Category: 26018-73-5

26018-73-5, 6-Chlorobenzo[b]thiophene-2-carboxylic acid is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

[000924] Compound 242C (420 mg, 1.98 mmol) and copper powder (63 mg, 0.99 mmol) were suspended in quinoline (10 mL) and the resulting mixture was heated at 185 C for 2 h. After cooling down to room temperature, ethyl acetate (25 mL) was added and the suspension was filtered. The filtered cake was washed with ethyl acetate (5 mL x 2) and the combined organic layers were washed with aqueous HC1 solution (2 N, 10 mL x 2). After drying over anhydrous sodium sulfate, the solution was filtered and evaporated in vacuo to give a residue. The crude product was purified with flash column chromatography on silica gel (ethyl acetate in petroleum ether, from 0% to 10% v/v) to afford Compound 242D.

26018-73-5, The synthetic route of 26018-73-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BIOMARIN PHARMACEUTICAL INC.; WANG, Bing; CHU, Daniel; BRIDGES, Alexander, James; WO2015/42397; (2015); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.26018-73-5,6-Chlorobenzo[b]thiophene-2-carboxylic acid,as a common compound, the synthetic route is as follows.,26018-73-5

To a solution of 6-chlorobenzothiophene-2-carboxylic acid Xl-9b (1.00 g, 4.70 mmol) inDMA (5 ml) was added DBU (2.86 g, 18.8 mmol) and reaction mixture was heated in10 microwave at 200C for 1 h. Progress of the reaction was monitored by TLC. Aftercompletion, the reaction mixture was diluted with H20 (30 ml) and extracted with EtOAc(3 x 20 ml). The organic layer was separated, dried over anhydrous Na2S04 andconcentrated under vacuum to afford 6-chlorobenzothiophene Xl-9 (0.51 g) as an offwhitesolid.15 This compound was used as such for the next reaction without further purification.20Yield: 65%1H NMR (400 MHz, DMSO-d5) o 7.41 (dd, J=8.56, 1.71 Hz, 1 H) 7.47 (d, J=5.38 Hz, 1 H)7.80 (d, J=5.38 Hz, 1 H) 7.89 (d, J=8.80 Hz, 1 H) 8.17 (d, J=0.98 Hz, 1 H).

As the paragraph descriping shows that 26018-73-5 is playing an increasingly important role.

Reference£º
Patent; UCB PHARMA GMBH; MUELLER, Christa E.; PEGURIER, Cecile; DELIGNY, Michael Louis Robert; EL-TAYEB, Ali; HOCKEMEYER, Joerg; LEDECQ, Marie; MERCIER, Joel; PROVINS, Laurent; BOSHTA, Nader M.; BHATTARAI, Sanjay; NAMASIVAYAM, Vigneshwaran; FUNKE, Mario; SCHWACH, Lukas; GOLLOS, Sabrina; VON LAUFENBERG, Daniel; BARRE, Anais; (493 pag.)WO2018/122232; (2018); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem