Analyzing the synthesis route of 34761-09-6

The synthetic route of 34761-09-6 has been constantly updated, and we look forward to future research findings.

34761-09-6, Ethyl 3-aminobenzo[b]thiophene-2-carboxylate is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A 100mL RBF was charged with ethyl 3-aminobenzo[b]thiophene-2-carboxylate (17.7 g, 80 mmol), treated with formamide (60.6 mL, 1520 mmol) and heated to 190 C for 2 hrs. Precipitate formed upon cooling. The solid was collected by filtration and washed with ether, then recrystallized from ethanol/THF. Benzo[4,5]thieno[3,2-d]pyrimidin-4(3H)-one (9.9 g, 61% yield) was obtained., 34761-09-6

The synthetic route of 34761-09-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Universal Display Corporation; Xia, Chuanjun; Joseph, Scott; EP2826781; (2015); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

 

Some tips on 34761-09-6

34761-09-6 Ethyl 3-aminobenzo[b]thiophene-2-carboxylate 731510, abenzothiophene compound, is more and more widely used in various fields.

34761-09-6, Ethyl 3-aminobenzo[b]thiophene-2-carboxylate is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(2) Ethyl 3-aminobenzo[b]thiophene-2-carboxylate (10 g, 45.2 mmol), and carbamimidic chloride hydrochloride (7.27 g, 63.3 mmol) in diglyme (90 mL) were heated to 160C for 12 hrs. The reaction solution was cooled to room temperature, filtered, washed with ether and hexanes and dried in vacuo for 3 hrs yielding 10.56 g (108% yield) of crude grey solids of the 2-aminobenzo[4,5]thieno[3,2-d]pyrimidin-4(3H)-one. Used as is without further purification., 34761-09-6

34761-09-6 Ethyl 3-aminobenzo[b]thiophene-2-carboxylate 731510, abenzothiophene compound, is more and more widely used in various fields.

Reference:
Patent; Universal Display Corporation; Joseph, Scott; Boudreault, Pierre-Luc T.; Dyatkin, Alexey Borisovich; Li, David Zenan; Xia, Chuanjun; Yamamoto, Hitoshi; EP2910555; (2015); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

 

Analyzing the synthesis route of 34761-09-6

34761-09-6, The synthetic route of 34761-09-6 has been constantly updated, and we look forward to future research findings.

34761-09-6, Ethyl 3-aminobenzo[b]thiophene-2-carboxylate is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a solution of 3-aminobenzo[b]thiophene-2-carboxylate 7 (0.9 mmol) in glacial acetic acid (5ml) water solution of NaNO2( 1.8 mmol) was added dropwise. The mixture was left under stirring for 2h at rt. Then ammonium acetate (32.4 mmol) and an appropriate primary amine 9a-e (10 mmol) were added. The precipitate was filtered off, and the crude was recrystallized from ethanol.

34761-09-6, The synthetic route of 34761-09-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Lauria, Antonino; Alfio, Alessia; Bonsignore, Riccardo; Gentile, Carla; Martorana, Annamaria; Gennaro, Giuseppe; Barone, Giampaolo; Terenzi, Alessio; Almerico, Anna Maria; Bioorganic and Medicinal Chemistry Letters; vol. 24; 15; (2014); p. 3291 – 3297;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

 

New learning discoveries about 34761-09-6

As the paragraph descriping shows that 34761-09-6 is playing an increasingly important role.

34761-09-6, Ethyl 3-aminobenzo[b]thiophene-2-carboxylate is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a solution of 3-aminobenzo[b]thiophene-2-carboxylate 7 (0.9 mmol) in glacial acetic acid (5ml) water solution of NaNO2( 1.8 mmol) was added dropwise. The mixture was left under stirring for 2h at rt. Then ammonium acetate (32.4 mmol) and an appropriate primary amine 9a-e (10 mmol) were added. The precipitate was filtered off, and the crude was recrystallized from ethanol., 34761-09-6

As the paragraph descriping shows that 34761-09-6 is playing an increasingly important role.

Reference£º
Article; Lauria, Antonino; Alfio, Alessia; Bonsignore, Riccardo; Gentile, Carla; Martorana, Annamaria; Gennaro, Giuseppe; Barone, Giampaolo; Terenzi, Alessio; Almerico, Anna Maria; Bioorganic and Medicinal Chemistry Letters; vol. 24; 15; (2014); p. 3291 – 3297;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

 

Some tips on 34761-09-6

34761-09-6, 34761-09-6 Ethyl 3-aminobenzo[b]thiophene-2-carboxylate 731510, abenzothiophene compound, is more and more widely used in various fields.

34761-09-6, Ethyl 3-aminobenzo[b]thiophene-2-carboxylate is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of ethyl 3-amino-benzo[b]thiophene-2-carboxylate (8) (0.50 g, 2.3 mmol) in acetic acid (6 mL), was cooled in an ice bath to -5 C. Then, a solution of sodium nitrite (0.32 g, 4.6 mmol), in water (2 mL), was slowly added, under vigorous stirring. After 30 min, sodium azide (0.60 g, 9.2 mmol) in water (2 mL), was added over 10 min. The reaction mixture was stirred for further 3 h at room temperature and then slowly poured onto water/ice. The precipitate was collected by filtration to give 5, 0.40 g. Yield 70%. Mp 100 C (dec). IR: 2130 (N3), 1689 (CO) cm-1. 1H NMR delta: 1.30 (t, J = 7.1 Hz, 3H), 4.33 (q, J = 7.1 Hz, 2H), 7.34-7.51 (m, 2H), 7.88 (d, J = 8.1 Hz, 1H), 8.14 (d, J = 7.7 Hz, 1H). 13C NMR delta: 14.4 (q), 59.7 (t), 122.9 (d), 123.0 (d), 123.8 (d), 128.4 (d), 131.5 (s), 133.7 (s), 138.8 (s), 149.7 (s), 164.5 (s). Elem. Anal. calcd. for C11H9N3O2S: C, 53.43; H, 3.67; N, 16.99; found: C, 53.62; H, 3.55; N, 17.30.

34761-09-6, 34761-09-6 Ethyl 3-aminobenzo[b]thiophene-2-carboxylate 731510, abenzothiophene compound, is more and more widely used in various fields.

Reference£º
Article; Lauria, Antonino; Abbate, Ilenia; Patella, Chiara; Martorana, Annamaria; Dattolo, Gaetano; Almerico, Anna Maria; European Journal of Medicinal Chemistry; vol. 62; (2013); p. 416 – 424;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

 

Downstream synthetic route of 34761-09-6

34761-09-6, As the paragraph descriping shows that 34761-09-6 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.34761-09-6,Ethyl 3-aminobenzo[b]thiophene-2-carboxylate,as a common compound, the synthetic route is as follows.

General procedure: To a solution of 3-aminobenzo[b]thiophene-2-carboxylate 7 (0.9 mmol) in glacial acetic acid (5ml) water solution of NaNO2( 1.8 mmol) was added dropwise. The mixture was left under stirring for 2h at rt. Then ammonium acetate (32.4 mmol) and an appropriate primary amine 9a-e (10 mmol) were added. The precipitate was filtered off, and the crude was recrystallized from ethanol.

34761-09-6, As the paragraph descriping shows that 34761-09-6 is playing an increasingly important role.

Reference£º
Article; Lauria, Antonino; Alfio, Alessia; Bonsignore, Riccardo; Gentile, Carla; Martorana, Annamaria; Gennaro, Giuseppe; Barone, Giampaolo; Terenzi, Alessio; Almerico, Anna Maria; Bioorganic and Medicinal Chemistry Letters; vol. 24; 15; (2014); p. 3291 – 3297;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

 

Brief introduction of 34761-09-6

The synthetic route of 34761-09-6 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.34761-09-6,Ethyl 3-aminobenzo[b]thiophene-2-carboxylate,as a common compound, the synthetic route is as follows.

General procedure: To a solution of 3-aminobenzo[b]thiophene-2-carboxylate 7 (0.9 mmol) in glacial acetic acid (5ml) water solution of NaNO2( 1.8 mmol) was added dropwise. The mixture was left under stirring for 2h at rt. Then ammonium acetate (32.4 mmol) and an appropriate primary amine 9a-e (10 mmol) were added. The precipitate was filtered off, and the crude was recrystallized from ethanol., 34761-09-6

The synthetic route of 34761-09-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Lauria, Antonino; Alfio, Alessia; Bonsignore, Riccardo; Gentile, Carla; Martorana, Annamaria; Gennaro, Giuseppe; Barone, Giampaolo; Terenzi, Alessio; Almerico, Anna Maria; Bioorganic and Medicinal Chemistry Letters; vol. 24; 15; (2014); p. 3291 – 3297;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

 

Brief introduction of 34761-09-6

34761-09-6, The synthetic route of 34761-09-6 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.34761-09-6,Ethyl 3-aminobenzo[b]thiophene-2-carboxylate,as a common compound, the synthetic route is as follows.

Synthesis 1B3H-[1]benzothieno[3,2-d]pyrimid-4-oneA stirred mixture of ethyl 3-aminobenzo[b]thiophene-2-carboxylate (3.62 mmol) in formamide (5 mL) was heated to 150C. Formamidine acetate (3.62 mmol) was added and the mixture heated at 150C for 45 min. The addition of formamidine acetate (3.62 mmol) was repeated every 45 min for 6 h. Ice-water was added and the precipitate that was formed was filtered off, washed with water, and dried in a vacuum oven to obtain the pyrimidine as a tanned solid (95%).LCMS rt 5.20; M+H 203; 1H-NMR (DMSO) delta D8.33 (1H, s), 8.26-8.21 (1H, m), 8.16-8.12 (1H, m), 7.69-7.56 (1H, m).

34761-09-6, The synthetic route of 34761-09-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BAELL, Jonathan Bayldon; STREET, Ian Philip; SLEEBS, Brad Edmund; WO2012/131297; (2012); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

 

Simple exploration of 34761-09-6

34761-09-6 Ethyl 3-aminobenzo[b]thiophene-2-carboxylate 731510, abenzothiophene compound, is more and more widely used in various fields.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.34761-09-6,Ethyl 3-aminobenzo[b]thiophene-2-carboxylate,as a common compound, the synthetic route is as follows.

General procedure: To a solution of 3-aminobenzo[b]thiophene-2-carboxylate 7 (0.9 mmol) in glacial acetic acid (5ml) water solution of NaNO2( 1.8 mmol) was added dropwise. The mixture was left under stirring for 2h at rt. Then ammonium acetate (32.4 mmol) and an appropriate primary amine 9a-e (10 mmol) were added. The precipitate was filtered off, and the crude was recrystallized from ethanol., 34761-09-6

34761-09-6 Ethyl 3-aminobenzo[b]thiophene-2-carboxylate 731510, abenzothiophene compound, is more and more widely used in various fields.

Reference£º
Article; Lauria, Antonino; Alfio, Alessia; Bonsignore, Riccardo; Gentile, Carla; Martorana, Annamaria; Gennaro, Giuseppe; Barone, Giampaolo; Terenzi, Alessio; Almerico, Anna Maria; Bioorganic and Medicinal Chemistry Letters; vol. 24; 15; (2014); p. 3291 – 3297;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

 

Simple exploration of 34761-09-6

34761-09-6 Ethyl 3-aminobenzo[b]thiophene-2-carboxylate 731510, abenzothiophene compound, is more and more widely used in various.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.34761-09-6,Ethyl 3-aminobenzo[b]thiophene-2-carboxylate,as a common compound, the synthetic route is as follows.

A 100 mL RBF was charged with ethyl 3-aminobenzo[b]thiophene-2-carboxylate (17.7 g, 80 mmol), treated with formamide (60.6 mL, 1520 mmol) and heated to 190 C. for 2 hrs. Precipitate formed upon cooling. The solid precipitate was collected by filtration and washed with ether, then recrystallized from ethanol/tetrahydrofuran. Benzo[4,5]thieno[3,2-d]pyrimidin-4(3H)-one (9.9 g, 61% yield) was obtained., 34761-09-6

34761-09-6 Ethyl 3-aminobenzo[b]thiophene-2-carboxylate 731510, abenzothiophene compound, is more and more widely used in various.

Reference£º
Patent; Universal Display Corporation; Joseph, Scott; Kwang, Raymond; Lee, Chi Hang; Shia, Chuan Jun; Ram, SiV Cheung; (131 pag.)KR2015/9461; (2015); A;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem