Category: 25288-76-0

Desulfurization of benzo- and dibenzothiophenes with nickel boride was written by Back, Thomas G.;Yang, Kexin;Krouse, H. Roy. And the article was included in Journal of Organic Chemistry in 1992.Application In Synthesis of Dibenzo[b,d]thiophen-3-amine This article mentions the following:

Nickel boride, prepared from the reduction of nickel chloride hexahydrate with sodium borohydride in methanol-tetrahydrofuran, reduces benzothiophenes to alkylbenzenes and dibenzothiophenes to biphenyls. The reaction is rapid at or below room temperature and does not require protection from the atm. Best results are obtained when the nickel boride is generated in situ in the presence of the sulfur compound Hydroxyl, carboxyl, ester, and amino groups are unaffected while chloro, bromo, and nitro substituents are also reduced under these conditions. A short-lived intermediate, possibly a nickel hydride species, appears to be required in the desulfurization. Complexation of the substrate to the nickel boride surface, followed by stepwise reduction of the two CS bonds, occurs. The faster disappearance of dibenzothiophene containing the lighter ³²S isotope compared to that with ³⁴S [k(³²S)/k(³⁴S) = 1.005 to 1.006] suggests that CS bond cleavage is the rate determining step. In the experiment, the researchers used many compounds, for example, Dibenzo[b,d]thiophen-3-amine (cas: 25288-76-0Application In Synthesis of Dibenzo[b,d]thiophen-3-amine).

Dibenzo[b,d]thiophen-3-amine (cas: 25288-76-0) belongs to benzothiophene derivatives. Benzothiophene finds use in research as a starting material for the synthesis of larger, usually bioactive structures. It is found within the chemical structures of pharmaceutical drugs such as zileuton, raloxifene, and sertaconazole, and also BTCP.Application In Synthesis of Dibenzo[b,d]thiophen-3-amine

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Antibacterial effect of lichen substances and related compounds VI. Dibenzothiophene, fluorene, and carbazole derivatives was written by Natori, Shinsaku;Ito, Masao;Nakagome, Takenari. And the article was included in Pharmaceutical Bulletin in 1957.Category: benzothiophene This article mentions the following:

Since isosteric compounds often show similar biol. effects, the preceding study was extended to derivatives of compounds having S, SO, SO₂, CH₂, CO, or NH in place of the O of dibenzofuran. About 40 such compounds were synthesized by familiar methods. Five less well-known syntheses are described. The 2-Br derivative of dibenzothiophene 5-dioxide (I) (3.5 g.) heated 7 hrs. at 200° in an autoclave with 0.2 g. powd. Cu and 70 cc. concentrated NH₄OH yielded on cooling 1.8 g. 2-H₂N derivative of I, m. 269-70° (BuOH), previously prepared (Brown, et al., C.A. 47, 12346i) by the reduction of the 2-O₂N derivative of I. Cyclohexanone condensed with m-O₂NC₆H₄NHNH₂ and the product cyclized in the presence of HCl gave a mixture of 5- and 7-O₂N derivatives of 1,2,3,4-tetrahydrocarbazole (II), and chromatography separated the 5-O₂N derivative, m. 153° (hot C₆H₆ with rapid cooling) or 116° (hot C₆H₆ with gradual cooling), dimorphic forms. The 2-O₂N derivative of II dehydrogenated with chloranil and the product purified by chromatography in C₆H₆ over Al₂O₃ gave the 2-O₂N derivative of carbazole (III), m. 174-5° (C₆H₆), and this catalytically reduced (Pd-C) in EtOH gave the 2-H₂N derivative of III, m. 226-38° (decomposition); trinitrobenzene complex, m. 186-8° (EtOH). The 4-O₂N derivative of III reduced by Sn and HCl gave the HCl salt of the 4-H₂N derivative of III, m. above 300°; free base, m. 230-50° (decomposition); trinitrobenzene complex, m. 216-20° (EtOH). Other compounds prepared and tested were: dibenzothiophene, its 2-Br, 2-H₂N, 2-AcNH, 2,8-Br₂, 2,8-(H₂N)₂, 2,8-(AcNH)₂, 3-O₂N, 3-H₂N, 3-AcNH, and 3,7-(O₂N)₂ derivatives; dibenzothiophene 5-oxide, its 3-O₂N, 3-H₂N, 3,7-(O₂N)₂ derivatives; I, its 2-Br, 2-AcNH, 3-O₂N, 3-H₂N, 3-AcNH, 2,8-Br₂, 2,8-(H₂N)₂, and 2,8-(AcNH)₂ derivatives; fluorene, its 2-O₂N, and 2-H₂N derivatives; fluorenone, its 2-O₂N, and 2-H₂N derivatives; II, its 7-O₂N, 5-H₂N, and 7-H₂N derivatives; and III, its 4-O₂N, and 9-Ac derivatives The antibacterial activities of these 40 compounds were tested and recorded as above, and compared with those of the corresponding dibenzofuran derivatives In the experiment, the researchers used many compounds, for example, Dibenzo[b,d]thiophen-3-amine (cas: 25288-76-0Category: benzothiophene).

Dibenzo[b,d]thiophen-3-amine (cas: 25288-76-0) belongs to benzothiophene derivatives. Functionalized benzothiophenes are important constructs found in molecules with wide ranging biological activity and in organic materials. The different substitution patterns in these heterocycles offer new opportunities for drug discovery and other applications in materials science.Category: benzothiophene

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Some derivatives of dibenzothiophene was written by Brown, Robert K.;Christiansen, Robert G.;Sandin, Reuben B.. And the article was included in Journal of the American Chemical Society in 1948.Application of 25288-76-0 This article mentions the following:

Dibenzothiophene (15 g.) in 150 ml. CCl₄, treated at 0-5° with 6 g. Cl and the addition compound hydrolyzed by shaking with ice and H₂O, gives 77% of the 5-oxide (I), m. 185-7°. I (15 g.), 33 ml. AcOH, and 33 ml. concentrated H₂SO₄ at 0° treated (15 min.) with 36 ml. HNO₃ (d. 1.5), kept 30 min. at 0-5°, and poured onto ice, give 76% 3-nitrodibenzothiophene 5-oxide (II), m. 209.5-10.5°. II (10 g.) in 100 ml. AcOH, reduced with 51 g. SnCl₂.2H₂O in 65 ml. concentrated HCl, gives 65% 3-aminodibenzothiophene, m. 121-2.5°. II (5 g.) in 60 ml. AcOH, treated with 26 g. SnCl₂.2H₂O in 40 ml. 6 N HCl, kept 30 min. at 40° and 3 hrs. at room temperature, gives 91% 3-aminodibenzothiophene 5-oxide, light yellow, m. 208-9°; Ac derivative, light yellow, m. 265-7°. In the experiment, the researchers used many compounds, for example, Dibenzo[b,d]thiophen-3-amine (cas: 25288-76-0Application of 25288-76-0).

Dibenzo[b,d]thiophen-3-amine (cas: 25288-76-0) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The core structure is a part of various pharmaceutical substances and natural products. It is found within the chemical structures of pharmaceutical drugs such as zileuton, raloxifene, and sertaconazole, and also BTCP.Application of 25288-76-0

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem