Category: 254905-58-3

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Conformationally restrained carbamoylcholine homologues. Synthesis, pharmacology at neuronal nicotinic acetylcholine receptors and biostructural considerations, published in 2015-09-18, which mentions a compound: 254905-58-3, Name is tert-Butyl 4-(dimethylcarbamoyl)piperidine-1-carboxylate, Molecular C13H24N2O3, COA of Formula: C13H24N2O3.

Exploration of small selective ligands for the nicotinic acetylcholine receptors (nAChRs) based on acetylcholine (ACh) has led to the development of potent agonists with clear preference for the α4β2 nAChR, the most prevalent nAChR subtype in the central nervous system. In this work the authors present the continuation of these efforts aimed at increasing this subtype selectivity by introduction of conformational restriction in the carbamoylcholine homolog, 3-(dimethylaminobutyl) dimethylcarbamate (DMABC). The results highlight the importance of the N-carbamoyl substitution in α4β2-subtype selectivity. Moreover, the authors have confirmed the non-linear conformation of DMABC bound to nAChRs suggested by recent crystal structures of the compound in complex with the Lymnaea stagnalis ACh binding protein.

If you want to learn more about this compound(tert-Butyl 4-(dimethylcarbamoyl)piperidine-1-carboxylate)COA of Formula: C13H24N2O3, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(254905-58-3).

Reference:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: tert-Butyl 4-(dimethylcarbamoyl)piperidine-1-carboxylate, is researched, Molecular C13H24N2O3, CAS is 254905-58-3, about Conformationally restrained carbamoylcholine homologues. Synthesis, pharmacology at neuronal nicotinic acetylcholine receptors and biostructural considerations.Synthetic Route of C13H24N2O3.

Exploration of small selective ligands for the nicotinic acetylcholine receptors (nAChRs) based on acetylcholine (ACh) has led to the development of potent agonists with clear preference for the α4β2 nAChR, the most prevalent nAChR subtype in the central nervous system. In this work the authors present the continuation of these efforts aimed at increasing this subtype selectivity by introduction of conformational restriction in the carbamoylcholine homolog, 3-(dimethylaminobutyl) dimethylcarbamate (DMABC). The results highlight the importance of the N-carbamoyl substitution in α4β2-subtype selectivity. Moreover, the authors have confirmed the non-linear conformation of DMABC bound to nAChRs suggested by recent crystal structures of the compound in complex with the Lymnaea stagnalis ACh binding protein.

If you want to learn more about this compound(tert-Butyl 4-(dimethylcarbamoyl)piperidine-1-carboxylate)Synthetic Route of C13H24N2O3, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(254905-58-3).

Reference:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Conformationally restrained carbamoylcholine homologues. Synthesis, pharmacology at neuronal nicotinic acetylcholine receptors and biostructural considerations, published in 2015-09-18, which mentions a compound: 254905-58-3, Name is tert-Butyl 4-(dimethylcarbamoyl)piperidine-1-carboxylate, Molecular C13H24N2O3, Recommanded Product: 254905-58-3.

Exploration of small selective ligands for the nicotinic acetylcholine receptors (nAChRs) based on acetylcholine (ACh) has led to the development of potent agonists with clear preference for the α4β2 nAChR, the most prevalent nAChR subtype in the central nervous system. In this work the authors present the continuation of these efforts aimed at increasing this subtype selectivity by introduction of conformational restriction in the carbamoylcholine homolog, 3-(dimethylaminobutyl) dimethylcarbamate (DMABC). The results highlight the importance of the N-carbamoyl substitution in α4β2-subtype selectivity. Moreover, the authors have confirmed the non-linear conformation of DMABC bound to nAChRs suggested by recent crystal structures of the compound in complex with the Lymnaea stagnalis ACh binding protein.

If you want to learn more about this compound(tert-Butyl 4-(dimethylcarbamoyl)piperidine-1-carboxylate)Recommanded Product: 254905-58-3, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(254905-58-3).

Reference:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Mallinger, Aurelie; Crumpler, Simon; Pichowicz, Mark; Waalboer, Dennis; Stubbs, Mark; Adeniji-Popoola, Olajumoke; Wood, Bozena; Smith, Elizabeth; Thai, Ching; Henley, Alan T.; Georgi, Katrin; Court, William; Hobbs, Steve; Box, Gary; Ortiz-Ruiz, Maria-Jesus; Valenti, Melanie; De Haven Brandon, Alexis; Te Poele, Robert; Leuthner, Birgitta; Workman, Paul; Aherne, Wynne; Poeschke, Oliver; Dale, Trevor; Wienke, Dirk; Esdar, Christina; Rohdich, Felix; Raynaud, Florence; Clarke, Paul A.; Eccles, Suzanne A.; Stieber, Frank; Schiemann, Kai; Blagg, Julian published an article about the compound: tert-Butyl 4-(dimethylcarbamoyl)piperidine-1-carboxylate( cas:254905-58-3,SMILESS:O=C(N1CCC(C(N(C)C)=O)CC1)OC(C)(C)C ).HPLC of Formula: 254905-58-3. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:254905-58-3) through the article.

WNT signaling is frequently deregulated in malignancy, particularly in colon cancer, and plays a key role in the generation and maintenance of cancer stem cells. The authors report the discovery and optimization of a 3,4,5-trisubstituted pyridine, 1-(3,5-Dichloropyridin-4-yl)piperidine-4-carboxamide (9), using a high-throughput cell-based reporter assay of WNT pathway activity. The authors demonstrate a twisted conformation about the pyridine-piperidine bond of (9) by small-mol. x-ray crystallog. Medicinal chem. optimization to maintain this twisted conformation, cognisant of physicochem. properties likely to maintain good cell permeability, led to 8-[3-Chloro-5-[4-(1-methyl-1H-pyrazol-4-yl)phenyl]pyridin-4-yl]-2,8-diazaspiro[4,5]decan-1-one (74) (CCT251545), a potent small-mol. inhibitor of WNT signaling with good oral pharmacokinetics. The authors demonstrate inhibition of WNT pathway activity in a solid human tumor xenograft model with evidence for tumor growth inhibition following oral dosing. This work provides a successful example of hypothesis-driven medicinal chem. optimization from a singleton hit against a cell-based pathway assay without knowledge of the biochem. target.

Here is a brief introduction to this compound(254905-58-3)HPLC of Formula: 254905-58-3, if you want to know about other compounds related to this compound(254905-58-3), you can read my other articles.

Reference:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem