Category: 188240-63-3

On March 21, 1997, Taylor, Edward C.; Dowling, James E. published an article.Safety of 3-Bromo-4,5,6,7-tetrahydrobenzo[c]thiophene-1-carboxylic acid The title of the article was Replacement of the 1′,4′-Phenylene Region in 5,10-Dideaza-5,6,7,8-tetrahydrofolic Acid (DDATHF) by 4,5,6,7-Tetrahydrobenzo[c]thiophene and 4,5,6,7-Tetrahydroisobenzofuran Nuclei. And the article contained the following:

Two new analogs of DDATHF, in which the 1′,4′-phenylene unit is replaced by 4,5,6,7-tetrahydrobenzo[c]thiophene and 4,5,6,7-tetrahydroisobenzofuran nuclei, have been prepared and evaluated for in vitro cytotoxicity, glycinamide ribonucleotide formyltransferase (GARFT) inhibition, and folyl polyglutamate synthetase (FPGS) affinity as potential antitumor agents. The experimental process involved the reaction of 3-Bromo-4,5,6,7-tetrahydrobenzo[c]thiophene-1-carboxylic acid(cas: 188240-63-3).Safety of 3-Bromo-4,5,6,7-tetrahydrobenzo[c]thiophene-1-carboxylic acid

The Article related to dideazatetrahydrofolate derivative preparation antitumor, glycinamide ribonucleotide formyltransferase inhibition dideazatetrahydrofolate derivative, folyl polyglutamate synthetase affinity dideazatetrahydrofolate derivative and other aspects.Safety of 3-Bromo-4,5,6,7-tetrahydrobenzo[c]thiophene-1-carboxylic acid

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

On May 6, 2021, Wang, Jianfei; Zhang, Yang; Zhu, Wenyuan; Li, Jian; Chen, Shuhui published a patent.Product Details of 188240-63-3 The title of the patent was Uricosuric agent, synthetic method therefor, and pharmaceutical application thereof. And the patent contained the following:

A compound of a uricosuric agent used as a uric acid transporter (URAT1) inhibitor, and application thereof in preparation of a medication for treating a disease related to abnormal uric acid levels. The experimental process involved the reaction of 3-Bromo-4,5,6,7-tetrahydrobenzo[c]thiophene-1-carboxylic acid(cas: 188240-63-3).Product Details of 188240-63-3

The Article related to uricosuric agent uric acid transporter inhibitor preparation, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Product Details of 188240-63-3

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

On August 26, 2015, Chen, Shuhui; Zhu, Wenyuan; Wang, Jianfei; Li, Jian; Wei, Yuquan; Yu, Luoting; Tao, Xin published a patent.Reference of 3-Bromo-4,5,6,7-tetrahydrobenzo[c]thiophene-1-carboxylic acid The title of the patent was Thiophene-imidazole derivatives as hepatitis c virus inhibitors and their preparation, pharmaceutical compositions and use in the treatment of chronic hepatitis C virus infection. And the patent contained the following:

The invention discloses a series of thiophene or its variant derivative and composition as hepatitis C virus inhibitor, and relating to its application in preparation chronic HCV infection treatment medicine.In particular it relates to the series compound as NS5A inhibitor and composition thereof and pharmaceutical applications. Disclosed is thiophene-imidazole derivatives, e.g., I, as hepatitis C virus (HCV) inhibitors or variant derivatives thereof and compositions thereof. The invention further relates to the application in preparing chronic hepatitis C virus infection drugs. Particularly, the invention relates to a series of compounds used as NS5A inhibitors and compositions thereof and uses thereof for drug preparation Compound I was prepared by using cyclization, cross-coupling and condensation as the key steps. All the invention compounds were evaluated for their hepatitis c virus and NS5A inhibitory activity. From the assay, it was determined that example compound I exhibited the EC50 and CC50 values of 0.001 – 0.1 nM and > 10 nM against HCV 1b. The experimental process involved the reaction of 3-Bromo-4,5,6,7-tetrahydrobenzo[c]thiophene-1-carboxylic acid(cas: 188240-63-3).Reference of 3-Bromo-4,5,6,7-tetrahydrobenzo[c]thiophene-1-carboxylic acid

The Article related to thiophene imidazole preparation ns5a inhibitor treatment chronic hepatitis c, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Reference of 3-Bromo-4,5,6,7-tetrahydrobenzo[c]thiophene-1-carboxylic acid

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

On August 27, 2015, Chen, Shuhui; Zhu, Wenyuan; Wang, Jianfei; Li, Jian; Wei, Yuquan; Yu, Luoting; Tao, Xin published a patent.COA of Formula: C9H9BrO2S The title of the patent was Thiophene-imidazole derivatives as hepatitis c virus inhibitors and their preparation, pharmaceutical compositions and use in the treatment of chronic hepatitis C virus infection. And the patent contained the following:

Disclosed is thiophene-imidazole derivatives, e.g., I, as hepatitis C virus (HCV) inhibitors or variant derivatives thereof and compositions thereof. The invention further relates to the application in preparing chronic hepatitis C virus infection drugs. Particularly, the invention relates to a series of compounds used as NS5A inhibitors and compositions thereof and uses thereof for drug preparation Compound I was prepared by using cyclization, cross-coupling and condensation as the key steps. All the invention compounds were evaluated for their hepatitis c virus and NS5A inhibitory activity. From the assay, it was determined that example compound I exhibited the EC50 and CC50 values of 0.001 – 0.1 nM and > 10 nM against HCV 1b. The experimental process involved the reaction of 3-Bromo-4,5,6,7-tetrahydrobenzo[c]thiophene-1-carboxylic acid(cas: 188240-63-3).COA of Formula: C9H9BrO2S

The Article related to thiophene imidazole preparation ns5a inhibitor treatment chronic hepatitis c, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.COA of Formula: C9H9BrO2S

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

On May 6, 2021, Zhang, Yang; Wu, Wentao; Zhu, Wenyuan; Chen, Shuhui published a patent.Safety of 3-Bromo-4,5,6,7-tetrahydrobenzo[c]thiophene-1-carboxylic acid The title of the patent was Thiophene derivatives as xanthine oxidase inhibitors and application thereof. And the patent contained the following:

A class of xanthine oxidase (XO) inhibitors, and application thereof in the preparation of drugs for treating XO-related diseases. Specifically disclosed is a compound represented by formula I (R1 is independently selected from H, halide, OH, NH2, CN, etc.; n = 0, 1, 2, 3, or 4; R2 is selected from H, halide, OH, NH2 or CN; cyclic A is selected from C5-C6 cycloalkane or heterocylocalkane group) and a pharmaceutically acceptable salt thereof. For example, compound II is prepared by a multi-step synthesis starting from benzothiophene compound (CAS Number 2105532-70-3). The experimental process involved the reaction of 3-Bromo-4,5,6,7-tetrahydrobenzo[c]thiophene-1-carboxylic acid(cas: 188240-63-3).Safety of 3-Bromo-4,5,6,7-tetrahydrobenzo[c]thiophene-1-carboxylic acid

The Article related to thiophene derivative xanthine oxidase inhibitor drug disease, Heterocyclic Compounds (One Hetero Atom): Thiophenes and other aspects.Safety of 3-Bromo-4,5,6,7-tetrahydrobenzo[c]thiophene-1-carboxylic acid

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem