Category: 17402-83-4

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 17402-83-4, In a patent£¬Which mentioned a new discovery about 17402-83-4

PROCESS FOR THE PREPARATION OF BREXPIPRAZOLE

Processes for preparation of Brexpiprazole, intermediates used during preparation, and polymorphs of Brexpiprazole are provided.

Because enzymes can increase reaction rates by enormous factors and tend to be very specific, 17402-83-4, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 17402-83-4

Reference£º
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

17402-83-4, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In a patent, 17402-83-4, molecular formula is C8H7NS, introducing its new discovery.

Herbicides

The invention provides certain herbicidal thiazolotriazole sulphonamides, processes for their preparation, and compositions containing them, the compounds being of the formula: STR1 where: R1 and R2, which may be the same or different, each represent hydrogen, hydroxy, halo, cyano, substituted or unsubstituted alkyl, alkoxy, alkenyloxy, alkynyloxy, aryl, aralkyl, heteroaryl or carbamoyl, or a group –CORa or –CO2 Ra or where Ra is hydrogen or alkyl; or R1 and R2 together represent an alkylene chain of 3 or 4 carbon atoms; R3 represents a substituted or unsubstituted aryl, heterocyclyl or benzheterocyclyl group; and R4 represents hydrogen, an alkali-metal atom, an ammonium group, a substituted or unsubstituted alkyl, alkenyl, alkynyl, acyl, alkoxycarbonyl or aralkyl group, a heterocyclic group, or a group of the formula: STR2 where R1 and R2 are as defined hereinbefore.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.17402-83-4, you can also check out more blogs about17402-83-4

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Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

Chemistry is traditionally divided into organic and inorganic chemistry. 17402-83-4, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 17402-83-4

This new pharmaceutical use (6-1, 6-dihydro-2-yl) amide derivative, as the inhibitor of this preparation and AKT (PKB) phosphoenzyme (by machine translation)

The invention relates to the novel materials of formula (I), wherein each of the substituents R, R1, R2, R3, R4 and R5 is as defined herein. The materials are useful as inhibitors of AKT(PKB) phosphorylation.

One of the oldest and most widely used commercial enzyme inhibitors is aspirin, 17402-83-4, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 17402-83-4

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Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

In an article, published in an article,authors is Bonini, Carlo, once mentioned the application of 17402-83-4, Name is Benzo[b]thiophen-4-amine,molecular formula is C8H7NS, is a conventional compound. this article was the specific content is as follows. 17402-83-4

Smiles rearrangement for the synthesis of 5-amino-substituted [1]benzothieno[2,3-b]pyridine

The Smiles rearrangement was successfully applied to 4-hydroxybenzo[b]thiophene furnishing a facile entry to the 4-amino derivative. The rearrangement was extended to 5-methoxy-4-methoxycarbonyl[1]benzothieno[2,3-b]pyridine obtained via aza-Wittig/electrocyclization reaction of novel N-(4-methoxybenzothiophen-2-yl)iminomethyldiphenylphosphorane with methyl trans-4-oxo-2-pentenoate. The preparation of a novel 5-amino-4-methoxycarbonyl[1]benzothieno[2,3-b]pyridine, which is of interest as a potential secondary peptide structure mimic, was successfully achieved.

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Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

17402-83-4, Benzo[b]thiophen-4-amine is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

In a round bottom flask, 5.0 g 7-(4-(bis (2-chloroethyl) ammo) butoxy) quinolin-2(1H)-one, 20 ml n-butanol were taken at 25-35¡ã C. 2.29 g benzo[b]thiophen-4-amine was added into the reaction mixture at 25-35¡ã C. The reaction mixture was stirred at 110-125¡ã C. After completion of the reaction, the reaction mixture was cooled to 20-25 ¡ã C. and filtered and washed with toluene. The solid was dried in a hot air oven at 45-50¡ã C. to obtain brexpiprazole. The brexpiprazole can be purified by isopropanol and water. Yield: 90percent.

17402-83-4, As the paragraph descriping shows that 17402-83-4 is playing an increasingly important role.

Reference£º
Patent; CADILA HEALTHCARE LIMITED; DESAI, Sanjay Jagdish; PARIHAR, Jayprakash Ajitsingh; SHAH, Alpesh Pravinchandra; (21 pag.)US2017/320862; (2017); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

 

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17402-83-4,Benzo[b]thiophen-4-amine,as a common compound, the synthetic route is as follows.

Example 8 N2-(1 ,1-dioxido-1-benzothien-4-yl)-N4-(5-fluoro-1 H-indazol-3-yl)-2,4-pyrimidinediamineA solution of N-(2-chloro-4-pyrimidinyl)-5-fluoro-1 H-indazol-3-amine (25.00 mg, 0.095 mmol) and 1-benzothien-4-ylamine (14.15 mg, 0.095 mmol) in N-Methyl-2-pyrrolidone (NMP) (474 pi) was treated with 2 drops of 2N HCI in Et20 and stirred at 100 ¡ãC for 20 hours. Solid NaHC03 was added followed by oxone (58.3 mg, 0.095 mmol), and a few drops of water. The reaction was stirred at rt for 20 hours. The reaction mixture was filtered through a 0.2 muetaeta ptfe frit and diluted with MeOH then purified via prep HPLC using a Sunfire 5 pm, 30×150 mm, C18 column eluting with 25-65percent MeCN/water (with 0.1 percent TFA) to give the title compound as the TFA salt. 1H NMR (DMSO-d6) delta : 12.97 (s, 1 H), 9.32 (s, 1 H), 9.18 (s, 1 H), 8.18 (s, 1 H), 7.68 (d, J = 5.6 Hz, 1 H), 7.59 (dd, J = 9.0, 4.2 Hz, 1 H), 7.55 (d, J = 5.6 Hz, 1 H), 7.42 (d, J = 7.8 Hz, 1 H), 7.25 – 7.37 (m, 3H), 6.57 (t, J = 8.0 Hz, 1 H).; MS (m/z) 409 (M+H+).

17402-83-4, 17402-83-4 Benzo[b]thiophen-4-amine 298484, abenzothiophene compound, is more and more widely used in various fields.

Reference£º
Patent; GLAXO GROUP LIMITED; CASILLAS, Linda, N.; CHAKRAVORTY, Subhas, J.; CHARNLEY, Adam, Kenneth; EIDAM, Patrick; HAILE, Pamela, A.; HUGHES, Terry, Vincent; JEONG, Jae, U.; KANG, Jianxing; LAKDAWALA SHAH, Ami; LEISTER, Lara, Kathryn; MARQUIS, Robert, W.; MILLER, Nathan, Andrew; PRICE, Daniel, J.; SEHON, Clark, L.; WANG, Gren, Z.; ZHANG, Daohua; WO2011/120025; (2011); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

 

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17402-83-4,Benzo[b]thiophen-4-amine,as a common compound, the synthetic route is as follows.

General procedure: 2 ml of pyridine, 257 mg of N-[3-(dimethylamino)propyl]-N?-ethylcarbodiimide hydrochloride and 223 mg of benzo[B]thiophen-4-ylamine are added to a solution of 250 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate prepared in stage 2 of example 1, in 2 ml of N,N-dimethylformamide. The reaction mixture is stirred at ambient temperature for 15 hours, and then concentrated under reduced pressure. Water and ethyl acetate are added and the resulting mixture is thus stirred for 30 minutes. The precipitate formed is filtered off, and rinsed with water, ethyl ether and petroleum ether. The solid obtained is dried under vacuum. 262 mg of N-(1-benzothiophen-4-yl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide are obtained in the formed of an off-white solid

17402-83-4, As the paragraph descriping shows that 17402-83-4 is playing an increasingly important role.

Reference£º
Patent; Sanofi; Cali, Jean – Christophe; Sertar, Victor; Array, Frank; Carlson, Carl Andreas; Shio, Laulan; Thompson, Fabienne; (178 pag.)JP5680638; (2015); B2;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

 

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17402-83-4,Benzo[b]thiophen-4-amine,as a common compound, the synthetic route is as follows.

l-Benzothiophen-4-amine (3.3g, 0.022 mol) was added to a stirred solution of ((4-((2-oxo-l,2- dihydroquinolin-7-yl)oxy)butyl)azanediyl)bis(ethane-2,l-diyl)dimethanesulfonate (10 g, 0.021 mol) in toluene (90 ml) at 25-35¡ãC. Then potassium tertiary butoxide (7.1g, 0.063 mol) was added to the reaction mixture slowly. Completion of reaction was confirmed using thin layer chromatography (TLC). After completion of the reaction, water (50 ml) was added to reaction mixture and extracted. The organic phase was separated and evaporated under vacuum to obtain residue. Methanol (50 ml) was added to the residue and stirred for 2 h at 25-35¡ãC. The solid obtained was filtered, washed with methanol (20 ml) then dried to obtain the title product as off white solid (10 g)., 17402-83-4

As the paragraph descriping shows that 17402-83-4 is playing an increasingly important role.

Reference£º
Patent; AMNEAL PHARMACEUTICALS COMPANY GMBH; JAGTAP, Bhushan Nimba; BADGUJAR, Narendra Dattatray; MAHETA, Abhay Subodhbhai; BUTANI, Pankaj Chhaganbhai; AJUDIA, Paragkumar Vrujlal; KOILPILLAI, Joseph Prabahar; AGARWAL, Virendra Kumar; HEDAPARA, Kalpesh Ratilal; (96 pag.)WO2018/172463; (2018); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

 

17402-83-4, Benzo[b]thiophen-4-amine is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

14.92 g of 4-aminobenzothiophene, 17.85 g of bis(2-chloroethyl)amine hydrochloride and 11.13 g of sodium carbonate were dissolved in 120 mL of n-butanol.The reaction was refluxed for 6 h, and cooled to give benzo[b]thiophen-4-ylpiperazine hydrochloride. The benzo[b]thiophen-4-ylpiperazine hydrochloride was dissolved in water, adjusted to pH 12 with 2 mol/L NaOH, and extracted with ethyl acetate.The ethyl acetate extract was washed successively with saturated sodium chloride solution and deionized water until neutral.Drying with anhydrous sodium sulfate, removing the solvent to obtain benzo[b]thiophen-4-ylpiperazine;, 17402-83-4

The synthetic route of 17402-83-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Wuhan Xing Hua Knowledge Pharmaceutical Technology Co., Ltd.; Lu Shan; Chen Jingrun; Zhang Chuantao; (16 pag.)CN109988162; (2019); A;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

 

17402-83-4, Benzo[b]thiophen-4-amine is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

4-Aminobenzo [b] thiophene 14. 92 g(100 mmol) was added to the reaction flask with di (2-chloroethyl) amine hydrochloride and 85 g (5 mmol) of p-toluenesulfonamide and 225 mL of xylene were added at 120 to 150 ¡ã C C under stirring for 16 hours. And then naturally dropped to room temperature, and then reduced to 0 ¡ã C for 2 hours, filtered to obtain white solid crystal 21. 66g, the yield of 85. 0percent, 98percent purity.

17402-83-4, The synthetic route of 17402-83-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Shenzhen Foncoo Pharmaceutical Co., Ltd.,; Peng, Jin An; Zhou, Gewen; (6 pag.)CN105461703; (2016); A;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem