Archives for Chemistry Experiments of 3395-91-3

《Smart carbon dots as chemosensor for control of water contamination in organic media》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(Methyl 3-bromopropanoate)Formula: C4H7BrO2.

Formula: C4H7BrO2. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: Methyl 3-bromopropanoate, is researched, Molecular C4H7BrO2, CAS is 3395-91-3, about Smart carbon dots as chemosensor for control of water contamination in organic media. Author is Espina-Casado, Jorge; Fernandez-Gonzalez, Alfonso; Diaz-Garcia, Marta E.; Badia-Laino, Rosana.

A novel nanoprobe was synthesized by functionalizing gluthatione/citric acid-carbon dots (CDs) with a benzo-isoquinolin-based mol., Me 3-(4-(2-(5-((methylsulfonyl)oxy)pentyl)-1,3-dioxo-2,3-dihydro-1H-benzo[de]isoquinolin-6-yl)piperazin-1-yl)propanoate (water chemosensor, WCS), to detect trace amounts of water in non-aqueous media via on-off fluorescence. The design and synthesis of the free mol. WCS and the functionalized nanoprobe (CD-WCS) are described in detail and as well as their full characterization by different spectroscopic methods. WCS was found to be an excellent indicator of pH in aqueous media and exhibited, in solvents of different polarity, solvatochromic behavior. On the other hand, the modified fluorescence intensity of CD-WCS was found to be an excellent indicator for water in non-aqueous media (organic solvents and oil-based lubricants). In these media, CD-WCS showed weak fluorescence intensity due to a photoinduced electron transfer (PET) process. Sequential addition of trace amount of water led to revival of CD-WCS fluorescence intensity. The fluorescence on-off mechanisms are proposed for WCS in aqueous media as well as for CD-WCS in non-aqueous media. The anal. performance characteristics of CD-WCS showed a limit of detection for water of 0.00021% (volume/volume) in toluene and 0.00014% volume/volume in base-oil lubricant. The potential application of CD-WCS as chemosensor of water contamination in oil-based lubricants as well as green anti-wear/anti-friction lubricant additive are outlined.

《Smart carbon dots as chemosensor for control of water contamination in organic media》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(Methyl 3-bromopropanoate)Formula: C4H7BrO2.

Reference:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

Some scientific research about 3395-91-3

《Synthesis and Biological Validation of a Harmine-Based, Central Nervous System (CNS)-Avoidant, Selective, Human β-Cell Regenerative Dual-Specificity Tyrosine Phosphorylation-Regulated Kinase A (DYRK1A) Inhibitor》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(Methyl 3-bromopropanoate)HPLC of Formula: 3395-91-3.

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Kumar, Kunal; Wang, Peng; Wilson, Jessica; Zlatanic, Viktor; Berrouet, Cecilia; Khamrui, Susmita; Secor, Cody; Swartz, Ethan A.; Lazarus, Michael; Sanchez, Roberto; Stewart, Andrew F.; Garcia-Ocana, Adolfo; DeVita, Robert J. researched the compound: Methyl 3-bromopropanoate( cas:3395-91-3 ).HPLC of Formula: 3395-91-3.They published the article 《Synthesis and Biological Validation of a Harmine-Based, Central Nervous System (CNS)-Avoidant, Selective, Human β-Cell Regenerative Dual-Specificity Tyrosine Phosphorylation-Regulated Kinase A (DYRK1A) Inhibitor》 about this compound( cas:3395-91-3 ) in Journal of Medicinal Chemistry. Keywords: harmine derivative preparation DYRK1A inhibitory activity diabetes SAR. We’ll tell you more about this compound (cas:3395-91-3).

Recently, our group identified that harmine is able to induce β-cell proliferation both in vitro and in vivo, mediated via the DYRK1A-NFAT pathway. Since, harmine suffers from a lack of selectivity, both against other kinases and CNS off-targets, we therefore sought to expand structure-activity relationships for harmine’s DYRK1A activity, to enhance selectivity for off-targets while retaining human β-cell proliferation activity. We carried out optimization of the 9-N-position of harmine to synthesize 29 harmine-based analogs. Several novel inhibitors showed excellent DYRK1A inhibition and human β-cell proliferation capability. An optimized DYRK1A inhibitor, compound I, was identified as a novel, efficacious in vivo lead candidate. Compound I also demonstrates improved selectivity for kinases and CNS off-targets, as well as in vivo efficacy for β-cell proliferation and regeneration at lower doses than harmine. Collectively, these findings demonstrate that compound I is a much improved in vivo lead candidate as compared to harmine for the treatment of diabetes.

《Synthesis and Biological Validation of a Harmine-Based, Central Nervous System (CNS)-Avoidant, Selective, Human β-Cell Regenerative Dual-Specificity Tyrosine Phosphorylation-Regulated Kinase A (DYRK1A) Inhibitor》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(Methyl 3-bromopropanoate)HPLC of Formula: 3395-91-3.

Reference:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

Derivation of elementary reaction about 3395-91-3

《Synthesis of Highly Enantioenriched Sulfonimidoyl Fluorides and Sulfonimidamides by Stereospecific Sulfur-Fluorine Exchange (SuFEx) Reaction》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(Methyl 3-bromopropanoate)Quality Control of Methyl 3-bromopropanoate.

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 3395-91-3, is researched, SMILESS is O=C(OC)CCBr, Molecular C4H7BrO2Journal, Article, Chemistry – A European Journal called Synthesis of Highly Enantioenriched Sulfonimidoyl Fluorides and Sulfonimidamides by Stereospecific Sulfur-Fluorine Exchange (SuFEx) Reaction, Author is Greed, Stephanie; Briggs, Edward L.; Idiris, Fahima I. M.; White, Andrew J. P.; Luecking, Ulrich; Bull, James A., the main research direction is enantioenriched sulfonimidoyl fluoride sulfonimidamide preparation stereospecific SuFEx; SuFEx reactions; chirality; sulfonimidamides; sulfur; synthetic methods.Quality Control of Methyl 3-bromopropanoate.

Sulfonimidamides present exciting opportunities as chiral isosteres of sulfonamides, with potential for addnl. directional interactions. Here the authors present the first modular enantioselective synthesis of sulfonimidamides, including the first stereoselective synthesis of enantioenriched sulfonimidoyl fluorides, and studies on their reactivity. A new route to sulfonimidoyl fluorides is presented from solid bench-stable, N-Boc-sulfinamide salt building blocks. Enantioenriched arylsulfonimidoyl fluorides are shown to be readily racemized by fluoride ions. Conditions are developed, which trap fluoride and enable the stereospecific reaction of sulfonimidoyl fluorides with primary and secondary amines (100% es) generating sulfonimidamides with up to 99% ee. Aryl and alkyl sulfonimidoyl fluoride reagents are suitable for mild late stage functionalization reactions, exemplified by coupling with a selection of complex amines in marketed drugs.

《Synthesis of Highly Enantioenriched Sulfonimidoyl Fluorides and Sulfonimidamides by Stereospecific Sulfur-Fluorine Exchange (SuFEx) Reaction》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(Methyl 3-bromopropanoate)Quality Control of Methyl 3-bromopropanoate.

Reference:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

Application of 3395-91-3

This compound(Methyl 3-bromopropanoate)Safety of Methyl 3-bromopropanoate was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 3395-91-3, is researched, Molecular C4H7BrO2, about Reductive sp3-sp2 Coupling Reactions Enable Late-Stage Modification of Pharmaceuticals, the main research direction is chloroaminopyrimidine bromide alkyl halide chemoselective cross electrophile reductive coupling.Safety of Methyl 3-bromopropanoate.

Late-stage derivatization of pharmaceutically relevant scaffolds relies on the availability of highly functional-group tolerant reactions. Reactions that increase the sp3 character of mols. enable the pursuit of more selective and well-tolerated pharmaceuticals. Herein, we report the use of sp3-sp2 cross-electrophile reductive couplings to modify a generic ATP-competitive kinase inhibitor with a broad range of primary and secondary alkyl halide coupling partners.

This compound(Methyl 3-bromopropanoate)Safety of Methyl 3-bromopropanoate was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

The Best Chemistry compound: 3395-91-3

This compound(Methyl 3-bromopropanoate)Category: benzothiophene was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 3395-91-3, is researched, SMILESS is O=C(OC)CCBr, Molecular C4H7BrO2Journal, Article, Research Support, Non-U.S. Gov’t, Journal of Medicinal Chemistry called Discovery of LYS006, a Potent and Highly Selective Inhibitor of Leukotriene A4 Hydrolase, Author is Markert, Christian; Thoma, Gebhard; Srinivas, Honnappa; Bollbuck, Birgit; Luond, Rainer M.; Miltz, Wolfgang; Walchli, Rudolf; Wolf, Romain; Hinrichs, Jurgen; Bergsdorf, Christian; Azzaoui, Kamal; Penno, Carlos A.; Klein, Kai; Wack, Nathalie; Jager, Petra; Hasler, Franziska; Beerli, Christian; Loetscher, Pius; Dawson, Janet; Wieczorek, Grazyna; Numao, Shin; Littlewood-Evans, Amanda; Rohn, Till A., the main research direction is tetrazole derivative LYS 006 preparation LTA4H inhibitor antiinflammatory activity.Category: benzothiophene.

The cytosolic metalloenzyme leukotriene A4 hydrolase (LTA4H) is the final and rate-limiting enzyme in the biosynthesis of pro-inflammatory leukotriene B4 (LTB4). Preclin. studies have validated this enzyme as an attractive drug target in chronic inflammatory diseases. Despite several attempts, no LTA4H inhibitor has reached the market, yet. Herein, we disclose the discovery and preclin. profile of LYS006 (I), a highly potent and selective LTA4H inhibitor. A focused fragment screen identified hits that could be cocrystd. with LTA4H and inspired a fragment merging. Further optimization led to chiral amino acids and ultimately to LYS006, a picomolar LTA4H inhibitor with exquisite whole blood potency and long-lasting pharmacodynamic effects. Due to its high selectivity and its ability to fully suppress LTB4 generation at low exposures in vivo, LYS006 has the potential for a best-in-class LTA4H inhibitor and is currently investigated in phase II clin. trials in inflammatory acne, hidradenitis suppurativa, ulcerative colitis, and NASH.

This compound(Methyl 3-bromopropanoate)Category: benzothiophene was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

The Best Chemistry compound: 3395-91-3

This compound(Methyl 3-bromopropanoate)Application of 3395-91-3 was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 3395-91-3, is researched, SMILESS is O=C(OC)CCBr, Molecular C4H7BrO2Journal, Article, Journal of Medicinal Chemistry called Discovery of Highly Potent and Selective IRAK1 Degraders to Probe Scaffolding Functions of IRAK1 in ABC DLBCL, Author is Fu, Liqiang; Zhang, Jing; Shen, Bin; Kong, Linglong; Liu, Yingtao; Tu, Wangyang; Wang, Wenqian; Cai, Xin; Wang, Xiaotao; Cheng, Na; Xia, Mingxuan; Zhou, Tianyuan; Liu, Qian; Xu, Yanping; Yang, Jennifer; Gavine, Paul; Philippar, Ulrike; Attar, Ricardo; Edwards, James P.; Venable, Jennifer D.; Dai, Xuedong, the main research direction is cancers IRAK1 degraders ABC DLBCL MyD88 antiproliferative scaffolding function.Application of 3395-91-3.

MyD88 gene mutation has been identified as one of the most prevalent driver mutations in the activated B-cell-like diffuse large B-cell lymphoma (ABC DLBCL). The published literature suggests that interleukin-1 receptor-associated kinase 1 (IRAK1) is an essential gene for ABC DLBCL harboring MyD88 mutation. Importantly, the scaffolding function of IRAK1, rather than its kinase activity, is required for tumor cell survival. Herein, we present our design, synthesis, and biol. evaluation of a novel series of potent and selective IRAK1 degraders. One of the most potent compounds, Degrader-3 (JNJ-1013) (I), effectively degraded cellular IRAK1 protein with a DC50 of 3 nM in HBL-1 cells. Furthermore, JNJ-1013 potently inhibited IRAK1 downstream signaling pathways and demonstrated strong anti-proliferative effects in ABC DLBCL cells with MyD88 mutation. This work suggests that IRAK1 degraders have the potential for treating cancers that are dependent on the IRAK1 scaffolding function.

This compound(Methyl 3-bromopropanoate)Application of 3395-91-3 was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

New downstream synthetic route of 3395-91-3

This compound(Methyl 3-bromopropanoate)Synthetic Route of C4H7BrO2 was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 3395-91-3, is researched, SMILESS is O=C(OC)CCBr, Molecular C4H7BrO2Journal, Synlett called Electrochemical Synthesis of 2-Bromoethyl and 2-Iodoethyl Ketones from Cyclopropanols, Author is Barysevich, Maryia V.; Aniskevich, Yauhen M.; Hurski, Alaksiej L., the main research direction is haloalkyl ketone preparation; alkyl cyclopropanol magnesium halide electrochem regioselective ring opening halogenation.Synthetic Route of C4H7BrO2.

A simple electrochem. protocol for the preparation of 2-bromoethyl- and 2-iodoethyl ketones from cyclopropanols and magnesium halides were developed. The reaction proceeded with exclusive regioselectivity and without epimerization of the α-stereocenter in the products. The synthesized diastereomerically pure 2-bromoethyl ketones underwent smooth copper and nickel-catalyzed alkylation, alkenylation, and arylations reactions.

This compound(Methyl 3-bromopropanoate)Synthetic Route of C4H7BrO2 was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

Our Top Choice Compound: 3395-91-3

Different reactions of this compound(Methyl 3-bromopropanoate)Synthetic Route of C4H7BrO2 require different conditions, so the reaction conditions are very important.

Tan, Fei; Pu, Maoping; He, Jun; Li, Jinzhao; Yang, Jian; Dong, Shunxi; Liu, Xiaohua; Wu, Yun-Dong; Feng, Xiaoming published an article about the compound: Methyl 3-bromopropanoate( cas:3395-91-3,SMILESS:O=C(OC)CCBr ).Synthetic Route of C4H7BrO2. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:3395-91-3) through the article.

The homologation of ketones with diazo compounds was a useful strategy to synthesize one-carbon chain-extended acyclic such as PhC(O)CMeCO2MeR [R = allyl, Bn, CH2(2-naphthyl), etc.] or ring-expanded cyclic ketones e.g., I. However, the asym. homologation of acyclic ketones with α-diazo esters remains a challenge due to the lower reactivity and complicated selectivity. Herein, the enantioselective catalytic homologation of acetophenone and related derivatives with α-alkyl α-diazo esters was reported utilizing a chiral scandium(III) N,N’-dioxide as the Lewis acid catalyst. This reaction supplies a highly chemo-, regio-, and enantioselective pathway for the synthesis of optically active β-keto esters with an all-carbon quaternary center through highly selective alkyl-group migration of the ketones. Moreover, the ring expansion of cyclic ketones was accomplished under slightly modified conditions, affording a series of enantioenriched cyclic β-keto esters. D. functional theory calculations was carried out to elucidate the reaction pathway and possible working models that could explain the observed regio- and enantioselectivity.

Different reactions of this compound(Methyl 3-bromopropanoate)Synthetic Route of C4H7BrO2 require different conditions, so the reaction conditions are very important.

Reference:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

A small discovery about 3395-91-3

《A bright NIR-II fluorescent probe for breast carcinoma imaging and image-guided surgery》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(Methyl 3-bromopropanoate)Safety of Methyl 3-bromopropanoate.

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Chemical Communications (Cambridge, United Kingdom) called A bright NIR-II fluorescent probe for breast carcinoma imaging and image-guided surgery, Author is Zeng, Xiaodong; Xie, Liru; Chen, Deliang; Li, Shanshan; Nong, Jinxia; Wang, Bo; Tang, Lin; Li, Qianqian; Li, Yang; Deng, Zixin; Hong, Xuechuan; Wu, Mingfu; Xiao, Yuling, which mentions a compound: 3395-91-3, SMILESS is O=C(OC)CCBr, Molecular C4H7BrO2, Safety of Methyl 3-bromopropanoate.

A novel bright near-IR II (NIR-II, 1000-1700 nm) fluorescent probe with excellent water-solubility, superior photostability, and excellent in vitro and in vivo biocompatibility was facilely synthesized for in vivo biomedical imaging of xenograft breast tumor and chem. induced spontaneous breast carcinoma. To the best of our knowledge, it is the first time that the superior practical applications of this NIR-II probe in dimethylbenzanthracene (DMBA)-induced rat mammary carcinoma imaging and image-guided rat carcinoma surgery were demonstrated.

《A bright NIR-II fluorescent probe for breast carcinoma imaging and image-guided surgery》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(Methyl 3-bromopropanoate)Safety of Methyl 3-bromopropanoate.

Reference:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

Final Thoughts on Chemistry for 3395-91-3

The article 《A bright NIR-II fluorescent probe for breast carcinoma imaging and image-guided surgery》 also mentions many details about this compound(3395-91-3)Quality Control of Methyl 3-bromopropanoate, you can pay attention to it or contacet with the author([email protected]) to get more information.

Quality Control of Methyl 3-bromopropanoate. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: Methyl 3-bromopropanoate, is researched, Molecular C4H7BrO2, CAS is 3395-91-3, about A bright NIR-II fluorescent probe for breast carcinoma imaging and image-guided surgery. Author is Zeng, Xiaodong; Xie, Liru; Chen, Deliang; Li, Shanshan; Nong, Jinxia; Wang, Bo; Tang, Lin; Li, Qianqian; Li, Yang; Deng, Zixin; Hong, Xuechuan; Wu, Mingfu; Xiao, Yuling.

A novel bright near-IR II (NIR-II, 1000-1700 nm) fluorescent probe with excellent water-solubility, superior photostability, and excellent in vitro and in vivo biocompatibility was facilely synthesized for in vivo biomedical imaging of xenograft breast tumor and chem. induced spontaneous breast carcinoma. To the best of our knowledge, it is the first time that the superior practical applications of this NIR-II probe in dimethylbenzanthracene (DMBA)-induced rat mammary carcinoma imaging and image-guided rat carcinoma surgery were demonstrated.

The article 《A bright NIR-II fluorescent probe for breast carcinoma imaging and image-guided surgery》 also mentions many details about this compound(3395-91-3)Quality Control of Methyl 3-bromopropanoate, you can pay attention to it or contacet with the author([email protected]) to get more information.

Reference:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem