Category: 55219-11-9

Facile Synthesis of Substituted 4-Alkoxy-2-oxazolines and Exploration of the Reaction Mechanism was written by Zhu, Jianming;Li, Xiaolong;Wang, Guimin;Li, Bo;Xu, Zhijian;Tian, Shikai;Hall, Adrian;Shen, Jingshan;Shi, Jiye;Zhu, Weiliang. And the article was included in Synthesis in 2016.Application In Synthesis of Benzo[b]thiophene-2-carbonitrile This article mentions the following:

Substituted 4-alkoxy-2-oxazolines, e.g., I [R = H, (2,3-MeO)₂, 4-F, etc.], have been synthesized via the reaction of nitriles with beta-hydroxyacetals promoted by trifluoromethanesulfonic acid. The reaction is proposed to be initiated by the protonation of the acetals to produce carbocations that are then attacked by nitrogen atom of the nitriles, followed by an intramol. cyclization reaction to form the 4-alkoxy-2-oxazolines. The proposed reaction mechanism has been validated by quantum chem. calculations, key intermediate synthesis, and NMR spectra. In the experiment, the researchers used many compounds, for example, Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9Application In Synthesis of Benzo[b]thiophene-2-carbonitrile).

Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9) belongs to benzothiophene derivatives. Benzothiophene finds use in research as a starting material for the synthesis of larger, usually bioactive structures. It is found within the chemical structures of pharmaceutical drugs such as zileuton, raloxifene, and sertaconazole, and also BTCP.Application In Synthesis of Benzo[b]thiophene-2-carbonitrile

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Simple one-pot conversion of alcohols into nitriles was written by Shimojo, Hiroyuki;Moriyama, Katsuhiko;Togo, Hideo. And the article was included in Synthesis in 2013.COA of Formula: C9H5NS This article mentions the following:

Various benzylic and primary alcs. were efficiently converted into the corresponding nitriles in good yields at room temperature by treatment with Me₃COCl, I₂, or 1,3-diiodo-5,5-dimethylhydantoin in the presence of TEMPO, followed by treatment with I₂ and aqueous NH₃. The nitriles were obtained in good yields and high purities simply by extraction of the reaction mixture with CHCl₃ and subsequent removal of the solvent. In the experiment, the researchers used many compounds, for example, Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9COA of Formula: C9H5NS).

Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9) belongs to benzothiophene derivatives. Benzothiophene is a fused ring compound of thiophene ring and benzene ring, which is an important class of heterocycles with advantageous structures. It is found within the chemical structures of pharmaceutical drugs such as zileuton, raloxifene, and sertaconazole, and also BTCP.COA of Formula: C9H5NS

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Cyanation of aromatic/vinylic boronic acids with α-cyanoacetates was written by Wang, Xian-Jin;Zhang, Song-Lin. And the article was included in New Journal of Chemistry in 2017.HPLC of Formula: 55219-11-9 This article mentions the following:

A friendly protocol was reported to achieve cyanation of aromatic and vinylic boronic acids using nontoxic and readily available α-cyanoacetates as a cyano source under aerobic conditions. Many aryl/vinyl boronic acids (as well as some iodides and bromides) were amenable substrates to give aryl nitriles ArCN [Ar = 4-MeOC₆H₄, 3-quinolinyl, 2-benzothienyl, etc.] and acrylonitriles I [R¹ = H, Ph; R² = Ph, 4-MeOC₆H₄, 4-BrC₆H₄; R³ = H, Ph]. This cyanation method provided a safe and operationally convenient alternative to traditional ones requiring toxic cyanide salts. In the experiment, the researchers used many compounds, for example, Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9HPLC of Formula: 55219-11-9).

Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The core structure is a part of various pharmaceutical substances and natural products. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization.HPLC of Formula: 55219-11-9

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Versatile and chemoselective transformation of aliphatic and aromatic secondary amides to nitriles was written by Geng, Hui;Huang, Pei-Qiang. And the article was included in Tetrahedron in 2015.Reference of 55219-11-9 This article mentions the following:

Triflic anhydride in combination with 2-fluoropyridine effectively dehydrates secondary amides to afford nitriles under mild reaction conditions. The reaction is general in scope and compatible with the use of aliphatic, α,β-unsaturated, aromatic and heteroaromatic amides bearing either secondary, tertiary, or benzylic N-alkyl groups. The reaction also shows good to excellent chemoselectivity for the secondary amide and tolerates several labile functional groups. Under optimized conditions the synthesis of the target compounds was achieved using amides as starting materials, such as N-(isopropyl)benzenebutanamide, N-(isopropyl)benzenepropanamide, adamantanecarboxamide derivatives, N-(tert-butyl)benzamide, 3-(phenyl)-2-propenamide derivatives (unsaturated amides), 1,3-benzodioxole-5-carboxamide, 2-thiophenecarboxamide (thiophene), benzo[b]thiophene-2-carboxamide derivatives, (aminocarbonyl)benzoic acid derivatives In the experiment, the researchers used many compounds, for example, Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9Reference of 55219-11-9).

Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9) belongs to benzothiophene derivatives. Benzothiophene is a fused ring compound of thiophene ring and benzene ring, which is an important class of heterocycles with advantageous structures. The different substitution patterns in these heterocycles offer new opportunities for drug discovery and other applications in materials science.Reference of 55219-11-9

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

One-Pot Transformation of Carboxylic Acids into Nitriles was written by Miyagi, Kotaro;Moriyama, Katsuhiko;Togo, Hideo. And the article was included in European Journal of Organic Chemistry in 2013.Quality Control of Benzo[b]thiophene-2-carbonitrile This article mentions the following:

A variety of aromatic and aliphatic carboxylic acids were smoothly converted into the corresponding nitriles in good yields in a one-pot procedure by treatment with Et iodide/K₂CO₃/18-crown-6, followed by sodium diisobutyl-tert-butoxyaluminum hydride (SDBBA-H), and finally treatment with mol. iodine or 1,3-diiodo-5,5-dimethylhydantoin (DIH), and aqueous ammonia. This method is useful for the conversion of various aromatic and aliphatic carboxylic acids into the corresponding nitriles in a one-pot procedure. In the experiment, the researchers used many compounds, for example, Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9Quality Control of Benzo[b]thiophene-2-carbonitrile).

Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9) belongs to benzothiophene derivatives. Benzothiophenes are valuable heterocycles that are widely used in medicines, agrochemicals, and materials science. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, sertaconazole, and also BTCP.Quality Control of Benzo[b]thiophene-2-carbonitrile

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

New catalytic properties of iron complexes. Dehydration of amides to nitriles was written by Zhou, Shaolin;Addis, Daniele;Das, Shoubhik;Junge, Kathrin;Beller, Matthias. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2009.Application In Synthesis of Benzo[b]thiophene-2-carbonitrile This article mentions the following:

Various iron carbonyl clusters such as Fe₂(CO)₉ or [Et₃NH][HFe₃(CO)₁₁] catalyzed the dehydration of amides into the corresponding nitriles in the presence of silanes in high yields. This novel protocol showed good functional group tolerance and wide substrate scope. In the experiment, the researchers used many compounds, for example, Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9Application In Synthesis of Benzo[b]thiophene-2-carbonitrile).

Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The core structure is a part of various pharmaceutical substances and natural products. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, and sertaconazole, and also BTCP.Application In Synthesis of Benzo[b]thiophene-2-carbonitrile

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Direct release of nitriles from solid phase was written by Hone, N. D.;Payne, L. J.;Tice, C. M.. And the article was included in Tetrahedron Letters in 2001.Product Details of 55219-11-9 This article mentions the following:

Cleavage conditions are described which allow resin-bound secondary amides to be liberated from Sieber or Rink resin as nitriles. The method was applied to the synthesis of a series of cyano biaryls. In the experiment, the researchers used many compounds, for example, Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9Product Details of 55219-11-9).

Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9) belongs to benzothiophene derivatives. Benzothiophenes are valuable heterocycles that are widely used in medicines, agrochemicals, and materials science. Due to its aromaticity, thiophenes do not exhibit the same properties as conventional thioethers.Product Details of 55219-11-9

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Chloro-oxime derivatives as novel small molecule chaperone amplifiers was written by Zhou, Yuefen;Vu, Khang;Chen, Yongsheng;Pham, John;Brady, Thomas;Liu, Gang;Chen, Jinhua;Nam, Joonwoo;Murali Mohan Reddy, P. S.;Au, Qingyan;Yoon, Il Sang;Tremblay, Marie-Helene;Yip, Gary;Cher, Charmian;Zhang, Bin;Barber, Jack R.;Ng, Shi Chung. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2009.SDS of cas: 55219-11-9 This article mentions the following:

Chloro-oxime derivatives were investigated as novel small mol. chaperone amplifiers. Lead optimization led to the discovery of compounds that displayed potent HSF1 activation activity, significant cytoprotection in MG-132 stress, ER stress and PolyQ stress cell models (EC₅₀ < 10 μM). In the experiment, the researchers used many compounds, for example, Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9SDS of cas: 55219-11-9).

Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The electrophilic substitution of benzothiophene systems is much less regioselective than that of indoles. It has been used as a raw material for the synthesis of biologically active structures and is found in pharmaceuticals such as leukotriene synthesis inhibitors and antifungals, as well as in many natural products.SDS of cas: 55219-11-9

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

A novel synthesis of benzo[b]thiophene was written by Liao, Zutai;Lv, Xuehao;Tao, Ming. And the article was included in Research on Chemical Intermediates in 2013.Reference of 55219-11-9 This article mentions the following:

A convenient method of preparation of benzo[b]thiophene by the using 2-chlorobenzaldehyde and 2-mercaptoacetonitrile as starting materials was reported. The process comprises two steps, neither of which was reported previously. The reactions in this work are clean and efficient. In the experiment, the researchers used many compounds, for example, Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9Reference of 55219-11-9).

Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The core structure is a part of various pharmaceutical substances and natural products. Due to its aromaticity, thiophenes do not exhibit the same properties as conventional thioethers.Reference of 55219-11-9

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

A highly efficient one-pot reaction of 2-(gem-dibromovinyl)phenols(thiophenols) with K₄Fe(CN)₆ to 2-cyanobenzofurans(thiophenes) was written by Zhou, Wei;Chen, Wei;Wang, Lei. And the article was included in Organic & Biomolecular Chemistry in 2012.HPLC of Formula: 55219-11-9 This article mentions the following:

2-Cyanobenzofurans and 2-cyanobenzothiophenes I [R = H, 5-Me, 5-tBu, etc.; X = O, S] were prepared through an efficient one-pot Ullmann-reaction/cyanation reaction. In the presence of CuI/Na₂CO₃-Pd(OAc)₂/PPh₃ in DMF, the reaction of 2-(gem-dibromovinyl)phenols and 2-(gem-dibromovinyl)thiophenols with K₄Fe(CN)₆, as nontoxic and user-friendly cyanating reagent, proceeded smoothly to generate the corresponding 2-cyanobenzofurans and 2-cyanobenzothiophenes in good yields. In the experiment, the researchers used many compounds, for example, Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9HPLC of Formula: 55219-11-9).

Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9) belongs to benzothiophene derivatives. Benzothiophene finds use in research as a starting material for the synthesis of larger, usually bioactive structures. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, and sertaconazole, and also BTCP.HPLC of Formula: 55219-11-9

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem