Category: 32595-59-8

Editing of non-cognate aminoacyl adenylates by peptide synthetases was written by Pavela-Vrancic, Maja;Dieckmann, Ralf;Von Dohren, Hans;Kleinkauf, Horst. And the article was included in Biochemical Journal in 1999.Synthetic Route of C7H9NO3S This article mentions the following:

Non-ribosomally formed peptides display both highly conserved and variable amino acid positions, the variations leading to a wide range of peptide families. Activation of the amino acid substrate proceeds in analogy to the ribosomal biosynthetic mechanism generating aminoacyl adenylate and acyl intermediates. To approach the mechanism of fidelity of amino acid selection, the stability of the aminoacyl adenylates was studied by employing a continuous coupled spectrophotometric assay. The apo-form of tyrocidine synthetase 1 (apo-TY1) was used, generating an L-phenylalanyl-adenylate intermediate stabilized by the interaction of two structural subdomains of the adenylation domain. Adenylates of substrate analogs have shown variable and reduced degrees of stability, thus leading to an enhanced generation of pyrophosphate due to hydrolysis and continuous adenylate formation. Discrimination of the nonaromatic amino acids L-Leu and L-Met, or L-Phe analogs such as p-amino- and p-chloro-L-Phe derivatives, as well as the stereospecific selection of L-Phe, is supported by less-stable adenylate intermediates exhibiting elevated susceptibility to hydrolysis. Breakdown of the L-phenylalanyl intermediate utilizing 2′-deoxy-ATP as the nucleotide substrate was significantly enhanced compared with the natural analog. Apo-TY1 engineered at positions involved in adenylate formation showed variable protection against hydrolysis. The results imply that stability of the aminoacyl intermediates may act as an essential factor in substrate selection and fidelity of non-ribosomal-peptide-forming systems. In the experiment, the researchers used many compounds, for example, 2-Amino-3-hydroxy-3-(thiophen-2-yl)propanoic acid (cas: 32595-59-8Synthetic Route of C7H9NO3S).

2-Amino-3-hydroxy-3-(thiophen-2-yl)propanoic acid (cas: 32595-59-8) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The electrophilic substitution of benzothiophene systems is much less regioselective than that of indoles. It is found within the chemical structures of pharmaceutical drugs such as zileuton, raloxifene, and sertaconazole, and also BTCP.Synthetic Route of C7H9NO3S

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Raney nickel desulfurization was written by Hurd, Charles D.;Rudner, Bernard. And the article was included in Journal of the American Chemical Society in 1951.Formula: C7H9NO3S This article mentions the following:

Three Raney-Ni preparations were investigated in the desulfuration of S-containing compounds o-Tolyl isothiocyanate or o-tolylthiourea gave o-MeC₆H₄NH₂; PhSO₂ derivative, white plates from 80% EtOH, m. 125-6° and 124-4.5°; Bz derivative, m. 144-5° and 142-3°. There were no secondary amines. Thiobenzanilide gave PhNHCH₂Ph; PhCONHPh, m. 164-6°; benzenesulfon(N-benzylanilide), m. 117-18°; benzo(N-benzylanilide), m. 106.5-107° (white needles from EtOH). 2-Mercaptobenzothiazole gave mostly PhNH₂, with smaller amounts of o-H₂NC₆H₄SH and benzothiazole; picrate, needles from 90% EtOH, m. 178-9.5°. 2-Mercapto- (I) and 2-amino-4-phenylthiazole (II) yielded MeCOPh; 2,4-dinitrophenylhydrazone, m. 246-8°. I also gave 4-phenylthiazole; HCl salt, m. 76-8°; picrate, m. 162-3°. II gave MeNH₂ and PhEtNH. 2-Amino- and 2-mercapto-4-hydroxythiazole gave AcNH₂ and AcH, resp. 2-Thienyl Me ketone gave BuCOMe [2,4-dinitrophenylhydrazone, m. 104-5° (orange-red rods from EtOH)], and small amounts of AcH and EtOH. In the experiment, the researchers used many compounds, for example, 2-Amino-3-hydroxy-3-(thiophen-2-yl)propanoic acid (cas: 32595-59-8Formula: C7H9NO3S).

2-Amino-3-hydroxy-3-(thiophen-2-yl)propanoic acid (cas: 32595-59-8) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The electrophilic substitution of benzothiophene systems is much less regioselective than that of indoles. Due to its aromaticity, thiophenes do not exhibit the same properties as conventional thioethers.Formula: C7H9NO3S

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Labeling of unnatural amino acids with technetium-99m and tissue distribution of the labeled products in mice was written by Tamemasa, Osamu;Goto, Rensuke;Takeda, Atsushi. And the article was included in Radioisotopes in 1981.HPLC of Formula: 32595-59-8 This article mentions the following:

^99mTc-labeled unnatural amino acids were prepared by conventional methods and their distribution in mice organs after i.v. injection was determined Most of the labeled amino acids were found in the kidney, whereas only small amounts in the pancreas. ^99mTc-labeled 4-azaleucine and -azaserine showed the highest distribution in the liver (19.3 and 17.1% dose/g wet weight, resp.). A low distribution in the stomach was shown only by a few of the labeled amino acids. In the experiment, the researchers used many compounds, for example, 2-Amino-3-hydroxy-3-(thiophen-2-yl)propanoic acid (cas: 32595-59-8HPLC of Formula: 32595-59-8).

2-Amino-3-hydroxy-3-(thiophen-2-yl)propanoic acid (cas: 32595-59-8) belongs to benzothiophene derivatives. Benzothiophenes are valuable heterocycles that are widely used in medicines, agrochemicals, and materials science. It is also used in the manufacturing of dyes such as thioindigo.HPLC of Formula: 32595-59-8

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Proteolytic susceptibility of hemoglobin synthesized in the presence of amino acid analogs was written by Ayukawa, Saburo;Fisher, Joyce M.;Rabinovitz, Marco. And the article was included in Molecular Pharmacology in 1981.Formula: C7H9NO3S This article mentions the following:

α-Amino acid analogs with a hetero atom on the β-C, when incorporated into protein by a reticulocyte lysate, render the newly formed protein particularly sensitive to proteolytic hydrolysis. In the experiment, the researchers used many compounds, for example, 2-Amino-3-hydroxy-3-(thiophen-2-yl)propanoic acid (cas: 32595-59-8Formula: C7H9NO3S).

2-Amino-3-hydroxy-3-(thiophen-2-yl)propanoic acid (cas: 32595-59-8) belongs to benzothiophene derivatives. Benzothiophene scaffolds are of great importance due to its increased presence in bioactive molecules. Due to its aromaticity, thiophenes do not exhibit the same properties as conventional thioethers.Formula: C7H9NO3S

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem