6314-28-9, Benzo[b]thiophene-2-carboxylic acid is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a dichloromethane solution of 1 ,1 -dimethylethyl {3-[(3-cyclohexyl-L- alanyl)amino]propyl}methylcarbamate (3.5 g, 10.26mmol) was added 1 -benzothiophene-2- carboxylic acid (2.192g g, 12.32 mmol), HOOBT (33 mg, 0.205 mmol), and NMM (3.38ml, 30.78mmol). The mixture was stirred several minutes whereupon EDCHCI (2.362 g, 12.32 mmol) was added. The reaction mixture was stirred overnight at RT. The solution was washed with 10% citric acid and brine, dried (MgSO4), filtered and concentrated to a solid. Purification by silica gel column chromatography (30%-90% ethyl acetate/hexane) gave the product as a white solid in 86% yield (4.4g): MS (m/z): 502(M+H).
The synthetic route of 6314-28-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; SMITHKLINE BEECHAM CORPORATION; WO2006/29210; (2006); A2;,
Benzothiophene – Wikipedia
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