Category: 35212-85-2

Some scientific research about Methyl 3-aminobenzo[b]thiophene-2-carboxylate

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Related Products of 35212-85-2, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 35212-85-2, molcular formula is C10H9NO2S, introducing its new discovery.

ORGANIC COMPOUND AND ORGANIC OPTOELECTRONIC DEVICE AND DISPLAY DEVICE

For an organic compound represented by formula 1, organic optoelectronic device and the display device are disclosed. [Formula 1] In said formula 1, Ar1 , Ar2 , L1 , L2 , R1 To R3 Efined specification is based on. (by machine translation)

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Synthesis of New Polycyclic Systems Containing the Pyrimido<2,1-a>phthalazine Skeleton

The synthesis of new polyheterocycles containing the pyrimido<2,1-a>phthalazine system 5, 6 and 7, obtained by condensation of phthalic anhydride with the appropriate hydrazides 2, 3 and 4, respectively, are reported.It was also synthesized the 14H-<1>Benzothieno<3',2':4,5>pyrimido<2,1-a><1,2,4>triazolo<4,3-c>phthalazin-14-one (16).

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35212-85-2, Name is Methyl 3-aminobenzo[b]thiophene-2-carboxylate, belongs to benzothiophene compound, is a common compound. category: benzothiopheneIn an article, once mentioned the new application about 35212-85-2.

Synthesis and evaluation of heterocyclic carboxamides as potential antipsychotic agents

Heterocyclic analogues of 1192U90, 2-amino-N-(4-(4-(1,2-benzisothiazol- 3-yl)-1-piperazinyl)-butyl)benzamide hydrochloride (1), were prepared and evaluated as potential antipsychotic agents. These analogues were evaluated in vitro for their binding to the dopamine D2, serotonin 5-HT2, and serotonin 5-HT(1a) receptors and in vivo for their ability to antagonize the apomorphine-induced climbing response in mice. Nine different types of heterocyclic carboxamides were studied in this investigation (i.e., pyridine- , thiophene-, benzothiophene-, quinoline-, 1,2,3,4-tetrahydroquinoline-, 2,3- dihydroindole-, indole-, benzimidazole-, and indazolecarbox-amides). Two derivatives exhibited potent in vivo activities comparable to 1: 3-amino-N- (4(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)butyl)-2-pyridinecarboxamide (16) and 3-amino-N-(4(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)butyl)-2- thiophenecarboxamide (29). Furthermore, these derivatives were found to be much less active in behavioral models predictive of extrapyramidal side effects than in the mouse climbing assay, which predicts antipsychotic activity. Carboxamides 16 and 29 were selected for further evaluation as potential backup compounds to 1.

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Benzothiophene – Wikipedia,
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New explortion of Methyl 3-aminobenzo[b]thiophene-2-carboxylate

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35212-85-2, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In a patent, 35212-85-2, molecular formula is C10H9NO2S, introducing its new discovery.

Novel hetero-cyclic compound and organic light emitting device comprising the same

The present invention refers to novel heterocyclic compound and organic light emitting number including […] substrate. (by machine translation)

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Brief introduction of Methyl 3-aminobenzo[b]thiophene-2-carboxylate

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 35212-85-2

Reference of 35212-85-2, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.35212-85-2, Name is Methyl 3-aminobenzo[b]thiophene-2-carboxylate, molecular formula is C10H9NO2S. In a Article£¬once mentioned of 35212-85-2

Synthesis and Reactions of 2H-Benzothieno<3,2-d><1,3>oxazine-2,4(1H)-dione

The title compound 5 is synthesized by the reaction of the potassium salt of 3-aminobenzothiophene-2-carboxylic acid with phosgene.Compound 5 is readily alkylated to give 6 with methyl iodide, benzyl bromide, or propargyl bromide in the presence of sodium hydride.Reaction of 5 and 6 with nucleophiles follows specifically different pathways.Compound 5 is readily ionized to the isocyanate species 13 and subsequently reacts with methanol or methylamine to produce exclusively the carbamate 7 or ureido acid 9.The N-substituted derivative 6, in analogous reaction withmethanol or methylamine, produce exclusively the amino ester 8 or the amino amide 10.The N-benzyl derivative 6b reacts with the cyclic S-methylthiopseudourea 11 to give the tetracycle 12, a new ring system.

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More research is needed about 35212-85-2

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Synthetic Route of 35212-85-2. In my other articles, you can also check out more blogs about 35212-85-2

Synthetic Route of 35212-85-2, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 35212-85-2, Name is Methyl 3-aminobenzo[b]thiophene-2-carboxylate, molecular formula is C10H9NO2S. In a Article£¬once mentioned of 35212-85-2

Synthesis of 4-Oxo-3,4-dihydro-1H-thieno<3,4-c>– and thieno<3,2-c><1,2,6>thiadiazine 2,2-Dioxides

4-Oxo-3,4-dihydro-1H-thieno<3,4-c><1,2,6>thiadiazine 2,2-dioxide (3) has been synthesized in a two-step approach involving sulfamoylation of 3-amino-4-methoxycarbonylthiophene (1) and subsequent ring closure.A modification of this procedure, which involves isolation of the intermediate thiphenecarboxylic acid derivatives 4 and 9, has been used to prepare new 4-oxo-3,4-dihydro-1H-thieno<3,4-c>– and thieno<3,2-c><1,2,6>thiadiazine 2,2-dioxides 6 and 10, respectively.

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Benzothiophene – Wikipedia,
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The Absolute Best Science Experiment for 35212-85-2

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The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. HPLC of Formula: C10H9NO2S, In an article, mentioned the application of 35212-85-2, Name is Methyl 3-aminobenzo[b]thiophene-2-carboxylate, molecular formula is C10H9NO2S

Functionalization of the 3-position of thiophene and benzo[b]thiophene moieties by palladium-catalyzed C-C bond forming reactions using diazonium salts

The palladium-catalyzed Matsuda-Heck and Suzuki-Miyaura cross-couplings of 2-methoxycarbonylthiophene-3-diazonium tetrafluoroborate 1 were performed to synthesize a series of thiophene derivatives functionalized in the beta-position. Good to excellent yields of the cross-coupling products were obtained using palladium acetate [Pd(OAc)2], a ligandless palladium catalyst, without a base, at room temperature, under aerobic conditions and with short reaction times. A diazotization and cross-coupling sequence can also be performed in a one-pot process avoiding the isolation of the thiophenediazonium salt derivative. In addition, 2-methoxycarbonylbenzo[b]thiophene-3-diazonium tetrafluoroborate 8 was also efficiently arylated by applying the same Suzuki-Miyaura optimized reaction conditions. Copyright

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Reference of 35212-85-2, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.35212-85-2, Name is Methyl 3-aminobenzo[b]thiophene-2-carboxylate, molecular formula is C10H9NO2S. In a Article£¬once mentioned of 35212-85-2

c-MYC G-quadruplex binding by the RNA polymerase I inhibitor BMH-21 and analogues revealed by a combined NMR and biochemical Approach

Background Pyridoquinazolinecarboxamides have been reported as RNA polymerase I inhibitors and represent a novel class of potential antitumor agents. BMH-21, was reported to intercalate with GC-rich rDNA, resulting in nucleolar stress as a primary mechanism of cytotoxicity. Methods The interaction of BMH-21 and analogues with DNA G-quadruplex structures was studied by NMR and molecular modelling. The cellular response was investigated in a panel of human tumor cell lines and protein expression was examined by Western Blot analysis. Results and conclusions We explored the ability of BMH-21 and its analogue 2 to bind to G-quadruplex present in the c-MYC promoter, by NMR and molecular modelling studies. We provide evidence that both compounds are not typical DNA intercalators but are effective binders of the tested G-quadruplex. The interaction with c-MYC G-quadruplex was reflected in down-regulation of c-Myc expression in human tumor cells. The inhibitory effect was almost complete in lymphoma cells SUDHL4 characterized by overexpression of c-Myc protein. This downregulation reflected an early and persistent modulation of cMyc mRNA. Given the relevance of c-MYC in regulation of ribosome biogenesis, it is conceivable that the inhibition of c-MYC contributes to the perturbation of nuclear functions and RNA polymerase I activity. Similar experiments with CX-5461, another RNA polymerase I transcription inhibitor, indicate the same behaviour in G-quadruplex stabilization. General significance Our results support the hypothesis that BMH-21 and analogue compounds share the same mechanism, i.e. G-quadruplex binding as a primary event of a cascade leading to inhibition of RNA polymerase I and apoptosis.

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Benzothiophene – Wikipedia,
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Archives for Chemistry Experiments of Methyl 3-aminobenzo[b]thiophene-2-carboxylate

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 35212-85-2

Related Products of 35212-85-2, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.35212-85-2, Name is Methyl 3-aminobenzo[b]thiophene-2-carboxylate, molecular formula is C10H9NO2S. In a article£¬once mentioned of 35212-85-2

Novel compound and organic light-emitting element containing the same (by machine translation)

The present invention provides a novel indeno carbazole compound and comprising an organic light emitting element. (by machine translation)

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 35212-85-2

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Benzothiophene – Wikipedia,
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We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 35212-85-2, and how the biochemistry of the body works.Reference of 35212-85-2

Reference of 35212-85-2, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.35212-85-2, Name is Methyl 3-aminobenzo[b]thiophene-2-carboxylate, molecular formula is C10H9NO2S. In a Article£¬once mentioned of 35212-85-2

c-MYC G-quadruplex binding by the RNA polymerase I inhibitor BMH-21 and analogues revealed by a combined NMR and biochemical Approach

Background Pyridoquinazolinecarboxamides have been reported as RNA polymerase I inhibitors and represent a novel class of potential antitumor agents. BMH-21, was reported to intercalate with GC-rich rDNA, resulting in nucleolar stress as a primary mechanism of cytotoxicity. Methods The interaction of BMH-21 and analogues with DNA G-quadruplex structures was studied by NMR and molecular modelling. The cellular response was investigated in a panel of human tumor cell lines and protein expression was examined by Western Blot analysis. Results and conclusions We explored the ability of BMH-21 and its analogue 2 to bind to G-quadruplex present in the c-MYC promoter, by NMR and molecular modelling studies. We provide evidence that both compounds are not typical DNA intercalators but are effective binders of the tested G-quadruplex. The interaction with c-MYC G-quadruplex was reflected in down-regulation of c-Myc expression in human tumor cells. The inhibitory effect was almost complete in lymphoma cells SUDHL4 characterized by overexpression of c-Myc protein. This downregulation reflected an early and persistent modulation of cMyc mRNA. Given the relevance of c-MYC in regulation of ribosome biogenesis, it is conceivable that the inhibition of c-MYC contributes to the perturbation of nuclear functions and RNA polymerase I activity. Similar experiments with CX-5461, another RNA polymerase I transcription inhibitor, indicate the same behaviour in G-quadruplex stabilization. General significance Our results support the hypothesis that BMH-21 and analogue compounds share the same mechanism, i.e. G-quadruplex binding as a primary event of a cascade leading to inhibition of RNA polymerase I and apoptosis.

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 35212-85-2, and how the biochemistry of the body works.Reference of 35212-85-2

Reference£º
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem