Category: 5381-20-4

5381-20-4, Thianaphthene-3-carboxaldehyde is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

[0593j To a solution of 7-C (250 mg, 0.94 mmol) in anhydrous EtOH (6 mL) and AcOH (0.2 mL) was added benzo[b]thiophene-3-carboxaldehyde (151 mg, 0.94 mmol). The solution was stirred at 70C for 10 h and then cooled to rt. A precipitate was formed and was collected by filtration. The solid was washed with EA and EtOH to afford compound 700 (50 mg, 10 %). ESI-LCMS: mlz 412 [M+H].

5381-20-4, The synthetic route of 5381-20-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ALIOS BIOPHARMA, INC.; WANG, Guangyi; BEIGELMAN, Leonid; TRUONG, Anh; NAPOLITANO, Carmela; ANDREOTTI, Daniele; HE, Haiying; WO2014/31784; (2014); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5381-20-4,Thianaphthene-3-carboxaldehyde,as a common compound, the synthetic route is as follows.

5381-20-4, General procedure: The reaction was performed in a 20 mL V-type tube equipment with a triangle magnetic stirring bar. In a typical reaction, 4-hydroxyindole (0.4 mmol) was mixed with malonodinitrile (0.4 mmol) and aldehydes (0.4 mmol) in 2.0 mL of ethanol. KF (0.08 mmol) was then added. The mixture was subsequently heated to 60 C under stirring for 6 h. After the reaction, the mixture was cooled to room temperature, and the target product was isolated using a preparative thin-layer chromatograph (TLC) with eluting solution [petroleum ether/ethyl acetate 3/1 (v/v)].

5381-20-4 Thianaphthene-3-carboxaldehyde 227328, abenzothiophene compound, is more and more widely used in various fields.

Reference£º
Article; Bai, Rongxian; Yang, Jian; Min, Lijun; Liu, Changhui; Wu, Fengtian; Gu, Yanlong; Tetrahedron; vol. 72; 17; (2016); p. 2170 – 2177;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

5381-20-4, Thianaphthene-3-carboxaldehyde is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5381-20-4, Tetrolic acid (42 mg, 0.5 mmol) was dissolved in methanol (2 mL) followed by addition of 2-iodo-4,5-dimethoxyphenethylamine (154 mg, 0.5 mmol), benzothiophene-3-carbaldehyde (81 mg, 0.5 mmol) and tert-butyl isocianide (42 mg, 0.5 mmol). The reaction mixture was stirred at rt for 48 h in a sealed screw cap vial. The resulting mixture was concentrated and subjected to the column chromatography on silicagel with hepthane-EtOAc (15-25%) as eluent to give the desired propargylamide 7i?. Mixture of rotamers ?9:1.17 Yield: 142 mg, 46%. 1H NMR (300 MHz, CDCl3): delta 8.02 (s, 0.9H), 7.93-7.82 (m, 1H), 7.80-7.62 (m, 1.1H), 7.46-7.31 (m, 2H), 7.03 (s, 0.9H), 6.91 (s, 0.1H), 6.42 (s, 0.1H), 6.38 (s, 0.9H), 6.31 (s, 0.1H), 6.23 (s, 0.9H), 6.06 (br s, 0.9H), 5.65 (br s, 0.1H), 3.92-3.49 (m, 7.9H), 3.45-3.28 (m, 0.1H), 2.90-2.65 (m, 1H), 2.29-2.08 (m, 1.3H), 2.03 (s, 2.7H), 1.41 (s, 0.9H), 1.38 (s, 8.1H); 13C NMR (75 MHz, CDCl3, major rotamer): delta 168.0, 155.8, 149.3, 148.0, 139.6, 138.5, 134.2, 129.3, 128.1, 125.2, 125.0, 123.0, 121.6, 121.4, 112.7, 90.3, 87.3, 73.7, 56.1, 56.0, 54.6, 51.8, 46.9, 40.3, 28.6, 5.0; HRMS (EI, [M]+) for C28H31IN2O4S calcd 618.1049, found 618.1040.

As the paragraph descriping shows that 5381-20-4 is playing an increasingly important role.

Reference£º
Article; Peshkov, Anatoly A.; Peshkov, Vsevolod A.; Pereshivko, Olga P.; Van Der Eycken, Erik V.; Tetrahedron; vol. 71; 23; (2015); p. 3863 – 3871;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

5381-20-4, Thianaphthene-3-carboxaldehyde is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,5381-20-4

General procedure: An aqueous solution of NaOH (3M, 1.6mL) was added to a solution of aromatic ketone (1mmol) and 3-methoxybenzaldehyde (1.2 eq), in EtOH (1-2mL). The reaction was stirred at r.t for 18-24h. The reaction mixture was cooled in an ice-water bath and acidified to pH 2 with concentrated HCl (37%). The solid formed was filtered, washed with ethanol and then further purified by recrystallization from ethanol. When no precipitate occurred, the reaction mixture was extracted with dichloromethane and washed with water and brine. The organic layer was dried over Na2SO4 and concentrated under reduced pressure. Column chromatography was then utilized to purify the desired product.

As the paragraph descriping shows that 5381-20-4 is playing an increasingly important role.

Reference£º
Article; Borsari, Chiara; Jimenez-Anton, Maria Dolores; Eick, Julia; Bifeld, Eugenia; Torrado, Juan Jose; Olias-Molero, Ana Isabel; Corral, Maria Jesus; Santarem, Nuno; Baptista, Catarina; Severi, Leda; Gul, Sheraz; Wolf, Markus; Kuzikov, Maria; Ellinger, Bernhard; Reinshagen, Jeanette; Witt, Gesa; Linciano, Pasquale; Tait, Annalisa; Costantino, Luca; Luciani, Rosaria; Tejera Nevado, Paloma; Zander-Dinse, Dorothea; Franco, Caio H.; Ferrari, Stefania; Moraes, Carolina B.; Cordeiro-da-Silva, Anabela; Ponterini, Glauco; Clos, Joachim; Alunda, Jose Maria; Costi, Maria Paola; European Journal of Medicinal Chemistry; vol. 183; (2019);,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5381-20-4,Thianaphthene-3-carboxaldehyde,as a common compound, the synthetic route is as follows.

5381-20-4, The intermediate 1- (3,4,5-trimethoxyphenyl) propan-1-one (448 mg, 2 mmol) and benzo [b] thiophene-3-carboxaldehyde (162.2 mg, 1 mmol) were dissolved in ethanol (8 mL ) solution,Stir at room temperature for 30min,Then add sodium hydroxide (3mL) until the reaction is complete, extract with CH2Cl2, wash with saturated sodium chloride solution, dry over anhydrous sodium sulfate, filter, spin dry the organic phase,The remaining crude product was recrystallized from ethanol to obtain the target compound (E)-3-(benzo[b]thiophen-3-yl)-2-methyl-1-(3,4,5-trimethoxyphenyl)prop-2-en-1-one 206.1 mg, 56% yield.

The synthetic route of 5381-20-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Ningxia Medical University; Zhuang Chunlin; Shi Ying; Cong Hui; Zhang Wannian; Huang Jiaxuan; Yu Jianqiang; Xu Lijuan; Qu Zhuo; (21 pag.)CN110526854; (2019); A;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

5381-20-4,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5381-20-4,Thianaphthene-3-carboxaldehyde,as a common compound, the synthetic route is as follows.

General procedure: An aqueous solution of NaOH (3M, 1.6mL) was added to a solution of aromatic ketone (1mmol) and 3-methoxybenzaldehyde (1.2 eq), in EtOH (1-2mL). The reaction was stirred at r.t for 18-24h. The reaction mixture was cooled in an ice-water bath and acidified to pH 2 with concentrated HCl (37%). The solid formed was filtered, washed with ethanol and then further purified by recrystallization from ethanol. When no precipitate occurred, the reaction mixture was extracted with dichloromethane and washed with water and brine. The organic layer was dried over Na2SO4 and concentrated under reduced pressure. Column chromatography was then utilized to purify the desired product.

The synthetic route of 5381-20-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Borsari, Chiara; Jimenez-Anton, Maria Dolores; Eick, Julia; Bifeld, Eugenia; Torrado, Juan Jose; Olias-Molero, Ana Isabel; Corral, Maria Jesus; Santarem, Nuno; Baptista, Catarina; Severi, Leda; Gul, Sheraz; Wolf, Markus; Kuzikov, Maria; Ellinger, Bernhard; Reinshagen, Jeanette; Witt, Gesa; Linciano, Pasquale; Tait, Annalisa; Costantino, Luca; Luciani, Rosaria; Tejera Nevado, Paloma; Zander-Dinse, Dorothea; Franco, Caio H.; Ferrari, Stefania; Moraes, Carolina B.; Cordeiro-da-Silva, Anabela; Ponterini, Glauco; Clos, Joachim; Alunda, Jose Maria; Costi, Maria Paola; European Journal of Medicinal Chemistry; vol. 183; (2019);,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

5381-20-4,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5381-20-4,Thianaphthene-3-carboxaldehyde,as a common compound, the synthetic route is as follows.

General procedure: Aldehyde 1a (1.0 equiv, 0.5 mmol, 91.1 mg), potassium salt 2 (PhSO2CF2CO2K) (1.5 equiv, 0.75 mmol, 205.7 mg) and anhydrous acetonitrile (5.0 mL) were added into a 10 mL sealed tube under a N2 atmosphere. The resulting mixture was stirred at 50 C for 7 h, and was then stirred at 80 C for 3 h. The solvent was removed by concentration under reduced pressure. The residue was subjected to flash column chromatography to afford the pure product 4a

The synthetic route of 5381-20-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Chen, Jia; Lin, Jin-Hong; Xiao, Ji-Chang; Tetrahedron; vol. 74; 32; (2018); p. 4295 – 4297;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

5381-20-4, Thianaphthene-3-carboxaldehyde is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Benzo[b]thiophene-3-carbaldehyde (40 mg, 0.25 mmol, 1.0 equiv),Pd(TFA) 2 (4.2 mg, 5 mol%), (4-FC 6 H 4 ) 3 P (9.5 mg, 12 mol%), DPEphos (8mg, 6 mol%), and Cs 2 CO 3 (122 mg, 0.375 mmol) were placed in atransparent Schlenk tube equipped with a stirring bar. The tube wasevacuated and filled with argon for three times. Degassed DMF (2.5mL) and tert-butyl bromide (51 mg, 0.375 mmol, 1.5 equiv) were add-ed via a gastight syringe. The reaction mixture was stirred under theirradiation of 36 W blue LEDs (distance app. 2.0-3.0 cm from thebulb) at r.t. for 24 h. The mixture was quenched with brine and ex-tracted with EtOAc (3 ¡Á 10 mL). The organic layers were combinedand concentrated under reduced pressure. The product was purifiedby flash column chromatography on silica gel using PE or a mixture of PEand EtOAc (10:1 v/v) as eluent; yield: 50.1 mg (92%); pale yellow liquid., 5381-20-4

5381-20-4 Thianaphthene-3-carboxaldehyde 227328, abenzothiophene compound, is more and more widely used in various fields.

Reference£º
Article; Wang, Guang-Zu; Shang, Rui; Fu, Yao; Synthesis; vol. 50; 15; (2018); p. 2908 – 2914;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

5381-20-4, Thianaphthene-3-carboxaldehyde is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Compound 43 (1.62 g, 10 mmol) was weighed.N-bromosuccinimide (1.78 g, 10 mmol) was added to a three-necked flask and 20 mL of carbon tetrachloride was added.Irradiate with a 200w incandescent bulb and react at room temperature for 2 hours. Filter out the white solid,Concentrate the liquid. 2.2 g (92%) of a colorless transparent liquid were obtained., 5381-20-4

5381-20-4 Thianaphthene-3-carboxaldehyde 227328, abenzothiophene compound, is more and more widely used in various fields.

Reference£º
Patent; Shanghai Yilishe Biological Co., Ltd.; Zhang Lihai; Gao Zhichao; Huang Ximing; Liu Hui; Hu Min; Jiang Yan; (72 pag.)CN108250058; (2018); A;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

5381-20-4, Thianaphthene-3-carboxaldehyde is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5381-20-4, Compound 1 (200.0 mg, 0.46 mmol) and thianaphthene-3-carboxaldehyde(186.5 mg, 1.14 mmol) were dissolved in benzene (40 mL).Acetic acid (400 muL) and piperidine (400 muL) were added. The reactionmixture was refluxed using Dean-Stark apparatus until compound 1 wasconsumed. After the reaction was completed, it was extracted withCH2Cl2 and water. The organic layer was collected and dried with sodiumsulfate, evaporated under reduced pressure. The product waspurified by silica gel column chromatography using n-hexane-CH2Cl2(1:2) as mobile phase. Fractions containing compound 3 were collected,then the solvent was removed under reduced pressure (90.0 mg, 27%).MALDI TOF (m/z) Calc. 725.23, Found: 725.84 [M+]. 1H NMR(500 MHz, CDCl3) deltaH 8.09 (d, J=7.9 Hz, 2H, Ar-CH), 7.91 (d,J=7.9 Hz, 2H, Ar-CH), 7.88 (s, 2H, S-CH), 7.87 (d, J=16.2 Hz, 2H,trans-CH), 7.56 (d, J=16.2 Hz, 2H, trans-CH), 7.50 (t, J=7.4 Hz 2H,Ar-CH), 7.43 (t, J=7.4 Hz 2H, Ar-CH), 7.22 (d, J=8.2 Hz, 2H, Ar-CH), 7.03 (d, J=8.2 Hz, 2H, Ar-CH), 6.73 (s, 2H, Ar-CH), 4.07 (t,J=5.6 Hz 2H, OCH2), 3.41 (t, J=6.5 Hz, 2H, N3CH2), 1.9-1.8 (m, 4H,CH2CH2), 1.55 (s, 6H, Ar- CH3), ppm.13C NMR (126 MHz, CDCl3) deltaC159.5, 152.4,142.2, 140.5, 138.9, 137.4, 133.9, 133.7, 129.7, 127.3,127.2, 125.2, 124.8, 124.7, 122.9, 121.9, 120.3, 117.6, 114.9, 67.3,51.2, 26.5, 25.8, 14.9 ppm.

The synthetic route of 5381-20-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Tanr?verdi Ecik, Esra; ?enkuytu, Elif; Okutan, Elif; Yenilmez Ciftci, Goenuel; Inorganica Chimica Acta; vol. 495; (2019);,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem