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Amine-borane complexes: Air- and moisture-stable partners for palladium-catalyzed borylation of aryl bromides and chlorides

A method for using amine-borane complexes directly in palladium catalyzed borylation has been developed. The reaction proceeds through the sequential formation of a boronium species followed by deprotonation leading to the aminoborane. This reagent is then directly used in the borylation process leading, after work-up, to various boronic acid derivatives. The reaction was applied to (hetero)aryl triflates, iodides, bromides and chlorides.

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Reference£º
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

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Ni-Catalyzed Reductive Cyanation of Aryl Halides and Phenol Derivatives via Transnitrilation

Herein, we report a Ni-catalyzed reductive coupling for the synthesis of benzonitriles from aryl (pseudo)halides and an electrophilic cyanating reagent, 2-methyl-2-phenyl malononitrile (MPMN). MPMN is a bench-stable, carbon-bound electrophilic CN reagent that does not release cyanide under the reaction conditions. A variety of medicinally relevant benzonitriles can be made in good yields. Addition of NaBr to the reaction mixture allows for the use of more challenging aryl electrophiles such as aryl chlorides, tosylates, and triflates. Mechanistic investigations suggest that NaBr plays a role in facilitating oxidative addition with these substrates.

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Reference£º
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

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4923-87-9, In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 4923-87-9, name is 5-Bromobenzothiophene, introducing its new discovery.

HETERO-CYCLIC COMPOUND AND ORGANIC LIGHT EMITTING DEVICE USING THE SAME

The organic application of prolonging the life, efficiency, markedly improves the electrochemical stability and thermal stability can be heterocyclic compound, and said heterocyclic compound contained in the organic compound layer organic light emitting device number under public affairs substrate. (by machine translation)

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Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

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4923-87-9, In heterogeneous catalysis, the catalyst is in a different phase from the reactants. At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 4923-87-9, name is 5-Bromobenzothiophene. In an article£¬Which mentioned a new discovery about 4923-87-9

Palladacycle-catalyzed phosphonation of aryl halides in neat water

An efficient and generally applicable protocol for the palladacycle- catalyzed arylation of diisopropyl H-phosphonate in water was developed. The remarkable features of this C-P bond-forming reaction include wide substrate scope including the inactive electron-rich and electron-neutral aryl chlorides, the weak inorganic base KF instead of strong bases such as KOtBu or NaOtBu for the activation of C-Cl bond, and the addition of isopropanol to avoid the decomposition of diisopropyl H-phosphonate.

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Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

Discovery of 5-Bromobenzothiophene

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4923-87-9, In an article, published in an article,authors is Cai, Xiao, once mentioned the application of 4923-87-9, Name is 5-Bromobenzothiophene,molecular formula is C8H5BrS, is a conventional compound. this article was the specific content is as follows.

Br¡ãnsted Acid-Catalyzed Intramolecular Hydroarylation of beta-Benzylstyrenes

Using triphenylmethylium tetrakis(pentafluorophenyl)borate as a convenient Br¡ãnsted acid precatalyst, beta-(alpha,alpha-dimethylbenzyl)styrenes are shown to cyclize efficiently to afford a variety of new indanes that possess a benzylic quaternary center. The geminal dimethyl-containing quaternary center is proposed to be necessary to arm the substrate for cyclization through steric biasing.

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Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

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Parallel Approaches for the Functionalization of Thietes: alpha-Metalation versus C-H Activation

For the first time, an approach to 3,4-disubstituted thietes was developed through two complementary paths. While the first one relies on alpha-metalation, the second is based on direct C-H functionalization. A new library of sophisticated sulfur-containing four-membered rings is described, paving the way to new bioactive analogues and small heterocycle incorporation.

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Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

Discovery of 5-Bromobenzothiophene

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Metal-Free, Oxidant-Free, and Controllable Graphene Oxide Catalyzed Direct Iodination of Arenes and Ketones

A direct, metal-free, and oxidant-free method for the graphene oxide (GO)-catalyzed iodination of arenes and ketones with iodine in a neutral medium was explored. This iodination protocol was performed by using a simple technique to avoid the use of external metal catalysts and oxidants and harsh acidic/basic reaction conditions. In addition, by this method the degree of iodination could be controlled, and the reaction was scalable and compatible with air. This strategy opens a new field for GO-catalyzed chemistry and provides an avenue for the convenient direct iodination of arenes and ketones.

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Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

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Use of Benzo-Heteroaryl Sulfamide Derivatives for the Treatment of Depression

The present invention is a method for the treatment of depression comprising administering to a subject in need thereof a therapeutically effective amount of one or more novel benzo-heteroaryl sulfamide derivatives of formula (I) as herein defined. The present invention is directed to a method for the treatment of depression, which includes mono-therapy and alternatively, co-therapy with at least one antidepressant.

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Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

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Elevated intraocular pressure lowering benzo-[b]-thiophene-2-sulfonamide derivatives, compositions, and method of use therefor

Novel 2-sulfamoylbenzo[b]thiophenes and derivatives thereof are shown to be useful for the treatment of elevated intraocular pressure in compositions including ophthalmic drops and inserts.

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Reference£º
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

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Synthesis of Substituted Benzothiophenes by Acid-Catalyzed Cyclization of Thiophenylacetals and Ketones

Benzothiophenes substituted at the 3 position with methyl or carboxymethyl and at the 5 position with methyl, methoxy, chloro, bromo and nitro were prepared by cyclization of thiophenyl-acetals and ketones using a suspension of polyphosphoric acid in refluxing chlorobenzene.The overall efficiency of this method is superior to literature procedures because of the lower temperature and the limited amount of PPA used.

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Reference£º
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem