Category: 3541-37-5

3541-37-5, Benzo[b]thiophene-2-carboxaldehyde is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 8 Synthesis of (E)-2-(Benzo[b]thiophen-2-yl)-2-methoxy-N’-(3,4,5-trimethoxybenzylidene)acetohydrazide To a solution of benzo[b]thiophene-2-carbaldehyde (2.19 g, 13.5 mmol) in anhydrous THF (200 mL) was added a solution of NaHSO3 (6.18 g, 59.4 mmol) in water (50 mL). KCN (3.248 g, 49.9 mmol) was added and the mixture was stirred at room temperature for 22 hours. The reaction mixture was then heated at 45 C. for 1 hour. After cooling to room temperature, the mixture was diluted with water and brine and extracted with EtOAc three times. The combined organics were washed with brine, dried over Na2SO4 and concentrated in vacuo. Purification by chromatography (0-25% EtOAc-hexanes) gave 2-(benzo[b]thiophen-2-yl)-2-hydroxyacetonitrile as an off-white solid (1.09 g, 46% yield).

3541-37-5, The synthetic route of 3541-37-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Omeros Corporation; US2010/35872; (2010); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3541-37-5,Benzo[b]thiophene-2-carboxaldehyde,as a common compound, the synthetic route is as follows.

General procedure: A mixture of appropriate piperazine base (i-vi, 1 mmol), aldehydes (1a-1d, 1 mmol) and around 1.1-1.3 mmol quantity of TMSCN was taken in 5-8 mL water. After stirring for a while, 10 mg Indium powder was added to the reaction mixture and the resulted reaction mass was allowed to stir at room temperature for 45 min-2.5 h. After the completion ofthe reaction as monitored by Thin Layer Chro-matography using toluene: acetone (8:2) or ethyl acetate: n-nexane (8:2) solvent system, after treatment with diethyl ether or ethyl acetate, solution was filtered and washed with water and brine followed by anhydrous sodium sulphate treatment to dry. The residue was purified by silica gel column chromatography (ethyl acetate: n-hexane) to afford compounds 2i-5vi., 3541-37-5

The synthetic route of 3541-37-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Patel, Rahul V.; Patel, Jigar K.; Nile, Shivraj H.; Park, Se Won; Letters in drug design and discovery; vol. 10; 5; (2013); p. 462 – 470;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

3541-37-5, Benzo[b]thiophene-2-carboxaldehyde is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Thiosemicarbazide (1.82 g, 20.0 mmol) was added to a stirredsolution of benzo [b]thiophene-2-carboxaldehyde (1) (3.24 g,20.0 mmol) in absolute ethyl alcohol (40 ml) and then (1.0 ml) ofacetic acid was added. The reaction mixture was stirred underreflux for 20 h, cooled to room temperature and separate precipitatewas collected by filtration, washed with ethyl alcohol to affordthe desired product to yield 3.90 g (83%); mp 218-219 C, mp219-220 C [22]; eluent: dichloromethane/methanol (95:5),Rf 0.67.1H NMR (DMSO-d6) d(ppm): 7.35-7.43 (m, 2H, 2CHAr);7.59 (bs, 1H, NH2); 7.77 (s, 1H, CH); 7.81-7.86 (m, 1H, CHAr);7.91-7.96 (m, 1H, CH); 8.32 (bs, 1H, NH2); 8.37 (s, 1H, CH]N); 11.62(bs, 1H, NH). 13C NMR (DMSO-d6) d(ppm): 122.98 (C); 124.74 (C);125.28 (C); 126.44 (C); 128.16 (C); 138.27 (C); 139.63 (C); 139.78 (C);139.85 (C); 178.34 (C]S)., 3541-37-5

The synthetic route of 3541-37-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Rosada, Beata; Bekier, Adrian; Cytarska, Joanna; P?azi?ski, Wojciech; Zavyalova, Olga; Sikora, Adam; Dzitko, Katarzyna; ??czkowski, Krzysztof Z.; European Journal of Medicinal Chemistry; vol. 184; (2019);,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

3541-37-5, Benzo[b]thiophene-2-carboxaldehyde is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a mixture of benzo[b]thiophene-2-carbaldehyde (12 g, 0.074 mol) and hydroxylamine hydrochloride (15.32 g, 0.222 mol) in anhydrous methanol (250 mL) was added potassium carbonate (30.64 g, 0.222 mol) at room temperature. The mixture was stirred at room temperature for 4 hours. On completion, the mixture was filtered and purified by column chromatography [petroleum ether/ethyl acetate=20: l] to give compound B-102 (1 1.8 g, 90% yield) as a white solid. LCMS: (ES+) m/z (M+H)+ = 178.1 , tR=1.218., 3541-37-5

3541-37-5 Benzo[b]thiophene-2-carboxaldehyde 736500, abenzothiophene compound, is more and more widely used in various fields.

Reference£º
Patent; FORUM PHARMACEUTICALS, INC.; BURNETT, Duane, A.; BURSAVICH, Matthew, Gregory; MCRINER, Andrew, J.; WO2015/66371; (2015); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3541-37-5,Benzo[b]thiophene-2-carboxaldehyde,as a common compound, the synthetic route is as follows.

General procedure: A mixture of amine 1 (46.4mg, 0.24mmol), 2-(trimethylsilyl)phenyl triflate (89.5mg, 0.30mmol), CsF (91.1mg, 0.60mmol), and acetonitrile (0.80mL) in a sealed tube was heated at 60C (oil bath) for 10 min, and a solution of aldehyde 2 (0.20mmol) in acetonitrile (0.40mL) was added. The mixture was stirred at 60C for 24h, cooled to room temperature, and purified by silica gel chromatography, eluting with ethyl acetate/petroleum ether (1:10 v/v), to give epoxide 3.

3541-37-5, 3541-37-5 Benzo[b]thiophene-2-carboxaldehyde 736500, abenzothiophene compound, is more and more widely used in various fields.

Reference£º
Article; Xu, Ya-Nan; Tian, Shi-Kai; Tetrahedron; vol. 75; 12; (2019); p. 1632 – 1638;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3541-37-5,Benzo[b]thiophene-2-carboxaldehyde,as a common compound, the synthetic route is as follows.

General procedure: To a solution of benzo[b]thiophene-2-carboxaldehyde (2?mmol) in ethanol (5?mL), 4-ethylthiosemicarbazide (2?mmol) and acetic acid (0.5?mL) were added. The mixture was stirred for 10?min?at 80?C. After cooling to room temperature, the white precipitate was obtained. The white solid was collected by filtration and the crude product was further purified by recrystallization from ethanol. (E)-2-(benzo[b]thiophen-2-ylmethylene)-N-ethylhydrazine-1-carbothioamide was obtained (BS2C-ETSC). The other two compounds, (E)-2-(benzo[b]thiophen-2-ylmethylene)hydrazine-1-carbothioamide (BS2C-TSC) and (E)-2-(benzo[b]thiophen-2-ylmethylene)-N-methylhydrazine-1-carbothioamide (BS2C-MTSC) were prepared with the same procedure as BS2C-ETSC., 3541-37-5

As the paragraph descriping shows that 3541-37-5 is playing an increasingly important role.

Reference£º
Article; Qiao, Yuqian; Che, Yuanyuan; Yu, Yuming; Tang, Yakun; Liu, Lang; Zhao, Xianmei; Zhao, Jianzhang; Dyes and Pigments; vol. 156; (2018); p. 326 – 331;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3541-37-5,Benzo[b]thiophene-2-carboxaldehyde,as a common compound, the synthetic route is as follows.

[0054] Calixarene 6 (benzothiophene-resorcinol calix[4]arene,) was prepared by the following method. To a 250 mL round bottom flask, resorcinol (2.00 g, 18.2 mmol), benzo[b]thiophene-2-carboxaldehyde (2.95 g, 18.2 mmol), ethanol (100 mL), and HCl (concentrated, 10 mL) were added. A nitrogen inlet was equipped and the reaction was stirred at 80 C. for 16 h. The reaction began as a clear solution but slowly formed a purple precipitate. After completion of the reaction, the resulting solution was filtered through a fritted funnel and the solid collected was washed with water (50 mL) and ethanol (50 mL). The washed product was dried in vacuo at 60 C. for 16 hours (yield: 4.05 g, 88%). LC-MS m/z=1017.2 g/mol.

3541-37-5, 3541-37-5 Benzo[b]thiophene-2-carboxaldehyde 736500, abenzothiophene compound, is more and more widely used in various fields.

Reference£º
Patent; ROHM AND HAAS ELECTRONIC MATERIALS LLC; Green, D. Patrick; Jain, Vipul; Bailey, Brad C.; US2013/157195; (2013); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3541-37-5,Benzo[b]thiophene-2-carboxaldehyde,as a common compound, the synthetic route is as follows.

General procedure: A mixture of 4-aminoacetophenone (0.01 mol) with 0.01 mol of NaOH dissolved in 50 mL of water and 50 mL of ethanole was stirred for 30 min. Upon addition of 5-phenylthiophene-2-carboxy aldehyde or benzo[b]thiophene-2-carboxy aldehyde (0.01 mol), the reaction mixture was stirred at room temperature for 8-10 h. The reaction progress was monitored by TLC. Upon completion of the process, the mixture was cooled down to room temperature. The separated crystalline solid was purified by crystallization from ethanol-water (2 : 1) and dried.

3541-37-5, The synthetic route of 3541-37-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Uenver; Tuluk; Kahriman; Emirik; Bekta?; Direkel; Russian Journal of General Chemistry; vol. 89; 4; (2019); p. 794 – 799;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

3541-37-5, Benzo[b]thiophene-2-carboxaldehyde is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a solution of pyrrole-2-carbaldehyde 1a,b (2 mmol) in MeOH (3 mL) were added successively Na2SO4 (0.3 g), the appropriate amine 2ad (1.2 equiv), acid 3a (1.2 equiv), and isonitrile 4a,b (1.2 equiv) in a screw capped vial equipped with a magnetic stir bar. The reaction mixture was stirred at 50 C for 2448 h in a closed vial. After completion of the reaction (as indicated on TLC), the mixture was diluted with EtOAc (100 mL) and extracted with H2O (50 mL). The organic layer was washed with brine (50 mL), dried (MgSO4) and evaporated under reduced pressure to obtain a residue, which was subjected to silica gel column chromatography (50% EtOAc in heptane) to afford the desired products 5ad (Table 1)., 3541-37-5

As the paragraph descriping shows that 3541-37-5 is playing an increasingly important role.

Reference£º
Article; Kumar, Amit; Vachhani, Dipak D.; Modha, Sachin G.; Sharma, Sunil K.; Parmar, Virinder S.; Van Der Eycken, Erik V.; Synthesis; vol. 45; 18; (2013); p. 2571 – 2582;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

3541-37-5, Benzo[b]thiophene-2-carboxaldehyde is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of benzo [b] thiophene-2-carbaldehyde (1.0 g, 6.17 mmol) and carbon tetrabromide (3.1 g, 9.25 mmol) in methylene chloride (50 mL) was cooled to 0C. A solution of triphenylphosphine (4.86 g, 18.3 mmol) in methylene chloride (20 mL) was added dropwise. After 1/2 hour the solution was placed on a plug of silica gel and eluted with 20% ethyl acetate: hexane. Concentration of the eluent resulted in the isolation of 1.3 g (67%) of 2-(2, 2-Dibromo-vinvl)-benzorb1thiophene as a yellow oil, which was used as such in the next step

3541-37-5, 3541-37-5 Benzo[b]thiophene-2-carboxaldehyde 736500, abenzothiophene compound, is more and more widely used in various fields.

Reference£º
Patent; WYETH; WO2005/37207; (2005); A2;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem