17402-83-4 | Page 7 of 7 | Heterocyclic Building Blocks-Benzothiophene

Simple exploration of 17402-83-4

17402-83-4, As the paragraph descriping shows that 17402-83-4 is playing an increasingly important role.

17402-83-4, Benzo[b]thiophen-4-amine is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

[00348] To a stirred solution of benzo[b]thiophen-4-amine (1 g, 6.70 mmol) and pyridine (1.355 mL, 16.75 mmol) in (?(? (15 mL) was added dropwise methanesulfonyl chloride (0.574 mL, 7.37 mmol) at 0 ¡ãC under nitrogen atmosphere. The reaction mixture was then allowed to warm to room temperature while stirring overnight. The reaction mixture was washed with saturated sodium bicarbonate solution, water, brine and dried over sodium sulfate. Evaporation of the solvent furnished a crude residue, which was subjected to BIOTAGE? (100percent methylene chloride) to give the title compound as a white solid (1.2g, 79percent). LC/MS: Example 105A (at) 2.88 min (RT) (Condition H). MS (ES): m/z=226.0, [M+H]+. XH NMR (400 MHz, MeOD) delta ppm 7.77 (1 hr, d, J=7.81 Hz), 7.59 (2 hr, d, J=1.26 Hz), 7.25-7.42 (2 hr, m), 2.94 (3 hr, s).

17402-83-4, As the paragraph descriping shows that 17402-83-4 is playing an increasingly important role.

Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; BALOG, James Aaron; HUANG, Audris; VELAPARTHI, Upender; LIU, Peiying; WO2013/49263; (2013); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

Downstream synthetic route of 17402-83-4

The synthetic route of 17402-83-4 has been constantly updated, and we look forward to future research findings.

17402-83-4, Benzo[b]thiophen-4-amine is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 122 N-(benzo[b]thiophen-4-yl)-6-methylthiazolo[3,2-b][1,2,4]triazole-2-sulphonamide The product of Example 1 stage (c) (1.1 g) was added portionwise with stirring to 4-aminobenzo(b)thiophene (0.7 g) in dimethylaniline (4 ml.). The mixture was allowed to stand for 3 days prior to treatment with dilute hydrochloric acid and ether. The precipitated solid was isolated by filtration, washed with dilute hydrochloric acid, water and ether, and dried to give 1.4 g of crude product. This solid was treated with dilute ammonia solution, filtered, and the filtrate acidified. The precipitated product was filtered off, washed with water and ether, and dried to give 0.8 g of desired product, mp 205¡ã-209¡ã C., 17402-83-4

The synthetic route of 17402-83-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Schering Agrochemicals; US4795483; (1989); A;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

Analyzing the synthesis route of 17402-83-4

17402-83-4 Benzo[b]thiophen-4-amine 298484, abenzothiophene compound, is more and more widely used in various fields.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17402-83-4,Benzo[b]thiophen-4-amine,as a common compound, the synthetic route is as follows.

Intermediate IV 74. 6g (0 ¡¤ 5mol), n-butanol 1300ml, bis (2-chloroethyl) amine hydrochloride 71. 5g (0 ¡¤ 5mol), and potassium carbonate 35g (0. 25mol), stirred suspension of and heated to reflux, the reaction 24h, the reaction end point TLC (developing solvent: ethyl acetate – methanol = 9: 1), completion of the reaction, cooled to room temperature, the supernatant was decanted, filtered, and the filtrates were combined The supernatant was concentrated to dryness and the crude product was recrystallized from methanol to give a white solid intermediate V (107g, 0 42mol.), a yield of 84percent, Murho: 214~217. . ., 17402-83-4

17402-83-4 Benzo[b]thiophen-4-amine 298484, abenzothiophene compound, is more and more widely used in various fields.

Reference£º
Patent; anhui yi xin ming pharmaceutical co. ltd; Xu, Hui; TAO, Jun-yu; LIU, JINGXING; (10 pag.)CN105399736; (2016); A;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

New learning discoveries about 17402-83-4

17402-83-4, The synthetic route of 17402-83-4 has been constantly updated, and we look forward to future research findings.

(Step 1) Diisopropylethylamine (0.10 ml) was added to a solution of ethyl 5-chloro-3-(methylthio)-1,2,4-triazine-6-carboxylate (70 mg) and benzo[b]thiophen-4-amine (70 mg) in THF (1 ml), and the reaction solution was stirred at room temperature for 35 minutes. The solvent was evaporated under vacuum, and then the resultant residue was purified by column chromatography on silica gel (developing solvent: hexane/ethyl acetate) to obtain ethyl 5-(benzo[b]thiophen-4-ylamino)-3-(methylthio)-1,2,4-triazine-6-carboxylate as a white solid.

17402-83-4, The synthetic route of 17402-83-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Taiho Pharmaceutical Co., Ltd.; SAKAMOTO, Toshihiro; MITA, Takashi; SHIBATA, Kazuaki; OGINO, Yoshio; KOMATANI, Hideya; EP2762476; (2014); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

Brief introduction of 17402-83-4

17402-83-4 Benzo[b]thiophen-4-amine 298484, abenzothiophene compound, is more and more widely used in various.

17402-83-4, Benzo[b]thiophen-4-amine is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(d) 71.4 g (0.2 mol) of compound (IV), 122 g (1.2 mol, 6 ep) of triethylamine, and 860 ml of dichloromethane were placed in a flask and stirred at 20¡ãC for 1 hour.A mixture of 55 g (0.48 mol, 2.4 ep) of methanesulfonyl chloride and 50 ml of chloroform was added dropwise, and the addition was completed for 3 hours. After completion of the dropwise addition, the reaction was stirred at 30¡ãC for 6 hours.After the disappearance of the compound (IV) raw material, 28.3 g of compound (II) was added.(0.19 mol, 0.95 ep), the reaction was warmed at reflux and the reaction was carried out for 8 hours.After the reaction is completed, cool to room temperature and add 100mlX3 water to wash.The polyester and the organic phase were dried over anhydrous sodium sulfate, suction-filtered, and concentrated. Ethyl acetate (400 ml) was added to the residue, and the mixture was stirred and dissolved. The crystal was crystallized at room temperature for 3 hours, and then cooled to 0¡ã C. and crystallized for 3 hours.It was suction filtered, rinsed with cold ethyl acetate and sucked dry to give a white solid: crude ipripiprazole (I). The crude product was dissolved in 400 ml of anhydrous ethanol, and hydrochloric acid was added dropwise at 20¡ã C., adjusting the pH to 2 and stirring for 1 hour. After cooling to 0¡ãC, the crystals were stirred for 4 hours. Filtering, rinsing with cold ethanol, and draining. The obtained hydrochloride was dissolved in 320 ml of purified water, and 10percent sodium carbonate solution was added dropwise at 20¡ãC. The pH was adjusted to 9. The addition was complete, and the mixture was stirred for 30 minutes. The retest pH was 9 and the mixture was stirred for 30 minutes. 100ml of water was rinsed, drained, and dried white solid 70g, yield 80.5percent.

17402-83-4 Benzo[b]thiophen-4-amine 298484, abenzothiophene compound, is more and more widely used in various.

Reference£º
Patent; Zhejiang Liaoyuan Pharmaceutical Co., Ltd.; Song Zhigang; Yang Minhua; Cui Jianfeng; Chen Weijun; (16 pag.)CN106831739; (2017); A;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

Brief introduction of 17402-83-4

17402-83-4 Benzo[b]thiophen-4-amine 298484, abenzothiophene compound, is more and more widely used in various.

17402-83-4, Benzo[b]thiophen-4-amine is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(Step 1) Sulfuryl chloride (0.30 ml) was added to ethyl 5-chloro-3-(methylthio)-1,2,4-triazine-6-carboxylate (234 mg), and the reaction solution was stirred at room temperature for 10 hours. The solvent was evaporated under vacuum, and the resultant residue was dissolved in THF (5 ml). Benzo[b]thiophen-4-amine (179 mg) and diisopropylethylamine (0.51 ml) were added, and the reaction solution was stirred at room temperature for 5 minutes. The reaction solution was diluted with ethyl acetate, and washed successively with an aqueous sodium bicarbonate solution and a saturated saline solution. After drying over anhydrous sodium sulfate, the solvent was evaporated under vacuum. The residue was purified by column chromatography on silica gel (developing solvent: hexane-ethyl acetate) to obtain ethyl 3-chloro-5-(benzo[b]thiophen-4-ylamino)-1,2,4-triazine-6-carboxylate as a white solid.

17402-83-4 Benzo[b]thiophen-4-amine 298484, abenzothiophene compound, is more and more widely used in various.