Category: 310466-37-6

Allen, Daniel; Callaghan, Owen; Cordier, Frederic L.; Dobson, David R.; Harris, John R.; Hotten, Terry M.; Owton, W. Martin; Rathmell, Richard E.; Wood, Virginia A. published their research in Tetrahedron Letters on December 20 ,2004. The article was titled 《An improved synthesis of substituted benzo[b]thiophenes using microwave irradiation》.COA of Formula: C9H5FO2S The article contains the following contents:

An easy and high-yielding method for the synthesis of substituted benzo[b]thiophenes using microwave irradiation is described. After reading the article, we found that the author used 4-Fluorobenzo[b]thiophene-2-carboxylic acid(cas: 310466-37-6COA of Formula: C9H5FO2S)

4-Fluorobenzo[b]thiophene-2-carboxylic acid(cas: 310466-37-6) belongs to benzothiophene.Benzothiophene is a fused ring compound of thiophene ring and benzene ring, which is an important class of heterocycles with advantageous structures. COA of Formula: C9H5FO2SIt has been used as a raw material for the synthesis of biologically active structures and is found in pharmaceuticals such as selective estrogen receptor modulators, leukotriene synthesis inhibitors and antifungals, as well as in many natural products.

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Application In Synthesis of 4-Fluorobenzo[b]thiophene-2-carboxylic acidOn May 8, 2013 ,《Acid controlled generation of indanes and oxazolines from β-hydroxyarylethanamide》 appeared in Tetrahedron Letters. The author of the article were Suresh, Rajendran; Muthusubramanian, Shanmugam; Boominathan, Muthusamy; Manickam, Govindaswamy. The article conveys some information:

Simple and efficient protocols for the construction of substituted indans and oxazolines through intramol. cyclization of β-hydroxyarylethanamide using trifluoromethanesulfonic acid and titanium tetrachloride in 1,2-dichloroethane, resp., have been described. The selectivity due to different acid catalysts was explored and optimized to achieve good to excellent yield. E.g., in presence of TiCl4 in 1,2-dichloroethane, intramol. cyclization of β-hydroxyarylethanamide derivative (I, a mixture of diastereomers) gave 94% oxazoline derivative (II). E.g., in presence of trifluoromethanesulfonic acid, intramol. cyclization of β-hydroxyarylethanamide derivative (I, a mixture of diastereomers) gave 89% indan derivative (III). The results came from multiple reactions, including the reaction of 4-Fluorobenzo[b]thiophene-2-carboxylic acid(cas: 310466-37-6Application In Synthesis of 4-Fluorobenzo[b]thiophene-2-carboxylic acid)

4-Fluorobenzo[b]thiophene-2-carboxylic acid(cas: 310466-37-6) belongs to benzothiophene.Benzothiophene is a fused ring compound of thiophene ring and benzene ring, which is an important class of heterocycles with advantageous structures. It has been used as a raw material for the synthesis of biologically active structures and is found in pharmaceuticals such as selective estrogen receptor modulators, leukotriene synthesis inhibitors and antifungals, as well as in many natural products. Application In Synthesis of 4-Fluorobenzo[b]thiophene-2-carboxylic acid

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Reference of 4-Fluorobenzo[b]thiophene-2-carboxylic acidOn March 14, 2013, Katane, Masumi; Osaka, Naoko; Matsuda, Satsuki; Maeda, Kazuhiro; Kawata, Tomonori; Saitoh, Yasuaki; Sekine, Masae; Furuchi, Takemitsu; Doi, Issei; Hirono, Shuichi; Homma, Hiroshi published an article in Journal of Medicinal Chemistry. The article was 《Identification of Novel d-Amino Acid Oxidase Inhibitors by in Silico Screening and Their Functional Characterization in Vitro》. The article mentions the following:

D-Amino acid oxidase (DAO) is a degradative enzyme that is stereospecific for d-amino acids, including d-serine and d-alanine, which are potential coagonists of the N-methyl-d-aspartate (NMDA) receptor. Dysfunction of NMDA receptor-mediated neurotransmission has been implicated in the onset of various mental disorders such as schizophrenia. Hence, a DAO inhibitor that augments the brain levels of d-serine and/or d-alanine and thereby activates NMDA receptor function is expected to be an antipsychotic drug, for instance, in the treatment of schizophrenia. In the search for potent DAO inhibitor(s), a large number of compounds were screened in silico, and several compounds were estimated as candidates. These compounds were then characterized and evaluated as novel DAO inhibitors in vitro. The results reported in this study indicate that some of these compounds are possible lead compounds for the development of a clin. useful DAO inhibitor and have the potential to serve as active site probes to elucidate the structure-function relationships of DAO. The results came from multiple reactions, including the reaction of 4-Fluorobenzo[b]thiophene-2-carboxylic acid(cas: 310466-37-6Reference of 4-Fluorobenzo[b]thiophene-2-carboxylic acid)

4-Fluorobenzo[b]thiophene-2-carboxylic acid(cas: 310466-37-6) belongs to benzothiophene.Benzothiophene is a fused ring compound of thiophene ring and benzene ring, which is an important class of heterocycles with advantageous structures. It has been used as a raw material for the synthesis of biologically active structures and is found in pharmaceuticals such as selective estrogen receptor modulators, leukotriene synthesis inhibitors and antifungals, as well as in many natural products. Reference of 4-Fluorobenzo[b]thiophene-2-carboxylic acid

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Reference of 4-Fluorobenzo[b]thiophene-2-carboxylic acidOn March 1, 2010, Planty, Bruno; Pujol, Chantal; Lamothe, Marie; Maraval, Catherine; Horn, Clemens; Le Grand, Bruno; Perez, Michel published an article in Bioorganic & Medicinal Chemistry Letters. The article was 《Exploration of a new series of PAR1 antagonists》. The article mentions the following:

Two series of new PAR1 antagonists have been identified. The first incorporates a cinnamoylpiperidine motif and the second a cinnamoylpyridine pattern. The synthesis, biol. activity and structure-activity relationship of these compounds are presented. In each series, one analog showed potent in vivo antithrombotic activity in a rat AV shunt model, with up to 53% inhibition at 1.25 mpk iv for compound I. The experimental part of the paper was very detailed, including the reaction process of 4-Fluorobenzo[b]thiophene-2-carboxylic acid(cas: 310466-37-6Reference of 4-Fluorobenzo[b]thiophene-2-carboxylic acid)

4-Fluorobenzo[b]thiophene-2-carboxylic acid(cas: 310466-37-6) belongs to benzothiophene.Benzothiophene is a fused ring compound of thiophene ring and benzene ring, which is an important class of heterocycles with advantageous structures. Reference of 4-Fluorobenzo[b]thiophene-2-carboxylic acidIt has been used as a raw material for the synthesis of biologically active structures and is found in pharmaceuticals such as selective estrogen receptor modulators, leukotriene synthesis inhibitors and antifungals, as well as in many natural products.

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem