Category: 4298-52-6

Bimetallic CoNi Nanoflowers for Catalytic Transfer Hydrogenation of Terminal Alkynes was written by Choudhary, Neha;Kumar, Viresh;Mobin, Shaikh M.. And the article was included in ChemistrySelect in 2022.Product Details of 4298-52-6 This article mentions the following:

The development of bimetallic and magnetic nanomaterials as a catalyst is highly desirable for organic transformations due to their recyclability for the sustainable future of chem. industries. Bimetallic CoNi nanoflowers were developed via the facile liquid-phase reduction method and were employed for the hydrogenation of terminal alkynes. The structural and morphol. studies were analyzed by X-ray diffraction, Field-Emission SEM, and High Resolution Transmission Electron Microscopy. The bimetallic CoNi nanoflower exhibited 100% conversion with ∼100% selectivity towards alkane products with recyclability up to six cycles. The transfer hydrogenation mechanism was proposed via diimide formation with Co(0)/Ni(0) state, confirmed by X-ray Photoemission Spectroscopy anal. In the experiment, the researchers used many compounds, for example, 2-Ethynylthiophene (cas: 4298-52-6Product Details of 4298-52-6).

2-Ethynylthiophene (cas: 4298-52-6) belongs to benzothiophene derivatives. Benzothiophene is a fused ring compound of thiophene ring and benzene ring, which is an important class of heterocycles with advantageous structures. It has been used as a raw material for the synthesis of biologically active structures and is found in pharmaceuticals such as leukotriene synthesis inhibitors and antifungals, as well as in many natural products.Product Details of 4298-52-6

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Catalytic activity and mechanistic investigation of 1D 2-picolinic acid based Cu(II) coordination polymer in the selective construction of 1,4-disubstituted triazoles was written by Aier, Merangmenla;Gayen, Firdaus Rahaman;Puzari, Amrit. And the article was included in Scientific Reports in 2022.COA of Formula: C6H4S This article mentions the following:

The catalytic activity of 1D 2-picolinic acid based Cu(II) coordination polymer (CP1) in click reaction to selectively generate 1,4-disubstituted 1,2,3-triazoles has been evaluated. The CP1 catalyst loading of 2 mol% was applied successfully in the reactions of primary azides with diverse terminal alkynes in green solvent (aqueous ethylene glycol). Moreover, the one-pot, multicomponent click reaction involving benzyl bromide, sodium azide, and phenylacetylene was also catalyzed by CP1. The findings show that 2-picolinic acid based Cu(II) coordination polymer catalytic systems are highly efficient for green click triazoles synthesis. DFT calculation supported the plausible mechanism involved in the CP1 catalyzed click reaction. In the experiment, the researchers used many compounds, for example, 2-Ethynylthiophene (cas: 4298-52-6COA of Formula: C6H4S).

2-Ethynylthiophene (cas: 4298-52-6) belongs to benzothiophene derivatives. Benzothiophenes are valuable heterocycles that are widely used in medicines, agrochemicals, and materials science. Due to its aromaticity, thiophenes do not exhibit the same properties as conventional thioethers.COA of Formula: C6H4S

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Palladium-Catalyzed Alkynylation of Enones with Alkynylsilanes via C-C Bond Activation was written by Liu, Yu-Wen;Li, Ling-Jun;Xu, Hui;Dai, Hui-Xiong. And the article was included in Journal of Organic Chemistry in 2022.SDS of cas: 4298-52-6 This article mentions the following:

The synthesis of 1,3-enynes via palladium-catalyzed cross coupling between enone derivatives and alkynylsilanes was reported. The employment of appropriate pyridine-oxazoline ligand is the key to the C-C cleavage and the high E/Z stereoselectivity. This protocol features broad substrate scope and wide functional-group tolerance, affording the desired products in moderate-to-good yields. Late-stage diversification of natural product β-ionone further demonstrated the synthetic utility of this protocol. In the experiment, the researchers used many compounds, for example, 2-Ethynylthiophene (cas: 4298-52-6SDS of cas: 4298-52-6).

2-Ethynylthiophene (cas: 4298-52-6) belongs to benzothiophene derivatives. Benzothiophene scaffolds are of great importance due to its increased presence in bioactive molecules. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, sertaconazole, and also BTCP.SDS of cas: 4298-52-6

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Cu-Catalyzed asymmetric addition of alcohols to β,γ-alkynyl-α-imino esters for the construction of linear chiral N,O-ketals was written by Sheng, Cheng;Ling, Zheng;Luo, Yicong;Zhang, Wanbin. And the article was included in Nature Communications in 2022.Quality Control of 2-Ethynylthiophene This article mentions the following:

Herein, a Cu-catalyzed asym. addition of alcs. to β,γ-alkynyl-α-imino esters was developed under mild conditions, providing the corresponding linear chiral N,O-ketals I [R¹ = n-Bu, Ph, 2-thienyl, etc.; R² = Me, Et, n-Pr, n-Bu; R³ = Me, Et, cyclobutyl, Bn, etc.] with up to 96% ee. The method tolerated some variation in the β,γ-alkynyl-α-imino esters and alc. scope, including some glucose and natural amino acid derivatives Computational results indicated that the Boc group of the substrates assist in the extraction of hydrogen atoms from the alcs. to promote the addition reactions. These products could be synthesized on a gram-scale and can be used in several transformations. This asym. addition system provided an efficient, mild, gram-scale, and transition-metal-catalyzed synthesis of linear chiral N,O-ketals. In the experiment, the researchers used many compounds, for example, 2-Ethynylthiophene (cas: 4298-52-6Quality Control of 2-Ethynylthiophene).

2-Ethynylthiophene (cas: 4298-52-6) belongs to benzothiophene derivatives. Benzothiophene is a fused ring compound of thiophene ring and benzene ring, which is an important class of heterocycles with advantageous structures. It is found within the chemical structures of pharmaceutical drugs such as zileuton, raloxifene, and sertaconazole, and also BTCP.Quality Control of 2-Ethynylthiophene

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

A₃ adenosine receptor agonists containing dopamine moieties for enhanced inter-species affinity was written by Tosh, Dilip K.;Salmaso, Veronica;Campbell, Ryan G.;Rao, Harsha;Bitant, Amelia;Pottie, Eline;Stove, Christophe P.;Liu, Naili;Gavrilova, Oksana;Gao, Zhan-Guo;Auchampach, John A.;Jacobson, Kenneth A.. And the article was included in European Journal of Medicinal Chemistry in 2022.Name: 2-Ethynylthiophene This article mentions the following:

Following our study of 4′-truncated (N)-methanocarba-adenosine derivatives that displayed unusually high mouse (m) A₃AR affinity, we incorporated dopamine-related N⁶ substituents in the full agonist 5′-methylamide series. N⁶-(2-(4-Hydroxy-3-methoxy-phenyl)ethyl) derivative MRS7618 I displayed K_i (nM) 0.563 at hA₃AR (∼20,000-fold selective) and 1.54 at mA₃AR. 2-Alkyl ethers maintained A₃ affinity, but with less selectivity than 2-alkynes. Parallel functional assays of G protein-dependent and β-arrestin 2 (βarr2)-dependent pathways indicate these are full agonists but not biased. Through use of computational modeling, we hypothesized that Ph OH/OMe groups interact with polar residues, particularly Gln261, on the mA₃AR extracellular loops as the basis for the affinity enhancement. Although the pharmacokinetic indicated facile clearance of parent O-Me catechol nucleosides, prolonged mA₃AR activation in vivo was observed in a hypothermia model, suggested potential formation of active metabolites through demethylation. Selected analogs induced mouse hypothermia following i.p. injection, indicative of peripheral A₃AR agonism in vivo. In the experiment, the researchers used many compounds, for example, 2-Ethynylthiophene (cas: 4298-52-6Name: 2-Ethynylthiophene).

2-Ethynylthiophene (cas: 4298-52-6) belongs to benzothiophene derivatives. Benzothiophene scaffolds are of great importance due to its increased presence in bioactive molecules. It has been used as a raw material for the synthesis of biologically active structures and is found in pharmaceuticals such as leukotriene synthesis inhibitors and antifungals, as well as in many natural products.Name: 2-Ethynylthiophene

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Searching for highly active cobalt catalysts bearing Schiff base ligands for Markovnikov-selective hydrosilylation of alkynes with tertiary silanes was written by Skrodzki, Maciej;Ortega Garrido, Victor;Csaky, Aurelio G.;Pawluc, Piotr. And the article was included in Journal of Catalysis in 2022.Recommanded Product: 2-Ethynylthiophene This article mentions the following:

The search for simple and easy-to-synthesize ligands for bench stable cobalt (pre)catalysts that would ensure high activity and selectivity in alkyne hydrosilylation reactions is an interesting current challenge. Herein, we report that a cobalt(II) complex bearing pyrimidine-imine-2H-imidazole ligand activated by LiHBEt₃ exhibits not only high catalytic activity, but also unprecedented tolerance towards tertiary silanes in highly regioselective Markovnikov hydrosilylation of aliphatic and aromatic terminal alkynes to give α-vinylsilanes. In addition, a variety of 1-aryl-2-(trimethylsilyl)acetylenes have been hydrosilylated efficiently by diphenylsilane in the presence of [Co(L)Cl₂]/LiHBEt₃ catalytic system to yield (E)-1-aryl-1,2-bis(silyl)ethenes with high selectivity. Such selectivity is very rarely observed for cobalt-catalyzed hydrosilylation of silylacetylenes. In the experiment, the researchers used many compounds, for example, 2-Ethynylthiophene (cas: 4298-52-6Recommanded Product: 2-Ethynylthiophene).

2-Ethynylthiophene (cas: 4298-52-6) belongs to benzothiophene derivatives. Benzothiophene is a fused ring compound of thiophene ring and benzene ring, which is an important class of heterocycles with advantageous structures. Due to its aromaticity, thiophenes do not exhibit the same properties as conventional thioethers.Recommanded Product: 2-Ethynylthiophene

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Synthesis of Cyclopentene Derivatives via Electrochemically Induced Intermolecular Selective (3+2) Annulation was written by Guan, Zhipeng;Zhu, Shuxiang;Ye, Yayu;Li, Xiangwei;Liu, Yanlong;Wang, Pengjie;Zhang, Heng;Huang, Zhiliang;Lei, Aiwen. And the article was included in Angewandte Chemie, International Edition in 2022.Product Details of 4298-52-6 This article mentions the following:

An electrochem. mediator-induced intermol. selective (3+2) annulation of readily available alkenes and alkynes/alkenes, which provided a simple and efficient method for the synthesis of a library of decorated cyclopentenes and cyclopentanes was developed. This protocol features high efficiency, mild reaction conditions, broad substrate scope, good functional group tolerance and high regioselectivity. Potential applications was demonstrated by gram-scale synthesis as well as the construction of structural diversity and complexity. A preliminary mechanistic investigation was performed, which indicated that an iodine radical and carbon radicals are involved in this transformation. In the experiment, the researchers used many compounds, for example, 2-Ethynylthiophene (cas: 4298-52-6Product Details of 4298-52-6).

2-Ethynylthiophene (cas: 4298-52-6) belongs to benzothiophene derivatives. Benzothiophene is a fused ring compound of thiophene ring and benzene ring, which is an important class of heterocycles with advantageous structures. Due to its aromaticity, thiophenes do not exhibit the same properties as conventional thioethers.Product Details of 4298-52-6

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Triazole-substituted phenylboronic acids as tunable lead inhibitors of KPC-2 antibiotic resistance was written by Zhou, Jingyuan;Stapleton, Paul;Xavier-Junior, Francisco Humberto;Schatzlein, Andreas;Haider, Shozeb;Healy, Jess;Wells, Geoffrey. And the article was included in European Journal of Medicinal Chemistry in 2022.Related Products of 4298-52-6 This article mentions the following:

Inhibition of β-lactamases is a promising strategy to overcome antimicrobial resistance to commonly used β-lactam antibiotics. Boronic acid derivatives have proven to be effective inhibitors of β-lactamases due to their direct interaction with the catalytic site of these enzymes. We synthesized a series of phenylboronic acid derivatives and evaluated their structure-activity relationships as Klebsiella pneumoniae carbapenemase (KPC-2) inhibitors. We identified potent KPC-2 inhibitors 2e & 6c (Ki = 0.032 μM and 0.038 μM, resp.) that enhance the activity of cefotaxime in KPC-2 expressing Escherichia coli. The measured acid dissociation constants (pKa) of selected triazole-containing phenylboronic acids was broad (5.98-10.0), suggesting that this is an addnl. property of the compounds that could be tuned to optimize the target interaction and/or the physicochem. properties of the compounds These findings will help to guide the future development of boronic acid compounds as inhibitors of KPC-2 and other target proteins. In the experiment, the researchers used many compounds, for example, 2-Ethynylthiophene (cas: 4298-52-6Related Products of 4298-52-6).

2-Ethynylthiophene (cas: 4298-52-6) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The electrophilic substitution of benzothiophene systems is much less regioselective than that of indoles. It is also used in the manufacturing of dyes such as thioindigo.Related Products of 4298-52-6

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Synthesis of Pyrrolo[2,1-a]isoquinolines through Cu-Catalyzed Condensation/Addition/Oxidation/Cyclization Cascade was written by Cui, Hai-Lei;Chen, Xiao-Hui. And the article was included in Journal of Organic Chemistry in 2022.COA of Formula: C6H4S This article mentions the following:

A copper-catalyzed synthesis of pyrrolo[2,1-a]isoquinolines I [R¹ = H, 6-Br, 8-OMe, etc.; R² = Ph, 4-O₂NC₆H₄, 4-ClC₆H₄, etc.; R³ = Ph, 4-EtC₆H₄, 4-FC₆H₄, etc.] via Cu-catalyzed cascade condensation/addition/oxidation/cyclization of terminal alkynes, aldehydes and tetrahydroisoquinolines. A variety of pyrrolo[2,1-a]isoquinolines I were prepared in 17-69% yield. Modifications through simple chem. transformations provided highly functionalized mols. containing a privileged framework. In the experiment, the researchers used many compounds, for example, 2-Ethynylthiophene (cas: 4298-52-6COA of Formula: C6H4S).

2-Ethynylthiophene (cas: 4298-52-6) belongs to benzothiophene derivatives. Functionalized benzothiophenes are important constructs found in molecules with wide ranging biological activity and in organic materials. It is found within the chemical structures of pharmaceutical drugs such as zileuton, raloxifene, and sertaconazole, and also BTCP.COA of Formula: C6H4S

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem