Category: 3541-37-5

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3541-37-5,Benzo[b]thiophene-2-carboxaldehyde,as a common compound, the synthetic route is as follows.

General procedure: A mixture of appropriate piperazine base (i-vi, 1 mmol), aldehydes (1a-1d, 1 mmol) and around 1.1-1.3 mmol quantity of TMSCN was taken in 5-8 mL water. After stirring for a while, 10 mg Indium powder was added to the reaction mixture and the resulted reaction mass was allowed to stir at room temperature for 45 min-2.5 h. After the completion ofthe reaction as monitored by Thin Layer Chro-matography using toluene: acetone (8:2) or ethyl acetate: n-nexane (8:2) solvent system, after treatment with diethyl ether or ethyl acetate, solution was filtered and washed with water and brine followed by anhydrous sodium sulphate treatment to dry. The residue was purified by silica gel column chromatography (ethyl acetate: n-hexane) to afford compounds 2i-5vi.

3541-37-5 Benzo[b]thiophene-2-carboxaldehyde 736500, abenzothiophene compound, is more and more widely used in various.

Reference£º
Article; Patel, Rahul V.; Patel, Jigar K.; Nile, Shivraj H.; Park, Se Won; Letters in drug design and discovery; vol. 10; 5; (2013); p. 462 – 470;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

3541-37-5, Benzo[b]thiophene-2-carboxaldehyde is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a dry glass reaction tube purged with argon and equipped with a magnetic stir bar were added molecular sieves (3-4 A, 100 mg), aldehyde 3a (46 mg, 0.25 mmol), Pd-gamma-Fe2O3 (24 mg, 5 mol% Pd), and cyclohexane (1 mL) and the sealed tube was heated at 130 C for 24 h. The reaction mixture was decanted with the help of an external magnet and the catalyst was washed with CH2Cl2 (5 x 5 mL). The crude product was purified by dry-flash chromatography (SiO2: hexane) to afford 4a (31 mg, 82%) as a white solid; mp 66-68 C.

The synthetic route of 3541-37-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Ajda?i?, Vladimir; Nikoli?, Andrea; Simi?, Stefan; Manojlovi?, Dragan; Stojanovi?, Zoran; Nikodinovic-Runic, Jasmina; Opsenica, Igor M.; Synthesis; vol. 50; 1; (2018); p. 119 – 126;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem