Category: 20532-28-9

Archives for Chemistry Experiments of 20532-28-9

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. 20532-28-9, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 20532-28-9, in my other articles.

20532-28-9, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 20532-28-9, Name is 5-Aminobenzothiophene, molecular formula is C8H7NS. In a Article, authors is Murakami, Yasushi£¬once mentioned of 20532-28-9

1,3-Disubstituted benzazepines as novel, potent, selective neuropeptide Y Y1 receptor antagonists

A novel series of potent and selective non-peptide neuropeptide Y (NPY) Y1 receptor antagonists, having benzazepine nuclei, have been designed, synthesized, and evaluated for activity. Chemical modification of the R1 and R3 substituents in structure 1 (Chart 1) yields several compounds that show high affinity for the Y1 receptor (K(i) values of less than 10 nM). SAR studies revealed that introduction of an isopropylurea group at R1 and a 3- (benzo-condensed-urea) group, 3-(fluorophenylurea) group, or a 3-(N-(4- hydroxyphenyl)guanidine) group at R3 in structure 1 afforded potent and subtype-selective NPY Y1 receptor antagonists. 3-(3-(Benzothiazol-6- yl)ureido)-1-N-(3-(N’-(3-isopropylureido))benzyl)-2,3,4,5-tetrahydro-1H-1- benzazepin-2-one (21), which was one of the most potent derivatives, competitively inhibited specific [125I]peptide YY (PYY) binding to Y1 receptors in human neuroblastoma SK-N-MC cells (K(i) = 5.1 nM). 21 not only inhibited the Y1 receptor-mediated increase in cytosolic free Ca2+ concentration in SK-N-MC cells but also antagonized the Y1 receptor-mediated inhibitory effect of peptide YY on gastrin-induced histamine release in rat enterochromaffin-like cells. 21 showed no significant affinity in 17 receptor binding assays including Y2, Y4, and Y5 receptors.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. 20532-28-9, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 20532-28-9, in my other articles.

Reference£º
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

Brief introduction of 20532-28-9

20532-28-9 5-Aminobenzothiophene 288032, abenzothiophene compound, is more and more widely used in various fields.

20532-28-9, 5-Aminobenzothiophene is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,20532-28-9

A stirred solution of benzo[b]thiophen-5-amine (2.48 g, 17.0 mmol), hexane-2,5-dione (1.95 mL, 17.0 mmol) and glacial acetic acid (0.2 mL) in benzene (35 mL) was heated to reflux under a Dean-Stark head. After 14 h the reaction was cooled to r.t., diluted with diethyl ether (40 mL), and successively washed with aqueous 2 N hydrochloric acid (30 mL), brine (30 mL), a saturated aqueous solution of sodium hydrogen carbonate (30 mL) and finally brine (30 mL). The organic layer was separated, dried over magnesium sulfate, filtered and the solvent evaporated in vacuo to yield l-(benzo[b]thiophen-5-yl)- 2,5-dimethyl-lH-pyrrole (3.67 g, 97%) as a light orange crystalline solid. 1H NMR delta (CDCl3, 400 MHz) 2.04 (s, 6 H), 5.93 (s, 2 H), 7.19 (dd, /= 8, 2 Hz, 1 H), 7.37 (d, J = 5 Hz, 1 H), 7.55 (d, J = 5 Hz, 1 H), 7.66 (d, / = 2 Hz, 1 H), 7.94 (d, J = 9 Hz, 1 H).

20532-28-9 5-Aminobenzothiophene 288032, abenzothiophene compound, is more and more widely used in various fields.

Reference£º
Patent; AMGEN, INC.; WO2006/66172; (2006); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

 

Downstream synthetic route of 20532-28-9

The synthetic route of 20532-28-9 has been constantly updated, and we look forward to future research findings.

20532-28-9, 5-Aminobenzothiophene is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,20532-28-9

EXAMPLE 61 Benzo[b]thiophen-5-yl-(6-methyl-pyrido[3,4-d]pyrimidin-4-yl)-aminehydrochloride This material was prepared from 6-methyl-pyrido[3,4-d]pyrimid -4-one (1.0 eq.) and 5-amino-benzo[b]thiophene (1.5 eq.) as described for Example 60. The polymer was filtered off and washed several times with 30% methanol/70% chloroform. Triethylamine (3.0 eq) was added to the filtrate and washings before they were concentrated in vacuo. The residue was flash chromatographed on silica in 10% methanol/methylenechloride to afford 135 mg of product as the free base (LC-MS: 293(MH+)). This material was dissolved in a minimum volume of chloroform and 1 mole equivalent of HCl in ether was added dropwise with stirring. The reaction mixture was diluted with ether (4volumes) and the precipitated title product was filtered and dried in vacuo (152 mg; M.P. 273-276 C.; LC-MS: 293 (MH+); anal. RP-HPLC:4.10 min.).

The synthetic route of 20532-28-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Pfizer Inc; US6395733; (2002); B1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

 

Some tips on 20532-28-9

As the paragraph descriping shows that 20532-28-9 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20532-28-9,5-Aminobenzothiophene,as a common compound, the synthetic route is as follows.

A solution of 540 mg of benzo[b]thiophen-5-ylamine in 5 ml of diethyl ethoxymethylenemalonate is stirred at 130C for 1.5 hours. The reaction mixture is then diluted with ethyl acetate. It is washed with saturated aqueous sodium chloride solution, dried over sodium sulphate and concentrated in vacuo. The crude product is purified by column chromatography on silica gel with a hexane/ethyl acetate mixture. 1.88 g of product are obtained.1H-NMR (CDCl3): delta= 1.30-1.45 (6H); 4.20-4.38 (4H); 7.16 (1 H); 7.30 (1 H); 7.51 (1H); 7.58 (1H); 7.86 (1 H); 8.60 (1H) 11.12 (1 H).

As the paragraph descriping shows that 20532-28-9 is playing an increasingly important role.

Reference£º
Patent; BAYER SCHERING PHARMA AKTIENGESELLSCHAFT; WO2007/147578; (2007); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem