Category: 17402-83-4

New Advances in Chemical Research in 2021. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction by binding to a specific portion of an enzyme and thus slowing or preventing a reaction from occurring. COA of Formula: C8H7NS, In an article, mentioned the application of 17402-83-4, Name is Benzo[b]thiophen-4-amine, molecular formula is C8H7NS

We present the fabrication of highly durable catalysts with the functionalized carbon nanotube (CNT) via diazonium chemistry for polymer electrolyte membrane fuel cell (PEMFC). The functionalization of the CNT with the thiolphenyl groups by diazonium coupling reaction was shown to enhance the dispersion of Pt nanoparticles with narrow size distribution deposited on the CNT surfaces as well as their electrochemical stability. The electrochemical analysis demonstrates that the Pt/functionalized CNT show higher electrochemical durability and catalytic activity than the Pt/unmodified CNT. The enhanced electrochemical performance of the Pt/functionalized CNT is attributed to the uniform distribution of Pt nanoparticles with smaller size and the strong interaction between Pt and the functionalized CNT support through the formation of Pt-sulfur bonding. This study shows that this simple functionalization of CNT by the in situ grafting of the thiolphenyl groups as the linker onto the surface is an effective way to fabricate a highly durable Pt catalyst for PEMFC, thus providing a design guide of the functionalized CNT support catalyst with a great potential as a PEMFC catalyst.

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New Advances in Chemical Research in 2021. Chemistry is a science major with cience and engineering. The main research directions are chemical synthesis, new energy materials, preparation and modification of special coatings. 17402-83-4. Introducing a new discovery about 17402-83-4, Name is Benzo[b]thiophen-4-amine

The Smiles rearrangement was successfully applied to 4-hydroxybenzo[b]thiophene furnishing a facile entry to the 4-amino derivative. The rearrangement was extended to 5-methoxy-4-methoxycarbonyl[1]benzothieno[2,3-b]pyridine obtained via aza-Wittig/electrocyclization reaction of novel N-(4-methoxybenzothiophen-2-yl)iminomethyldiphenylphosphorane with methyl trans-4-oxo-2-pentenoate. The preparation of a novel 5-amino-4-methoxycarbonyl[1]benzothieno[2,3-b]pyridine, which is of interest as a potential secondary peptide structure mimic, was successfully achieved.

The result showed that such a combination of chemo- and biocatalysis improved the catalytic yield more than two times compared with that of sole metal catalysis.I hope my blog about 17402-83-4 is helpful to your research.

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17402-83-4, Chemical Research Letters, May 2021. This type of reactivity has quickly become one of the cornerstones of modern catalysis . In a article, 17402-83-4, molcular formula is C8H7NS, introducing its new discovery.

Disclosed are azaindazole compounds of Formula (I): or a pharmaceutically acceptable salt thereof, wherein: X is O and Y is N; or X is S and Y is CH; Z is CR2 or N; Q is a heteroaryl; and R1 is defined herein. Also disclosed are methods of using such compounds in the treatment of at least one CYP 17 associated condition, such as, for example, cancer, and pharmaceutical compositions comprising such compounds.

Because enzymes can increase reaction rates by enormous factors and tend to be very specific, 17402-83-4, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 17402-83-4

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New Advances in Chemical Research, May 2021. The prevalence of solvent effects in heterogeneous catalysis in condensed media has motivated developing quantitative kinetic, and theoretical assessments of solvent structures and transition states. Application In Synthesis of Benzo[b]thiophen-4-amine, C8H7NS. A document type is Article, introducing its new discovery., Application In Synthesis of Benzo[b]thiophen-4-amine

SGC-GAK-1 (1) is a potent, selective, cell-active chemical probe for cyclin G-associated kinase (GAK). However, 1 was rapidly metabolized in mouse liver microsomes by cytochrome P450-mediated oxidation, displaying rapid clearance in liver microsomes and in mice, which limited its utility in in vivo studies. Chemical modifications of 1 that improved metabolic stability, generally resulted in decreased GAK potency. The best analog in terms of GAK activity in cells was 6-bromo-N-(1H-indazol-6-yl)quinolin-4-amine (35) (IC50 = 1.4 muM), showing improved stability in liver microsomes while still maintaining a narrow spectrum activity across the kinome. As an alternative to scaold modifications we also explored the use of the broad-spectrum cytochrome P450 inhibitor 1-aminobenzotriazole (ABT) to decrease intrinsic clearance of aminoquinoline GAK inhibitors. Taken together, these approaches point towards the development of an in vivo chemical probe for the dark kinase GAK.

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Synthetic Route of 17402-83-4, New research progress on 17402-83-4 in 2021. The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. In a article, 17402-83-4, molcular formula is C8H7NS, introducing its new discovery.

The invention provides a method for synthesizing according to the matching of the paipai zuo preparation method, specific steps are as follows: to 4 – nitrobenzene [b] thiophene as raw materials hydrogenation reaction synthetic intermediate compound (II), in order to 7 – hydroxy – 1H – quinoline – 2 – ketone as a raw material 1st step reaction to synthesize compound (III), 2nd step to obtain the intermediate compound (IV). Then the intermediate compound (II) and (IV) intermediate compound condensation to obtain the target compound (I), namely according to the paipai zuo. The invention the whole synthetic route of the reaction raw materials, simple operation, low operation cost, environmental protection, and the various steps in the yield of the reaction is high, it is very suitable for industrial production, has a very high industrial application value. (by machine translation)

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 17402-83-4

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Chemical Research Letters, May 2021. Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction.Product Details of 17402-83-4, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 17402-83-4, Name is Benzo[b]thiophen-4-amine, molecular formula is C8H7NS

The present invention provides a new method for preparing according to […], which belongs to the technical field of pharmaceutical and chemical synthesis. It solves the problem that the existing according to[…] of the preparation method of the impurity is high, the yield is low, the problem of serious pollution. This method, in order to 4-hydroxybenzene and thiophene as the starting material 4 is prepared by the step of reaction intermediates V, to 7-hydroxy-2-quinolone by 2 VII is prepared by the step of reaction intermediates, intermediate V and intermediates prepared by condensation VII clinical medicine […]according to. The raw materials of this invention is easy to obtain, the price is low, the operation is simple, mild reaction conditions, has excellent industrial application value. (by machine translation)

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Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction by binding to a specific portion of an enzyme and thus slowing or preventing a reaction from occurring. Recommanded Product: 17402-83-4, C8H7NS. A document type is Patent, introducing its new discovery., Recommanded Product: 17402-83-4

Provided are a pyrimidinyl amino compound having protein kinase inhibitor activity, and a pharmaceutical composition containing said compound; also provided are a use and application of said compound. What is provided is selected from a group consisting of the compound represented by formula (I), a stereoisomer thereof, a tautomer thereof, a pharmacologically acceptable salt thereof, a solvate thereof, and a prodrug thereof. The described compound has good inhibitory activity against the JAK family of kinases and the SYK family of kinases, and therefore may serve as a JAK inhibitor and SYK inhibitor, and is effective in use for the prevention or treatment of diseases related to the JAK and SYK families of kinases.

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Benzothiophene – Wikipedia,
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New Advances in Chemical Research in 2021. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction by binding to a specific portion of an enzyme and thus slowing or preventing a reaction from occurring. Product Details of 17402-83-4, In an article, mentioned the application of 17402-83-4, Name is Benzo[b]thiophen-4-amine, molecular formula is C8H7NS

Disclosed are compounds having the formula: or a salt thereof, wherein A, n, R1, R1A, and R2 are as defined herein, and methods of making and using the same

The potential utility of systematic synthetic strategy will be applicable to efficient generations of chemical libraries of compounds to find ‘hit’ molecules.Read on for other articles about 17402-83-4

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Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Synthetic Route of 17402-83-4, Chemical Research Letters, May 2021. The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. In a article, 17402-83-4, molcular formula is C8H7NS, introducing its new discovery.

The present invention provides a compound represented by the following general formula (I) or a salt thereof which has a Syk inhibitory effect (in the formula R1 represents a hydrogen atom or an optionally Ra-substituted C1-C6 alkyl group; A represents a hydrogen atom, an optionally Ra-substituted C1-C8 alkyl group, an optionally Ra-substituted C2-C6 alkenyl group, an optionally Ra-substituted C2-C6 alkynyl group, an optionally Rb-substituted C3-C10 cycloalkyl group, an optionally Rb-substituted C6-C14 aromatic hydrocarbon group, an optionally Rb-substituted 4- to 10-membered unsaturated heterocyclic group, or an optionally Rb-substituted 4-to 10-membered saturated heterocyclic group, or optionally forms a 4- to 10-membered unsaturated heterocyclic ring or a 4- to 10-membered saturated heterocyclic ring together with R1 and the nitrogen atom bonded thereto; R2 represents a hydrogen atom or an optionally Ra-substituted C1-C6 alkyl group; and B represents an optionally Rc-substituted unsaturated heterocyclic group).

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Synthetic Route of 17402-83-4. In my other articles, you can also check out more blogs about 17402-83-4

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Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

New Advances in Chemical Research in 2021. Chemistry is a science major with cience and engineering. The main research directions are chemical synthesis, new energy materials, preparation and modification of special coatings. 17402-83-4. Introducing a new discovery about 17402-83-4, Name is Benzo[b]thiophen-4-amine

The invention relates to the novel materials of formula (I), wherein each of the substituents R, R1, R2, R3, R4 and R5 is as defined herein. The materials are useful as inhibitors of AKT(PKB) phosphorylation.

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Reference：
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem