthiophene (cas: 638-02-8Reference of 638-02-8).

2,5-Dimethylthiophene (cas: 638-02-8) belongs to benzothiophene derivatives. Benzothiophene scaffolds are of great importance due to its increased presence in bioactive molecules. The different substitution patterns in these heterocycles offer new opportunities for drug discovery and other applications in materials science.Reference of 638-02-8

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Characterization of the key aroma compounds in mulberry fruits by application of gas chromatography-olfactometry (GC-O), odor activity value (OAV), gas chromatography-mass spectrometry (GC-MS) and flame photometric detection (FPD) was written by Zhu, JianCai;Wang, LingYing;Xiao, ZuoBing;Niu, YunWei. And the article was included in Food Chemistry in 2018.Formula: C6H8S The following contents are mentioned in the article:

The volatile compounds of mulberries obtained from three cultivars (M. nigra, Y1, M. Macroura, Y2 and M. Alba, Y3) were investigated by gas chromatog.-olfactometry (GC-O), odor activity value (OAV), gas chromatog.-mass spectrometry (GC-MS) and flame photometric detection (FPD). The results showed that 41, 37 and 41 compounds were detected in Y1, Y2 and Y3 samples, resp. In addition, 12, 11, and 12 sulfur compounds were identified in three samples by FPD, resp. Quant. anal. showed 2-(methylthio)ethanol, methionol, di-Me sulfide, methional and 3-ethylthiophene were present in relatively high amounts in each of the three samples. Furthermore, benzaldehyde, Et butanoate, (E)-2-nonenal, 1-hexanol, hexanal, methional, 3-mercaptohexyl acetate and 3-mercaptohexanol were present with much higher OAVs than other compounds Finally, four compounds (pentanal, Et acetate, acetic acid, methionol) were selected to investigate possible effects on six descriptors, which indicated that the volatile compounds at sub-threshold concentrations are likely to contribute to overall aroma. This study involved multiple reactions and reactants, such as 2,5-Dimethylthiophene (cas: 638-02-8Formula: C6H8S).

2,5-Dimethylthiophene (cas: 638-02-8) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The core structure is a part of various pharmaceutical substances and natural products. The different substitution patterns in these heterocycles offer new opportunities for drug discovery and other applications in materials science.Formula: C6H8S

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Characterization of the volatile organic compounds produced from avocado during ripening by gas chromatography ion mobility spectrometry was written by Liu, Yijun;Bu, Mengting;Gong, Xiao;He, Jinna;Zhan, Yu. And the article was included in Journal of the Science of Food and Agriculture in 2021.Product Details of 638-02-8 The following contents are mentioned in the article:

BACKGROUND : The volatile organic compounds (VOCs) produced from avocados during storage may be distinct at different periods, and this difference may be related to their degree of maturity, for which no relevant research has been conducted yet. RESULTS : A total of 30 typical target compounds were identified by gas chromatog.-ion mobility spectrometry (GC-IMS) combined with principal component anal. (PCA) for the VOCs produced during the post-harvesting process of avocado. With an increase in storage time, the VOCs content produced by avocado due to ripening continued to increase, and the uptrend was particularly obvious on day 13. The storage time of avocado could be distinguished according to the PC1 and PC2 values in the PCA chart. Conclusion : GC-IMS detection combined with PCA was used to establish the fingerprints of VOCs in avocado for the first time. The maturity of avocados was determined by identifying the signal strength of characteristic VOCs, and this method could be of great potential to predict the maturity of fruits in the future. This study involved multiple reactions and reactants, such as 2,5-Dimethylthiophene (cas: 638-02-8Product Details of 638-02-8).

2,5-Dimethylthiophene (cas: 638-02-8) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The electrophilic substitution of benzothiophene systems is much less regioselective than that of indoles. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization.Product Details of 638-02-8

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Efficient Synthesis of Bis(dibromomethyl)arenes as Important Precursors of Synthetically Useful Dialdehydes was written by Bodzioch, Agnieszka;Owsianik, Krzysztof;Skalik, Joanna;Kowalska, Emilia;Stasiak, Anna;Rozycka-Sokolowska, Ewa;Marciniak, Bernard;Balczewski, Piotr. And the article was included in Synthesis in 2016.Electric Literature of C6H8S The following contents are mentioned in the article:

This work presents an efficient synthesis of bis(dibromomethyl)benzenes and a bis(dibromomethyl)thiophene as precursors of aromatic dialdehydes by bromination of dimethyl-substituted arenes under various reaction conditions (yields up to 99%). Several new variants of this reaction, including the use of N-bromosuccinimide (NBS) and bromine, and various solvents to replace carbon tetrachloride, benzene and carbon disulfide, were also tested. In the optimized protocols, the inconvenient solvents were replaced by 1,2-dichloroethane (DCE) and/or acetonitrile. In the DCE protocols, we reduced reaction times 24-32-fold, reduced the amount of NBS a few-fold and lowered power consumption relative to the literature protocols. The procedures also allowed elimination of long-lasting incandescent irradiation (100-500 W). The replacement of NBS by bromine led to a further reduction in the amount of brominating agent. The obtained bromo derivatives were efficiently converted into the corresponding dialdehydes (90-96%), which in turn are useful in materials chem. This study involved multiple reactions and reactants, such as 2,5-Dimethylthiophene (cas: 638-02-8Electric Literature of C6H8S).

2,5-Dimethylthiophene (cas: 638-02-8) belongs to benzothiophene derivatives. Benzothiophenes are valuable heterocycles that are widely used in medicines, agrochemicals, and materials science. The different substitution patterns in these heterocycles offer new opportunities for drug discovery and other applications in materials science.Electric Literature of C6H8S

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Diverse Reactions of Thiophenes, Selenophenes, and Tellurophenes with Strongly Oxidizing I(III) PhI(L)₂ Reagents was written by Egalahewa, Sathsara;Albayer, Mohammad;Aprile, Antonino;Dutton, Jason L.. And the article was included in Inorganic Chemistry in 2017.Safety of 2,5-Dimethylthiophene The following contents are mentioned in the article:

The authors report the outcomes of the reactions of aromatic group 16 thiophene, selenophene, and tellurophene rings with the I(III) oxidants PhI(OAc)(OTf) and [PhI(Pyr)₂][OTf]₂ (Pyr = pyridine). In all reactions, oxidative processes take place, with generation of PhI as the reduction product. However, with the exception of tellurophene with PhI(OAc)(OTf), +4 oxidation state complexes are not observed, but rather a variety of other processes occur. In general, where a C-H unit is available on the 5-membered ring, an electrophilic aromatic substitution reaction of either -IPh or pyridine onto the ring occurs. When all positions are blocked, reactions with PhI(OAc)(OTf) give acetic and triflic anhydride as the identifiable oxidative byproducts, while [PhI(Pyr)₂][OTf]₂ gives pyridine electrophilic aromatic substitution onto the peripheral rings. Qual. mechanistic studies indicate that the presence of the oxidizable heteroatom is required for pyridine to act as an electrophile in a substantial manner. This study involved multiple reactions and reactants, such as 2,5-Dimethylthiophene (cas: 638-02-8Safety of 2,5-Dimethylthiophene).

2,5-Dimethylthiophene (cas: 638-02-8) belongs to benzothiophene derivatives. Benzothiophenes are valuable heterocycles that are widely used in medicines, agrochemicals, and materials science. It is found within the chemical structures of pharmaceutical drugs such as zileuton, raloxifene, and sertaconazole, and also BTCP.Safety of 2,5-Dimethylthiophene

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Synthesis and application of near-infrared dyes based on sulfur-substituted dicyanomethylene-4H-chromene and diarylethene was written by Wang, Yuesong;Yu, Haoli;Chen, Yan;Cui, Mengyuan;Ji, Min. And the article was included in New Journal of Chemistry in 2022.Safety of 2,5-Dimethylthiophene The following contents are mentioned in the article:

Four novel compounds (S-DCM-1O, S-DCM-2O, S-DCM-3O, and S-DCM-4O) based on sulfur-substituted dicyanomethylene-4H-chromene (S-DCM) and diarylethene were synthesized. The detailed investigations on the fluorescence spectra, absorption spectra, and time-dependent d. functional theory calculations (DFT/TD-DFT) were presented. The encapsulation of mPEG2000-DSPE effectively increased the solubility of all the as-prepared samples. The results of TEM showed that the nanoparticles had a good dispersion coefficient All the nanomaterials (S-DCM-1O@PEG, S-DCM-2O@PEG, S-DCM-3O@PEG, and S-DCM-4O@PEG) exhibited near-IR emission (650-900 nm) and thus reduced light damage and light scattering for cell imaging in biol. applications. Furthermore, PLL (poly-L-lysine hydrobromide) was used to modify the surface of nanoparticles to facilitate easy uptake by A549 cells by changing their electronegativity. The results suggested that S-DCM-2O@PEG@PLL was a highly suitable candidate for cell imaging because of its low toxicity and excellent biocompatibility. This study involved multiple reactions and reactants, such as 2,5-Dimethylthiophene (cas: 638-02-8Safety of 2,5-Dimethylthiophene).

2,5-Dimethylthiophene (cas: 638-02-8) belongs to benzothiophene derivatives. Benzothiophenes are valuable heterocycles that are widely used in medicines, agrochemicals, and materials science. It is also used in the manufacturing of dyes such as thioindigo.Safety of 2,5-Dimethylthiophene

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Desulfurization of hexyl sulfide and hexanethiol using supercritical water was written by Kang, Jimoon;Sim, Seungjae;Jung, Hyunwook;Han, Byungchan;Lee, Youn-Woo. And the article was included in Journal of Supercritical Fluids in 2020.Synthetic Route of C6H8S The following contents are mentioned in the article:

Desulfurization of hexyl sulfide and hexanethiol using supercritical water (SCW) was investigated by combining exptl. and computational methods to study the desulfurization of alkyl sulfides and thiols in SCW. Desulfurization was conducted for 0 ∼ 30 min at 400°C using thermal decomposition and SCW decomposition (24.7 ∼ 25.6 MPa), and the reaction pathways were built using the automated Reaction Mechanism Generator (RMG) and Gaussian 09. In thermal decomposition, C6-hydrocarbons (hexane, hexene) are main products, but in SCW, C5-hydrocarbon (pentane) in addition to C6-hydrocarbons are main products with higher alkane to alkene ratio. For the reaction pathways, in SCW, water participates as catalysts and reactants donating hydrogens with inhibited production of cyclic sulfides while in thermal decomposition, the hydrogen was deficient producing aromatic sulfur compounds such as thiophenes and alkyl-thiacycloalkanes. This study is expected to clarify the decomposition reactions of alkyl sulfides and alkyl thiols in SCW. This study involved multiple reactions and reactants, such as 2,5-Dimethylthiophene (cas: 638-02-8Synthetic Route of C6H8S).

2,5-Dimethylthiophene (cas: 638-02-8) belongs to benzothiophene derivatives. Benzothiophene is a fused ring compound of thiophene ring and benzene ring, which is an important class of heterocycles with advantageous structures. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization.Synthetic Route of C6H8S

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem